DNA topoisomerase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA topoisomerase 2

Gene product:

DNA topoisomerase ii

Species:

Leishmania mexicana

UniProt:

E9B049_LEIMU

TriTrypDb:

LmxM.28.2280

Length:

1497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B049

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	13
GO:0006259	DNA metabolic process	4	13
GO:0006265	DNA topological change	5	13
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0006996	organelle organization	4	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016043	cellular component organization	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0046483	heterocycle metabolic process	3	13
GO:0051276	chromosome organization	5	13
GO:0071103	DNA conformation change	6	13
GO:0071704	organic substance metabolic process	2	13
GO:0071840	cellular component organization or biogenesis	2	13
GO:0090304	nucleic acid metabolic process	4	13
GO:1901360	organic cyclic compound metabolic process	3	13
GO:0000712	resolution of meiotic recombination intermediates	4	1
GO:0000819	sister chromatid segregation	4	1
GO:0007059	chromosome segregation	2	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0098813	nuclear chromosome segregation	3	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003676	nucleic acid binding	3	13
GO:0003677	DNA binding	4	13
GO:0003824	catalytic activity	1	13
GO:0003916	DNA topoisomerase activity	3	13
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0008094	ATP-dependent activity, acting on DNA	2	13
GO:0016853	isomerase activity	2	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140097	catalytic activity, acting on DNA	3	13
GO:0140640	catalytic activity, acting on a nucleic acid	2	13
GO:0140657	ATP-dependent activity	1	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0016491	oxidoreductase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1060	1064	PF00656	0.279
CLV_C14_Caspase3-7	1328	1332	PF00656	0.747
CLV_C14_Caspase3-7	1460	1464	PF00656	0.619
CLV_C14_Caspase3-7	1471	1475	PF00656	0.650
CLV_C14_Caspase3-7	1487	1491	PF00656	0.373
CLV_C14_Caspase3-7	430	434	PF00656	0.285
CLV_C14_Caspase3-7	493	497	PF00656	0.404
CLV_C14_Caspase3-7	683	687	PF00656	0.237
CLV_MEL_PAP_1	271	277	PF00089	0.203
CLV_NRD_NRD_1	1003	1005	PF00675	0.232
CLV_NRD_NRD_1	1028	1030	PF00675	0.239
CLV_NRD_NRD_1	1040	1042	PF00675	0.233
CLV_NRD_NRD_1	1099	1101	PF00675	0.344
CLV_NRD_NRD_1	1132	1134	PF00675	0.401
CLV_NRD_NRD_1	1173	1175	PF00675	0.424
CLV_NRD_NRD_1	1184	1186	PF00675	0.422
CLV_NRD_NRD_1	1216	1218	PF00675	0.625
CLV_NRD_NRD_1	1249	1251	PF00675	0.583
CLV_NRD_NRD_1	1311	1313	PF00675	0.729
CLV_NRD_NRD_1	1317	1319	PF00675	0.771
CLV_NRD_NRD_1	1343	1345	PF00675	0.648
CLV_NRD_NRD_1	1458	1460	PF00675	0.581
