NTP_transferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B065_LEIMU

TriTrypDb:

LmxM.28.2440

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005851	eukaryotic translation initiation factor 2B complex	2	1
GO:0032045	guanyl-nucleotide exchange factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

E9B065

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B065

Function

Biological processes
Term	Name	Level	Count
GO:0002183	cytoplasmic translational initiation	4	1
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0009058	biosynthetic process	2	6

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003743	translation initiation factor activity	4	1
GO:0003824	catalytic activity	1	7
GO:0005085	guanyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016779	nucleotidyltransferase activity	4	7
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0045182	translation regulator activity	1	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1
GO:0140678	molecular function inhibitor activity	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0008879	glucose-1-phosphate thymidylyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.320
CLV_C14_Caspase3-7	449	453	PF00656	0.494
CLV_C14_Caspase3-7	588	592	PF00656	0.529
CLV_NRD_NRD_1	228	230	PF00675	0.593
CLV_NRD_NRD_1	352	354	PF00675	0.374
CLV_NRD_NRD_1	389	391	PF00675	0.493
CLV_PCSK_KEX2_1	230	232	PF00082	0.678
CLV_PCSK_KEX2_1	352	354	PF00082	0.374
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.678
CLV_PCSK_PC7_1	226	232	PF00082	0.605
CLV_PCSK_SKI1_1	110	114	PF00082	0.471
CLV_PCSK_SKI1_1	190	194	PF00082	0.337
CLV_PCSK_SKI1_1	317	321	PF00082	0.468
CLV_PCSK_SKI1_1	33	37	PF00082	0.311
CLV_PCSK_SKI1_1	372	376	PF00082	0.454
CLV_PCSK_SKI1_1	391	395	PF00082	0.411
CLV_PCSK_SKI1_1	523	527	PF00082	0.576
CLV_PCSK_SKI1_1	57	61	PF00082	0.365
DEG_APCC_DBOX_1	371	379	PF00400	0.449
DEG_APCC_DBOX_1	522	530	PF00400	0.585
DEG_SCF_FBW7_2	48	53	PF00400	0.376
DEG_SPOP_SBC_1	284	288	PF00917	0.570
DOC_CKS1_1	412	417	PF01111	0.474
DOC_MAPK_gen_1	108	115	PF00069	0.449
DOC_MAPK_gen_1	352	358	PF00069	0.395
DOC_MAPK_gen_1	390	396	PF00069	0.493
DOC_MAPK_gen_1	418	425	PF00069	0.516
DOC_MAPK_MEF2A_6	418	425	PF00069	0.516
DOC_PP1_RVXF_1	39	46	PF00149	0.447
DOC_PP2B_LxvP_1	445	448	PF13499	0.559
DOC_PP4_FxxP_1	412	415	PF00568	0.397
DOC_PP4_FxxP_1	524	527	PF00568	0.618
DOC_USP7_MATH_1	122	126	PF00917	0.559
DOC_USP7_MATH_1	160	164	PF00917	0.659
DOC_USP7_MATH_1	254	258	PF00917	0.521
DOC_USP7_MATH_1	280	284	PF00917	0.662
DOC_USP7_MATH_1	285	289	PF00917	0.686
DOC_USP7_MATH_1	382	386	PF00917	0.400
DOC_USP7_MATH_1	490	494	PF00917	0.601
DOC_USP7_MATH_1	525	529	PF00917	0.748
DOC_USP7_MATH_1	554	558	PF00917	0.624
DOC_USP7_MATH_1	562	566	PF00917	0.522
DOC_USP7_MATH_1	632	636	PF00917	0.342
DOC_USP7_UBL2_3	104	108	PF12436	0.417
DOC_WW_Pin1_4	142	147	PF00397	0.738
DOC_WW_Pin1_4	309	314	PF00397	0.734
DOC_WW_Pin1_4	411	416	PF00397	0.479
DOC_WW_Pin1_4	46	51	PF00397	0.432
