Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acetyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B048_LEIMU

TriTrypDb:

LmxM.28.2270

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B048

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B048

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004402	histone acetyltransferase activity	4	12
GO:0008080	N-acetyltransferase activity	6	12
GO:0016407	acetyltransferase activity	5	12
GO:0016410	N-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0034212	peptide N-acetyltransferase activity	7	12
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0003712	transcription coregulator activity	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.481
CLV_C14_Caspase3-7	309	313	PF00656	0.569
CLV_C14_Caspase3-7	625	629	PF00656	0.756
CLV_NRD_NRD_1	242	244	PF00675	0.598
CLV_NRD_NRD_1	4	6	PF00675	0.485
CLV_NRD_NRD_1	42	44	PF00675	0.530
CLV_NRD_NRD_1	459	461	PF00675	0.309
CLV_NRD_NRD_1	501	503	PF00675	0.284
CLV_NRD_NRD_1	525	527	PF00675	0.276
CLV_NRD_NRD_1	540	542	PF00675	0.431
CLV_NRD_NRD_1	556	558	PF00675	0.547
CLV_NRD_NRD_1	610	612	PF00675	0.598
CLV_NRD_NRD_1	621	623	PF00675	0.561
CLV_NRD_NRD_1	84	86	PF00675	0.399
CLV_PCSK_FUR_1	240	244	PF00082	0.592
CLV_PCSK_KEX2_1	242	244	PF00082	0.598
CLV_PCSK_KEX2_1	4	6	PF00082	0.492
CLV_PCSK_KEX2_1	459	461	PF00082	0.309
CLV_PCSK_KEX2_1	501	503	PF00082	0.282
CLV_PCSK_KEX2_1	525	527	PF00082	0.276
CLV_PCSK_KEX2_1	540	542	PF00082	0.427
CLV_PCSK_KEX2_1	610	612	PF00082	0.691
CLV_PCSK_KEX2_1	623	625	PF00082	0.671
CLV_PCSK_KEX2_1	84	86	PF00082	0.427
CLV_PCSK_PC1ET2_1	623	625	PF00082	0.671
CLV_PCSK_PC7_1	521	527	PF00082	0.192
CLV_PCSK_SKI1_1	126	130	PF00082	0.511
CLV_PCSK_SKI1_1	327	331	PF00082	0.401
CLV_PCSK_SKI1_1	387	391	PF00082	0.299
CLV_PCSK_SKI1_1	394	398	PF00082	0.327
CLV_PCSK_SKI1_1	530	534	PF00082	0.285
CLV_PCSK_SKI1_1	665	669	PF00082	0.615
CLV_PCSK_SKI1_1	711	715	PF00082	0.380
CLV_Separin_Metazoa	743	747	PF03568	0.414
DEG_APCC_DBOX_1	220	228	PF00400	0.518
DEG_APCC_DBOX_1	241	249	PF00400	0.562
DEG_SPOP_SBC_1	194	198	PF00917	0.496
DEG_SPOP_SBC_1	659	663	PF00917	0.548
DEG_SPOP_SBC_1	678	682	PF00917	0.478
DOC_ANK_TNKS_1	355	362	PF00023	0.358
DOC_ANK_TNKS_1	609	616	PF00023	0.602
DOC_CYCLIN_RxL_1	382	395	PF00134	0.445
DOC_MAPK_DCC_7	72	81	PF00069	0.400
DOC_MAPK_gen_1	540	547	PF00069	0.480
DOC_MAPK_gen_1	664	670	PF00069	0.569
DOC_MAPK_MEF2A_6	72	81	PF00069	0.400
DOC_PP1_RVXF_1	733	740	PF00149	0.396
DOC_PP2B_LxvP_1	357	360	PF13499	0.331
DOC_PP2B_LxvP_1	730	733	PF13499	0.349
DOC_PP4_FxxP_1	330	333	PF00568	0.364
