Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B039_LEIMU

TriTrypDb:

LmxM.28.2180

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B039

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B039

PDB structure(s): 7ane_ap

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.646
CLV_C14_Caspase3-7	27	31	PF00656	0.704
CLV_NRD_NRD_1	138	140	PF00675	0.395
CLV_NRD_NRD_1	8	10	PF00675	0.437
CLV_PCSK_KEX2_1	138	140	PF00082	0.395
CLV_PCSK_KEX2_1	8	10	PF00082	0.437
CLV_PCSK_SKI1_1	206	210	PF00082	0.509
CLV_PCSK_SKI1_1	81	85	PF00082	0.356
DEG_APCC_DBOX_1	80	88	PF00400	0.363
DEG_Nend_UBRbox_2	1	3	PF02207	0.611
DEG_SCF_FBW7_2	63	69	PF00400	0.597
DEG_SPOP_SBC_1	122	126	PF00917	0.435
DOC_CKS1_1	63	68	PF01111	0.507
DOC_MAPK_gen_1	138	146	PF00069	0.284
DOC_MAPK_HePTP_8	89	101	PF00069	0.511
DOC_MAPK_MEF2A_6	81	89	PF00069	0.365
DOC_MAPK_MEF2A_6	92	101	PF00069	0.412
DOC_PP1_RVXF_1	204	210	PF00149	0.491
DOC_PP2B_LxvP_1	85	88	PF13499	0.368
DOC_USP7_MATH_1	122	126	PF00917	0.435
DOC_USP7_MATH_1	88	92	PF00917	0.519
DOC_WW_Pin1_4	25	30	PF00397	0.594
DOC_WW_Pin1_4	62	67	PF00397	0.491
LIG_14-3-3_CanoR_1	110	115	PF00244	0.535
LIG_14-3-3_CanoR_1	123	128	PF00244	0.437
LIG_14-3-3_CanoR_1	220	224	PF00244	0.508
LIG_deltaCOP1_diTrp_1	160	168	PF00928	0.417
LIG_DLG_GKlike_1	123	131	PF00625	0.393
LIG_FHA_2	32	38	PF00498	0.691
LIG_FHA_2	63	69	PF00498	0.480
LIG_LIR_Gen_1	147	156	PF02991	0.382
LIG_LIR_Gen_1	225	234	PF02991	0.436
LIG_NRBOX	78	84	PF00104	0.479
LIG_PCNA_PIPBox_1	114	123	PF02747	0.505
LIG_Pex14_1	164	168	PF04695	0.419
LIG_Pex14_1	233	237	PF04695	0.462
LIG_Pex14_2	168	172	PF04695	0.576
LIG_SH2_SRC	127	130	PF00017	0.477
LIG_SH2_STAP1	127	131	PF00017	0.481
LIG_SH2_STAT3	154	157	PF00017	0.358
LIG_SH3_1	60	66	PF00018	0.500
LIG_SH3_3	60	66	PF00018	0.477
LIG_Sin3_3	95	102	PF02671	0.399
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.360
LIG_TRAF2_1	20	23	PF00917	0.588
LIG_TRAF2_1	34	37	PF00917	0.577
LIG_TRAF2_1	44	47	PF00917	0.587
LIG_TRAF2_1	66	69	PF00917	0.566
LIG_TRFH_1	59	63	PF08558	0.395
LIG_WRC_WIRS_1	223	228	PF05994	0.564
MOD_CDK_SPK_2	62	67	PF00069	0.491
MOD_CK1_1	113	119	PF00069	0.406
MOD_CK1_1	222	228	PF00069	0.545
MOD_CK1_1	28	34	PF00069	0.724
MOD_CK2_1	123	129	PF00069	0.396
MOD_CK2_1	172	178	PF00069	0.573
MOD_CK2_1	222	228	PF00069	0.547
MOD_CK2_1	239	245	PF00069	0.440
MOD_CK2_1	31	37	PF00069	0.691
MOD_CK2_1	62	68	PF00069	0.482
MOD_GSK3_1	24	31	PF00069	0.694
MOD_NEK2_1	121	126	PF00069	0.390
MOD_NEK2_1	137	142	PF00069	0.526
MOD_NEK2_1	152	157	PF00069	0.375
MOD_NEK2_1	172	177	PF00069	0.262
MOD_PKA_2	122	128	PF00069	0.546
MOD_PKA_2	137	143	PF00069	0.493
MOD_PKA_2	219	225	PF00069	0.512
MOD_Plk_1	29	35	PF00069	0.461
MOD_ProDKin_1	25	31	PF00069	0.592
MOD_ProDKin_1	62	68	PF00069	0.501
MOD_SUMO_rev_2	193	202	PF00179	0.528
MOD_SUMO_rev_2	211	218	PF00179	0.568
MOD_SUMO_rev_2	35	45	PF00179	0.644
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.358
TRG_ENDOCYTIC_2	149	152	PF00928	0.383
TRG_ER_diArg_1	137	139	PF00400	0.393
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCE2	Leptomonas seymouri	74%	74%
A0A0S4IX75	Bodo saltans	46%	80%
A0A1X0NQT5	Trypanosomatidae	55%	83%
A0A3R7N764	Trypanosoma rangeli	54%	88%
A0A3S7X1T5	Leishmania donovani	94%	100%
A4HGS2	Leishmania braziliensis	87%	100%
A4I3U7	Leishmania infantum	94%	100%
D0A916	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	87%
Q4Q847	Leishmania major	93%	100%
V5B8A1	Trypanosoma cruzi	54%	88%