Translation initiation factor eIF-2B subunit epsilon

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translation initiation factor eIF-2B subunit epsilon, putative

Species:

Leishmania mexicana

UniProt:

E9B050_LEIMU

TriTrypDb:

LmxM.28.2290

Length:

833

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005851	eukaryotic translation initiation factor 2B complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

E9B050

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B050

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003743	translation initiation factor activity	4	3
GO:0005085	guanyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	3
GO:0005515	protein binding	2	1
GO:0008135	translation factor activity, RNA binding	3	3
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0031369	translation initiation factor binding	3	1
GO:0045182	translation regulator activity	1	3
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1
GO:0140678	molecular function inhibitor activity	2	1
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.559
CLV_C14_Caspase3-7	588	592	PF00656	0.650
CLV_C14_Caspase3-7	785	789	PF00656	0.710
CLV_NRD_NRD_1	125	127	PF00675	0.504
CLV_NRD_NRD_1	174	176	PF00675	0.500
CLV_NRD_NRD_1	370	372	PF00675	0.462
CLV_NRD_NRD_1	459	461	PF00675	0.520
CLV_NRD_NRD_1	607	609	PF00675	0.539
CLV_NRD_NRD_1	761	763	PF00675	0.481
CLV_PCSK_KEX2_1	125	127	PF00082	0.498
CLV_PCSK_KEX2_1	370	372	PF00082	0.462
CLV_PCSK_KEX2_1	459	461	PF00082	0.498
CLV_PCSK_KEX2_1	607	609	PF00082	0.539
CLV_PCSK_KEX2_1	761	763	PF00082	0.481
CLV_PCSK_SKI1_1	125	129	PF00082	0.492
CLV_PCSK_SKI1_1	190	194	PF00082	0.513
CLV_PCSK_SKI1_1	370	374	PF00082	0.414
CLV_PCSK_SKI1_1	460	464	PF00082	0.500
CLV_PCSK_SKI1_1	488	492	PF00082	0.512
CLV_PCSK_SKI1_1	552	556	PF00082	0.626
CLV_PCSK_SKI1_1	674	678	PF00082	0.510
CLV_PCSK_SKI1_1	762	766	PF00082	0.493
CLV_PCSK_SKI1_1	827	831	PF00082	0.588
DEG_APCC_DBOX_1	487	495	PF00400	0.447
DEG_Nend_UBRbox_2	1	3	PF02207	0.562
DEG_SPOP_SBC_1	284	288	PF00917	0.587
DEG_SPOP_SBC_1	389	393	PF00917	0.529
DOC_CYCLIN_RxL_1	367	376	PF00134	0.456
DOC_MAPK_FxFP_2	640	643	PF00069	0.467
DOC_MAPK_gen_1	250	257	PF00069	0.512
DOC_PP2B_LxvP_1	150	153	PF13499	0.369
DOC_PP4_FxxP_1	640	643	PF00568	0.467
DOC_USP7_MATH_1	345	349	PF00917	0.496
DOC_USP7_MATH_1	353	357	PF00917	0.371
DOC_USP7_MATH_1	389	393	PF00917	0.474
DOC_USP7_MATH_1	406	410	PF00917	0.403
DOC_USP7_MATH_1	585	589	PF00917	0.704
DOC_WW_Pin1_4	212	217	PF00397	0.564
DOC_WW_Pin1_4	44	49	PF00397	0.512
DOC_WW_Pin1_4	496	501	PF00397	0.433
DOC_WW_Pin1_4	532	537	PF00397	0.500
DOC_WW_Pin1_4	62	67	PF00397	0.242
DOC_WW_Pin1_4	662	667	PF00397	0.587
