Methyltransf_25 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B037_LEIMU

TriTrypDb:

LmxM.28.2160

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B037

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B037

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0032259	methylation	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008168	methyltransferase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016741	transferase activity, transferring one-carbon groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	171	173	PF00082	0.641
CLV_PCSK_KEX2_1	184	186	PF00082	0.508
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.601
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.594
CLV_PCSK_SKI1_1	184	188	PF00082	0.530
CLV_PCSK_SKI1_1	205	209	PF00082	0.551
CLV_PCSK_SKI1_1	41	45	PF00082	0.547
CLV_PCSK_SKI1_1	74	78	PF00082	0.414
DOC_CKS1_1	178	183	PF01111	0.535
DOC_MAPK_gen_1	122	129	PF00069	0.456
DOC_MAPK_gen_1	184	195	PF00069	0.574
DOC_MAPK_gen_1	7	15	PF00069	0.529
DOC_USP7_MATH_1	14	18	PF00917	0.627
DOC_USP7_MATH_1	34	38	PF00917	0.521
DOC_USP7_MATH_1	48	52	PF00917	0.527
DOC_USP7_UBL2_3	118	122	PF12436	0.344
DOC_WW_Pin1_4	149	154	PF00397	0.682
DOC_WW_Pin1_4	177	182	PF00397	0.540
LIG_14-3-3_CanoR_1	188	195	PF00244	0.551
LIG_14-3-3_CanoR_1	235	241	PF00244	0.689
LIG_BRCT_BRCA1_1	129	133	PF00533	0.300
LIG_BRCT_BRCA1_1	161	165	PF00533	0.420
LIG_CaM_IQ_9	163	179	PF13499	0.641
LIG_Clathr_ClatBox_1	105	109	PF01394	0.344
LIG_eIF4E_1	226	232	PF01652	0.614
LIG_FHA_1	178	184	PF00498	0.543
LIG_FHA_1	226	232	PF00498	0.624
LIG_FHA_1	28	34	PF00498	0.652
LIG_FHA_2	189	195	PF00498	0.561
LIG_FHA_2	197	203	PF00498	0.574
LIG_FHA_2	77	83	PF00498	0.333
LIG_LIR_Gen_1	121	129	PF02991	0.374
LIG_LIR_Gen_1	130	140	PF02991	0.309
LIG_LIR_Nem_3	121	127	PF02991	0.374
LIG_LIR_Nem_3	130	136	PF02991	0.337
LIG_LIR_Nem_3	192	198	PF02991	0.596
LIG_LIR_Nem_3	37	43	PF02991	0.553
LIG_MLH1_MIPbox_1	161	165	PF16413	0.420
LIG_Pex14_2	129	133	PF04695	0.300
LIG_Pex14_2	165	169	PF04695	0.533
LIG_SH2_PTP2	178	181	PF00017	0.531
LIG_SH2_STAP1	200	204	PF00017	0.586
LIG_SH2_STAP1	28	32	PF00017	0.540
LIG_SH2_STAT3	226	229	PF00017	0.627
LIG_SH2_STAT5	128	131	PF00017	0.300
LIG_SH2_STAT5	178	181	PF00017	0.548
LIG_SH2_STAT5	87	90	PF00017	0.325
LIG_SH3_3	152	158	PF00018	0.642
LIG_SUMO_SIM_anti_2	212	217	PF11976	0.567
LIG_SUMO_SIM_anti_2	228	234	PF11976	0.464
LIG_SUMO_SIM_par_1	11	18	PF11976	0.525
MOD_CDK_SPxxK_3	149	156	PF00069	0.585
MOD_CDK_SPxxK_3	177	184	PF00069	0.544
MOD_CK1_1	22	28	PF00069	0.659
MOD_GlcNHglycan	129	132	PF01048	0.330
MOD_GlcNHglycan	221	224	PF01048	0.423
MOD_GlcNHglycan	50	53	PF01048	0.370
MOD_GlcNHglycan	89	92	PF01048	0.416
MOD_GSK3_1	159	166	PF00069	0.580
MOD_GSK3_1	217	224	PF00069	0.602
MOD_GSK3_1	70	77	PF00069	0.420
MOD_N-GLC_1	116	121	PF02516	0.403
MOD_NEK2_1	127	132	PF00069	0.334
MOD_NEK2_1	76	81	PF00069	0.309
MOD_NEK2_2	159	164	PF00069	0.425
MOD_PIKK_1	135	141	PF00454	0.344
MOD_PIKK_1	163	169	PF00454	0.560
MOD_PIKK_1	225	231	PF00454	0.629
MOD_PKA_1	74	80	PF00069	0.403
MOD_PKA_2	236	242	PF00069	0.647
MOD_Plk_1	196	202	PF00069	0.596
MOD_Plk_4	129	135	PF00069	0.325
MOD_Plk_4	159	165	PF00069	0.491
MOD_Plk_4	221	227	PF00069	0.596
MOD_Plk_4	60	66	PF00069	0.265
MOD_ProDKin_1	149	155	PF00069	0.671
MOD_ProDKin_1	177	183	PF00069	0.535
TRG_DiLeu_BaEn_2	169	175	PF01217	0.650
TRG_ENDOCYTIC_2	40	43	PF00928	0.586
TRG_ER_diArg_1	235	238	PF00400	0.672
TRG_NES_CRM1_1	125	139	PF08389	0.394
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P1	Leptomonas seymouri	75%	100%
A0A0S4IRT5	Bodo saltans	47%	98%
A0A1X0NQR6	Trypanosomatidae	50%	100%
A0A3Q8IGV9	Leishmania donovani	91%	100%
A0A422N7I7	Trypanosoma rangeli	41%	100%
A4HGS0	Leishmania braziliensis	86%	100%
A4I3U5	Leishmania infantum	91%	100%
Q4Q849	Leishmania major	88%	100%