CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial import receptor subunit ATOM69, putative

Species:

Leishmania mexicana

UniProt:

E9B038_LEIMU

TriTrypDb:

LmxM.28.2170

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4
GO:0005741	mitochondrial outer membrane	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0032991	protein-containing complex	1	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1

Expansion

Sequence features

E9B038

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B038

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006626	protein targeting to mitochondrion	5	1
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.619
CLV_C14_Caspase3-7	44	48	PF00656	0.627
CLV_C14_Caspase3-7	475	479	PF00656	0.630
CLV_NRD_NRD_1	489	491	PF00675	0.402
CLV_NRD_NRD_1	585	587	PF00675	0.623
CLV_PCSK_KEX2_1	355	357	PF00082	0.358
CLV_PCSK_KEX2_1	489	491	PF00082	0.393
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.420
CLV_PCSK_SKI1_1	174	178	PF00082	0.586
CLV_PCSK_SKI1_1	236	240	PF00082	0.361
CLV_PCSK_SKI1_1	348	352	PF00082	0.319
CLV_PCSK_SKI1_1	355	359	PF00082	0.318
CLV_PCSK_SKI1_1	380	384	PF00082	0.329
CLV_PCSK_SKI1_1	39	43	PF00082	0.389
CLV_PCSK_SKI1_1	414	418	PF00082	0.407
CLV_PCSK_SKI1_1	507	511	PF00082	0.476
CLV_PCSK_SKI1_1	586	590	PF00082	0.434
CLV_PCSK_SKI1_1	620	624	PF00082	0.364
CLV_Separin_Metazoa	486	490	PF03568	0.701
DEG_APCC_DBOX_1	120	128	PF00400	0.610
DEG_SCF_FBW7_2	109	115	PF00400	0.549
DOC_CDC14_PxL_1	635	643	PF14671	0.442
DOC_CKS1_1	109	114	PF01111	0.580
DOC_CYCLIN_yCln2_LP_2	532	538	PF00134	0.824
DOC_CYCLIN_yCln2_LP_2	615	621	PF00134	0.367
DOC_MAPK_gen_1	118	126	PF00069	0.632
DOC_MAPK_gen_1	37	45	PF00069	0.553
DOC_MAPK_JIP1_4	37	43	PF00069	0.603
DOC_MAPK_MEF2A_6	37	45	PF00069	0.553
DOC_MAPK_MEF2A_6	489	496	PF00069	0.578
DOC_PP1_RVXF_1	57	64	PF00149	0.679
DOC_PP2B_LxvP_1	532	535	PF13499	0.685
DOC_PP4_FxxP_1	571	574	PF00568	0.648
DOC_USP7_MATH_1	181	185	PF00917	0.704
DOC_USP7_MATH_1	251	255	PF00917	0.642
DOC_USP7_MATH_1	416	420	PF00917	0.625
DOC_USP7_MATH_1	429	433	PF00917	0.665
DOC_USP7_MATH_1	479	483	PF00917	0.563
DOC_USP7_MATH_1	539	543	PF00917	0.692
DOC_USP7_MATH_1	557	561	PF00917	0.680
DOC_USP7_MATH_1	563	567	PF00917	0.710
DOC_USP7_MATH_1	67	71	PF00917	0.663
DOC_WW_Pin1_4	108	113	PF00397	0.673
DOC_WW_Pin1_4	343	348	PF00397	0.531
DOC_WW_Pin1_4	515	520	PF00397	0.707
LIG_14-3-3_CanoR_1	118	128	PF00244	0.637
LIG_14-3-3_CanoR_1	250	256	PF00244	0.614
LIG_14-3-3_CanoR_1	414	422	PF00244	0.535
