Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B053_LEIMU

TriTrypDb:

LmxM.28.2320

Length:

904

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B053

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B053

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.695
CLV_C14_Caspase3-7	584	588	PF00656	0.583
CLV_C14_Caspase3-7	654	658	PF00656	0.686
CLV_C14_Caspase3-7	802	806	PF00656	0.544
CLV_C14_Caspase3-7	830	834	PF00656	0.583
CLV_NRD_NRD_1	106	108	PF00675	0.706
CLV_NRD_NRD_1	113	115	PF00675	0.666
CLV_NRD_NRD_1	146	148	PF00675	0.514
CLV_NRD_NRD_1	338	340	PF00675	0.699
CLV_NRD_NRD_1	36	38	PF00675	0.625
CLV_NRD_NRD_1	414	416	PF00675	0.836
CLV_NRD_NRD_1	420	422	PF00675	0.788
CLV_NRD_NRD_1	466	468	PF00675	0.570
CLV_NRD_NRD_1	608	610	PF00675	0.574
CLV_NRD_NRD_1	649	651	PF00675	0.665
CLV_NRD_NRD_1	8	10	PF00675	0.631
CLV_PCSK_FUR_1	146	150	PF00082	0.665
CLV_PCSK_FUR_1	647	651	PF00082	0.533
CLV_PCSK_KEX2_1	106	108	PF00082	0.706
CLV_PCSK_KEX2_1	113	115	PF00082	0.666
CLV_PCSK_KEX2_1	146	148	PF00082	0.584
CLV_PCSK_KEX2_1	338	340	PF00082	0.699
CLV_PCSK_KEX2_1	35	37	PF00082	0.637
CLV_PCSK_KEX2_1	414	416	PF00082	0.836
CLV_PCSK_KEX2_1	420	422	PF00082	0.788
CLV_PCSK_KEX2_1	466	468	PF00082	0.570
CLV_PCSK_KEX2_1	565	567	PF00082	0.541
CLV_PCSK_KEX2_1	608	610	PF00082	0.574
CLV_PCSK_KEX2_1	649	651	PF00082	0.665
CLV_PCSK_KEX2_1	679	681	PF00082	0.665
CLV_PCSK_KEX2_1	8	10	PF00082	0.635
CLV_PCSK_KEX2_1	827	829	PF00082	0.584
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.607
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.541
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.665
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.584
CLV_PCSK_SKI1_1	114	118	PF00082	0.724
CLV_PCSK_SKI1_1	284	288	PF00082	0.547
CLV_PCSK_SKI1_1	344	348	PF00082	0.559
CLV_PCSK_SKI1_1	452	456	PF00082	0.627
CLV_PCSK_SKI1_1	497	501	PF00082	0.600
CLV_PCSK_SKI1_1	734	738	PF00082	0.669
DEG_APCC_DBOX_1	283	291	PF00400	0.551
DEG_APCC_DBOX_1	351	359	PF00400	0.499
DEG_COP1_1	329	337	PF00400	0.597
DEG_SCF_FBW7_1	318	325	PF00400	0.668
DOC_CKS1_1	164	169	PF01111	0.629
DOC_CKS1_1	183	188	PF01111	0.591
DOC_CKS1_1	319	324	PF01111	0.667
DOC_CKS1_1	717	722	PF01111	0.538
DOC_CYCLIN_yCln2_LP_2	246	249	PF00134	0.603
DOC_CYCLIN_yCln2_LP_2	571	577	PF00134	0.722
DOC_CYCLIN_yCln2_LP_2	898	904	PF00134	0.605
DOC_MAPK_MEF2A_6	724	731	PF00069	0.693
DOC_PP2B_LxvP_1	196	199	PF13499	0.520