DOC_USP7_MATH_1	112	116	PF00917	0.510
DOC_USP7_MATH_1	189	193	PF00917	0.558
DOC_USP7_MATH_1	298	302	PF00917	0.647
DOC_USP7_MATH_1	313	317	PF00917	0.632
DOC_USP7_MATH_1	470	474	PF00917	0.629
DOC_USP7_MATH_1	475	479	PF00917	0.537
DOC_USP7_MATH_1	617	621	PF00917	0.543
DOC_USP7_MATH_1	659	663	PF00917	0.548
DOC_USP7_MATH_1	678	682	PF00917	0.485
DOC_USP7_MATH_1	95	99	PF00917	0.608
DOC_USP7_UBL2_3	554	558	PF12436	0.585
DOC_WW_Pin1_4	105	110	PF00397	0.603
DOC_WW_Pin1_4	195	200	PF00397	0.662
DOC_WW_Pin1_4	201	206	PF00397	0.501
DOC_WW_Pin1_4	229	234	PF00397	0.572
DOC_WW_Pin1_4	255	260	PF00397	0.447
DOC_WW_Pin1_4	302	307	PF00397	0.516
DOC_WW_Pin1_4	504	509	PF00397	0.481
DOC_WW_Pin1_4	615	620	PF00397	0.533
DOC_WW_Pin1_4	673	678	PF00397	0.778
LIG_14-3-3_CanoR_1	126	135	PF00244	0.531
LIG_14-3-3_CanoR_1	257	263	PF00244	0.467
LIG_14-3-3_CanoR_1	337	343	PF00244	0.351
LIG_14-3-3_CanoR_1	370	375	PF00244	0.435
LIG_14-3-3_CanoR_1	4	10	PF00244	0.564
LIG_14-3-3_CanoR_1	459	467	PF00244	0.642
LIG_14-3-3_CanoR_1	644	654	PF00244	0.600
LIG_14-3-3_CanoR_1	721	728	PF00244	0.464
LIG_BRCT_BRCA1_1	165	169	PF00533	0.359
LIG_DLG_GKlike_1	5	12	PF00625	0.471
LIG_eIF4E_1	247	253	PF01652	0.531
LIG_eIF4E_1	278	284	PF01652	0.409
LIG_FHA_1	52	58	PF00498	0.568
LIG_FHA_1	655	661	PF00498	0.648
LIG_FHA_1	678	684	PF00498	0.509
LIG_FHA_2	629	635	PF00498	0.627
LIG_FHA_2	692	698	PF00498	0.584
LIG_LIR_Apic_2	328	333	PF02991	0.322
LIG_LIR_Gen_1	225	236	PF02991	0.530
LIG_LIR_Gen_1	340	347	PF02991	0.345
LIG_LIR_Gen_1	738	745	PF02991	0.389
LIG_LIR_Nem_3	225	231	PF02991	0.520
LIG_LIR_Nem_3	261	267	PF02991	0.350
LIG_LIR_Nem_3	34	40	PF02991	0.413
LIG_LYPXL_S_1	36	40	PF13949	0.415
LIG_LYPXL_yS_3	37	40	PF13949	0.415
LIG_NRBOX	11	17	PF00104	0.475
LIG_NRBOX	709	715	PF00104	0.364
LIG_PCNA_yPIPBox_3	19	30	PF02747	0.431
LIG_Pex14_2	330	334	PF04695	0.339
LIG_Pex14_2	433	437	PF04695	0.444
LIG_PTB_Apo_2	282	289	PF02174	0.411
LIG_PTB_Apo_2	405	412	PF02174	0.469
LIG_PTB_Phospho_1	282	288	PF10480	0.408
LIG_Rb_pABgroove_1	735	743	PF01858	0.378
LIG_SH2_CRK	153	157	PF00017	0.380
LIG_SH2_GRB2like	267	270	PF00017	0.380
LIG_SH2_NCK_1	496	500	PF00017	0.444
LIG_SH2_STAP1	339	343	PF00017	0.442
LIG_SH2_STAP1	496	500	PF00017	0.445
LIG_SH2_STAP1	741	745	PF00017	0.398
LIG_SH2_STAT5	175	178	PF00017	0.354
LIG_SH2_STAT5	247	250	PF00017	0.528
LIG_SH2_STAT5	264	267	PF00017	0.304
LIG_SH2_STAT5	271	274	PF00017	0.404
LIG_SH2_STAT5	385	388	PF00017	0.469
LIG_SH2_STAT5	410	413	PF00017	0.478
LIG_SH2_STAT5	420	423	PF00017	0.487
LIG_SH2_STAT5	424	427	PF00017	0.491
LIG_SH2_STAT5	432	435	PF00017	0.434
LIG_SH2_STAT5	736	739	PF00017	0.386
