Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B036_LEIMU

TriTrypDb:

LmxM.28.2150

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B036

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B036

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	526	530	PF00656	0.524
CLV_C14_Caspase3-7	642	646	PF00656	0.680
CLV_NRD_NRD_1	100	102	PF00675	0.662
CLV_NRD_NRD_1	103	105	PF00675	0.655
CLV_NRD_NRD_1	19	21	PF00675	0.618
CLV_NRD_NRD_1	500	502	PF00675	0.491
CLV_NRD_NRD_1	537	539	PF00675	0.677
CLV_NRD_NRD_1	772	774	PF00675	0.753
CLV_NRD_NRD_1	826	828	PF00675	0.641
CLV_NRD_NRD_1	97	99	PF00675	0.615
CLV_PCSK_FUR_1	98	102	PF00082	0.720
CLV_PCSK_KEX2_1	100	102	PF00082	0.659
CLV_PCSK_KEX2_1	103	105	PF00082	0.650
CLV_PCSK_KEX2_1	18	20	PF00082	0.612
CLV_PCSK_KEX2_1	500	502	PF00082	0.491
CLV_PCSK_KEX2_1	537	539	PF00082	0.777
CLV_PCSK_KEX2_1	762	764	PF00082	0.726
CLV_PCSK_KEX2_1	828	830	PF00082	0.651
CLV_PCSK_KEX2_1	97	99	PF00082	0.613
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.726
CLV_PCSK_PC1ET2_1	828	830	PF00082	0.651
CLV_PCSK_PC7_1	824	830	PF00082	0.641
CLV_PCSK_SKI1_1	113	117	PF00082	0.613
CLV_PCSK_SKI1_1	259	263	PF00082	0.743
CLV_PCSK_SKI1_1	269	273	PF00082	0.637
CLV_PCSK_SKI1_1	44	48	PF00082	0.700
CLV_PCSK_SKI1_1	488	492	PF00082	0.520
CLV_PCSK_SKI1_1	500	504	PF00082	0.432
CLV_PCSK_SKI1_1	591	595	PF00082	0.567
CLV_PCSK_SKI1_1	604	608	PF00082	0.584
CLV_PCSK_SKI1_1	714	718	PF00082	0.690
CLV_Separin_Metazoa	84	88	PF03568	0.701
DEG_APCC_DBOX_1	411	419	PF00400	0.616
DEG_APCC_DBOX_1	470	478	PF00400	0.619
DEG_APCC_DBOX_1	590	598	PF00400	0.587
DEG_Nend_UBRbox_3	1	3	PF02207	0.737
DOC_CDC14_PxL_1	272	280	PF14671	0.706
DOC_CKS1_1	512	517	PF01111	0.631
DOC_MAPK_FxFP_2	47	50	PF00069	0.709
DOC_MAPK_gen_1	269	277	PF00069	0.649
DOC_MAPK_gen_1	483	492	PF00069	0.530
DOC_MAPK_gen_1	589	597	PF00069	0.692
DOC_MAPK_gen_1	762	769	PF00069	0.729
DOC_MAPK_HePTP_8	482	494	PF00069	0.634
DOC_MAPK_MEF2A_6	270	279	PF00069	0.712
DOC_MAPK_MEF2A_6	485	494	PF00069	0.640
DOC_MAPK_MEF2A_6	740	747	PF00069	0.684
DOC_MAPK_MEF2A_6	762	771	PF00069	0.732
DOC_PP1_RVXF_1	200	206	PF00149	0.554
DOC_PP1_RVXF_1	618	625	PF00149	0.598
DOC_PP2B_LxvP_1	220	223	PF13499	0.743
DOC_PP2B_LxvP_1	236	239	PF13499	0.397
DOC_PP2B_LxvP_1	509	512	PF13499	0.648
DOC_PP4_FxxP_1	328	331	PF00568	0.770
DOC_PP4_FxxP_1	47	50	PF00568	0.709
DOC_USP7_MATH_1	232	236	PF00917	0.511
DOC_USP7_MATH_1	271	275	PF00917	0.727
DOC_USP7_MATH_1	28	32	PF00917	0.701
DOC_USP7_MATH_1	373	377	PF00917	0.620
DOC_USP7_MATH_1	398	402	PF00917	0.568
DOC_USP7_MATH_1	587	591	PF00917	0.652
DOC_USP7_MATH_1	605	609	PF00917	0.699
DOC_USP7_MATH_1	677	681	PF00917	0.782
DOC_USP7_MATH_1	781	785	PF00917	0.651