DOC_PP2B_LxvP_1	246	249	PF13499	0.603
DOC_PP2B_LxvP_1	571	574	PF13499	0.717
DOC_PP2B_LxvP_1	898	901	PF13499	0.608
DOC_USP7_MATH_1	10	14	PF00917	0.633
DOC_USP7_MATH_1	118	122	PF00917	0.738
DOC_USP7_MATH_1	128	132	PF00917	0.538
DOC_USP7_MATH_1	191	195	PF00917	0.682
DOC_USP7_MATH_1	197	201	PF00917	0.663
DOC_USP7_MATH_1	372	376	PF00917	0.729
DOC_USP7_MATH_1	424	428	PF00917	0.681
DOC_USP7_MATH_1	477	481	PF00917	0.712
DOC_USP7_MATH_1	586	590	PF00917	0.698
DOC_USP7_MATH_1	66	70	PF00917	0.638
DOC_USP7_MATH_1	741	745	PF00917	0.535
DOC_USP7_MATH_1	754	758	PF00917	0.725
DOC_USP7_MATH_1	817	821	PF00917	0.673
DOC_USP7_MATH_1	880	884	PF00917	0.626
DOC_USP7_MATH_1	885	889	PF00917	0.628
DOC_USP7_MATH_1	891	895	PF00917	0.545
DOC_WW_Pin1_4	163	168	PF00397	0.627
DOC_WW_Pin1_4	182	187	PF00397	0.634
DOC_WW_Pin1_4	223	228	PF00397	0.790
DOC_WW_Pin1_4	257	262	PF00397	0.602
DOC_WW_Pin1_4	311	316	PF00397	0.794
DOC_WW_Pin1_4	318	323	PF00397	0.667
DOC_WW_Pin1_4	327	332	PF00397	0.545
DOC_WW_Pin1_4	400	405	PF00397	0.781
DOC_WW_Pin1_4	420	425	PF00397	0.514
DOC_WW_Pin1_4	483	488	PF00397	0.800
DOC_WW_Pin1_4	598	603	PF00397	0.571
DOC_WW_Pin1_4	665	670	PF00397	0.609
DOC_WW_Pin1_4	681	686	PF00397	0.666
DOC_WW_Pin1_4	716	721	PF00397	0.613
DOC_WW_Pin1_4	73	78	PF00397	0.588
DOC_WW_Pin1_4	774	779	PF00397	0.603
DOC_WW_Pin1_4	818	823	PF00397	0.674
DOC_WW_Pin1_4	90	95	PF00397	0.579
DOC_WW_Pin1_4	99	104	PF00397	0.633
LIG_14-3-3_CanoR_1	153	159	PF00244	0.684
LIG_14-3-3_CanoR_1	170	180	PF00244	0.541
LIG_14-3-3_CanoR_1	201	207	PF00244	0.672
LIG_14-3-3_CanoR_1	3	7	PF00244	0.659
LIG_14-3-3_CanoR_1	35	43	PF00244	0.548
LIG_14-3-3_CanoR_1	622	631	PF00244	0.611
LIG_14-3-3_CanoR_1	701	706	PF00244	0.671
LIG_14-3-3_CanoR_1	734	739	PF00244	0.812
LIG_14-3-3_CanoR_1	8	18	PF00244	0.614
LIG_Actin_WH2_2	687	703	PF00022	0.528
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_BRCT_BRCA1_1	344	348	PF00533	0.593
LIG_BRCT_BRCA1_1	545	549	PF00533	0.509
LIG_BRCT_BRCA1_1	743	747	PF00533	0.503
LIG_BRCT_BRCA1_1	855	859	PF00533	0.651
LIG_eIF4E_1	293	299	PF01652	0.586
LIG_FHA_1	239	245	PF00498	0.641
LIG_FHA_1	319	325	PF00498	0.672
LIG_FHA_1	712	718	PF00498	0.681
LIG_FHA_1	731	737	PF00498	0.569
LIG_FHA_1	754	760	PF00498	0.650
LIG_FHA_1	793	799	PF00498	0.507
LIG_FHA_1	819	825	PF00498	0.662
LIG_FHA_2	421	427	PF00498	0.649
LIG_FHA_2	577	583	PF00498	0.656
LIG_FHA_2	652	658	PF00498	0.708
