Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0220), putative

Species:

Leishmania mexicana

UniProt:

E9B030_LEIMU

TriTrypDb:

LmxM.28.2095

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

E9B030

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B030

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007034	vacuolar transport	4	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.358
CLV_PCSK_KEX2_1	3	5	PF00082	0.372
CLV_PCSK_SKI1_1	78	82	PF00082	0.287
DOC_CDC14_PxL_1	40	48	PF14671	0.413
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.475
DOC_MAPK_gen_1	3	10	PF00069	0.567
DOC_MAPK_gen_1	78	85	PF00069	0.521
DOC_PP1_RVXF_1	107	114	PF00149	0.381
LIG_14-3-3_CanoR_1	3	9	PF00244	0.571
LIG_APCC_ABBA_1	20	25	PF00400	0.413

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6R2	Leptomonas seymouri	61%	100%
A0A0S4IPW8	Bodo saltans	38%	77%
A0A0S4IVS2	Bodo saltans	27%	92%
A0A1X0NQU1	Trypanosomatidae	36%	100%
A0A3S7X1P5	Leishmania donovani	92%	100%
A0A422NBE9	Trypanosoma rangeli	36%	100%
A4HGR3	Leishmania braziliensis	78%	100%
A4I3T8	Leishmania infantum	92%	100%
D0A870	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4Q856	Leishmania major	92%	100%

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