DUF676 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative serine esterase (DUF676), putative

Species:

Leishmania mexicana

UniProt:

E9B066_LEIMU

TriTrypDb:

LmxM.28.2445

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B066

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B066

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.566
CLV_MEL_PAP_1	270	276	PF00089	0.454
CLV_NRD_NRD_1	16	18	PF00675	0.396
CLV_NRD_NRD_1	207	209	PF00675	0.478
CLV_NRD_NRD_1	245	247	PF00675	0.393
CLV_NRD_NRD_1	395	397	PF00675	0.606
CLV_NRD_NRD_1	53	55	PF00675	0.331
CLV_NRD_NRD_1	68	70	PF00675	0.316
CLV_NRD_NRD_1	94	96	PF00675	0.413
CLV_PCSK_KEX2_1	110	112	PF00082	0.311
CLV_PCSK_KEX2_1	207	209	PF00082	0.492
CLV_PCSK_KEX2_1	245	247	PF00082	0.361
CLV_PCSK_KEX2_1	272	274	PF00082	0.548
CLV_PCSK_KEX2_1	395	397	PF00082	0.578
CLV_PCSK_KEX2_1	68	70	PF00082	0.357
CLV_PCSK_KEX2_1	94	96	PF00082	0.413
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.203
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.419
CLV_PCSK_SKI1_1	156	160	PF00082	0.337
CLV_PCSK_SKI1_1	195	199	PF00082	0.386
CLV_PCSK_SKI1_1	200	204	PF00082	0.440
CLV_PCSK_SKI1_1	245	249	PF00082	0.362
CLV_PCSK_SKI1_1	357	361	PF00082	0.397
CLV_PCSK_SKI1_1	438	442	PF00082	0.492
CLV_PCSK_SKI1_1	71	75	PF00082	0.540
CLV_Separin_Metazoa	14	18	PF03568	0.408
DEG_APCC_DBOX_1	155	163	PF00400	0.337
DEG_APCC_DBOX_1	244	252	PF00400	0.473
DEG_Nend_UBRbox_2	1	3	PF02207	0.617
DOC_CKS1_1	187	192	PF01111	0.393
DOC_MAPK_DCC_7	357	367	PF00069	0.425
DOC_MAPK_gen_1	17	27	PF00069	0.435
DOC_MAPK_gen_1	195	204	PF00069	0.339
DOC_MAPK_gen_1	242	251	PF00069	0.437
DOC_MAPK_gen_1	68	75	PF00069	0.336
DOC_MAPK_gen_1	94	102	PF00069	0.468
DOC_MAPK_MEF2A_6	18	27	PF00069	0.290
DOC_MAPK_MEF2A_6	242	251	PF00069	0.319
DOC_MAPK_MEF2A_6	95	104	PF00069	0.365
DOC_PP1_RVXF_1	138	144	PF00149	0.467
DOC_PP2B_LxvP_1	342	345	PF13499	0.379
DOC_PP4_FxxP_1	372	375	PF00568	0.280
DOC_PP4_FxxP_1	74	77	PF00568	0.375
DOC_USP7_MATH_1	10	14	PF00917	0.567
DOC_USP7_MATH_1	277	281	PF00917	0.364
DOC_USP7_MATH_1	482	486	PF00917	0.532
DOC_USP7_UBL2_3	106	110	PF12436	0.203
DOC_USP7_UBL2_3	134	138	PF12436	0.203
DOC_USP7_UBL2_3	420	424	PF12436	0.285
DOC_USP7_UBL2_3	51	55	PF12436	0.453
DOC_WW_Pin1_4	186	191	PF00397	0.390
DOC_WW_Pin1_4	336	341	PF00397	0.562
DOC_WW_Pin1_4	54	59	PF00397	0.532
LIG_14-3-3_CanoR_1	357	365	PF00244	0.386
LIG_14-3-3_CanoR_1	378	385	PF00244	0.491
LIG_14-3-3_CanoR_1	47	51	PF00244	0.335
LIG_14-3-3_CanoR_1	54	58	PF00244	0.330
LIG_Actin_WH2_2	143	158	PF00022	0.437
LIG_BRCT_BRCA1_1	260	264	PF00533	0.357
LIG_CSL_BTD_1	342	345	PF09270	0.379
LIG_deltaCOP1_diTrp_1	178	184	PF00928	0.370
LIG_EH1_1	147	155	PF00400	0.337
LIG_EH1_1	434	442	PF00400	0.327
LIG_eIF4E_1	435	441	PF01652	0.459
LIG_FHA_1	123	129	PF00498	0.433
LIG_FHA_1	187	193	PF00498	0.492
LIG_FHA_1	20	26	PF00498	0.438
LIG_FHA_1	221	227	PF00498	0.238
LIG_FHA_1	265	271	PF00498	0.517