CLV_NRD_NRD_1	161	163	PF00675	0.305
CLV_NRD_NRD_1	216	218	PF00675	0.284
CLV_NRD_NRD_1	256	258	PF00675	0.396
CLV_NRD_NRD_1	401	403	PF00675	0.396
CLV_NRD_NRD_1	634	636	PF00675	0.220
CLV_NRD_NRD_1	692	694	PF00675	0.284
CLV_NRD_NRD_1	750	752	PF00675	0.392
CLV_NRD_NRD_1	993	995	PF00675	0.240
CLV_PCSK_FUR_1	1455	1459	PF00082	0.637
CLV_PCSK_KEX2_1	1003	1005	PF00082	0.237
CLV_PCSK_KEX2_1	1028	1030	PF00082	0.237
CLV_PCSK_KEX2_1	1040	1042	PF00082	0.237
CLV_PCSK_KEX2_1	1099	1101	PF00082	0.344
CLV_PCSK_KEX2_1	1132	1134	PF00082	0.324
CLV_PCSK_KEX2_1	1184	1186	PF00082	0.425
CLV_PCSK_KEX2_1	1215	1217	PF00082	0.554
CLV_PCSK_KEX2_1	1248	1250	PF00082	0.560
CLV_PCSK_KEX2_1	1310	1312	PF00082	0.718
CLV_PCSK_KEX2_1	1342	1344	PF00082	0.587
CLV_PCSK_KEX2_1	1435	1437	PF00082	0.626
CLV_PCSK_KEX2_1	1455	1457	PF00082	0.566
CLV_PCSK_KEX2_1	1458	1460	PF00082	0.564
CLV_PCSK_KEX2_1	215	217	PF00082	0.285
CLV_PCSK_KEX2_1	701	703	PF00082	0.264
CLV_PCSK_KEX2_1	993	995	PF00082	0.249
CLV_PCSK_PC1ET2_1	1028	1030	PF00082	0.336
CLV_PCSK_PC1ET2_1	1248	1250	PF00082	0.584
CLV_PCSK_PC1ET2_1	1310	1312	PF00082	0.718
CLV_PCSK_PC1ET2_1	1435	1437	PF00082	0.608
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.356
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.237
CLV_PCSK_PC1ET2_1	993	995	PF00082	0.355
CLV_PCSK_PC7_1	1306	1312	PF00082	0.621
CLV_PCSK_SKI1_1	1003	1007	PF00082	0.285
CLV_PCSK_SKI1_1	1032	1036	PF00082	0.285
CLV_PCSK_SKI1_1	1099	1103	PF00082	0.344
CLV_PCSK_SKI1_1	1175	1179	PF00082	0.564
CLV_PCSK_SKI1_1	1196	1200	PF00082	0.398
CLV_PCSK_SKI1_1	1205	1209	PF00082	0.433
CLV_PCSK_SKI1_1	1250	1254	PF00082	0.675
CLV_PCSK_SKI1_1	1347	1351	PF00082	0.547
CLV_PCSK_SKI1_1	1443	1447	PF00082	0.665
CLV_PCSK_SKI1_1	227	231	PF00082	0.382
CLV_PCSK_SKI1_1	388	392	PF00082	0.440
CLV_PCSK_SKI1_1	517	521	PF00082	0.365
CLV_PCSK_SKI1_1	693	697	PF00082	0.240
CLV_PCSK_SKI1_1	770	774	PF00082	0.250
CLV_PCSK_SKI1_1	781	785	PF00082	0.352
CLV_PCSK_SKI1_1	902	906	PF00082	0.237
DEG_APCC_DBOX_1	606	614	PF00400	0.423
DEG_COP1_1	107	115	PF00400	0.310
DEG_SPOP_SBC_1	1438	1442	PF00917	0.449
DOC_ANK_TNKS_1	1016	1023	PF00023	0.392
DOC_CDC14_PxL_1	405	413	PF14671	0.414
DOC_CKS1_1	541	546	PF01111	0.411
DOC_CYCLIN_RxL_1	1028	1037	PF00134	0.285
DOC_CYCLIN_RxL_1	1193	1202	PF00134	0.543
DOC_CYCLIN_RxL_1	689	698	PF00134	0.344
DOC_MAPK_gen_1	104	112	PF00069	0.237
DOC_MAPK_gen_1	1040	1046	PF00069	0.375
DOC_MAPK_gen_1	1184	1190	PF00069	0.455
DOC_MAPK_gen_1	402	408	PF00069	0.406
DOC_MAPK_MEF2A_6	205	214	PF00069	0.423
DOC_MAPK_MEF2A_6	268	275	PF00069	0.403
DOC_MAPK_MEF2A_6	327	334	PF00069	0.403
DOC_PP1_RVXF_1	556	563	PF00149	0.424
DOC_PP1_RVXF_1	607	613	PF00149	0.403
DOC_PP1_RVXF_1	691	698	PF00149	0.237
DOC_PP2B_LxvP_1	110	113	PF13499	0.250
