Mannosyl-oligosaccharide glucosidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mannosyl oligosaccharide glucosidase, putative

Species:

Leishmania mexicana

UniProt:

E9B041_LEIMU

TriTrypDb:

LmxM.28.2200

Length:

947

Annotations

LeishMANIAdb annotations

Mannosyl glucosidase, conserved ER resident enzyme. Only duplicated in T. rangeli, T.theileri and T. cruzi.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	10
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

E9B041

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B041

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	10
GO:0006486	protein glycosylation	4	10
GO:0006487	protein N-linked glycosylation	5	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009311	oligosaccharide metabolic process	4	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	10
GO:0004573	Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	6	10
GO:0015926	glucosidase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.160
CLV_C14_Caspase3-7	254	258	PF00656	0.252
CLV_C14_Caspase3-7	877	881	PF00656	0.265
CLV_NRD_NRD_1	310	312	PF00675	0.517
CLV_NRD_NRD_1	349	351	PF00675	0.535
CLV_NRD_NRD_1	381	383	PF00675	0.485
CLV_NRD_NRD_1	4	6	PF00675	0.412
CLV_NRD_NRD_1	615	617	PF00675	0.502
CLV_NRD_NRD_1	626	628	PF00675	0.472
CLV_NRD_NRD_1	657	659	PF00675	0.475

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEY5	Leptomonas seymouri	74%	100%
A0A0S4JC40	Bodo saltans	26%	100%
A0A1X0NS89	Trypanosomatidae	38%	100%
A0A3Q8IB45	Leishmania donovani	94%	100%
A0A3R7LQE3	Trypanosoma rangeli	39%	100%
A4HGS4	Leishmania braziliensis	86%	100%
A4I3U9	Leishmania infantum	93%	100%
P53008	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q13724	Homo sapiens	23%	100%
Q4Q845	Leishmania major	94%	100%

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