Metal-dependent HD superfamily phosphohydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hd phosphohydrolase family protein

Species:

Leishmania mexicana

UniProt:

E9B045_LEIMU

TriTrypDb:

LmxM.28.2240

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B045

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B045

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.565
CLV_NRD_NRD_1	280	282	PF00675	0.337
CLV_PCSK_KEX2_1	280	282	PF00082	0.358
CLV_PCSK_SKI1_1	288	292	PF00082	0.550
CLV_PCSK_SKI1_1	34	38	PF00082	0.592
DEG_Nend_Nbox_1	1	3	PF02207	0.523
DEG_SPOP_SBC_1	90	94	PF00917	0.512
DOC_CDC14_PxL_1	139	147	PF14671	0.549
DOC_CKS1_1	266	271	PF01111	0.436
DOC_CYCLIN_yCln2_LP_2	179	185	PF00134	0.588
DOC_MAPK_gen_1	166	173	PF00069	0.497
DOC_MAPK_MEF2A_6	205	213	PF00069	0.518
DOC_PP2B_LxvP_1	179	182	PF13499	0.558
DOC_USP7_MATH_1	102	106	PF00917	0.456
DOC_USP7_MATH_1	113	117	PF00917	0.601
DOC_USP7_MATH_1	119	123	PF00917	0.649
DOC_USP7_MATH_1	138	142	PF00917	0.684
DOC_USP7_MATH_1	186	190	PF00917	0.641
DOC_USP7_MATH_1	26	30	PF00917	0.595
DOC_USP7_MATH_1	91	95	PF00917	0.624
DOC_WW_Pin1_4	181	186	PF00397	0.619
DOC_WW_Pin1_4	265	270	PF00397	0.433
LIG_14-3-3_CanoR_1	157	165	PF00244	0.307
LIG_APCC_ABBA_1	209	214	PF00400	0.355
LIG_BRCT_BRCA1_1	53	57	PF00533	0.429
LIG_Clathr_ClatBox_1	145	149	PF01394	0.365
LIG_FHA_1	159	165	PF00498	0.561
LIG_FHA_1	289	295	PF00498	0.533
LIG_FHA_1	45	51	PF00498	0.421
LIG_FHA_2	123	129	PF00498	0.746
LIG_FHA_2	188	194	PF00498	0.658
LIG_FHA_2	35	41	PF00498	0.587
LIG_FHA_2	63	69	PF00498	0.550
LIG_Integrin_RGD_1	66	68	PF01839	0.520
LIG_LIR_Gen_1	54	64	PF02991	0.427
LIG_LIR_Nem_3	239	243	PF02991	0.476
LIG_LIR_Nem_3	268	273	PF02991	0.438
LIG_LIR_Nem_3	54	60	PF02991	0.426
LIG_Pex14_1	14	18	PF04695	0.551
LIG_Pex14_2	255	259	PF04695	0.381
LIG_REV1ctd_RIR_1	269	278	PF16727	0.494
LIG_SH2_CRK	266	270	PF00017	0.437
LIG_SH2_NCK_1	139	143	PF00017	0.604
LIG_SH2_SRC	18	21	PF00017	0.588
LIG_SH2_STAP1	232	236	PF00017	0.390
LIG_SH2_STAT5	163	166	PF00017	0.473
LIG_SH2_STAT5	18	21	PF00017	0.635
LIG_SH2_STAT5	270	273	PF00017	0.442
LIG_SH3_3	145	151	PF00018	0.506
LIG_SH3_3	172	178	PF00018	0.618
LIG_SH3_3	179	185	PF00018	0.566
LIG_SH3_3	58	64	PF00018	0.381
LIG_SUMO_SIM_anti_2	216	221	PF11976	0.351
LIG_SUMO_SIM_anti_2	49	54	PF11976	0.402
LIG_SUMO_SIM_par_1	47	54	PF11976	0.429
LIG_TRAF2_1	283	286	PF00917	0.553
LIG_WW_1	136	139	PF00397	0.642
MOD_CK1_1	122	128	PF00069	0.741
MOD_CK1_1	159	165	PF00069	0.474
MOD_CK1_1	93	99	PF00069	0.589
MOD_CK2_1	122	128	PF00069	0.653
MOD_CK2_1	181	187	PF00069	0.611
MOD_GlcNHglycan	104	107	PF01048	0.453
MOD_GlcNHglycan	115	118	PF01048	0.597
MOD_GlcNHglycan	119	122	PF01048	0.540
MOD_GlcNHglycan	140	143	PF01048	0.684
MOD_GlcNHglycan	190	193	PF01048	0.564
MOD_GlcNHglycan	197	200	PF01048	0.583
MOD_GlcNHglycan	28	31	PF01048	0.665
MOD_GlcNHglycan	70	75	PF01048	0.423
MOD_GlcNHglycan	93	96	PF01048	0.598
MOD_GSK3_1	113	120	PF00069	0.739
MOD_GSK3_1	26	33	PF00069	0.651
MOD_GSK3_1	85	92	PF00069	0.503
MOD_N-GLC_1	157	162	PF02516	0.419
MOD_NEK2_1	51	56	PF00069	0.441
MOD_NEK2_1	80	85	PF00069	0.453
MOD_PIKK_1	129	135	PF00454	0.560
MOD_PKA_2	156	162	PF00069	0.467
MOD_PKA_2	85	91	PF00069	0.580
MOD_Plk_1	238	244	PF00069	0.463
MOD_Plk_2-3	169	175	PF00069	0.421
MOD_Plk_4	159	165	PF00069	0.509
MOD_Plk_4	46	52	PF00069	0.408
MOD_ProDKin_1	181	187	PF00069	0.621
MOD_ProDKin_1	265	271	PF00069	0.433
MOD_SUMO_rev_2	169	178	PF00179	0.614
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.545
TRG_ER_diArg_1	228	231	PF00400	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I496	Leptomonas seymouri	46%	94%
A0A0S4J1A5	Bodo saltans	28%	100%
A0A1X0NQQ5	Trypanosomatidae	33%	97%
A0A3Q8IER6	Leishmania donovani	89%	100%
A0A422N9C9	Trypanosoma rangeli	38%	97%
A4HGS8	Leishmania braziliensis	78%	99%
A4I3V5	Leishmania infantum	89%	100%
D0A923	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q840	Leishmania major	89%	99%
V5D5P4	Trypanosoma cruzi	38%	99%