DOC_PP2B_LxvP_1	1186	1189	PF13499	0.405
DOC_PP2B_LxvP_1	532	535	PF13499	0.291
DOC_PP4_FxxP_1	541	544	PF00568	0.403
DOC_PP4_FxxP_1	563	566	PF00568	0.403
DOC_PP4_FxxP_1	806	809	PF00568	0.375
DOC_PP4_FxxP_1	931	934	PF00568	0.250
DOC_SPAK_OSR1_1	200	204	PF12202	0.335
DOC_USP7_MATH_1	1252	1256	PF00917	0.556
DOC_USP7_MATH_1	1374	1378	PF00917	0.602
DOC_USP7_MATH_1	1390	1394	PF00917	0.430
DOC_USP7_MATH_1	1399	1403	PF00917	0.600
DOC_USP7_MATH_1	1431	1435	PF00917	0.560
DOC_USP7_MATH_1	1438	1442	PF00917	0.505
DOC_USP7_MATH_1	1475	1479	PF00917	0.550
DOC_USP7_MATH_2	835	841	PF00917	0.258
DOC_USP7_UBL2_3	1028	1032	PF12436	0.322
DOC_USP7_UBL2_3	1175	1179	PF12436	0.398
DOC_USP7_UBL2_3	1201	1205	PF12436	0.427
DOC_USP7_UBL2_3	1243	1247	PF12436	0.584
DOC_USP7_UBL2_3	1316	1320	PF12436	0.653
DOC_USP7_UBL2_3	1446	1450	PF12436	0.621
DOC_USP7_UBL2_3	164	168	PF12436	0.431
DOC_USP7_UBL2_3	314	318	PF12436	0.406
DOC_USP7_UBL2_3	547	551	PF12436	0.403
DOC_USP7_UBL2_3	868	872	PF12436	0.265
DOC_WW_Pin1_4	1139	1144	PF00397	0.250
DOC_WW_Pin1_4	1298	1303	PF00397	0.585
DOC_WW_Pin1_4	1376	1381	PF00397	0.513
DOC_WW_Pin1_4	51	56	PF00397	0.307
DOC_WW_Pin1_4	540	545	PF00397	0.255
LIG_14-3-3_CanoR_1	1003	1012	PF00244	0.392
LIG_14-3-3_CanoR_1	1436	1444	PF00244	0.634
LIG_14-3-3_CanoR_1	237	247	PF00244	0.428
LIG_14-3-3_CanoR_1	257	263	PF00244	0.233
LIG_14-3-3_CanoR_1	398	406	PF00244	0.420
LIG_14-3-3_CanoR_1	424	428	PF00244	0.334
LIG_14-3-3_CanoR_1	607	613	PF00244	0.363
LIG_14-3-3_CanoR_1	657	662	PF00244	0.479
LIG_14-3-3_CanoR_1	83	93	PF00244	0.392
LIG_APCC_ABBA_1	36	41	PF00400	0.341
LIG_BRCT_BRCA1_1	148	152	PF00533	0.237
LIG_Clathr_ClatBox_1	985	989	PF01394	0.237
LIG_CSL_BTD_1	110	113	PF09270	0.250
LIG_CSL_BTD_1	52	55	PF09270	0.294
LIG_deltaCOP1_diTrp_1	109	117	PF00928	0.285
LIG_deltaCOP1_diTrp_1	1264	1269	PF00928	0.529
LIG_deltaCOP1_diTrp_1	637	642	PF00928	0.513
LIG_DLG_GKlike_1	464	471	PF00625	0.462
LIG_EH1_1	299	307	PF00400	0.433
LIG_eIF4E_1	771	777	PF01652	0.392
LIG_EVH1_1	1044	1048	PF00568	0.392
LIG_FHA_1	1004	1010	PF00498	0.331
LIG_FHA_1	1021	1027	PF00498	0.150
LIG_FHA_1	1181	1187	PF00498	0.295
LIG_FHA_1	31	37	PF00498	0.373
LIG_FHA_1	359	365	PF00498	0.412
LIG_FHA_1	424	430	PF00498	0.325
LIG_FHA_1	438	444	PF00498	0.298
LIG_FHA_1	493	499	PF00498	0.288
LIG_FHA_1	52	58	PF00498	0.250
LIG_FHA_1	541	547	PF00498	0.403
LIG_FHA_1	817	823	PF00498	0.237
LIG_FHA_1	919	925	PF00498	0.409
LIG_FHA_1	957	963	PF00498	0.237
LIG_FHA_2	1055	1061	PF00498	0.287
LIG_FHA_2	11	17	PF00498	0.414
LIG_FHA_2	1140	1146	PF00498	0.262
LIG_FHA_2	1154	1160	PF00498	0.375
LIG_FHA_2	1358	1364	PF00498	0.576
LIG_FHA_2	18	24	PF00498	0.431
LIG_FHA_2	240	246	PF00498	0.323
LIG_FHA_2	250	256	PF00498	0.324
LIG_FHA_2	428	434	PF00498	0.293
LIG_FHA_2	862	868	PF00498	0.265