LIG_LIR_Apic_2	57	62	PF02991	0.598
LIG_LIR_Apic_2	73	77	PF02991	0.620
LIG_LIR_Gen_1	160	168	PF02991	0.594
LIG_LIR_Gen_1	345	355	PF02991	0.582
LIG_LIR_Gen_1	93	103	PF02991	0.521
LIG_LIR_Nem_3	160	164	PF02991	0.593
LIG_LIR_Nem_3	345	351	PF02991	0.590
LIG_LIR_Nem_3	93	99	PF02991	0.515
LIG_Pex14_1	789	793	PF04695	0.651
LIG_Pex14_2	747	751	PF04695	0.548
LIG_SH2_CRK	180	184	PF00017	0.537
LIG_SH2_CRK	302	306	PF00017	0.573
LIG_SH2_CRK	59	63	PF00017	0.598
LIG_SH2_CRK	74	78	PF00017	0.602
LIG_SH2_GRB2like	84	87	PF00017	0.670
LIG_SH2_NCK_1	180	184	PF00017	0.537
LIG_SH2_NCK_1	793	797	PF00017	0.583
LIG_SH2_SRC	84	87	PF00017	0.619
LIG_SH2_STAT3	141	144	PF00017	0.653
LIG_SH2_STAT3	293	296	PF00017	0.582
LIG_SH2_STAT3	611	614	PF00017	0.642
LIG_SH2_STAT5	47	50	PF00017	0.625
LIG_SH2_STAT5	611	614	PF00017	0.591
LIG_SH2_STAT5	836	839	PF00017	0.489
LIG_SH3_1	106	112	PF00018	0.663
LIG_SH3_1	180	186	PF00018	0.531
LIG_SH3_1	316	322	PF00018	0.609
LIG_SH3_2	108	113	PF14604	0.710
LIG_SH3_3	105	111	PF00018	0.707
LIG_SH3_3	161	167	PF00018	0.555
LIG_SH3_3	18	24	PF00018	0.650
LIG_SH3_3	180	186	PF00018	0.672
LIG_SH3_3	242	248	PF00018	0.586
LIG_SH3_3	316	322	PF00018	0.699
LIG_SH3_3	329	335	PF00018	0.576
LIG_SH3_3	450	456	PF00018	0.721
LIG_SH3_3	512	518	PF00018	0.760
LIG_SH3_3	531	537	PF00018	0.570
LIG_SH3_3	587	593	PF00018	0.659
LIG_SH3_3	717	723	PF00018	0.774
LIG_SH3_3	726	732	PF00018	0.575
LIG_SH3_3	775	781	PF00018	0.656
LIG_SH3_3	855	861	PF00018	0.510
LIG_SH3_CIN85_PxpxPR_1	108	113	PF14604	0.710
LIG_TRAF2_2	861	866	PF00917	0.513
LIG_WW_3	110	114	PF00397	0.716
LIG_WW_3	32	36	PF00397	0.663
MOD_CDC14_SPxK_1	330	333	PF00782	0.664
MOD_CDK_SPK_2	311	316	PF00069	0.604
MOD_CDK_SPK_2	90	95	PF00069	0.507
MOD_CDK_SPxK_1	327	333	PF00069	0.665
MOD_CDK_SPxxK_3	163	170	PF00069	0.662
MOD_CDK_SPxxK_3	73	80	PF00069	0.593
MOD_CDK_SPxxK_3	99	106	PF00069	0.672
MOD_CK1_1	154	160	PF00069	0.629
MOD_CK1_1	172	178	PF00069	0.794
MOD_CK1_1	2	8	PF00069	0.718
MOD_CK1_1	200	206	PF00069	0.631
MOD_CK1_1	226	232	PF00069	0.754
MOD_CK1_1	323	329	PF00069	0.641
MOD_CK1_1	39	45	PF00069	0.689
MOD_CK1_1	391	397	PF00069	0.640
MOD_CK1_1	403	409	PF00069	0.664
MOD_CK1_1	478	484	PF00069	0.684
MOD_CK1_1	626	632	PF00069	0.736
MOD_CK1_1	651	657	PF00069	0.784
MOD_CK1_1	684	690	PF00069	0.791
MOD_CK1_1	70	76	PF00069	0.649
MOD_CK1_1	704	710	PF00069	0.733
MOD_CK1_1	847	853	PF00069	0.675
MOD_CK2_1	664	670	PF00069	0.615