LIG_14-3-3_CanoR_1	125	131	PF00244	0.479
LIG_14-3-3_CanoR_1	198	202	PF00244	0.563
LIG_14-3-3_CanoR_1	232	240	PF00244	0.623
LIG_14-3-3_CanoR_1	241	246	PF00244	0.555
LIG_14-3-3_CanoR_1	252	256	PF00244	0.453
LIG_14-3-3_CanoR_1	39	43	PF00244	0.544
LIG_14-3-3_CanoR_1	404	413	PF00244	0.584
LIG_14-3-3_CanoR_1	532	536	PF00244	0.497
LIG_14-3-3_CanoR_1	560	565	PF00244	0.584
LIG_BRCT_BRCA1_1	533	537	PF00533	0.497
LIG_BRCT_BRCA1_1	575	579	PF00533	0.561
LIG_BRCT_BRCA1_1	636	640	PF00533	0.528
LIG_Clathr_ClatBox_1	151	155	PF01394	0.464
LIG_Clathr_ClatBox_1	751	755	PF01394	0.406
LIG_eIF4E_1	70	76	PF01652	0.363
LIG_FHA_1	242	248	PF00498	0.600
LIG_FHA_1	252	258	PF00498	0.391
LIG_FHA_1	260	266	PF00498	0.321
LIG_FHA_1	324	330	PF00498	0.465
LIG_FHA_1	367	373	PF00498	0.246
LIG_FHA_1	394	400	PF00498	0.461
LIG_FHA_1	497	503	PF00498	0.489
LIG_FHA_1	548	554	PF00498	0.649
LIG_FHA_1	573	579	PF00498	0.512
LIG_FHA_1	63	69	PF00498	0.332
LIG_FHA_1	631	637	PF00498	0.563
LIG_FHA_1	648	654	PF00498	0.433
LIG_FHA_1	82	88	PF00498	0.338
LIG_FHA_2	117	123	PF00498	0.497
LIG_FHA_2	127	133	PF00498	0.557
LIG_FHA_2	167	173	PF00498	0.462
LIG_FHA_2	561	567	PF00498	0.372
LIG_FHA_2	658	664	PF00498	0.641
LIG_GBD_Chelix_1	193	201	PF00786	0.537
LIG_GBD_Chelix_1	22	30	PF00786	0.464
LIG_Integrin_RGD_1	525	527	PF01839	0.689
LIG_LIR_Apic_2	242	246	PF02991	0.413
LIG_LIR_Apic_2	637	643	PF02991	0.485
LIG_LIR_Apic_2	679	683	PF02991	0.415
LIG_LIR_Gen_1	148	157	PF02991	0.380
LIG_LIR_Gen_1	159	167	PF02991	0.410
LIG_LIR_Gen_1	319	329	PF02991	0.456
LIG_LIR_Gen_1	479	490	PF02991	0.495
LIG_LIR_Gen_1	740	751	PF02991	0.419
LIG_LIR_Nem_3	148	152	PF02991	0.338
LIG_LIR_Nem_3	159	163	PF02991	0.375
LIG_LIR_Nem_3	319	324	PF02991	0.432
LIG_LIR_Nem_3	332	338	PF02991	0.393
LIG_LIR_Nem_3	479	485	PF02991	0.490
LIG_LIR_Nem_3	740	746	PF02991	0.431
LIG_LYPXL_yS_3	642	645	PF13949	0.461
LIG_MLH1_MIPbox_1	534	538	PF16413	0.497
LIG_PCNA_yPIPBox_3	691	701	PF02747	0.520
LIG_Pex14_1	680	684	PF04695	0.399
LIG_Pex14_2	684	688	PF04695	0.409
LIG_SH2_CRK	243	247	PF00017	0.561
LIG_SH2_CRK	335	339	PF00017	0.507
LIG_SH2_CRK	743	747	PF00017	0.397
LIG_SH2_PTP2	482	485	PF00017	0.421
LIG_SH2_STAP1	180	184	PF00017	0.337
LIG_SH2_STAP1	685	689	PF00017	0.435
LIG_SH2_STAT3	721	724	PF00017	0.472
LIG_SH2_STAT5	243	246	PF00017	0.552
LIG_SH2_STAT5	360	363	PF00017	0.341
LIG_SH2_STAT5	398	401	PF00017	0.399
LIG_SH2_STAT5	482	485	PF00017	0.421
LIG_SH2_STAT5	70	73	PF00017	0.327
LIG_SH2_STAT5	743	746	PF00017	0.405
LIG_SH2_STAT5	768	771	PF00017	0.572
LIG_SH3_1	243	249	PF00018	0.563
LIG_SH3_3	213	219	PF00018	0.674
LIG_SH3_3	243	249	PF00018	0.506
LIG_SH3_3	275	281	PF00018	0.592
LIG_SH3_3	347	353	PF00018	0.401
