Protein RFT1 homolog

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichyl-lipid chaperone, putative

Species:

Leishmania mexicana

UniProt:

E9B062_LEIMU

TriTrypDb:

LmxM.28.2410

Length:

728

Annotations

LeishMANIAdb annotations

Highly conserved Eukaryotic protein. Involved in N-linked oligosaccharide assembly.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B062

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B062

Function

Biological processes
Term	Name	Level	Count
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	11
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	11
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006810	transport	3	1
GO:0006869	lipid transport	5	1
GO:0016043	cellular component organization	3	1
GO:0034203	glycolipid translocation	5	1
GO:0034204	lipid translocation	4	1
GO:0046836	glycolipid transport	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0061024	membrane organization	4	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071702	organic substance transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097035	regulation of membrane lipid distribution	3	1
GO:1901264	carbohydrate derivative transport	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.533
CLV_C14_Caspase3-7	372	376	PF00656	0.567
CLV_NRD_NRD_1	173	175	PF00675	0.671
CLV_NRD_NRD_1	381	383	PF00675	0.386
CLV_NRD_NRD_1	704	706	PF00675	0.641
CLV_NRD_NRD_1	718	720	PF00675	0.667
CLV_PCSK_KEX2_1	381	383	PF00082	0.386
CLV_PCSK_KEX2_1	703	705	PF00082	0.610
CLV_PCSK_KEX2_1	718	720	PF00082	0.656
CLV_PCSK_SKI1_1	24	28	PF00082	0.355
CLV_PCSK_SKI1_1	276	280	PF00082	0.529
CLV_PCSK_SKI1_1	36	40	PF00082	0.396
CLV_PCSK_SKI1_1	360	364	PF00082	0.359
CLV_PCSK_SKI1_1	382	386	PF00082	0.250
CLV_PCSK_SKI1_1	397	401	PF00082	0.304
CLV_PCSK_SKI1_1	432	436	PF00082	0.282
CLV_PCSK_SKI1_1	463	467	PF00082	0.386
CLV_PCSK_SKI1_1	485	489	PF00082	0.528
CLV_PCSK_SKI1_1	495	499	PF00082	0.490
CLV_PCSK_SKI1_1	61	65	PF00082	0.393
CLV_PCSK_SKI1_1	643	647	PF00082	0.313
CLV_PCSK_SKI1_1	686	690	PF00082	0.623
CLV_PCSK_SKI1_1	698	702	PF00082	0.653
DEG_APCC_DBOX_1	391	399	PF00400	0.562
DEG_MDM2_SWIB_1	578	586	PF02201	0.480
DEG_ODPH_VHL_1	4	17	PF01847	0.453
DEG_SCF_FBW7_1	688	695	PF00400	0.486
DOC_CKS1_1	496	501	PF01111	0.362
DOC_CKS1_1	689	694	PF01111	0.462
DOC_CYCLIN_RxL_1	429	439	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	352	358	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	627	633	PF00134	0.473
DOC_MAPK_FxFP_2	364	367	PF00069	0.562
DOC_MAPK_MEF2A_6	10	19	PF00069	0.346
DOC_MAPK_MEF2A_6	126	133	PF00069	0.562
DOC_MAPK_MEF2A_6	392	400	PF00069	0.523
DOC_MAPK_MEF2A_6	463	470	PF00069	0.543
DOC_MAPK_MEF2A_6	583	592	PF00069	0.355
DOC_MAPK_NFAT4_5	10	18	PF00069	0.362
DOC_MAPK_NFAT4_5	463	471	PF00069	0.586
DOC_MAPK_RevD_3	688	704	PF00069	0.363
