Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B055_LEIMU

TriTrypDb:

LmxM.28.2350

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B055

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B055

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.509
CLV_NRD_NRD_1	254	256	PF00675	0.680
CLV_NRD_NRD_1	259	261	PF00675	0.713
CLV_NRD_NRD_1	38	40	PF00675	0.525
CLV_NRD_NRD_1	67	69	PF00675	0.640
CLV_PCSK_KEX2_1	132	134	PF00082	0.581
CLV_PCSK_KEX2_1	254	256	PF00082	0.680
CLV_PCSK_KEX2_1	67	69	PF00082	0.640
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.683
CLV_PCSK_PC7_1	250	256	PF00082	0.677
CLV_PCSK_SKI1_1	133	137	PF00082	0.573
CLV_PCSK_SKI1_1	153	157	PF00082	0.489
CLV_PCSK_SKI1_1	96	100	PF00082	0.496
DEG_APCC_DBOX_1	27	35	PF00400	0.562
DEG_Nend_Nbox_1	1	3	PF02207	0.672
DEG_SPOP_SBC_1	221	225	PF00917	0.678
DOC_MAPK_DCC_7	3	11	PF00069	0.681
DOC_MAPK_gen_1	86	95	PF00069	0.570
DOC_MAPK_MEF2A_6	3	11	PF00069	0.648
DOC_PP1_RVXF_1	78	84	PF00149	0.695
DOC_PP4_FxxP_1	4	7	PF00568	0.644
DOC_SPAK_OSR1_1	3	7	PF12202	0.692
DOC_USP7_MATH_1	232	236	PF00917	0.728
DOC_USP7_MATH_1	240	244	PF00917	0.681
DOC_USP7_MATH_1	262	266	PF00917	0.701
DOC_USP7_UBL2_3	132	136	PF12436	0.658
DOC_USP7_UBL2_3	37	41	PF12436	0.538
DOC_WW_Pin1_4	180	185	PF00397	0.686
DOC_WW_Pin1_4	22	27	PF00397	0.529
LIG_14-3-3_CanoR_1	113	117	PF00244	0.543
LIG_14-3-3_CanoR_1	245	253	PF00244	0.468
LIG_14-3-3_CanoR_1	254	258	PF00244	0.753
LIG_14-3-3_CanoR_1	3	7	PF00244	0.609
LIG_APCC_ABBAyCdc20_2	172	178	PF00400	0.635
LIG_CSL_BTD_1	181	184	PF09270	0.681
LIG_FHA_1	120	126	PF00498	0.559
LIG_FHA_1	254	260	PF00498	0.755
LIG_FHA_1	30	36	PF00498	0.546
LIG_FHA_1	68	74	PF00498	0.492
LIG_Integrin_RGD_1	192	194	PF01839	0.694
LIG_LIR_Apic_2	178	184	PF02991	0.669
LIG_LIR_Gen_1	103	111	PF02991	0.541
LIG_LIR_Nem_3	48	53	PF02991	0.627
LIG_Pex14_1	150	154	PF04695	0.466
LIG_Pex14_2	131	135	PF04695	0.595
LIG_SH2_PTP2	154	157	PF00017	0.436
LIG_SH2_STAP1	176	180	PF00017	0.553
LIG_SH2_STAT5	111	114	PF00017	0.689
LIG_SH2_STAT5	154	157	PF00017	0.436
LIG_SH2_STAT5	45	48	PF00017	0.559
LIG_SH2_STAT5	72	75	PF00017	0.548
LIG_SH3_3	123	129	PF00018	0.349
LIG_SH3_3	211	217	PF00018	0.551
LIG_SH3_3	256	262	PF00018	0.653
LIG_SUMO_SIM_par_1	32	38	PF11976	0.557
LIG_TRAF2_1	139	142	PF00917	0.542
LIG_TYR_ITIM	152	157	PF00017	0.442
LIG_UBA3_1	156	162	PF00899	0.495
LIG_UBA3_1	33	41	PF00899	0.539
MOD_CDK_SPxK_1	22	28	PF00069	0.529
MOD_CK1_1	119	125	PF00069	0.542
MOD_CK1_1	185	191	PF00069	0.629
MOD_CK1_1	222	228	PF00069	0.618
MOD_CK1_1	230	236	PF00069	0.647
MOD_GlcNHglycan	224	227	PF01048	0.647
MOD_GlcNHglycan	229	232	PF01048	0.651
MOD_GlcNHglycan	247	250	PF01048	0.732
MOD_GlcNHglycan	264	267	PF01048	0.572
MOD_GSK3_1	100	107	PF00069	0.461
MOD_GSK3_1	112	119	PF00069	0.474
MOD_GSK3_1	220	227	PF00069	0.727
MOD_GSK3_1	240	247	PF00069	0.539
MOD_N-GLC_1	109	114	PF02516	0.566
MOD_NEK2_1	100	105	PF00069	0.508
MOD_NEK2_1	120	125	PF00069	0.414
MOD_NEK2_1	2	7	PF00069	0.663
MOD_NEK2_1	220	225	PF00069	0.679
MOD_NEK2_1	253	258	PF00069	0.698
MOD_NEK2_1	29	34	PF00069	0.554
MOD_PIKK_1	100	106	PF00454	0.536
MOD_PKA_1	161	167	PF00069	0.544
MOD_PKA_1	67	73	PF00069	0.599
MOD_PKA_2	112	118	PF00069	0.545
MOD_PKA_2	2	8	PF00069	0.648
MOD_PKA_2	244	250	PF00069	0.740
MOD_PKA_2	253	259	PF00069	0.723
MOD_PKA_2	67	73	PF00069	0.599
MOD_Plk_1	109	115	PF00069	0.589
MOD_Plk_1	116	122	PF00069	0.519
MOD_Plk_1	140	146	PF00069	0.568
MOD_Plk_1	29	35	PF00069	0.561
MOD_Plk_4	161	167	PF00069	0.557
MOD_Plk_4	29	35	PF00069	0.547
MOD_ProDKin_1	180	186	PF00069	0.688
MOD_ProDKin_1	22	28	PF00069	0.529
MOD_SUMO_for_1	139	142	PF00179	0.608
TRG_DiLeu_BaEn_1	30	35	PF01217	0.585
TRG_DiLeu_BaEn_3	141	147	PF01217	0.299
TRG_ENDOCYTIC_2	105	108	PF00928	0.667
TRG_ENDOCYTIC_2	111	114	PF00928	0.609
TRG_ENDOCYTIC_2	154	157	PF00928	0.436
TRG_ER_diArg_1	253	255	PF00400	0.685
TRG_ER_diArg_1	66	68	PF00400	0.669
TRG_ER_diArg_1	83	86	PF00400	0.682
TRG_NES_CRM1_1	91	104	PF08389	0.348
TRG_NLS_MonoExtC_3	39	44	PF00514	0.533
TRG_NLS_MonoExtN_4	37	44	PF00514	0.527
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ2	Leptomonas seymouri	61%	100%
A0A0S4IRF0	Bodo saltans	43%	100%
A0A1X0NQP5	Trypanosomatidae	48%	100%
A0A3Q8IB55	Leishmania donovani	90%	96%
A4HGT8	Leishmania braziliensis	81%	100%
A4I3W5	Leishmania infantum	89%	96%
D0A933	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4Q830	Leishmania major	89%	100%
V5D5Q3	Trypanosoma cruzi	48%	86%