DOC_USP7_MATH_1	93	97	PF00917	0.711
DOC_WW_Pin1_4	134	139	PF00397	0.659
DOC_WW_Pin1_4	153	158	PF00397	0.551
DOC_WW_Pin1_4	169	174	PF00397	0.524
DOC_WW_Pin1_4	376	381	PF00397	0.597
DOC_WW_Pin1_4	384	389	PF00397	0.512
DOC_WW_Pin1_4	511	516	PF00397	0.622
DOC_WW_Pin1_4	555	560	PF00397	0.691
DOC_WW_Pin1_4	63	68	PF00397	0.607
DOC_WW_Pin1_4	670	675	PF00397	0.588
LIG_14-3-3_CanoR_1	213	223	PF00244	0.526
LIG_14-3-3_CanoR_1	381	387	PF00244	0.477
LIG_14-3-3_CanoR_1	447	453	PF00244	0.610
LIG_14-3-3_CanoR_1	501	511	PF00244	0.558
LIG_14-3-3_CanoR_1	52	58	PF00244	0.641
LIG_14-3-3_CanoR_1	538	544	PF00244	0.701
LIG_14-3-3_CanoR_1	59	64	PF00244	0.654
LIG_14-3-3_CanoR_1	780	786	PF00244	0.650
LIG_BIR_III_4	391	395	PF00653	0.608
LIG_BRCT_BRCA1_1	160	164	PF00533	0.685
LIG_BRCT_BRCA1_1	324	328	PF00533	0.790
LIG_deltaCOP1_diTrp_1	428	432	PF00928	0.537
LIG_deltaCOP1_diTrp_1	571	581	PF00928	0.666
LIG_eIF4E_1	417	423	PF01652	0.452
LIG_EVH1_2	444	448	PF00568	0.603
LIG_FHA_1	215	221	PF00498	0.667
LIG_FHA_1	503	509	PF00498	0.624
LIG_FHA_1	531	537	PF00498	0.545
LIG_FHA_2	117	123	PF00498	0.665
LIG_FHA_2	508	514	PF00498	0.617
LIG_FHA_2	524	530	PF00498	0.607
LIG_FHA_2	640	646	PF00498	0.683
LIG_FHA_2	674	680	PF00498	0.813
LIG_FHA_2	684	690	PF00498	0.602
LIG_Integrin_isoDGR_2	410	412	PF01839	0.640
LIG_LIR_Apic_2	325	331	PF02991	0.779
LIG_LIR_Gen_1	118	128	PF02991	0.649
LIG_LIR_Gen_1	401	409	PF02991	0.496
LIG_LIR_Gen_1	416	425	PF02991	0.486
LIG_LIR_Gen_1	607	614	PF02991	0.636
LIG_LIR_Gen_1	689	699	PF02991	0.604
LIG_LIR_Gen_1	803	814	PF02991	0.709
LIG_LIR_Gen_1	821	830	PF02991	0.554
LIG_LIR_LC3C_4	592	596	PF02991	0.392
LIG_LIR_Nem_3	3	7	PF02991	0.618
LIG_LIR_Nem_3	365	370	PF02991	0.573
LIG_LIR_Nem_3	401	405	PF02991	0.492
LIG_LIR_Nem_3	416	420	PF02991	0.498
LIG_LIR_Nem_3	484	490	PF02991	0.512
LIG_LIR_Nem_3	607	613	PF02991	0.639
LIG_LIR_Nem_3	618	622	PF02991	0.481
LIG_LIR_Nem_3	676	681	PF02991	0.812
LIG_LIR_Nem_3	689	694	PF02991	0.506
LIG_LIR_Nem_3	803	809	PF02991	0.713
LIG_LIR_Nem_3	821	825	PF02991	0.541
LIG_NRBOX	111	117	PF00104	0.791
LIG_Pex14_1	487	491	PF04695	0.532
LIG_REV1ctd_RIR_1	769	778	PF16727	0.729
LIG_SH2_CRK	691	695	PF00017	0.702
LIG_SH2_GRB2like	473	476	PF00017	0.519
LIG_SH2_SRC	417	420	PF00017	0.459
LIG_SH2_STAT3	145	148	PF00017	0.655
LIG_SH2_STAT5	145	148	PF00017	0.580
LIG_SH2_STAT5	243	246	PF00017	0.489
LIG_SH2_STAT5	367	370	PF00017	0.671
LIG_SH2_STAT5	404	407	PF00017	0.473
LIG_SH2_STAT5	417	420	PF00017	0.389
LIG_SH2_STAT5	473	476	PF00017	0.494
LIG_SH3_2	512	517	PF14604	0.641
LIG_SH3_3	135	141	PF00018	0.615
LIG_SH3_3	191	197	PF00018	0.560
LIG_SH3_3	313	319	PF00018	0.725
LIG_SH3_3	374	380	PF00018	0.540