LIG_LIR_Apic_2	540	544	PF02991	0.138
LIG_LIR_Apic_2	561	566	PF02991	0.403
LIG_LIR_Apic_2	803	809	PF02991	0.284
LIG_LIR_Apic_2	929	934	PF02991	0.250
LIG_LIR_Gen_1	1102	1113	PF02991	0.243
LIG_LIR_Gen_1	186	196	PF02991	0.269
LIG_LIR_Gen_1	197	206	PF02991	0.247
LIG_LIR_Gen_1	245	253	PF02991	0.309
LIG_LIR_Gen_1	261	267	PF02991	0.328
LIG_LIR_Gen_1	600	610	PF02991	0.403
LIG_LIR_Gen_1	87	94	PF02991	0.392
LIG_LIR_Gen_1	925	936	PF02991	0.237
LIG_LIR_LC3C_4	1021	1026	PF02991	0.348
LIG_LIR_LC3C_4	910	915	PF02991	0.302
LIG_LIR_Nem_3	1102	1108	PF02991	0.243
LIG_LIR_Nem_3	114	120	PF02991	0.237
LIG_LIR_Nem_3	186	192	PF02991	0.270
LIG_LIR_Nem_3	193	198	PF02991	0.252
LIG_LIR_Nem_3	241	246	PF02991	0.281
LIG_LIR_Nem_3	261	265	PF02991	0.218
LIG_LIR_Nem_3	447	453	PF02991	0.277
LIG_LIR_Nem_3	600	605	PF02991	0.403
LIG_LIR_Nem_3	660	664	PF02991	0.407
LIG_LIR_Nem_3	803	808	PF02991	0.237
LIG_LIR_Nem_3	87	93	PF02991	0.392
LIG_LIR_Nem_3	898	904	PF02991	0.237
LIG_LIR_Nem_3	925	931	PF02991	0.237
LIG_LIR_Nem_3	982	986	PF02991	0.270
LIG_LYPXL_S_1	194	198	PF13949	0.262
LIG_LYPXL_S_1	249	253	PF13949	0.329
LIG_LYPXL_yS_3	250	253	PF13949	0.329
LIG_Pex14_1	638	642	PF04695	0.412
LIG_Pex14_1	857	861	PF04695	0.237
LIG_Pex14_1	897	901	PF04695	0.237
LIG_Pex14_2	148	152	PF04695	0.237
LIG_Pex14_2	165	169	PF04695	0.326
LIG_Pex14_2	194	198	PF04695	0.262
LIG_Pex14_2	523	527	PF04695	0.320
LIG_Pex14_2	537	541	PF04695	0.196
LIG_PTB_Apo_2	337	344	PF02174	0.403
LIG_SH2_CRK	1105	1109	PF00017	0.237
LIG_SH2_CRK	189	193	PF00017	0.259
LIG_SH2_CRK	262	266	PF00017	0.307
LIG_SH2_CRK	587	591	PF00017	0.403
LIG_SH2_GRB2like	492	495	PF00017	0.361
LIG_SH2_NCK_1	189	193	PF00017	0.259
LIG_SH2_NCK_1	219	223	PF00017	0.274
LIG_SH2_NCK_1	262	266	PF00017	0.328
LIG_SH2_NCK_1	39	43	PF00017	0.342
LIG_SH2_NCK_1	973	977	PF00017	0.375
LIG_SH2_PTP2	246	249	PF00017	0.306
LIG_SH2_PTP2	807	810	PF00017	0.237
LIG_SH2_PTP2	90	93	PF00017	0.392
LIG_SH2_SRC	39	42	PF00017	0.345
LIG_SH2_SRC	807	810	PF00017	0.237
LIG_SH2_SRC	955	958	PF00017	0.249
LIG_SH2_STAP1	1105	1109	PF00017	0.237
LIG_SH2_STAT5	1043	1046	PF00017	0.285
LIG_SH2_STAT5	1107	1110	PF00017	0.237
LIG_SH2_STAT5	189	192	PF00017	0.259
LIG_SH2_STAT5	246	249	PF00017	0.385
LIG_SH2_STAT5	25	28	PF00017	0.322
LIG_SH2_STAT5	300	303	PF00017	0.403
LIG_SH2_STAT5	371	374	PF00017	0.479
LIG_SH2_STAT5	450	453	PF00017	0.295
LIG_SH2_STAT5	568	571	PF00017	0.426
LIG_SH2_STAT5	601	604	PF00017	0.403
LIG_SH2_STAT5	716	719	PF00017	0.280
LIG_SH2_STAT5	771	774	PF00017	0.249
LIG_SH2_STAT5	807	810	PF00017	0.265
LIG_SH2_STAT5	858	861	PF00017	0.281
LIG_SH2_STAT5	90	93	PF00017	0.392
LIG_SH2_STAT5	955	958	PF00017	0.249
LIG_SH2_STAT5	984	987	PF00017	0.323
LIG_SH2_STAT5	997	1000	PF00017	0.381
LIG_SH3_1	1238	1244	PF00018	0.433