LIG_SH3_3	39	45	PF00018	0.489
LIG_SH3_3	418	424	PF00018	0.416
LIG_SH3_3	581	587	PF00018	0.690
LIG_SH3_5	66	70	PF00018	0.362
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.455
LIG_SUMO_SIM_par_1	340	348	PF11976	0.452
LIG_SUMO_SIM_par_1	499	505	PF11976	0.392
LIG_SUMO_SIM_par_1	81	91	PF11976	0.482
LIG_SUMO_SIM_par_1	813	818	PF11976	0.488
LIG_TRAF2_1	596	599	PF00917	0.713
LIG_TRFH_1	149	153	PF08558	0.451
LIG_TYR_ITIM	480	485	PF00017	0.484
LIG_UBA3_1	255	260	PF00899	0.484
LIG_WRC_WIRS_1	157	162	PF05994	0.455
LIG_WRC_WIRS_1	320	325	PF05994	0.448
LIG_WRC_WIRS_1	685	690	PF05994	0.264
MOD_CK1_1	212	218	PF00069	0.665
MOD_CK1_1	322	328	PF00069	0.423
MOD_CK1_1	445	451	PF00069	0.467
MOD_CK1_1	47	53	PF00069	0.534
MOD_CK1_1	539	545	PF00069	0.686
MOD_CK1_1	747	753	PF00069	0.492
MOD_CK1_1	786	792	PF00069	0.729
MOD_CK1_1	793	799	PF00069	0.764
MOD_CK2_1	116	122	PF00069	0.488
MOD_CK2_1	166	172	PF00069	0.404
MOD_CK2_1	203	209	PF00069	0.622
MOD_CK2_1	308	314	PF00069	0.398
MOD_CK2_1	389	395	PF00069	0.505
MOD_CK2_1	537	543	PF00069	0.681
MOD_CK2_1	587	593	PF00069	0.715
MOD_CK2_1	619	625	PF00069	0.528
MOD_CK2_1	796	802	PF00069	0.548
MOD_Cter_Amidation	457	460	PF01082	0.487
MOD_DYRK1A_RPxSP_1	532	536	PF00069	0.497
MOD_GlcNHglycan	222	225	PF01048	0.727
MOD_GlcNHglycan	287	290	PF01048	0.527
MOD_GlcNHglycan	347	350	PF01048	0.502
MOD_GlcNHglycan	355	358	PF01048	0.431
MOD_GlcNHglycan	496	499	PF01048	0.558
MOD_GlcNHglycan	514	518	PF01048	0.463
MOD_GlcNHglycan	568	571	PF01048	0.592
MOD_GlcNHglycan	575	578	PF01048	0.547
MOD_GlcNHglycan	637	640	PF01048	0.497
MOD_GlcNHglycan	746	749	PF01048	0.491
MOD_GlcNHglycan	90	93	PF01048	0.420
MOD_GSK3_1	112	119	PF00069	0.455
MOD_GSK3_1	227	234	PF00069	0.662
MOD_GSK3_1	259	266	PF00069	0.462
MOD_GSK3_1	285	292	PF00069	0.520
MOD_GSK3_1	319	326	PF00069	0.460
MOD_GSK3_1	389	396	PF00069	0.451
MOD_GSK3_1	419	426	PF00069	0.429
MOD_GSK3_1	492	499	PF00069	0.456
MOD_GSK3_1	532	539	PF00069	0.688
MOD_GSK3_1	573	580	PF00069	0.557
MOD_GSK3_1	619	626	PF00069	0.511
MOD_GSK3_1	630	637	PF00069	0.337
MOD_GSK3_1	683	690	PF00069	0.432
MOD_GSK3_1	782	789	PF00069	0.719
MOD_GSK3_1	790	797	PF00069	0.768
MOD_GSK3_1	88	95	PF00069	0.434
MOD_GSK3_1	97	104	PF00069	0.422
MOD_N-GLC_1	116	121	PF02516	0.517
MOD_N-GLC_1	145	150	PF02516	0.462
MOD_N-GLC_1	406	411	PF02516	0.491
MOD_N-GLC_1	87	92	PF02516	0.368
MOD_NEK2_1	112	117	PF00069	0.541
MOD_NEK2_1	185	190	PF00069	0.436
MOD_NEK2_1	197	202	PF00069	0.485
MOD_NEK2_1	285	290	PF00069	0.487
MOD_NEK2_1	323	328	PF00069	0.451
MOD_NEK2_1	399	404	PF00069	0.433
MOD_NEK2_1	429	434	PF00069	0.461
MOD_NEK2_1	537	542	PF00069	0.490
MOD_NEK2_1	657	662	PF00069	0.555
MOD_NEK2_1	676	681	PF00069	0.490