LIG_SH3_3	487	493	PF00018	0.545
LIG_SH3_3	509	515	PF00018	0.624
LIG_SH3_3	666	672	PF00018	0.795
LIG_SH3_3	700	706	PF00018	0.676
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.399
LIG_SUMO_SIM_par_1	156	161	PF11976	0.457
LIG_SUMO_SIM_par_1	478	484	PF11976	0.500
LIG_SUMO_SIM_par_1	507	514	PF11976	0.672
LIG_SUMO_SIM_par_1	724	731	PF11976	0.678
LIG_TRAF2_1	31	34	PF00917	0.709
LIG_TRAF2_1	53	56	PF00917	0.686
LIG_TYR_ITIM	415	420	PF00017	0.472
LIG_TYR_ITIM	46	51	PF00017	0.795
LIG_WRC_WIRS_1	399	404	PF05994	0.484
LIG_WW_3	222	226	PF00397	0.625
LIG_WW_3	444	448	PF00397	0.603
MOD_CDK_SPK_2	376	381	PF00069	0.455
MOD_CDK_SPxK_1	511	517	PF00069	0.557
MOD_CK1_1	131	137	PF00069	0.673
MOD_CK1_1	172	178	PF00069	0.710
MOD_CK1_1	198	204	PF00069	0.492
MOD_CK1_1	302	308	PF00069	0.711
MOD_CK1_1	352	358	PF00069	0.445
MOD_CK1_1	376	382	PF00069	0.548
MOD_CK1_1	530	536	PF00069	0.700
MOD_CK1_1	61	67	PF00069	0.743
MOD_CK1_1	673	679	PF00069	0.715
MOD_CK1_1	68	74	PF00069	0.771
MOD_CK1_1	684	690	PF00069	0.667
MOD_CK1_1	727	733	PF00069	0.648
MOD_CK1_1	754	760	PF00069	0.719
MOD_CK1_1	96	102	PF00069	0.766
MOD_CK2_1	103	109	PF00069	0.759
MOD_CK2_1	116	122	PF00069	0.631
MOD_CK2_1	28	34	PF00069	0.706
MOD_CK2_1	413	419	PF00069	0.608
MOD_CK2_1	565	571	PF00069	0.818
MOD_CK2_1	683	689	PF00069	0.630
MOD_CK2_1	730	736	PF00069	0.563
MOD_Cter_Amidation	267	270	PF01082	0.713
MOD_GlcNHglycan	13	16	PF01048	0.678
MOD_GlcNHglycan	177	180	PF01048	0.628
MOD_GlcNHglycan	183	187	PF01048	0.647
MOD_GlcNHglycan	304	307	PF01048	0.681
MOD_GlcNHglycan	356	359	PF01048	0.675
MOD_GlcNHglycan	518	522	PF01048	0.786
MOD_GlcNHglycan	581	584	PF01048	0.617
MOD_GlcNHglycan	607	610	PF01048	0.685
MOD_GlcNHglycan	637	640	PF01048	0.709
MOD_GlcNHglycan	649	652	PF01048	0.685
MOD_GlcNHglycan	70	73	PF01048	0.775
MOD_GlcNHglycan	757	760	PF01048	0.623
MOD_GlcNHglycan	799	802	PF01048	0.739
MOD_GlcNHglycan	90	93	PF01048	0.584
MOD_GSK3_1	103	110	PF00069	0.590
MOD_GSK3_1	127	134	PF00069	0.623
MOD_GSK3_1	158	165	PF00069	0.594
MOD_GSK3_1	255	262	PF00069	0.757
MOD_GSK3_1	302	309	PF00069	0.746
MOD_GSK3_1	338	345	PF00069	0.668
MOD_GSK3_1	426	433	PF00069	0.528
MOD_GSK3_1	507	514	PF00069	0.450
MOD_GSK3_1	523	530	PF00069	0.678
MOD_GSK3_1	555	562	PF00069	0.708
MOD_GSK3_1	57	64	PF00069	0.775
MOD_GSK3_1	579	586	PF00069	0.643
MOD_GSK3_1	635	642	PF00069	0.658
MOD_GSK3_1	647	654	PF00069	0.621
MOD_GSK3_1	673	680	PF00069	0.796
MOD_GSK3_1	730	737	PF00069	0.722
MOD_GSK3_1	751	758	PF00069	0.577
MOD_GSK3_1	781	788	PF00069	0.581
MOD_GSK3_1	88	95	PF00069	0.778
MOD_N-GLC_1	302	307	PF02516	0.760
MOD_N-GLC_1	615	620	PF02516	0.588
MOD_N-GLC_1	684	689	PF02516	0.675
MOD_NEK2_1	115	120	PF00069	0.653