LIG_Actin_WH2_2	398	416	PF00022	0.541
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BRCT_BRCA1_1	449	453	PF00533	0.513
LIG_BRCT_BRCA1_1	567	571	PF00533	0.691
LIG_BRCT_BRCA1_1	594	598	PF00533	0.658
LIG_EH1_1	616	624	PF00400	0.367
LIG_FHA_1	301	307	PF00498	0.565
LIG_FHA_1	332	338	PF00498	0.549
LIG_FHA_1	4	10	PF00498	0.665
LIG_FHA_1	40	46	PF00498	0.540
LIG_FHA_1	547	553	PF00498	0.700
LIG_FHA_1	56	62	PF00498	0.555
LIG_FHA_2	13	19	PF00498	0.617
LIG_FHA_2	175	181	PF00498	0.801
LIG_FHA_2	20	26	PF00498	0.580
LIG_FHA_2	222	228	PF00498	0.650
LIG_FHA_2	229	235	PF00498	0.618
LIG_FHA_2	264	270	PF00498	0.533
LIG_LIR_Apic_2	568	574	PF02991	0.649
LIG_LIR_Nem_3	608	613	PF02991	0.339
LIG_MLH1_MIPbox_1	449	453	PF16413	0.526
LIG_NRBOX	164	170	PF00104	0.654
LIG_PCNA_PIPBox_1	405	414	PF02747	0.498
LIG_PCNA_yPIPBox_3	368	380	PF02747	0.583
LIG_PDZ_Class_1	646	651	PF00595	0.533
LIG_Pex14_2	382	386	PF04695	0.499
LIG_Rb_pABgroove_1	369	377	PF01858	0.580
LIG_SH2_CRK	341	345	PF00017	0.555
LIG_SH2_CRK	628	632	PF00017	0.391
LIG_SH2_CRK	66	70	PF00017	0.591
LIG_SH2_NCK_1	613	617	PF00017	0.323
LIG_SH2_NCK_1	628	632	PF00017	0.377
LIG_SH2_NCK_1	66	70	PF00017	0.535
LIG_SH2_SRC	476	479	PF00017	0.673
LIG_SH2_STAP1	613	617	PF00017	0.308
LIG_SH2_STAT3	391	394	PF00017	0.484
LIG_SH2_STAT5	391	394	PF00017	0.484
LIG_SH2_STAT5	452	455	PF00017	0.537
LIG_SH2_STAT5	476	479	PF00017	0.574
LIG_SH2_STAT5	613	616	PF00017	0.311
LIG_SH3_1	489	495	PF00018	0.608
LIG_SH3_3	122	128	PF00018	0.546
LIG_SH3_3	381	387	PF00018	0.510
LIG_SH3_3	489	495	PF00018	0.659
LIG_SUMO_SIM_par_1	40	47	PF11976	0.497
LIG_TRAF2_1	423	426	PF00917	0.682
LIG_TRAF2_1	511	514	PF00917	0.699
LIG_UBA3_1	50	56	PF00899	0.559
MOD_CDK_SPK_2	343	348	PF00069	0.531
MOD_CK1_1	223	229	PF00069	0.663
MOD_CK1_1	254	260	PF00069	0.607
MOD_CK1_1	361	367	PF00069	0.634
MOD_CK1_1	420	426	PF00069	0.643
MOD_CK1_1	611	617	PF00069	0.436
MOD_CK1_1	629	635	PF00069	0.337
MOD_CK2_1	12	18	PF00069	0.598
MOD_CK2_1	130	136	PF00069	0.698
MOD_CK2_1	174	180	PF00069	0.790
MOD_CK2_1	181	187	PF00069	0.809
MOD_CK2_1	19	25	PF00069	0.599
MOD_CK2_1	221	227	PF00069	0.662
MOD_CK2_1	228	234	PF00069	0.647
MOD_CK2_1	254	260	PF00069	0.617
MOD_CK2_1	287	293	PF00069	0.614
MOD_CK2_1	420	426	PF00069	0.636
MOD_CK2_1	51	57	PF00069	0.685
MOD_CK2_1	573	579	PF00069	0.771
MOD_GlcNHglycan	142	145	PF01048	0.608
MOD_GlcNHglycan	359	363	PF01048	0.391
MOD_GlcNHglycan	449	452	PF01048	0.300
MOD_GlcNHglycan	481	484	PF01048	0.374
MOD_GlcNHglycan	504	510	PF01048	0.472
MOD_GlcNHglycan	520	523	PF01048	0.485