LIG_SH3_1	1299	1305	PF00018	0.474
LIG_SH3_3	1042	1048	PF00018	0.309
LIG_SH3_3	1174	1180	PF00018	0.505
LIG_SH3_3	1238	1244	PF00018	0.474
LIG_SH3_3	1287	1293	PF00018	0.611
LIG_SH3_3	1299	1305	PF00018	0.523
LIG_SH3_3	1441	1447	PF00018	0.783
LIG_SH3_3	70	76	PF00018	0.250
LIG_SH3_3	806	812	PF00018	0.237
LIG_SH3_4	1243	1250	PF00018	0.495
LIG_SH3_4	1316	1323	PF00018	0.707
LIG_SH3_4	1446	1453	PF00018	0.679
LIG_SUMO_SIM_anti_2	1410	1417	PF11976	0.519
LIG_SUMO_SIM_par_1	1021	1027	PF11976	0.346
LIG_SUMO_SIM_par_1	177	183	PF11976	0.212
LIG_SUMO_SIM_par_1	425	431	PF11976	0.318
LIG_SUMO_SIM_par_1	834	840	PF11976	0.243
LIG_TRAF2_1	1058	1061	PF00917	0.392
LIG_TRAF2_1	1263	1266	PF00917	0.527
LIG_TRAF2_1	1479	1482	PF00917	0.739
LIG_TRAF2_1	473	476	PF00917	0.418
LIG_TRAF2_1	864	867	PF00917	0.278
LIG_TYR_ITIM	498	503	PF00017	0.333
LIG_UBA3_1	1108	1112	PF00899	0.344
LIG_UBA3_1	1413	1420	PF00899	0.549
LIG_UBA3_1	210	215	PF00899	0.378
LIG_UBA3_1	301	308	PF00899	0.449
LIG_UBA3_1	405	410	PF00899	0.421
LIG_UBA3_1	483	491	PF00899	0.281
LIG_WRC_WIRS_1	1158	1163	PF05994	0.409
LIG_WRC_WIRS_1	191	196	PF05994	0.259
MOD_CDC14_SPxK_1	1301	1304	PF00782	0.583
MOD_CDK_SPK_2	1139	1144	PF00069	0.250
MOD_CDK_SPK_2	1298	1303	PF00069	0.585
MOD_CDK_SPxK_1	1298	1304	PF00069	0.585
MOD_CDK_SPxxK_3	540	547	PF00069	0.237
MOD_CK1_1	1055	1061	PF00069	0.237
MOD_CK1_1	1329	1335	PF00069	0.671
MOD_CK1_1	1379	1385	PF00069	0.493
MOD_CK1_1	1434	1440	PF00069	0.667
MOD_CK1_1	1462	1468	PF00069	0.614
MOD_CK1_1	1476	1482	PF00069	0.542
MOD_CK1_1	1483	1489	PF00069	0.519
MOD_CK1_1	1491	1497	PF00069	0.399
MOD_CK1_1	183	189	PF00069	0.178
MOD_CK1_1	288	294	PF00069	0.403
MOD_CK1_1	434	440	PF00069	0.453
MOD_CK1_1	561	567	PF00069	0.426
MOD_CK1_1	680	686	PF00069	0.237
MOD_CK1_1	718	724	PF00069	0.344
MOD_CK2_1	1004	1010	PF00069	0.265
MOD_CK2_1	1054	1060	PF00069	0.348
MOD_CK2_1	1139	1145	PF00069	0.306
MOD_CK2_1	1153	1159	PF00069	0.451
MOD_CK2_1	1260	1266	PF00069	0.635
MOD_CK2_1	1475	1481	PF00069	0.660
MOD_CK2_1	239	245	PF00069	0.282
MOD_CK2_1	249	255	PF00069	0.333
MOD_CK2_1	590	596	PF00069	0.501
MOD_CK2_1	608	614	PF00069	0.465
MOD_CK2_1	837	843	PF00069	0.315
MOD_CK2_1	861	867	PF00069	0.298
MOD_CK2_1	971	977	PF00069	0.315
MOD_Cter_Amidation	1213	1216	PF01082	0.585
MOD_GlcNHglycan	1230	1233	PF01048	0.572
MOD_GlcNHglycan	1294	1297	PF01048	0.539
MOD_GlcNHglycan	1334	1337	PF01048	0.595
MOD_GlcNHglycan	1351	1354	PF01048	0.623
MOD_GlcNHglycan	1376	1379	PF01048	0.638
MOD_GlcNHglycan	1381	1384	PF01048	0.620
MOD_GlcNHglycan	1474	1478	PF01048	0.671
MOD_GlcNHglycan	185	188	PF01048	0.427
MOD_GlcNHglycan	374	377	PF01048	0.410
MOD_GlcNHglycan	433	436	PF01048	0.291
MOD_GlcNHglycan	592	595	PF01048	0.247
MOD_GlcNHglycan	719	723	PF01048	0.344
MOD_GSK3_1	1020	1027	PF00069	0.285