MOD_NEK2_1	158	163	PF00069	0.615
MOD_NEK2_1	214	219	PF00069	0.478
MOD_NEK2_1	260	265	PF00069	0.787
MOD_NEK2_1	286	291	PF00069	0.526
MOD_NEK2_1	310	315	PF00069	0.781
MOD_NEK2_1	349	354	PF00069	0.526
MOD_NEK2_1	448	453	PF00069	0.518
MOD_NEK2_1	550	555	PF00069	0.597
MOD_NEK2_1	681	686	PF00069	0.700
MOD_NEK2_1	734	739	PF00069	0.682
MOD_NEK2_2	306	311	PF00069	0.713
MOD_PIKK_1	625	631	PF00454	0.735
MOD_PIKK_1	718	724	PF00454	0.688
MOD_PK_1	59	65	PF00069	0.711
MOD_PKA_1	103	109	PF00069	0.681
MOD_PKA_2	103	109	PF00069	0.532
MOD_PKA_2	51	57	PF00069	0.760
MOD_PKA_2	58	64	PF00069	0.629
MOD_PKA_2	583	589	PF00069	0.666
MOD_PKA_2	88	94	PF00069	0.680
MOD_PKA_2	96	102	PF00069	0.620
MOD_PKB_1	101	109	PF00069	0.721
MOD_Plk_1	108	114	PF00069	0.745
MOD_Plk_1	255	261	PF00069	0.812
MOD_Plk_1	530	536	PF00069	0.772
MOD_Plk_1	730	736	PF00069	0.800
MOD_Plk_1	741	747	PF00069	0.535
MOD_Plk_1	820	826	PF00069	0.718
MOD_Plk_2-3	413	419	PF00069	0.483
MOD_Plk_4	116	122	PF00069	0.625
MOD_Plk_4	195	201	PF00069	0.513
MOD_Plk_4	286	292	PF00069	0.526
MOD_Plk_4	349	355	PF00069	0.513
MOD_Plk_4	362	368	PF00069	0.336
MOD_Plk_4	373	379	PF00069	0.540
MOD_Plk_4	413	419	PF00069	0.555
MOD_Plk_4	426	432	PF00069	0.487
MOD_Plk_4	531	537	PF00069	0.498
MOD_Plk_4	724	730	PF00069	0.638
MOD_Plk_4	741	747	PF00069	0.574
MOD_Plk_4	781	787	PF00069	0.647
MOD_ProDKin_1	134	140	PF00069	0.656
MOD_ProDKin_1	153	159	PF00069	0.548
MOD_ProDKin_1	169	175	PF00069	0.534
MOD_ProDKin_1	376	382	PF00069	0.590
MOD_ProDKin_1	384	390	PF00069	0.517
MOD_ProDKin_1	511	517	PF00069	0.631
MOD_ProDKin_1	555	561	PF00069	0.689
MOD_ProDKin_1	63	69	PF00069	0.607
MOD_ProDKin_1	670	676	PF00069	0.590
MOD_SUMO_rev_2	32	41	PF00179	0.791
MOD_SUMO_rev_2	600	606	PF00179	0.633
MOD_SUMO_rev_2	784	794	PF00179	0.600
TRG_DiLeu_BaEn_1	457	462	PF01217	0.533
TRG_ENDOCYTIC_2	121	124	PF00928	0.660
TRG_ENDOCYTIC_2	367	370	PF00928	0.671
TRG_ENDOCYTIC_2	417	420	PF00928	0.459
TRG_ENDOCYTIC_2	48	51	PF00928	0.682
TRG_ENDOCYTIC_2	691	694	PF00928	0.667
TRG_ENDOCYTIC_2	9	12	PF00928	0.642
TRG_ER_diArg_1	101	104	PF00400	0.603
TRG_ER_diArg_1	18	20	PF00400	0.615
TRG_ER_diArg_1	22	25	PF00400	0.661
TRG_ER_diArg_1	482	485	PF00400	0.488
TRG_ER_diArg_1	499	501	PF00400	0.600
TRG_ER_diArg_1	536	538	PF00400	0.503
TRG_ER_diArg_1	827	830	PF00400	0.651
TRG_ER_diArg_1	86	89	PF00400	0.673
TRG_ER_diArg_1	97	100	PF00400	0.632
TRG_NLS_MonoExtC_3	826	831	PF00514	0.650
TRG_NLS_MonoExtN_4	824	831	PF00514	0.645
TRG_Pf-PMV_PEXEL_1	828	832	PF00026	0.752

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P734	Leptomonas seymouri	46%	97%
A0A3S7X1T8	Leishmania donovani	89%	100%
A4HGR9	Leishmania braziliensis	81%	100%
Q4Q850	Leishmania major	91%	100%