DOC_PP1_RVXF_1	22	29	PF00149	0.355
DOC_PP1_RVXF_1	430	436	PF00149	0.482
DOC_PP1_RVXF_1	465	471	PF00149	0.408
DOC_PP2B_LxvP_1	352	355	PF13499	0.530
DOC_PP2B_LxvP_1	37	40	PF13499	0.614
DOC_PP2B_LxvP_1	479	482	PF13499	0.357
DOC_PP2B_LxvP_1	625	628	PF13499	0.692
DOC_PP4_FxxP_1	193	196	PF00568	0.264
DOC_PP4_FxxP_1	364	367	PF00568	0.562
DOC_USP7_MATH_1	108	112	PF00917	0.786
DOC_USP7_MATH_1	127	131	PF00917	0.272
DOC_USP7_MATH_1	132	136	PF00917	0.361
DOC_USP7_MATH_1	166	170	PF00917	0.435
DOC_USP7_MATH_1	337	341	PF00917	0.585
DOC_USP7_MATH_1	346	350	PF00917	0.474
DOC_USP7_MATH_1	499	503	PF00917	0.386
DOC_USP7_MATH_1	621	625	PF00917	0.743
DOC_USP7_MATH_1	80	84	PF00917	0.762
DOC_WW_Pin1_4	112	117	PF00397	0.591
DOC_WW_Pin1_4	257	262	PF00397	0.330
DOC_WW_Pin1_4	495	500	PF00397	0.313
DOC_WW_Pin1_4	527	532	PF00397	0.562
DOC_WW_Pin1_4	591	596	PF00397	0.571
DOC_WW_Pin1_4	626	631	PF00397	0.698
DOC_WW_Pin1_4	688	693	PF00397	0.459
DOC_WW_Pin1_4	719	724	PF00397	0.446
DOC_WW_Pin1_4	94	99	PF00397	0.754
LIG_14-3-3_CanoR_1	167	173	PF00244	0.489
LIG_14-3-3_CanoR_1	190	194	PF00244	0.381
LIG_14-3-3_CanoR_1	253	261	PF00244	0.337
LIG_14-3-3_CanoR_1	360	365	PF00244	0.539
LIG_14-3-3_CanoR_1	381	387	PF00244	0.528
LIG_14-3-3_CanoR_1	397	406	PF00244	0.501
LIG_14-3-3_CanoR_1	455	462	PF00244	0.524
LIG_14-3-3_CanoR_1	583	589	PF00244	0.199
LIG_14-3-3_CanoR_1	660	665	PF00244	0.454
LIG_Actin_WH2_2	384	399	PF00022	0.534
LIG_APCC_ABBA_1	49	54	PF00400	0.609
LIG_BRCT_BRCA1_1	472	476	PF00533	0.405
LIG_eIF4E_1	52	58	PF01652	0.522
LIG_FHA_1	200	206	PF00498	0.479
LIG_FHA_1	25	31	PF00498	0.339
LIG_FHA_1	287	293	PF00498	0.385
LIG_FHA_1	33	39	PF00498	0.369
LIG_FHA_1	46	52	PF00498	0.493
LIG_FHA_1	496	502	PF00498	0.349
LIG_FHA_1	62	68	PF00498	0.597
LIG_FHA_1	712	718	PF00498	0.381
LIG_FHA_2	269	275	PF00498	0.343
LIG_FHA_2	309	315	PF00498	0.530
LIG_FHA_2	76	82	PF00498	0.577
LIG_GBD_Chelix_1	15	23	PF00786	0.447
LIG_LIR_Apic_2	192	196	PF02991	0.472
LIG_LIR_Apic_2	363	367	PF02991	0.563
LIG_LIR_Apic_2	493	499	PF02991	0.313
LIG_LIR_Gen_1	385	395	PF02991	0.570
LIG_LIR_Gen_1	473	484	PF02991	0.433
LIG_LIR_Gen_1	587	597	PF02991	0.477
LIG_LIR_Gen_1	636	645	PF02991	0.595
LIG_LIR_Gen_1	691	702	PF02991	0.497
LIG_LIR_Nem_3	385	390	PF02991	0.520
LIG_LIR_Nem_3	473	479	PF02991	0.406
LIG_LIR_Nem_3	48	52	PF02991	0.531
LIG_LIR_Nem_3	587	592	PF02991	0.410
LIG_LIR_Nem_3	636	640	PF02991	0.596
LIG_LIR_Nem_3	691	697	PF02991	0.422
LIG_NRBOX	33	39	PF00104	0.449
LIG_PCNA_yPIPBox_3	518	526	PF02747	0.408
LIG_Pex14_2	364	368	PF04695	0.562
LIG_Pex14_2	470	474	PF04695	0.447
LIG_Pex14_2	578	582	PF04695	0.480
LIG_Pex14_2	637	641	PF04695	0.583
LIG_PTAP_UEV_1	104	109	PF05743	0.791
LIG_PTB_Apo_2	40	47	PF02174	0.565
LIG_PTB_Phospho_1	40	46	PF10480	0.566
LIG_SH2_CRK	383	387	PF00017	0.565
LIG_SH2_CRK	420	424	PF00017	0.482