LIG_14-3-3_CanoR_1	182	189	PF00244	0.504
LIG_14-3-3_CanoR_1	212	218	PF00244	0.494
LIG_14-3-3_CanoR_1	317	326	PF00244	0.465
LIG_14-3-3_CanoR_1	399	407	PF00244	0.317
LIG_14-3-3_CanoR_1	616	623	PF00244	0.430
LIG_Actin_WH2_2	100	116	PF00022	0.508
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BRCT_BRCA1_1	74	78	PF00533	0.562
LIG_Clathr_ClatBox_1	201	205	PF01394	0.484
LIG_EVH1_2	595	599	PF00568	0.520
LIG_FHA_1	197	203	PF00498	0.384
LIG_FHA_1	219	225	PF00498	0.490
LIG_FHA_1	257	263	PF00498	0.584
LIG_FHA_1	268	274	PF00498	0.511
LIG_FHA_1	402	408	PF00498	0.381
LIG_FHA_1	449	455	PF00498	0.465
LIG_FHA_1	47	53	PF00498	0.385
LIG_FHA_1	502	508	PF00498	0.721
LIG_FHA_1	599	605	PF00498	0.409
LIG_FHA_1	616	622	PF00498	0.298
LIG_FHA_1	639	645	PF00498	0.392
LIG_FHA_2	118	124	PF00498	0.565
LIG_FHA_2	26	32	PF00498	0.406
LIG_FHA_2	412	418	PF00498	0.477
LIG_FHA_2	457	463	PF00498	0.316
LIG_FHA_2	571	577	PF00498	0.616
LIG_FHA_2	96	102	PF00498	0.348
LIG_LIR_Apic_2	409	415	PF02991	0.428
LIG_LIR_Gen_1	211	222	PF02991	0.435
LIG_LIR_Gen_1	65	74	PF02991	0.397
LIG_LIR_Gen_1	82	92	PF02991	0.312
LIG_LIR_Nem_3	211	217	PF02991	0.452
LIG_LIR_Nem_3	478	483	PF02991	0.334
LIG_LIR_Nem_3	53	59	PF02991	0.363
LIG_LIR_Nem_3	65	70	PF02991	0.327
LIG_LIR_Nem_3	75	81	PF02991	0.389
LIG_LIR_Nem_3	82	88	PF02991	0.273
LIG_MAD2	650	658	PF02301	0.351
LIG_MYND_1	527	531	PF01753	0.608
LIG_Pex14_1	373	377	PF04695	0.363
LIG_Pex14_2	56	60	PF04695	0.455
LIG_SH2_CRK	214	218	PF00017	0.382
LIG_SH2_CRK	225	229	PF00017	0.386
LIG_SH2_CRK	480	484	PF00017	0.470
LIG_SH2_CRK	67	71	PF00017	0.357
LIG_SH2_GRB2like	333	336	PF00017	0.433
LIG_SH2_PTP2	85	88	PF00017	0.470
LIG_SH2_SRC	333	336	PF00017	0.470
LIG_SH2_STAP1	214	218	PF00017	0.451
LIG_SH2_STAP1	258	262	PF00017	0.389
LIG_SH2_STAT5	106	109	PF00017	0.358
LIG_SH2_STAT5	258	261	PF00017	0.427
LIG_SH2_STAT5	333	336	PF00017	0.445
LIG_SH2_STAT5	368	371	PF00017	0.285
LIG_SH2_STAT5	73	76	PF00017	0.355
LIG_SH2_STAT5	85	88	PF00017	0.340
LIG_SH3_3	565	571	PF00018	0.524
LIG_SH3_3	590	596	PF00018	0.542
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.470
LIG_SUMO_SIM_par_1	198	205	PF11976	0.436
LIG_SUMO_SIM_par_1	569	576	PF11976	0.608
LIG_TRAF2_1	266	269	PF00917	0.337
LIG_TRFH_1	85	89	PF08558	0.349
LIG_TYR_ITAM	211	228	PF00017	0.409
LIG_TYR_ITIM	223	228	PF00017	0.251
LIG_WRC_WIRS_1	206	211	PF05994	0.455
LIG_WRC_WIRS_1	586	591	PF05994	0.447
MOD_CDK_SPxxK_3	411	418	PF00069	0.477
MOD_CK1_1	147	153	PF00069	0.546
MOD_CK1_1	196	202	PF00069	0.310
MOD_CK1_1	2	8	PF00069	0.529
MOD_CK1_1	216	222	PF00069	0.349
MOD_CK1_1	283	289	PF00069	0.571
MOD_CK1_1	309	315	PF00069	0.708
MOD_CK1_1	385	391	PF00069	0.382
MOD_CK1_1	400	406	PF00069	0.304
MOD_CK1_1	435	441	PF00069	0.536
MOD_CK2_1	117	123	PF00069	0.554
MOD_CK2_1	147	153	PF00069	0.633
MOD_CK2_1	205	211	PF00069	0.519
MOD_CK2_1	25	31	PF00069	0.489
MOD_CK2_1	309	315	PF00069	0.757
MOD_CK2_1	411	417	PF00069	0.465
MOD_CK2_1	443	449	PF00069	0.594