MOD_CK2_1	737	743	PF00069	0.733
MOD_CK2_1	891	897	PF00069	0.662
MOD_CMANNOS	378	381	PF00535	0.512
MOD_Cter_Amidation	677	680	PF01082	0.670
MOD_Cter_Amidation	825	828	PF01082	0.595
MOD_GlcNHglycan	12	15	PF01048	0.721
MOD_GlcNHglycan	120	123	PF01048	0.697
MOD_GlcNHglycan	130	133	PF01048	0.573
MOD_GlcNHglycan	175	178	PF01048	0.737
MOD_GlcNHglycan	180	183	PF01048	0.801
MOD_GlcNHglycan	223	226	PF01048	0.765
MOD_GlcNHglycan	335	338	PF01048	0.771
MOD_GlcNHglycan	344	347	PF01048	0.526
MOD_GlcNHglycan	38	41	PF01048	0.697
MOD_GlcNHglycan	390	393	PF01048	0.539
MOD_GlcNHglycan	426	429	PF01048	0.732
MOD_GlcNHglycan	43	46	PF01048	0.621
MOD_GlcNHglycan	476	480	PF01048	0.678
MOD_GlcNHglycan	529	532	PF01048	0.769
MOD_GlcNHglycan	545	548	PF01048	0.515
MOD_GlcNHglycan	631	634	PF01048	0.712
MOD_GlcNHglycan	676	679	PF01048	0.664
MOD_GlcNHglycan	69	72	PF01048	0.652
MOD_GlcNHglycan	709	712	PF01048	0.556
MOD_GlcNHglycan	739	742	PF01048	0.617
MOD_GlcNHglycan	743	746	PF01048	0.616
MOD_GlcNHglycan	756	759	PF01048	0.679
MOD_GlcNHglycan	814	817	PF01048	0.646
MOD_GlcNHglycan	839	842	PF01048	0.527
MOD_GlcNHglycan	878	881	PF01048	0.587
MOD_GlcNHglycan	882	885	PF01048	0.587
MOD_GSK3_1	114	121	PF00069	0.773
MOD_GSK3_1	169	176	PF00069	0.676
MOD_GSK3_1	178	185	PF00069	0.631
MOD_GSK3_1	197	204	PF00069	0.534
MOD_GSK3_1	318	325	PF00069	0.639
MOD_GSK3_1	420	427	PF00069	0.691
MOD_GSK3_1	478	485	PF00069	0.713
MOD_GSK3_1	622	629	PF00069	0.538
MOD_GSK3_1	651	658	PF00069	0.714
MOD_GSK3_1	66	73	PF00069	0.663
MOD_GSK3_1	686	693	PF00069	0.830
MOD_GSK3_1	700	707	PF00069	0.694
MOD_GSK3_1	730	737	PF00069	0.669
MOD_GSK3_1	749	756	PF00069	0.713
MOD_GSK3_1	849	856	PF00069	0.728
MOD_GSK3_1	86	93	PF00069	0.541
MOD_GSK3_1	876	883	PF00069	0.655
MOD_N-GLC_1	128	133	PF02516	0.590
MOD_N-GLC_1	655	660	PF02516	0.546
MOD_N-GLC_1	891	896	PF02516	0.674
MOD_N-GLC_2	867	869	PF02516	0.501
MOD_NEK2_1	495	500	PF00069	0.629
MOD_NEK2_1	55	60	PF00069	0.539
MOD_NEK2_1	576	581	PF00069	0.765
MOD_NEK2_1	690	695	PF00069	0.635
MOD_NEK2_1	700	705	PF00069	0.694
MOD_NEK2_1	837	842	PF00069	0.563
MOD_NEK2_1	844	849	PF00069	0.615
MOD_PIKK_1	140	146	PF00454	0.654
MOD_PIKK_1	151	157	PF00454	0.556
MOD_PIKK_1	259	265	PF00454	0.649
MOD_PIKK_1	47	53	PF00454	0.646
MOD_PIKK_1	478	484	PF00454	0.684
MOD_PK_1	320	326	PF00069	0.525
MOD_PK_1	432	438	PF00069	0.534
MOD_PK_1	701	707	PF00069	0.583
MOD_PKA_1	36	42	PF00069	0.616