LIG_FHA_1	55	61	PF00498	0.373
LIG_FHA_2	230	236	PF00498	0.203
LIG_FHA_2	279	285	PF00498	0.610
LIG_FHA_2	47	53	PF00498	0.399
LIG_FHA_2	478	484	PF00498	0.531
LIG_LIR_Apic_2	371	375	PF02991	0.273
LIG_LIR_Gen_1	167	176	PF02991	0.390
LIG_LIR_Gen_1	178	188	PF02991	0.312
LIG_LIR_Gen_1	37	45	PF02991	0.348
LIG_LIR_Nem_3	167	173	PF02991	0.378
LIG_LIR_Nem_3	178	184	PF02991	0.290
LIG_LIR_Nem_3	37	42	PF02991	0.469
LIG_LIR_Nem_3	427	432	PF02991	0.392
LIG_LYPXL_yS_3	425	428	PF13949	0.544
LIG_MYND_1	340	344	PF01753	0.545
LIG_MYND_1	450	454	PF01753	0.390
LIG_SH2_STAP1	260	264	PF00017	0.434
LIG_SH2_STAT3	96	99	PF00017	0.365
LIG_SH2_STAT5	236	239	PF00017	0.301
LIG_SH2_STAT5	41	44	PF00017	0.364
LIG_SH2_STAT5	435	438	PF00017	0.460
LIG_SH2_STAT5	96	99	PF00017	0.413
LIG_SH3_3	271	277	PF00018	0.393
LIG_SH3_3	391	397	PF00018	0.397
LIG_SH3_3	448	454	PF00018	0.590
LIG_SH3_3	478	484	PF00018	0.675
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.260
LIG_SUMO_SIM_par_1	476	483	PF11976	0.483
LIG_TRAF2_1	172	175	PF00917	0.203
LIG_TRAF2_1	281	284	PF00917	0.583
LIG_TRAF2_1	324	327	PF00917	0.436
LIG_WW_3	18	22	PF00397	0.490
MOD_CDK_SPK_2	54	59	PF00069	0.422
MOD_CK2_1	277	283	PF00069	0.510
MOD_CK2_1	320	326	PF00069	0.430
MOD_CK2_1	477	483	PF00069	0.589
MOD_Cter_Amidation	418	421	PF01082	0.270
MOD_GlcNHglycan	143	146	PF01048	0.386
MOD_GlcNHglycan	380	383	PF01048	0.531
MOD_GlcNHglycan	447	450	PF01048	0.468
MOD_GlcNHglycan	483	487	PF01048	0.668
MOD_GSK3_1	122	129	PF00069	0.356
MOD_GSK3_1	196	203	PF00069	0.271
MOD_GSK3_1	256	263	PF00069	0.300
MOD_GSK3_1	441	448	PF00069	0.562
MOD_NEK2_1	141	146	PF00069	0.437
MOD_NEK2_1	183	188	PF00069	0.246
MOD_NEK2_1	220	225	PF00069	0.341
MOD_NEK2_1	258	263	PF00069	0.356
MOD_NEK2_1	441	446	PF00069	0.454
MOD_NEK2_1	53	58	PF00069	0.341
MOD_NEK2_2	46	51	PF00069	0.278
MOD_PK_1	424	430	PF00069	0.426
MOD_PKA_2	377	383	PF00069	0.601
MOD_PKA_2	46	52	PF00069	0.282
MOD_PKA_2	53	59	PF00069	0.331
MOD_Plk_1	116	122	PF00069	0.440
MOD_Plk_1	253	259	PF00069	0.473
MOD_Plk_2-3	230	236	PF00069	0.203
MOD_Plk_4	200	206	PF00069	0.301
MOD_Plk_4	222	228	PF00069	0.393
MOD_Plk_4	253	259	PF00069	0.431
MOD_Plk_4	424	430	PF00069	0.518
MOD_ProDKin_1	186	192	PF00069	0.390
MOD_ProDKin_1	336	342	PF00069	0.556
MOD_ProDKin_1	54	60	PF00069	0.535
TRG_DiLeu_BaEn_1	244	249	PF01217	0.246
TRG_ENDOCYTIC_2	425	428	PF00928	0.508
TRG_ER_diArg_1	207	209	PF00400	0.478
TRG_ER_diArg_1	245	247	PF00400	0.393
TRG_ER_diArg_1	394	396	PF00400	0.592
TRG_ER_diArg_1	68	71	PF00400	0.356
TRG_ER_diArg_1	75	78	PF00400	0.185
TRG_ER_diArg_1	94	96	PF00400	0.413
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P6	Leptomonas seymouri	41%	100%
A0A1X0NR47	Trypanosomatidae	27%	100%
A0A3Q8IQU6	Leishmania donovani	67%	100%
A0A3R7K6Z5	Trypanosoma rangeli	28%	100%
A4HGU8	Leishmania braziliensis	51%	100%
A4I3X6	Leishmania infantum	67%	100%
D0A944	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%