LIG_SH2_CRK	510	514	PF00017	0.341
LIG_SH2_CRK	674	678	PF00017	0.332
LIG_SH2_GRB2like	41	44	PF00017	0.542
LIG_SH2_NCK_1	371	375	PF00017	0.530
LIG_SH2_PTP2	294	297	PF00017	0.188
LIG_SH2_PTP2	553	556	PF00017	0.378
LIG_SH2_SRC	41	44	PF00017	0.588
LIG_SH2_STAP1	383	387	PF00017	0.565
LIG_SH2_STAP1	492	496	PF00017	0.356
LIG_SH2_STAP1	674	678	PF00017	0.480
LIG_SH2_STAT3	249	252	PF00017	0.362
LIG_SH2_STAT5	294	297	PF00017	0.253
LIG_SH2_STAT5	46	49	PF00017	0.505
LIG_SH2_STAT5	492	495	PF00017	0.339
LIG_SH2_STAT5	508	511	PF00017	0.224
LIG_SH2_STAT5	553	556	PF00017	0.328
LIG_SH2_STAT5	589	592	PF00017	0.496
LIG_SH3_3	102	108	PF00018	0.792
LIG_SH3_3	193	199	PF00018	0.379
LIG_SH3_3	525	531	PF00018	0.586
LIG_SH3_3	589	595	PF00018	0.447
LIG_SH3_3	614	620	PF00018	0.772
LIG_SH3_3	717	723	PF00018	0.458
LIG_Sin3_3	318	325	PF02671	0.586
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.364
LIG_SUMO_SIM_par_1	216	222	PF11976	0.391
LIG_SUMO_SIM_par_1	227	233	PF11976	0.517
LIG_SUMO_SIM_par_1	294	299	PF11976	0.266
LIG_TYR_ITIM	291	296	PF00017	0.447
LIG_TYR_ITIM	672	677	PF00017	0.402
LIG_UBA3_1	17	24	PF00899	0.402
LIG_WRC_WIRS_1	25	30	PF05994	0.335
LIG_WRC_WIRS_1	387	392	PF05994	0.480
LIG_WRC_WIRS_1	46	51	PF05994	0.504
LIG_WRC_WIRS_1	471	476	PF05994	0.484
MOD_CDK_SPK_2	719	724	PF00069	0.459
MOD_CDK_SPxxK_3	94	101	PF00069	0.708
MOD_CK1_1	106	112	PF00069	0.739
MOD_CK1_1	29	35	PF00069	0.447
MOD_CK1_1	410	416	PF00069	0.415
MOD_CK1_1	425	431	PF00069	0.264
MOD_CK1_1	663	669	PF00069	0.405
MOD_CK1_1	722	728	PF00069	0.513
MOD_CK2_1	268	274	PF00069	0.421
MOD_CK2_1	308	314	PF00069	0.448
MOD_CK2_1	398	404	PF00069	0.355
MOD_CK2_1	561	567	PF00069	0.439
MOD_CK2_1	75	81	PF00069	0.518
MOD_CK2_1	94	100	PF00069	0.707
MOD_DYRK1A_RPxSP_1	719	723	PF00069	0.458
MOD_GlcNHglycan	105	108	PF01048	0.752
MOD_GlcNHglycan	111	114	PF01048	0.705
MOD_GlcNHglycan	254	257	PF01048	0.416
MOD_GlcNHglycan	298	301	PF01048	0.432
MOD_GlcNHglycan	339	342	PF01048	0.437
MOD_GlcNHglycan	349	352	PF01048	0.392
MOD_GlcNHglycan	81	85	PF01048	0.711
MOD_GSK3_1	108	115	PF00069	0.661
MOD_GSK3_1	154	161	PF00069	0.485
MOD_GSK3_1	24	31	PF00069	0.332
MOD_GSK3_1	328	335	PF00069	0.466
MOD_GSK3_1	369	376	PF00069	0.425
MOD_GSK3_1	382	389	PF00069	0.467
MOD_GSK3_1	398	405	PF00069	0.422
MOD_GSK3_1	406	413	PF00069	0.414
MOD_GSK3_1	421	428	PF00069	0.285
MOD_GSK3_1	444	451	PF00069	0.432
MOD_GSK3_1	470	477	PF00069	0.453
MOD_GSK3_1	483	490	PF00069	0.338
MOD_GSK3_1	491	498	PF00069	0.354
MOD_GSK3_1	561	568	PF00069	0.473
MOD_GSK3_1	688	695	PF00069	0.597
MOD_N-GLC_2	440	442	PF02516	0.378
MOD_NEK2_1	17	22	PF00069	0.480
MOD_NEK2_1	189	194	PF00069	0.554
MOD_NEK2_1	219	224	PF00069	0.442
MOD_NEK2_1	26	31	PF00069	0.343
MOD_NEK2_1	296	301	PF00069	0.422
MOD_NEK2_1	307	312	PF00069	0.403
MOD_NEK2_1	386	391	PF00069	0.372