LIG_SH3_1	463	469	PF00018	0.554
LIG_SH3_3	269	275	PF00018	0.373
LIG_SH3_3	27	33	PF00018	0.421
LIG_SH3_3	287	293	PF00018	0.575
LIG_SH3_3	422	428	PF00018	0.433
LIG_SH3_3	463	469	PF00018	0.571
LIG_SH3_3	505	511	PF00018	0.491
LIG_SH3_3	71	77	PF00018	0.488
LIG_SH3_3	86	92	PF00018	0.451
LIG_SH3_3	99	105	PF00018	0.552
LIG_SUMO_SIM_anti_2	590	598	PF11976	0.518
LIG_SUMO_SIM_par_1	578	583	PF11976	0.581
LIG_SUMO_SIM_par_1	590	598	PF11976	0.517
LIG_TRAF2_1	360	363	PF00917	0.435
LIG_TRAF2_1	639	642	PF00917	0.535
LIG_TYR_ITIM	35	40	PF00017	0.407
LIG_UBA3_1	389	394	PF00899	0.478
LIG_WW_2	89	92	PF00397	0.502
LIG_WW_3	479	483	PF00397	0.438
MOD_CDK_SPxK_1	504	510	PF00069	0.481
MOD_CDK_SPxxK_3	615	622	PF00069	0.533
MOD_CK1_1	10	16	PF00069	0.470
MOD_CK1_1	108	114	PF00069	0.518
MOD_CK1_1	121	127	PF00069	0.518
MOD_CK1_1	426	432	PF00069	0.506
MOD_CK1_1	51	57	PF00069	0.551
MOD_CK1_1	609	615	PF00069	0.599
MOD_CK1_1	763	769	PF00069	0.686
MOD_CK1_1	97	103	PF00069	0.599
MOD_CK2_1	112	118	PF00069	0.548
MOD_CK2_1	392	398	PF00069	0.463
MOD_CK2_1	628	634	PF00069	0.626
MOD_CK2_1	636	642	PF00069	0.583
MOD_CK2_1	746	752	PF00069	0.368
MOD_Cter_Amidation	2	5	PF01082	0.497
MOD_Cter_Amidation	457	460	PF01082	0.281
MOD_GlcNHglycan	105	108	PF01048	0.723
MOD_GlcNHglycan	110	113	PF01048	0.666
MOD_GlcNHglycan	130	133	PF01048	0.485
MOD_GlcNHglycan	165	168	PF01048	0.420
MOD_GlcNHglycan	190	194	PF01048	0.686
MOD_GlcNHglycan	224	227	PF01048	0.534
MOD_GlcNHglycan	427	431	PF01048	0.245
MOD_GlcNHglycan	471	475	PF01048	0.522
MOD_GlcNHglycan	54	57	PF01048	0.548
MOD_GlcNHglycan	585	588	PF01048	0.563
MOD_GlcNHglycan	61	64	PF01048	0.541
MOD_GlcNHglycan	611	614	PF01048	0.586
MOD_GlcNHglycan	619	622	PF01048	0.536
MOD_GlcNHglycan	757	760	PF01048	0.356
MOD_GSK3_1	108	115	PF00069	0.505
MOD_GSK3_1	124	131	PF00069	0.511
MOD_GSK3_1	189	196	PF00069	0.636
MOD_GSK3_1	298	305	PF00069	0.592
MOD_GSK3_1	3	10	PF00069	0.587
MOD_GSK3_1	377	384	PF00069	0.495
MOD_GSK3_1	44	51	PF00069	0.537
MOD_GSK3_1	654	661	PF00069	0.704
MOD_GSK3_1	673	680	PF00069	0.720
MOD_GSK3_1	687	694	PF00069	0.497
MOD_GSK3_1	763	770	PF00069	0.572
MOD_GSK3_1	90	97	PF00069	0.560
MOD_LATS_1	42	48	PF00433	0.515
MOD_N-GLC_1	10	15	PF02516	0.471
MOD_N-GLC_1	377	382	PF02516	0.244
MOD_NEK2_1	235	240	PF00069	0.537
MOD_NEK2_1	532	537	PF00069	0.496
MOD_NEK2_1	654	659	PF00069	0.568
MOD_NEK2_1	660	665	PF00069	0.528
MOD_NEK2_1	760	765	PF00069	0.425
MOD_PIKK_1	121	127	PF00454	0.744
MOD_PIKK_1	235	241	PF00454	0.589
MOD_PIKK_1	377	383	PF00454	0.481
MOD_PIKK_1	687	693	PF00454	0.475
MOD_PKA_1	4	10	PF00069	0.481