MOD_CK2_1	456	462	PF00069	0.298
MOD_CK2_1	570	576	PF00069	0.605
MOD_CK2_1	666	672	PF00069	0.533
MOD_GlcNHglycan	139	143	PF01048	0.696
MOD_GlcNHglycan	160	163	PF01048	0.806
MOD_GlcNHglycan	184	187	PF01048	0.592
MOD_GlcNHglycan	249	252	PF01048	0.710
MOD_GlcNHglycan	282	285	PF01048	0.677
MOD_GlcNHglycan	294	297	PF01048	0.718
MOD_GlcNHglycan	304	307	PF01048	0.612
MOD_GlcNHglycan	308	311	PF01048	0.593
MOD_GlcNHglycan	380	383	PF01048	0.415
MOD_GlcNHglycan	433	437	PF01048	0.616
MOD_GlcNHglycan	488	491	PF01048	0.479
MOD_GlcNHglycan	540	543	PF01048	0.790
MOD_GlcNHglycan	550	553	PF01048	0.584
MOD_GlcNHglycan	556	559	PF01048	0.438
MOD_GSK3_1	138	145	PF00069	0.735
MOD_GSK3_1	166	173	PF00069	0.726
MOD_GSK3_1	256	263	PF00069	0.417
MOD_GSK3_1	279	286	PF00069	0.661
MOD_GSK3_1	292	299	PF00069	0.731
MOD_GSK3_1	302	309	PF00069	0.621
MOD_GSK3_1	378	385	PF00069	0.371
MOD_GSK3_1	397	404	PF00069	0.415
MOD_GSK3_1	486	493	PF00069	0.541
MOD_GSK3_1	585	592	PF00069	0.421
MOD_GSK3_1	634	641	PF00069	0.377
MOD_N-GLC_1	664	669	PF02516	0.548
MOD_NEK2_1	298	303	PF00069	0.682
MOD_NEK2_1	397	402	PF00069	0.358
MOD_NEK2_1	589	594	PF00069	0.408
MOD_PIKK_1	296	302	PF00454	0.708
MOD_PIKK_1	397	403	PF00454	0.359
MOD_PIKK_1	490	496	PF00454	0.602
MOD_PK_1	144	150	PF00069	0.585
MOD_PKA_2	343	349	PF00069	0.478
MOD_PKA_2	615	621	PF00069	0.339
MOD_Plk_1	254	260	PF00069	0.588
MOD_Plk_1	354	360	PF00069	0.430
MOD_Plk_1	385	391	PF00069	0.506
MOD_Plk_2-3	117	123	PF00069	0.554
MOD_Plk_2-3	205	211	PF00069	0.493
MOD_Plk_4	144	150	PF00069	0.601
MOD_Plk_4	196	202	PF00069	0.310
MOD_Plk_4	205	211	PF00069	0.347
MOD_Plk_4	31	37	PF00069	0.446
MOD_Plk_4	456	462	PF00069	0.327
MOD_Plk_4	525	531	PF00069	0.766
MOD_Plk_4	562	568	PF00069	0.481
MOD_Plk_4	585	591	PF00069	0.416
MOD_Plk_4	617	623	PF00069	0.356
MOD_Plk_4	634	640	PF00069	0.424
MOD_Plk_4	651	657	PF00069	0.454
MOD_Plk_4	666	672	PF00069	0.399
MOD_ProDKin_1	142	148	PF00069	0.739
MOD_ProDKin_1	309	315	PF00069	0.735
MOD_ProDKin_1	411	417	PF00069	0.480
MOD_ProDKin_1	46	52	PF00069	0.440
TRG_DiLeu_BaEn_1	269	274	PF01217	0.360
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.398
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.432
TRG_ENDOCYTIC_2	214	217	PF00928	0.364
TRG_ENDOCYTIC_2	225	228	PF00928	0.367
TRG_ENDOCYTIC_2	480	483	PF00928	0.359
TRG_ENDOCYTIC_2	67	70	PF00928	0.353
TRG_ENDOCYTIC_2	85	88	PF00928	0.340
TRG_ER_diArg_1	228	231	PF00400	0.616
TRG_ER_diArg_1	352	354	PF00400	0.383
TRG_NLS_MonoExtN_4	226	233	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	481	486	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCH8	Leptomonas seymouri	66%	100%
A0A0S4IV50	Bodo saltans	31%	100%
A0A1X0NS55	Trypanosomatidae	38%	100%
A0A3R7REE6	Trypanosoma rangeli	35%	100%
A0A3S7X1Y8	Leishmania donovani	93%	100%
A4HGU7	Leishmania braziliensis	82%	100%
A4I3X5	Leishmania infantum	93%	100%
D0A943	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q820	Leishmania major	95%	100%
V5BC43	Trypanosoma cruzi	36%	100%