2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like

Species:

Leishmania mexicana

UniProt:

E9B043_LEIMU

TriTrypDb:

LmxM.28.2220

Length:

833

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B043

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B043

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006082	organic acid metabolic process	3	12
GO:0006090	pyruvate metabolic process	7	12
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006096	glycolytic process	5	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006757	obsolete ATP generation from ADP	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009132	nucleoside diphosphate metabolic process	5	12
GO:0009135	purine nucleoside diphosphate metabolic process	6	12
GO:0009141	nucleoside triphosphate metabolic process	5	12
GO:0009144	purine nucleoside triphosphate metabolic process	6	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	12
GO:0009185	ribonucleoside diphosphate metabolic process	6	12
GO:0009199	ribonucleoside triphosphate metabolic process	6	12
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009987	cellular process	1	12
GO:0016052	carbohydrate catabolic process	4	12
GO:0016310	phosphorylation	5	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0032787	monocarboxylic acid metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046031	ADP metabolic process	7	12
GO:0046034	ATP metabolic process	7	12
GO:0046483	heterocycle metabolic process	3	12
GO:0046939	obsolete nucleotide phosphorylation	6	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072521	purine-containing compound metabolic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004619	phosphoglycerate mutase activity	5	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0016868	intramolecular transferase activity, phosphotransferases	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046537	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity	6	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	435	437	PF00675	0.231
CLV_NRD_NRD_1	490	492	PF00675	0.278
CLV_NRD_NRD_1	554	556	PF00675	0.276
CLV_NRD_NRD_1	565	567	PF00675	0.261
CLV_NRD_NRD_1	589	591	PF00675	0.347
CLV_NRD_NRD_1	736	738	PF00675	0.335
CLV_PCSK_KEX2_1	435	437	PF00082	0.232
CLV_PCSK_KEX2_1	490	492	PF00082	0.278
CLV_PCSK_KEX2_1	554	556	PF00082	0.268
CLV_PCSK_KEX2_1	565	567	PF00082	0.262
CLV_PCSK_KEX2_1	736	738	PF00082	0.335
CLV_PCSK_KEX2_1	782	784	PF00082	0.278
CLV_PCSK_KEX2_1	824	826	PF00082	0.344
CLV_PCSK_PC1ET2_1	782	784	PF00082	0.278
CLV_PCSK_PC1ET2_1	824	826	PF00082	0.344
CLV_PCSK_SKI1_1	439	443	PF00082	0.218
CLV_PCSK_SKI1_1	519	523	PF00082	0.238