MOD_GSK3_1	1139	1146	PF00069	0.187
MOD_GSK3_1	1153	1160	PF00069	0.398
MOD_GSK3_1	1326	1333	PF00069	0.643
MOD_GSK3_1	1347	1354	PF00069	0.550
MOD_GSK3_1	1399	1406	PF00069	0.572
MOD_GSK3_1	142	149	PF00069	0.237
MOD_GSK3_1	1422	1429	PF00069	0.603
MOD_GSK3_1	1434	1441	PF00069	0.664
MOD_GSK3_1	1458	1465	PF00069	0.595
MOD_GSK3_1	1469	1476	PF00069	0.565
MOD_GSK3_1	1480	1487	PF00069	0.475
MOD_GSK3_1	183	190	PF00069	0.403
MOD_GSK3_1	281	288	PF00069	0.403
MOD_GSK3_1	289	296	PF00069	0.403
MOD_GSK3_1	353	360	PF00069	0.468
MOD_GSK3_1	392	399	PF00069	0.559
MOD_GSK3_1	419	426	PF00069	0.338
MOD_GSK3_1	427	434	PF00069	0.296
MOD_GSK3_1	637	644	PF00069	0.505
MOD_GSK3_1	726	733	PF00069	0.261
MOD_GSK3_1	817	824	PF00069	0.291
MOD_GSK3_1	918	925	PF00069	0.392
MOD_GSK3_1	971	978	PF00069	0.302
MOD_N-GLC_1	577	582	PF02516	0.313
MOD_N-GLC_1	648	653	PF02516	0.223
MOD_N-GLC_1	816	821	PF02516	0.237
MOD_NEK2_1	1024	1029	PF00069	0.237
MOD_NEK2_1	1054	1059	PF00069	0.310
MOD_NEK2_1	120	125	PF00069	0.238
MOD_NEK2_1	1351	1356	PF00069	0.444
MOD_NEK2_1	1416	1421	PF00069	0.402
MOD_NEK2_1	167	172	PF00069	0.385
MOD_NEK2_1	285	290	PF00069	0.403
MOD_NEK2_1	384	389	PF00069	0.416
MOD_NEK2_1	590	595	PF00069	0.412
MOD_NEK2_1	704	709	PF00069	0.271
MOD_NEK2_1	730	735	PF00069	0.240
MOD_NEK2_1	741	746	PF00069	0.297
MOD_NEK2_1	826	831	PF00069	0.302
MOD_NEK2_1	859	864	PF00069	0.265
MOD_PIKK_1	10	16	PF00454	0.366
MOD_PIKK_1	1067	1073	PF00454	0.190
MOD_PIKK_1	342	348	PF00454	0.403
MOD_PIKK_1	895	901	PF00454	0.237
MOD_PKA_1	1003	1009	PF00069	0.392
MOD_PKA_1	1052	1058	PF00069	0.250
MOD_PKA_1	1099	1105	PF00069	0.392
MOD_PKA_1	1132	1138	PF00069	0.258
MOD_PKA_1	1457	1463	PF00069	0.547
MOD_PKA_1	316	322	PF00069	0.459
MOD_PKA_2	1003	1009	PF00069	0.392
MOD_PKA_2	1099	1105	PF00069	0.392
MOD_PKA_2	1132	1138	PF00069	0.258
MOD_PKA_2	1321	1327	PF00069	0.559
MOD_PKA_2	1400	1406	PF00069	0.599
MOD_PKA_2	1457	1463	PF00069	0.560
MOD_PKA_2	273	279	PF00069	0.410
MOD_PKA_2	397	403	PF00069	0.479
MOD_PKA_2	423	429	PF00069	0.331
MOD_PKA_2	608	614	PF00069	0.464
MOD_PKB_1	1155	1163	PF00069	0.246
MOD_PKB_1	1455	1463	PF00069	0.580
MOD_Plk_1	1330	1336	PF00069	0.543
MOD_Plk_1	1347	1353	PF00069	0.643
MOD_Plk_1	1480	1486	PF00069	0.538
MOD_Plk_1	1491	1497	PF00069	0.546
MOD_Plk_1	187	193	PF00069	0.260
MOD_Plk_1	225	231	PF00069	0.275
MOD_Plk_1	378	384	PF00069	0.404
MOD_Plk_1	464	470	PF00069	0.323
MOD_Plk_1	648	654	PF00069	0.408
MOD_Plk_1	677	683	PF00069	0.265
MOD_Plk_1	718	724	PF00069	0.265
MOD_Plk_1	726	732	PF00069	0.209
MOD_Plk_1	922	928	PF00069	0.237
MOD_Plk_2-3	1134	1140	PF00069	0.370
MOD_Plk_2-3	1260	1266	PF00069	0.562
MOD_Plk_2-3	204	210	PF00069	0.338
MOD_Plk_2-3	30	36	PF00069	0.298
MOD_Plk_2-3	798	804	PF00069	0.245
MOD_Plk_4	1020	1026	PF00069	0.285
