Protein RFT1 homolog

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichyl-lipid chaperone, putative

Species:

Leishmania mexicana

UniProt:

E9B062_LEIMU

TriTrypDb:

LmxM.28.2410

Length:

728

Annotations

LeishMANIAdb annotations

Highly conserved Eukaryotic protein. Involved in N-linked oligosaccharide assembly.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

Previous1 2Next

Expansion

Sequence features

E9B062

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B062

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	11
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	11
GO:0006629	lipid metabolic process	3	11
GO:0006810	transport	3	1
GO:0006869	lipid transport	5	1
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	1
GO:0034203	glycolipid translocation	5	1

Previous1 2 3Next

Could not find GO molecular_function term for this entry.

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.533
CLV_C14_Caspase3-7	372	376	PF00656	0.567
CLV_NRD_NRD_1	173	175	PF00675	0.671
CLV_NRD_NRD_1	381	383	PF00675	0.386
CLV_NRD_NRD_1	704	706	PF00675	0.641
CLV_NRD_NRD_1	718	720	PF00675	0.667
CLV_PCSK_KEX2_1	381	383	PF00082	0.386
CLV_PCSK_KEX2_1	703	705	PF00082	0.610
CLV_PCSK_KEX2_1	718	720	PF00082	0.656
CLV_PCSK_SKI1_1	24	28	PF00082	0.355

Previous1 2 3 4 5…27Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHL6	Leptomonas seymouri	59%	100%
A0A1X0NQN5	Trypanosomatidae	33%	100%
A0A3Q8IDZ2	Leishmania donovani	91%	100%
A0A3S5IQL5	Trypanosoma rangeli	33%	100%
A4HGU4	Leishmania braziliensis	77%	100%
A4I3X2	Leishmania infantum	91%	100%
D0A939	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q823	Leishmania major	92%	100%
V5AWN8	Trypanosoma cruzi	32%	100%

Previous1Next