CLV_PCSK_SKI1_1	554	558	PF00082	0.295
CLV_PCSK_SKI1_1	654	658	PF00082	0.278
CLV_PCSK_SKI1_1	669	673	PF00082	0.178
CLV_Separin_Metazoa	733	737	PF03568	0.478
DEG_APCC_DBOX_1	277	285	PF00400	0.442
DEG_APCC_DBOX_1	589	597	PF00400	0.446
DEG_APCC_DBOX_1	613	621	PF00400	0.535
DEG_APCC_DBOX_1	668	676	PF00400	0.535
DEG_COP1_1	96	106	PF00400	0.393
DEG_Nend_UBRbox_3	1	3	PF02207	0.372
DEG_ODPH_VHL_1	622	633	PF01847	0.535
DEG_SCF_FBW7_1	159	164	PF00400	0.539
DEG_SPOP_SBC_1	161	165	PF00917	0.461
DEG_SPOP_SBC_1	421	425	PF00917	0.437
DOC_CYCLIN_yClb5_NLxxxL_5	588	597	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	128	134	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	345	351	PF00134	0.535
DOC_MAPK_FxFP_2	466	469	PF00069	0.535
DOC_MAPK_gen_1	590	598	PF00069	0.500
DOC_MAPK_gen_1	813	822	PF00069	0.354
DOC_MAPK_gen_1	84	91	PF00069	0.425
DOC_MAPK_JIP1_4	257	263	PF00069	0.281
DOC_MAPK_MEF2A_6	726	734	PF00069	0.478
DOC_PP2B_LxvP_1	61	64	PF13499	0.231
DOC_PP4_FxxP_1	255	258	PF00568	0.515
DOC_PP4_FxxP_1	466	469	PF00568	0.535
DOC_USP7_MATH_1	113	117	PF00917	0.517
DOC_USP7_MATH_1	161	165	PF00917	0.398
DOC_USP7_MATH_1	288	292	PF00917	0.542
DOC_USP7_MATH_1	351	355	PF00917	0.482
DOC_USP7_MATH_1	421	425	PF00917	0.535
DOC_USP7_MATH_1	495	499	PF00917	0.478
DOC_USP7_MATH_1	577	581	PF00917	0.531
DOC_USP7_MATH_1	690	694	PF00917	0.580
DOC_USP7_MATH_1	759	763	PF00917	0.468
DOC_WW_Pin1_4	155	160	PF00397	0.500
DOC_WW_Pin1_4	240	245	PF00397	0.682
DOC_WW_Pin1_4	276	281	PF00397	0.466
DOC_WW_Pin1_4	293	298	PF00397	0.466
DOC_WW_Pin1_4	365	370	PF00397	0.360
DOC_WW_Pin1_4	694	699	PF00397	0.413
DOC_WW_Pin1_4	760	765	PF00397	0.442
LIG_14-3-3_CanoR_1	120	130	PF00244	0.616
LIG_14-3-3_CanoR_1	162	168	PF00244	0.430
LIG_14-3-3_CanoR_1	36	41	PF00244	0.411
LIG_14-3-3_CanoR_1	783	790	PF00244	0.643
LIG_Actin_WH2_2	307	325	PF00022	0.446
LIG_APCC_ABBA_1	177	182	PF00400	0.571
LIG_BRCT_BRCA1_1	113	117	PF00533	0.549
LIG_Clathr_ClatBox_1	261	265	PF01394	0.442
LIG_EH1_1	339	347	PF00400	0.542
LIG_eIF4E_1	340	346	PF01652	0.360
LIG_FHA_1	329	335	PF00498	0.528
LIG_FHA_1	357	363	PF00498	0.431
LIG_FHA_1	404	410	PF00498	0.451
LIG_FHA_1	497	503	PF00498	0.470
LIG_FHA_1	510	516	PF00498	0.417
LIG_FHA_1	539	545	PF00498	0.450
LIG_FHA_1	551	557	PF00498	0.431
LIG_FHA_1	608	614	PF00498	0.491
LIG_FHA_1	623	629	PF00498	0.378
LIG_FHA_1	686	692	PF00498	0.570
LIG_FHA_1	752	758	PF00498	0.434
LIG_FHA_1	793	799	PF00498	0.343
LIG_FHA_2	103	109	PF00498	0.337
LIG_FHA_2	269	275	PF00498	0.447
LIG_FHA_2	277	283	PF00498	0.435
LIG_FHA_2	323	329	PF00498	0.478
LIG_FHA_2	399	405	PF00498	0.540
LIG_FHA_2	508	514	PF00498	0.442
LIG_FHA_2	646	652	PF00498	0.462