MOD_Plk_4	1143	1149	PF00069	0.187
MOD_Plk_4	1157	1163	PF00069	0.393
MOD_Plk_4	187	193	PF00069	0.260
MOD_Plk_4	281	287	PF00069	0.403
MOD_Plk_4	364	370	PF00069	0.407
MOD_Plk_4	423	429	PF00069	0.331
MOD_Plk_4	527	533	PF00069	0.142
MOD_Plk_4	608	614	PF00069	0.502
MOD_Plk_4	680	686	PF00069	0.229
MOD_Plk_4	726	732	PF00069	0.255
MOD_Plk_4	77	83	PF00069	0.310
MOD_Plk_4	975	981	PF00069	0.310
MOD_ProDKin_1	1139	1145	PF00069	0.250
MOD_ProDKin_1	1298	1304	PF00069	0.585
MOD_ProDKin_1	1376	1382	PF00069	0.515
MOD_ProDKin_1	51	57	PF00069	0.304
MOD_ProDKin_1	540	546	PF00069	0.255
MOD_SUMO_rev_2	1145	1154	PF00179	0.348
MOD_SUMO_rev_2	124	134	PF00179	0.237
MOD_SUMO_rev_2	255	260	PF00179	0.350
MOD_SUMO_rev_2	395	405	PF00179	0.446
MOD_SUMO_rev_2	564	574	PF00179	0.423
TRG_DiLeu_BaEn_1	208	213	PF01217	0.316
TRG_DiLeu_BaEn_2	868	874	PF01217	0.237
TRG_DiLeu_BaEn_4	947	953	PF01217	0.250
TRG_DiLeu_BaLyEn_6	745	750	PF01217	0.250
TRG_ENDOCYTIC_2	1043	1046	PF00928	0.269
TRG_ENDOCYTIC_2	1105	1108	PF00928	0.237
TRG_ENDOCYTIC_2	189	192	PF00928	0.259
TRG_ENDOCYTIC_2	195	198	PF00928	0.263
TRG_ENDOCYTIC_2	246	249	PF00928	0.306
TRG_ENDOCYTIC_2	250	253	PF00928	0.317
TRG_ENDOCYTIC_2	262	265	PF00928	0.334
TRG_ENDOCYTIC_2	450	453	PF00928	0.295
TRG_ENDOCYTIC_2	500	503	PF00928	0.348
TRG_ENDOCYTIC_2	58	61	PF00928	0.259
TRG_ENDOCYTIC_2	587	590	PF00928	0.403
TRG_ENDOCYTIC_2	661	664	PF00928	0.403
TRG_ENDOCYTIC_2	807	810	PF00928	0.237
TRG_ENDOCYTIC_2	833	836	PF00928	0.239
TRG_ENDOCYTIC_2	858	861	PF00928	0.237
TRG_ENDOCYTIC_2	90	93	PF00928	0.392
TRG_ENDOCYTIC_2	901	904	PF00928	0.237
TRG_ER_diArg_1	1002	1004	PF00400	0.293
TRG_ER_diArg_1	1040	1042	PF00400	0.362
TRG_ER_diArg_1	1098	1100	PF00400	0.344
TRG_ER_diArg_1	1154	1157	PF00400	0.268
TRG_ER_diArg_1	1184	1187	PF00400	0.399
TRG_ER_diArg_1	1215	1217	PF00400	0.624
TRG_ER_diArg_1	1341	1344	PF00400	0.585
TRG_ER_diArg_1	1455	1458	PF00400	0.593
TRG_ER_diArg_1	216	218	PF00400	0.286
TRG_ER_diArg_1	607	610	PF00400	0.412
TRG_NES_CRM1_1	475	487	PF08389	0.344
TRG_NES_CRM1_1	637	650	PF08389	0.513
TRG_NES_CRM1_1	75	88	PF08389	0.344
TRG_NLS_Bipartite_1	1040	1055	PF00514	0.324
TRG_NLS_Bipartite_1	1303	1323	PF00514	0.705
TRG_NLS_MonoCore_2	1027	1032	PF00514	0.392
TRG_NLS_MonoCore_2	1246	1251	PF00514	0.604
TRG_NLS_MonoCore_2	1302	1307	PF00514	0.732
TRG_NLS_MonoCore_2	313	318	PF00514	0.513
TRG_NLS_MonoExtC_3	1027	1032	PF00514	0.392
TRG_NLS_MonoExtC_3	1173	1178	PF00514	0.463
TRG_NLS_MonoExtC_3	1246	1251	PF00514	0.572
TRG_NLS_MonoExtC_3	1317	1322	PF00514	0.637
TRG_NLS_MonoExtC_3	214	220	PF00514	0.353
TRG_NLS_MonoExtC_3	313	318	PF00514	0.404
TRG_NLS_MonoExtN_4	1048	1055	PF00514	0.265
TRG_NLS_MonoExtN_4	1174	1179	PF00514	0.463
TRG_NLS_MonoExtN_4	1244	1251	PF00514	0.553