MOD_NEK2_1	406	411	PF00069	0.150
MOD_NEK2_1	422	427	PF00069	0.319
MOD_NEK2_1	470	475	PF00069	0.362
MOD_NEK2_1	483	488	PF00069	0.388
MOD_NEK2_1	491	496	PF00069	0.338
MOD_NEK2_1	590	595	PF00069	0.539
MOD_NEK2_1	653	658	PF00069	0.421
MOD_NEK2_2	154	159	PF00069	0.501
MOD_NEK2_2	584	589	PF00069	0.447
MOD_PIKK_1	166	172	PF00454	0.632
MOD_PIKK_1	561	567	PF00454	0.402
MOD_PK_1	660	666	PF00069	0.480
MOD_PKA_2	166	172	PF00069	0.571
MOD_PKA_2	189	195	PF00069	0.351
MOD_PKA_2	252	258	PF00069	0.477
MOD_PKA_2	391	397	PF00069	0.405
MOD_PKA_2	454	460	PF00069	0.434
MOD_PKB_1	703	711	PF00069	0.502
MOD_Plk_1	199	205	PF00069	0.432
MOD_Plk_1	448	454	PF00069	0.422
MOD_Plk_2-3	75	81	PF00069	0.448
MOD_Plk_4	154	160	PF00069	0.539
MOD_Plk_4	184	190	PF00069	0.610
MOD_Plk_4	199	205	PF00069	0.368
MOD_Plk_4	233	239	PF00069	0.428
MOD_Plk_4	240	246	PF00069	0.358
MOD_Plk_4	29	35	PF00069	0.355
MOD_Plk_4	369	375	PF00069	0.428
MOD_Plk_4	382	388	PF00069	0.326
MOD_Plk_4	391	397	PF00069	0.366
MOD_Plk_4	425	431	PF00069	0.369
MOD_Plk_4	483	489	PF00069	0.462
MOD_Plk_4	542	548	PF00069	0.394
MOD_Plk_4	567	573	PF00069	0.440
MOD_Plk_4	577	583	PF00069	0.398
MOD_Plk_4	584	590	PF00069	0.298
MOD_Plk_4	636	642	PF00069	0.498
MOD_Plk_4	645	651	PF00069	0.425
MOD_ProDKin_1	112	118	PF00069	0.482
MOD_ProDKin_1	257	263	PF00069	0.402
MOD_ProDKin_1	495	501	PF00069	0.378
MOD_ProDKin_1	527	533	PF00069	0.447
MOD_ProDKin_1	591	597	PF00069	0.467
MOD_ProDKin_1	626	632	PF00069	0.620
MOD_ProDKin_1	688	694	PF00069	0.586
MOD_ProDKin_1	719	725	PF00069	0.563
MOD_ProDKin_1	94	100	PF00069	0.715
TRG_DiLeu_BaEn_1	233	238	PF01217	0.355
TRG_DiLeu_BaEn_1	684	689	PF01217	0.558
TRG_DiLeu_BaEn_2	438	444	PF01217	0.378
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.528
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.408
TRG_DiLeu_BaLyEn_6	696	701	PF01217	0.635
TRG_ENDOCYTIC_2	293	296	PF00928	0.408
TRG_ENDOCYTIC_2	371	374	PF00928	0.403
TRG_ENDOCYTIC_2	383	386	PF00928	0.367
TRG_ENDOCYTIC_2	419	422	PF00928	0.339
TRG_ENDOCYTIC_2	46	49	PF00928	0.486
TRG_ENDOCYTIC_2	471	474	PF00928	0.447
TRG_ENDOCYTIC_2	553	556	PF00928	0.360
TRG_ENDOCYTIC_2	589	592	PF00928	0.496
TRG_ENDOCYTIC_2	674	677	PF00928	0.415
TRG_ER_diArg_1	381	383	PF00400	0.402
TRG_ER_diArg_1	696	699	PF00400	0.519
TRG_ER_diArg_1	702	705	PF00400	0.591
TRG_ER_diArg_1	717	719	PF00400	0.473
TRG_NES_CRM1_1	200	214	PF08389	0.307
TRG_NES_CRM1_1	221	233	PF08389	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHL6	Leptomonas seymouri	59%	100%
A0A1X0NQN5	Trypanosomatidae	33%	100%
A0A3Q8IDZ2	Leishmania donovani	91%	100%
A0A3S5IQL5	Trypanosoma rangeli	33%	100%
A4HGU4	Leishmania braziliensis	77%	100%
A4I3X2	Leishmania infantum	91%	100%
D0A939	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q823	Leishmania major	92%	100%
V5AWN8	Trypanosoma cruzi	32%	100%