LIG_FHA_2	782	788	PF00498	0.558
LIG_LIR_Apic_2	154	159	PF02991	0.457
LIG_LIR_Apic_2	463	469	PF02991	0.360
LIG_LIR_Gen_1	269	280	PF02991	0.439
LIG_LIR_Gen_1	706	716	PF02991	0.557
LIG_LIR_Gen_1	799	807	PF02991	0.401
LIG_LIR_Nem_3	269	275	PF02991	0.442
LIG_LIR_Nem_3	41	46	PF02991	0.402
LIG_LIR_Nem_3	706	712	PF02991	0.529
LIG_LIR_Nem_3	743	749	PF02991	0.498
LIG_LIR_Nem_3	799	804	PF02991	0.374
LIG_NRBOX	592	598	PF00104	0.446
LIG_OCRL_FandH_1	610	622	PF00620	0.535
LIG_PCNA_PIPBox_1	823	832	PF02747	0.480
LIG_Pex14_1	607	611	PF04695	0.456
LIG_Pex14_2	395	399	PF04695	0.431
LIG_SH2_CRK	250	254	PF00017	0.526
LIG_SH2_CRK	709	713	PF00017	0.478
LIG_SH2_STAP1	535	539	PF00017	0.439
LIG_SH2_STAP1	540	544	PF00017	0.424
LIG_SH2_STAT5	146	149	PF00017	0.322
LIG_SH2_STAT5	272	275	PF00017	0.522
LIG_SH2_STAT5	431	434	PF00017	0.535
LIG_SH2_STAT5	540	543	PF00017	0.431
LIG_SH2_STAT5	6	9	PF00017	0.330
LIG_SH3_1	250	256	PF00018	0.396
LIG_SH3_3	229	235	PF00018	0.619
LIG_SH3_3	242	248	PF00018	0.519
LIG_SH3_3	250	256	PF00018	0.338
LIG_SH3_3	440	446	PF00018	0.446
LIG_SH3_3	48	54	PF00018	0.450
LIG_SH3_3	98	104	PF00018	0.411
LIG_SUMO_SIM_anti_2	279	285	PF11976	0.456
LIG_SUMO_SIM_anti_2	306	311	PF11976	0.446
LIG_SUMO_SIM_par_1	105	111	PF11976	0.484
LIG_SUMO_SIM_par_1	59	65	PF11976	0.221
LIG_TRAF2_1	648	651	PF00917	0.462
LIG_UBA3_1	501	508	PF00899	0.287
LIG_UBA3_1	819	824	PF00899	0.412
LIG_WRC_WIRS_1	399	404	PF05994	0.411
LIG_WRC_WIRS_1	608	613	PF05994	0.331
MOD_CDK_SPK_2	157	162	PF00069	0.550
MOD_CDK_SPxxK_3	155	162	PF00069	0.569
MOD_CDK_SPxxK_3	293	300	PF00069	0.167
MOD_CK1_1	157	163	PF00069	0.623
MOD_CK1_1	169	175	PF00069	0.463
MOD_CK1_1	296	302	PF00069	0.391
MOD_CK1_1	354	360	PF00069	0.320
MOD_CK1_1	423	429	PF00069	0.328
MOD_CK1_1	693	699	PF00069	0.414
MOD_CK1_1	96	102	PF00069	0.365
MOD_CK2_1	102	108	PF00069	0.369
MOD_CK2_1	268	274	PF00069	0.288
MOD_CK2_1	276	282	PF00069	0.271
MOD_CK2_1	305	311	PF00069	0.427
MOD_CK2_1	322	328	PF00069	0.154
MOD_CK2_1	645	651	PF00069	0.380
MOD_CK2_1	678	684	PF00069	0.314
MOD_CK2_1	781	787	PF00069	0.287
MOD_GlcNHglycan	113	116	PF01048	0.422
MOD_GlcNHglycan	171	174	PF01048	0.319
MOD_GlcNHglycan	316	319	PF01048	0.459
MOD_GlcNHglycan	331	334	PF01048	0.228
MOD_GlcNHglycan	342	345	PF01048	0.294
MOD_GlcNHglycan	486	489	PF01048	0.417
MOD_GlcNHglycan	548	551	PF01048	0.390
MOD_GlcNHglycan	579	582	PF01048	0.412
MOD_GlcNHglycan	737	740	PF01048	0.429
MOD_GlcNHglycan	790	793	PF01048	0.568
MOD_GlcNHglycan	807	810	PF01048	0.552
MOD_GlcNHglycan	81	84	PF01048	0.443
MOD_GlcNHglycan	93	98	PF01048	0.341
MOD_GSK3_1	120	127	PF00069	0.618
MOD_GSK3_1	157	164	PF00069	0.498
MOD_GSK3_1	199	206	PF00069	0.519
MOD_GSK3_1	296	303	PF00069	0.462