TRG_NLS_MonoExtN_4	1302	1307	PF00514	0.727
TRG_NLS_MonoExtN_4	1309	1314	PF00514	0.631
TRG_NLS_MonoExtN_4	1316	1323	PF00514	0.559
TRG_NLS_MonoExtN_4	160	166	PF00514	0.307
TRG_NLS_MonoExtN_4	314	319	PF00514	0.423
TRG_Pf-PMV_PEXEL_1	1032	1036	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	1196	1200	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P778	Leptomonas seymouri	33%	100%
A0A0N1HUJ9	Leptomonas seymouri	78%	100%
A0A0S4IZ11	Bodo saltans	72%	100%
A0A0S4JGE3	Bodo saltans	36%	100%
A0A1X0NR68	Trypanosomatidae	74%	99%
A0A1X0NUH3	Trypanosomatidae	36%	100%
A0A3Q8II93	Leishmania donovani	95%	100%
A0A3R7MTQ1	Trypanosoma rangeli	36%	100%
A0A3S7WTK8	Leishmania donovani	32%	100%
A0A422N9B0	Trypanosoma rangeli	67%	100%
A4H891	Leishmania braziliensis	35%	100%
A4HGT2	Leishmania braziliensis	90%	100%
A4HWL4	Leishmania infantum	32%	100%
A4I3V9	Leishmania infantum	97%	100%
C9ZXS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A926	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
D0A927	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AQC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O16140	Bombyx mori	46%	97%
O24308	Pisum sativum	47%	100%
O42130	Gallus gallus	40%	96%
O42131	Gallus gallus	43%	92%
O61078	Leishmania chagasi	32%	100%
O93794	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	45%	100%
P06786	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P08096	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
P0C9C0	African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)	25%	100%
P0C9C1	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	25%	100%
P0C9C2	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	25%	100%
P12531	Trypanosoma brucei brucei	36%	100%
P15348	Drosophila melanogaster	46%	100%
P27570	Crithidia fasciculata	33%	100%
P30182	Arabidopsis thaliana	47%	100%
P30190	Trypanosoma cruzi	36%	100%
P34203	African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)	25%	100%
P34534	Caenorhabditis elegans	39%	100%
P41515	Cricetulus griseus	46%	98%
P41516	Rattus norvegicus	40%	98%
P87078	Candida albicans	44%	100%
P90520	Dictyostelium discoideum	41%	100%
Q00942	African swine fever virus (strain Badajoz 1971 Vero-adapted)	25%	100%
Q01320	Mus musculus	40%	98%
Q01879	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	43%	100%
Q02880	Homo sapiens	45%	92%
Q196X4	Invertebrate iridescent virus 3	34%	100%
Q23670	Caenorhabditis elegans	45%	98%
Q4Q836	Leishmania major	94%	100%
Q4QF53	Leishmania major	33%	100%
Q55BP5	Dictyostelium discoideum	43%	98%
Q64399	Cricetulus longicaudatus	43%	93%
Q64511	Mus musculus	45%	93%
Q9QSK1	Invertebrate iridescent virus 6	33%	100%
Q9Y8G8	Penicillium chrysogenum	46%	94%
V5B5B2	Trypanosoma cruzi	66%	100%
V5BUD4	Trypanosoma cruzi	36%	100%