MOD_GlcNHglycan	565	568	PF01048	0.532
MOD_GlcNHglycan	579	582	PF01048	0.484
MOD_GlcNHglycan	590	593	PF01048	0.445
MOD_GlcNHglycan	628	631	PF01048	0.647
MOD_GlcNHglycan	90	93	PF01048	0.438
MOD_GSK3_1	126	133	PF00069	0.685
MOD_GSK3_1	216	223	PF00069	0.653
MOD_GSK3_1	226	233	PF00069	0.667
MOD_GSK3_1	251	258	PF00069	0.576
MOD_GSK3_1	296	303	PF00069	0.618
MOD_GSK3_1	339	346	PF00069	0.531
MOD_GSK3_1	416	423	PF00069	0.547
MOD_GSK3_1	51	58	PF00069	0.603
MOD_GSK3_1	514	521	PF00069	0.737
MOD_GSK3_1	573	580	PF00069	0.822
MOD_GSK3_1	588	595	PF00069	0.698
MOD_N-GLC_1	220	225	PF02516	0.450
MOD_N-GLC_1	296	301	PF02516	0.414
MOD_NEK2_1	119	124	PF00069	0.593
MOD_NEK2_1	263	268	PF00069	0.547
MOD_NEK2_1	358	363	PF00069	0.627
MOD_NEK2_1	51	56	PF00069	0.602
MOD_NEK2_1	626	631	PF00069	0.551
MOD_NEK2_2	605	610	PF00069	0.464
MOD_NEK2_2	646	651	PF00069	0.533
MOD_PIKK_1	119	125	PF00454	0.652
MOD_PIKK_1	12	18	PF00454	0.551
MOD_PIKK_1	244	250	PF00454	0.613
MOD_PIKK_1	251	257	PF00454	0.578
MOD_PIKK_1	263	269	PF00454	0.457
MOD_PIKK_1	339	345	PF00454	0.547
MOD_PK_1	46	52	PF00069	0.645
MOD_PKA_2	12	18	PF00069	0.568
MOD_PKB_1	37	45	PF00069	0.595
MOD_Plk_1	19	25	PF00069	0.599
MOD_Plk_1	216	222	PF00069	0.649
MOD_Plk_1	330	336	PF00069	0.522
MOD_Plk_1	39	45	PF00069	0.548
MOD_Plk_2-3	132	138	PF00069	0.652
MOD_Plk_2-3	20	26	PF00069	0.611
MOD_Plk_2-3	287	293	PF00069	0.616
MOD_Plk_4	331	337	PF00069	0.522
MOD_Plk_4	417	423	PF00069	0.564
MOD_Plk_4	46	52	PF00069	0.549
MOD_Plk_4	605	611	PF00069	0.381
MOD_ProDKin_1	108	114	PF00069	0.676
MOD_ProDKin_1	343	349	PF00069	0.527
MOD_ProDKin_1	515	521	PF00069	0.707
MOD_SUMO_for_1	195	198	PF00179	0.634
MOD_SUMO_for_1	460	463	PF00179	0.552
MOD_SUMO_rev_2	233	238	PF00179	0.646
MOD_SUMO_rev_2	86	91	PF00179	0.678
TRG_DiLeu_BaEn_1	331	336	PF01217	0.536
TRG_ENDOCYTIC_2	341	344	PF00928	0.530
TRG_ENDOCYTIC_2	628	631	PF00928	0.365
TRG_ENDOCYTIC_2	66	69	PF00928	0.526
TRG_ER_diArg_1	36	39	PF00400	0.642
TRG_ER_diArg_1	488	490	PF00400	0.619
TRG_ER_diArg_1	583	586	PF00400	0.726
TRG_NLS_MonoExtC_3	209	215	PF00514	0.631
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	39	44	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF2	Leptomonas seymouri	73%	100%
A0A0S4IMM1	Bodo saltans	42%	91%
A0A1X0NQQ8	Trypanosomatidae	50%	100%
A0A3Q8IE19	Leishmania donovani	96%	100%
A0A3R7RF21	Trypanosoma rangeli	48%	100%
A4HGS1	Leishmania braziliensis	87%	100%
D0A915	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	96%
Q4Q848	Leishmania major	96%	100%
V5BCV7	Trypanosoma cruzi	49%	100%