MOD_PKA_2	169	175	PF00069	0.671
MOD_PKA_2	2	8	PF00069	0.718
MOD_PKA_2	200	206	PF00069	0.677
MOD_PKA_2	36	42	PF00069	0.616
MOD_PKA_2	527	533	PF00069	0.748
MOD_PKA_2	55	61	PF00069	0.541
MOD_PKA_2	623	629	PF00069	0.647
MOD_PKA_2	648	654	PF00069	0.663
MOD_PKA_2	700	706	PF00069	0.672
MOD_PKB_1	430	438	PF00069	0.548
MOD_PKB_1	622	630	PF00069	0.667
MOD_Plk_1	191	197	PF00069	0.519
MOD_Plk_1	586	592	PF00069	0.656
MOD_Plk_1	690	696	PF00069	0.537
MOD_Plk_1	844	850	PF00069	0.628
MOD_Plk_4	231	237	PF00069	0.766
MOD_Plk_4	239	245	PF00069	0.697
MOD_Plk_4	50	56	PF00069	0.630
MOD_Plk_4	704	710	PF00069	0.607
MOD_Plk_4	844	850	PF00069	0.628
MOD_ProDKin_1	163	169	PF00069	0.627
MOD_ProDKin_1	182	188	PF00069	0.635
MOD_ProDKin_1	223	229	PF00069	0.791
MOD_ProDKin_1	257	263	PF00069	0.592
MOD_ProDKin_1	311	317	PF00069	0.796
MOD_ProDKin_1	318	324	PF00069	0.666
MOD_ProDKin_1	327	333	PF00069	0.546
MOD_ProDKin_1	400	406	PF00069	0.781
MOD_ProDKin_1	420	426	PF00069	0.515
MOD_ProDKin_1	483	489	PF00069	0.800
MOD_ProDKin_1	598	604	PF00069	0.568
MOD_ProDKin_1	665	671	PF00069	0.611
MOD_ProDKin_1	681	687	PF00069	0.668
MOD_ProDKin_1	716	722	PF00069	0.611
MOD_ProDKin_1	73	79	PF00069	0.591
MOD_ProDKin_1	774	780	PF00069	0.598
MOD_ProDKin_1	818	824	PF00069	0.675
MOD_ProDKin_1	90	96	PF00069	0.581
MOD_ProDKin_1	99	105	PF00069	0.631
MOD_SUMO_rev_2	755	764	PF00179	0.595
TRG_DiLeu_BaEn_1	294	299	PF01217	0.522
TRG_DiLeu_BaEn_2	742	748	PF01217	0.644
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.616
TRG_DiLeu_BaLyEn_6	571	576	PF01217	0.669
TRG_DiLeu_BaLyEn_6	640	645	PF01217	0.529
TRG_DiLeu_LyEn_5	294	299	PF01217	0.504
TRG_ENDOCYTIC_2	302	305	PF00928	0.566
TRG_ENDOCYTIC_2	96	99	PF00928	0.601
TRG_ER_diArg_1	106	108	PF00400	0.709
TRG_ER_diArg_1	112	114	PF00400	0.671
TRG_ER_diArg_1	146	149	PF00400	0.517
TRG_ER_diArg_1	34	37	PF00400	0.638
TRG_ER_diArg_1	351	354	PF00400	0.560
TRG_ER_diArg_1	414	416	PF00400	0.838
TRG_ER_diArg_1	419	421	PF00400	0.806
TRG_ER_diArg_1	429	432	PF00400	0.607
TRG_ER_diArg_1	444	447	PF00400	0.795
TRG_ER_diArg_1	456	459	PF00400	0.678
TRG_ER_diArg_1	647	650	PF00400	0.536
TRG_ER_diArg_1	8	10	PF00400	0.644
TRG_NLS_MonoExtN_4	146	151	PF00514	0.472
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B6	Leptomonas seymouri	30%	100%
A0A3Q8IE27	Leishmania donovani	86%	100%
A4HGT6	Leishmania braziliensis	59%	100%
A4I3W3	Leishmania infantum	86%	100%
Q4Q832	Leishmania major	82%	100%