Putative glycosomal membrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal membrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9B047_LEIMU

TriTrypDb:

LmxM.28.2260

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	1
GO:0020015	glycosome	7	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B047

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B047

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	14
GO:0009987	cellular process	1	14
GO:0016043	cellular component organization	3	14
GO:0016559	peroxisome fission	6	14
GO:0048285	organelle fission	5	14
GO:0071840	cellular component organization or biogenesis	2	14
GO:0032535	regulation of cellular component size	4	1
GO:0044375	regulation of peroxisome size	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0090066	regulation of anatomical structure size	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	90	92	PF00675	0.325
CLV_PCSK_KEX2_1	155	157	PF00082	0.450
CLV_PCSK_KEX2_1	90	92	PF00082	0.315
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.482
CLV_PCSK_SKI1_1	124	128	PF00082	0.287
CLV_PCSK_SKI1_1	150	154	PF00082	0.323
CLV_PCSK_SKI1_1	165	169	PF00082	0.455
CLV_PCSK_SKI1_1	6	10	PF00082	0.273
DOC_MAPK_gen_1	164	174	PF00069	0.274
DOC_MAPK_gen_1	42	49	PF00069	0.573
DOC_MAPK_gen_1	71	81	PF00069	0.548
DOC_MAPK_MEF2A_6	176	185	PF00069	0.272
DOC_PP1_RVXF_1	89	96	PF00149	0.510
DOC_USP7_MATH_1	35	39	PF00917	0.462
DOC_USP7_UBL2_3	124	128	PF12436	0.498
DOC_USP7_UBL2_3	164	168	PF12436	0.316
LIG_Actin_WH2_2	136	152	PF00022	0.295
LIG_Actin_WH2_2	178	194	PF00022	0.236
LIG_BIR_II_1	1	5	PF00653	0.605
LIG_LIR_Gen_1	2	11	PF02991	0.436
LIG_LIR_Nem_3	132	138	PF02991	0.372
LIG_LIR_Nem_3	18	24	PF02991	0.431
LIG_LIR_Nem_3	2	7	PF02991	0.560
LIG_LIR_Nem_3	94	99	PF02991	0.494
LIG_NRBOX	6	12	PF00104	0.538
LIG_Pex14_2	135	139	PF04695	0.293
LIG_Pex14_2	23	27	PF04695	0.477
LIG_Pex14_2	92	96	PF04695	0.549
LIG_PTB_Apo_2	98	105	PF02174	0.476
LIG_PTB_Phospho_1	98	104	PF10480	0.455
LIG_REV1ctd_RIR_1	25	33	PF16727	0.554
LIG_REV1ctd_RIR_1	93	101	PF16727	0.521
LIG_SH2_CRK	116	120	PF00017	0.390
LIG_SH2_CRK	21	25	PF00017	0.464
LIG_SH2_GRB2like	215	218	PF00017	0.462
LIG_SH2_PTP2	46	49	PF00017	0.447
LIG_SH2_STAT5	104	107	PF00017	0.437
LIG_SH2_STAT5	190	193	PF00017	0.256
LIG_SH2_STAT5	215	218	PF00017	0.484
LIG_SH2_STAT5	46	49	PF00017	0.447
LIG_SH3_3	191	197	PF00018	0.192
LIG_UBA3_1	59	64	PF00899	0.488
MOD_CK1_1	198	204	PF00069	0.233
MOD_CK1_1	38	44	PF00069	0.486
MOD_CK1_1	52	58	PF00069	0.465
MOD_CK2_1	160	166	PF00069	0.246
MOD_GlcNHglycan	119	122	PF01048	0.171
MOD_GlcNHglycan	208	211	PF01048	0.314
MOD_GlcNHglycan	54	57	PF01048	0.309
MOD_GSK3_1	172	179	PF00069	0.368
MOD_GSK3_1	45	52	PF00069	0.443
MOD_N-GLC_1	172	177	PF02516	0.382
MOD_N-GLC_1	216	221	PF02516	0.359
MOD_NEK2_1	216	221	PF00069	0.644
MOD_PIKK_1	195	201	PF00454	0.171
MOD_PIKK_1	35	41	PF00454	0.523
MOD_Plk_4	190	196	PF00069	0.264
MOD_Plk_4	211	217	PF00069	0.321
MOD_Plk_4	99	105	PF00069	0.527
MOD_SUMO_rev_2	120	126	PF00179	0.391
MOD_SUMO_rev_2	163	170	PF00179	0.246
TRG_DiLeu_BaEn_2	87	93	PF01217	0.542
TRG_ENDOCYTIC_2	116	119	PF00928	0.390
TRG_ENDOCYTIC_2	21	24	PF00928	0.455
TRG_ENDOCYTIC_2	46	49	PF00928	0.442
TRG_ER_diArg_1	90	92	PF00400	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG1	Leptomonas seymouri	32%	100%
A0A0N1PCA1	Leptomonas seymouri	81%	100%
A0A0S4IU25	Bodo saltans	51%	100%
A0A1X0NR15	Trypanosomatidae	53%	100%
A0A3S5H7J8	Leishmania donovani	32%	100%
A0A3S7X1W3	Leishmania donovani	92%	100%
A0A422N9F6	Trypanosoma rangeli	53%	100%
A4HD72	Leishmania braziliensis	25%	100%
A4HGS9	Leishmania braziliensis	30%	100%
A4HGT0	Leishmania braziliensis	85%	100%
A4I3V6	Leishmania infantum	33%	100%
A4I3V7	Leishmania infantum	91%	100%
D0A924	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B046	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4Q838	Leishmania major	87%	100%
Q4Q839	Leishmania major	32%	100%
V5BEE7	Trypanosoma cruzi	58%	100%