MOD_GSK3_1	356	363	PF00069	0.364
MOD_GSK3_1	417	424	PF00069	0.350
MOD_GSK3_1	503	510	PF00069	0.380
MOD_GSK3_1	546	553	PF00069	0.328
MOD_GSK3_1	645	652	PF00069	0.405
MOD_GSK3_1	690	697	PF00069	0.414
MOD_GSK3_1	788	795	PF00069	0.593
MOD_N-GLC_1	452	457	PF02516	0.411
MOD_N-GLC_1	568	573	PF02516	0.356
MOD_N-GLC_1	577	582	PF02516	0.272
MOD_NEK2_1	171	176	PF00069	0.421
MOD_NEK2_1	314	319	PF00069	0.307
MOD_NEK2_1	322	327	PF00069	0.251
MOD_NEK2_1	417	422	PF00069	0.446
MOD_NEK2_1	452	457	PF00069	0.335
MOD_NEK2_1	735	740	PF00069	0.428
MOD_NEK2_1	79	84	PF00069	0.287
MOD_NEK2_2	113	118	PF00069	0.447
MOD_NEK2_2	360	365	PF00069	0.364
MOD_NEK2_2	538	543	PF00069	0.411
MOD_NEK2_2	649	654	PF00069	0.411
MOD_PIKK_1	288	294	PF00454	0.430
MOD_PKA_1	782	788	PF00069	0.331
MOD_PKA_2	161	167	PF00069	0.415
MOD_PKA_2	322	328	PF00069	0.475
MOD_PKA_2	735	741	PF00069	0.442
MOD_PKA_2	782	788	PF00069	0.421
MOD_PKB_1	118	126	PF00069	0.609
MOD_PKB_1	36	44	PF00069	0.331
MOD_Plk_1	268	274	PF00069	0.330
MOD_Plk_1	417	423	PF00069	0.287
MOD_Plk_1	439	445	PF00069	0.287
MOD_Plk_1	568	574	PF00069	0.167
MOD_Plk_1	577	583	PF00069	0.151
MOD_Plk_2-3	137	143	PF00069	0.273
MOD_Plk_4	102	108	PF00069	0.397
MOD_Plk_4	172	178	PF00069	0.460
MOD_Plk_4	305	311	PF00069	0.430
MOD_Plk_4	360	366	PF00069	0.329
MOD_Plk_4	367	373	PF00069	0.445
MOD_ProDKin_1	155	161	PF00069	0.496
MOD_ProDKin_1	240	246	PF00069	0.677
MOD_ProDKin_1	276	282	PF00069	0.314
MOD_ProDKin_1	293	299	PF00069	0.314
MOD_ProDKin_1	365	371	PF00069	0.167
MOD_ProDKin_1	694	700	PF00069	0.240
MOD_ProDKin_1	760	766	PF00069	0.281
MOD_SUMO_for_1	730	733	PF00179	0.331
MOD_SUMO_rev_2	799	807	PF00179	0.361
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.357
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.281
TRG_ENDOCYTIC_2	272	275	PF00928	0.281
TRG_ENDOCYTIC_2	379	382	PF00928	0.341
TRG_ENDOCYTIC_2	43	46	PF00928	0.266
TRG_ENDOCYTIC_2	6	9	PF00928	0.324
TRG_ENDOCYTIC_2	709	712	PF00928	0.473
TRG_ENDOCYTIC_2	801	804	PF00928	0.356
TRG_ENDOCYTIC_2	830	833	PF00928	0.539
TRG_ER_diArg_1	117	120	PF00400	0.539
TRG_ER_diArg_1	373	376	PF00400	0.281
TRG_ER_diArg_1	490	492	PF00400	0.331
TRG_ER_diArg_1	554	556	PF00400	0.330
TRG_ER_diArg_1	735	737	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4B9	Leptomonas seymouri	69%	100%
A0A0S4J9H6	Bodo saltans	35%	100%
A0A1X0NQP8	Trypanosomatidae	41%	100%
A0A3S7X1Q9	Leishmania donovani	94%	100%
A0A422MUW5	Trypanosoma rangeli	46%	100%
A4HGS6	Leishmania braziliensis	84%	100%
A4I3V2	Leishmania infantum	94%	100%
D0A920	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4Q842	Leishmania major	93%	100%
V5D5P0	Trypanosoma cruzi	44%	100%