MOD_NEK2_1	684	689	PF00069	0.532
MOD_NEK2_1	86	91	PF00069	0.438
MOD_NEK2_2	227	232	PF00069	0.654
MOD_PIKK_1	210	216	PF00454	0.625
MOD_PIKK_1	585	591	PF00454	0.658
MOD_PKA_1	125	131	PF00069	0.445
MOD_PKA_1	175	181	PF00069	0.511
MOD_PKA_2	125	131	PF00069	0.445
MOD_PKA_2	197	203	PF00069	0.558
MOD_PKA_2	231	237	PF00069	0.631
MOD_PKA_2	251	257	PF00069	0.429
MOD_PKA_2	376	382	PF00069	0.427
MOD_PKA_2	38	44	PF00069	0.540
MOD_PKA_2	531	537	PF00069	0.592
MOD_PKA_2	566	572	PF00069	0.707
MOD_PKA_2	585	591	PF00069	0.695
MOD_PKA_2	766	772	PF00069	0.574
MOD_PKA_2	782	788	PF00069	0.686
MOD_PKB_1	173	181	PF00069	0.506
MOD_Plk_1	116	122	PF00069	0.439
MOD_Plk_1	406	412	PF00069	0.529
MOD_Plk_1	419	425	PF00069	0.580
MOD_Plk_1	442	448	PF00069	0.471
MOD_Plk_1	478	484	PF00069	0.415
MOD_Plk_1	624	630	PF00069	0.489
MOD_Plk_1	81	87	PF00069	0.422
MOD_Plk_2-3	308	314	PF00069	0.455
MOD_Plk_2-3	625	631	PF00069	0.485
MOD_Plk_4	116	122	PF00069	0.476
MOD_Plk_4	145	151	PF00069	0.385
MOD_Plk_4	180	186	PF00069	0.335
MOD_Plk_4	197	203	PF00069	0.446
MOD_Plk_4	251	257	PF00069	0.427
MOD_Plk_4	263	269	PF00069	0.404
MOD_Plk_4	308	314	PF00069	0.363
MOD_Plk_4	319	325	PF00069	0.361
MOD_Plk_4	38	44	PF00069	0.556
MOD_Plk_4	393	399	PF00069	0.380
MOD_Plk_4	406	412	PF00069	0.436
MOD_Plk_4	429	435	PF00069	0.438
MOD_Plk_4	478	484	PF00069	0.493
MOD_Plk_4	684	690	PF00069	0.296
MOD_Plk_4	747	753	PF00069	0.492
MOD_Plk_4	81	87	PF00069	0.427
MOD_ProDKin_1	212	218	PF00069	0.567
MOD_ProDKin_1	44	50	PF00069	0.509
MOD_ProDKin_1	496	502	PF00069	0.431
MOD_ProDKin_1	532	538	PF00069	0.500
MOD_ProDKin_1	62	68	PF00069	0.240
MOD_ProDKin_1	662	668	PF00069	0.584
MOD_SUMO_rev_2	804	814	PF00179	0.540
TRG_DiLeu_BaEn_1	308	313	PF01217	0.452
TRG_DiLeu_BaEn_1	810	815	PF01217	0.482
TRG_DiLeu_BaEn_1	82	87	PF01217	0.429
TRG_DiLeu_BaEn_4	802	808	PF01217	0.574
TRG_ENDOCYTIC_2	321	324	PF00928	0.444
TRG_ENDOCYTIC_2	335	338	PF00928	0.477
TRG_ENDOCYTIC_2	482	485	PF00928	0.485
TRG_ENDOCYTIC_2	642	645	PF00928	0.461
TRG_ENDOCYTIC_2	685	688	PF00928	0.475
TRG_ENDOCYTIC_2	743	746	PF00928	0.400
TRG_ENDOCYTIC_2	768	771	PF00928	0.572
TRG_ER_diArg_1	125	127	PF00400	0.498
TRG_ER_diArg_1	370	372	PF00400	0.462
TRG_ER_diArg_1	606	608	PF00400	0.527
TRG_NES_CRM1_1	644	655	PF08389	0.386
TRG_Pf-PMV_PEXEL_1	805	809	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B8	Leptomonas seymouri	67%	100%
A0A0S4IRE8	Bodo saltans	31%	100%
A0A3Q8IDY2	Leishmania donovani	93%	100%
A4HGT3	Leishmania braziliensis	83%	97%
A4I3W0	Leishmania infantum	93%	100%
D0A928	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
P56287	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q4Q835	Leishmania major	94%	100%