MOD_PKA_1	459	465	PF00069	0.637
MOD_PKA_1	502	508	PF00069	0.449
MOD_PKA_1	622	628	PF00069	0.660
MOD_PKA_2	118	124	PF00069	0.593
MOD_PKA_2	163	169	PF00069	0.377
MOD_PKA_2	18	24	PF00069	0.484
MOD_PKA_2	3	9	PF00069	0.576
MOD_PKA_2	458	464	PF00069	0.618
MOD_PKA_2	568	574	PF00069	0.593
MOD_PKA_2	609	615	PF00069	0.705
MOD_PKA_2	691	697	PF00069	0.445
MOD_PKA_2	720	726	PF00069	0.486
MOD_PKA_2	763	769	PF00069	0.545
MOD_Plk_1	10	16	PF00069	0.556
MOD_Plk_1	189	195	PF00069	0.599
MOD_Plk_1	24	30	PF00069	0.410
MOD_Plk_1	311	317	PF00069	0.510
MOD_Plk_1	747	753	PF00069	0.401
MOD_Plk_2-3	628	634	PF00069	0.626
MOD_Plk_4	267	273	PF00069	0.366
MOD_Plk_4	31	37	PF00069	0.397
MOD_Plk_4	370	376	PF00069	0.469
MOD_Plk_4	392	398	PF00069	0.444
MOD_ProDKin_1	105	111	PF00069	0.604
MOD_ProDKin_1	195	201	PF00069	0.662
MOD_ProDKin_1	229	235	PF00069	0.570
MOD_ProDKin_1	255	261	PF00069	0.434
MOD_ProDKin_1	302	308	PF00069	0.516
MOD_ProDKin_1	504	510	PF00069	0.481
MOD_ProDKin_1	615	621	PF00069	0.532
MOD_ProDKin_1	673	679	PF00069	0.777
MOD_SUMO_for_1	629	632	PF00179	0.636
MOD_SUMO_rev_2	138	148	PF00179	0.498
MOD_SUMO_rev_2	395	402	PF00179	0.478
MOD_SUMO_rev_2	550	560	PF00179	0.551
MOD_SUMO_rev_2	608	618	PF00179	0.603
MOD_SUMO_rev_2	625	631	PF00179	0.633
TRG_DiLeu_BaEn_4	640	646	PF01217	0.521
TRG_DiLeu_BaEn_4	705	711	PF01217	0.410
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.474
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.475
TRG_ENDOCYTIC_2	153	156	PF00928	0.378
TRG_ENDOCYTIC_2	228	231	PF00928	0.549
TRG_ENDOCYTIC_2	278	281	PF00928	0.345
TRG_ENDOCYTIC_2	288	291	PF00928	0.401
TRG_ENDOCYTIC_2	342	345	PF00928	0.368
TRG_ENDOCYTIC_2	37	40	PF00928	0.415
TRG_ENDOCYTIC_2	410	413	PF00928	0.450
TRG_ENDOCYTIC_2	520	523	PF00928	0.465
TRG_ENDOCYTIC_2	741	744	PF00928	0.377
TRG_ER_diArg_1	240	243	PF00400	0.591
TRG_ER_diArg_1	356	359	PF00400	0.428
TRG_ER_diArg_1	463	466	PF00400	0.629
TRG_ER_diArg_1	500	502	PF00400	0.448
TRG_ER_diArg_1	524	526	PF00400	0.472
TRG_ER_diArg_1	539	541	PF00400	0.413
TRG_ER_diArg_1	83	85	PF00400	0.386
TRG_NLS_Bipartite_1	610	627	PF00514	0.531
TRG_NLS_MonoExtC_3	621	626	PF00514	0.651
TRG_NLS_MonoExtN_4	619	626	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIW1	Leptomonas seymouri	55%	100%
A0A1X0NS80	Trypanosomatidae	41%	100%
A0A2D1QVA5	Leishmania donovani	91%	100%
A4H7H5	Leishmania braziliensis	28%	100%
A4HGT1	Leishmania braziliensis	78%	100%
A4HVV6	Leishmania infantum	28%	100%
A4I3V8	Leishmania infantum	91%	100%
D7RTH9	Leishmania donovani	28%	100%
E9APK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q837	Leishmania major	90%	100%