Threonylcarbamoyl-AMP synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family, putative

Species:

Leishmania mexicana

UniProt:

E9B027_LEIMU

TriTrypDb:

LmxM.28.2070

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B027

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B027

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006450	regulation of translational fidelity	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003725	double-stranded RNA binding	5	12
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016779	nucleotidyltransferase activity	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0061710	L-threonylcarbamoyladenylate synthase	5	11
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	12
GO:0000049	tRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.509
CLV_NRD_NRD_1	199	201	PF00675	0.293
CLV_NRD_NRD_1	70	72	PF00675	0.335
CLV_PCSK_KEX2_1	13	15	PF00082	0.509
CLV_PCSK_KEX2_1	199	201	PF00082	0.293
CLV_PCSK_KEX2_1	46	48	PF00082	0.226
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.226
CLV_PCSK_SKI1_1	332	336	PF00082	0.287
DOC_CKS1_1	255	260	PF01111	0.452
DOC_MAPK_gen_1	199	205	PF00069	0.293
DOC_MAPK_gen_1	276	283	PF00069	0.538
DOC_MAPK_HePTP_8	128	140	PF00069	0.226
DOC_MAPK_MEF2A_6	131	140	PF00069	0.328
DOC_MAPK_MEF2A_6	199	207	PF00069	0.413
DOC_PP1_RVXF_1	333	340	PF00149	0.481
DOC_USP7_MATH_1	104	108	PF00917	0.241
DOC_USP7_MATH_1	141	145	PF00917	0.293
DOC_USP7_UBL2_3	188	192	PF12436	0.401
DOC_WW_Pin1_4	102	107	PF00397	0.265
DOC_WW_Pin1_4	149	154	PF00397	0.293
DOC_WW_Pin1_4	232	237	PF00397	0.483
DOC_WW_Pin1_4	245	250	PF00397	0.406
DOC_WW_Pin1_4	254	259	PF00397	0.362
DOC_WW_Pin1_4	306	311	PF00397	0.526
DOC_WW_Pin1_4	5	10	PF00397	0.489
LIG_14-3-3_CanoR_1	200	206	PF00244	0.308
LIG_BIR_II_1	1	5	PF00653	0.399
LIG_BRCT_BRCA1_1	335	339	PF00533	0.456
LIG_Clathr_ClatBox_1	170	174	PF01394	0.308
LIG_CtBP_PxDLS_1	9	13	PF00389	0.479
LIG_FHA_1	127	133	PF00498	0.354
LIG_FHA_1	233	239	PF00498	0.429
LIG_FHA_1	27	33	PF00498	0.302
LIG_FHA_1	284	290	PF00498	0.491
LIG_FHA_1	326	332	PF00498	0.478
LIG_FHA_1	368	374	PF00498	0.478
LIG_FHA_2	217	223	PF00498	0.461
LIG_FHA_2	5	11	PF00498	0.522
LIG_GBD_Chelix_1	85	93	PF00786	0.413
LIG_LIR_Gen_1	304	310	PF02991	0.499
LIG_LIR_Gen_1	316	327	PF02991	0.481
LIG_LIR_LC3C_4	191	196	PF02991	0.428
LIG_LIR_Nem_3	147	151	PF02991	0.293
LIG_LIR_Nem_3	290	294	PF02991	0.491
LIG_LIR_Nem_3	304	308	PF02991	0.401
LIG_LIR_Nem_3	316	322	PF02991	0.481
LIG_LIR_Nem_3	336	342	PF02991	0.309
LIG_SH2_STAP1	160	164	PF00017	0.413
LIG_SH2_STAT5	118	121	PF00017	0.400
LIG_SH2_STAT5	273	276	PF00017	0.481
LIG_SH2_STAT5	294	297	PF00017	0.514
LIG_SH3_1	103	109	PF00018	0.350
LIG_SH3_3	103	109	PF00018	0.306
LIG_SH3_3	121	127	PF00018	0.201
LIG_SH3_3	133	139	PF00018	0.295
LIG_SH3_3	22	28	PF00018	0.293
LIG_SH3_3	246	252	PF00018	0.465
LIG_SUMO_SIM_anti_2	169	174	PF11976	0.299
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.327
LIG_SUMO_SIM_par_1	169	174	PF11976	0.314
LIG_SUMO_SIM_par_1	23	31	PF11976	0.335
LIG_SUMO_SIM_par_1	285	290	PF11976	0.481
LIG_TYR_ITIM	303	308	PF00017	0.343
MOD_CK1_1	144	150	PF00069	0.293
MOD_CK1_1	152	158	PF00069	0.293
MOD_CK1_1	232	238	PF00069	0.490
MOD_CK1_1	250	256	PF00069	0.430
MOD_CK1_1	367	373	PF00069	0.480
MOD_CK2_1	216	222	PF00069	0.545
MOD_CK2_1	4	10	PF00069	0.440
MOD_Cter_Amidation	44	47	PF01082	0.148
MOD_GlcNHglycan	115	118	PF01048	0.311
MOD_GlcNHglycan	143	146	PF01048	0.293
MOD_GlcNHglycan	177	180	PF01048	0.425
MOD_GlcNHglycan	366	369	PF01048	0.285
MOD_GlcNHglycan	42	45	PF01048	0.413
MOD_GSK3_1	212	219	PF00069	0.413
MOD_GSK3_1	232	239	PF00069	0.492
MOD_GSK3_1	247	254	PF00069	0.430
MOD_NEK2_1	229	234	PF00069	0.393
MOD_NEK2_1	283	288	PF00069	0.461
MOD_NEK2_1	298	303	PF00069	0.483
MOD_NEK2_1	40	45	PF00069	0.413
MOD_NEK2_1	85	90	PF00069	0.439
MOD_NEK2_2	28	33	PF00069	0.293
MOD_NEK2_2	327	332	PF00069	0.526
MOD_PKA_2	201	207	PF00069	0.262
MOD_PKA_2	223	229	PF00069	0.415
MOD_PKA_2	298	304	PF00069	0.527
MOD_PKA_2	325	331	PF00069	0.452
MOD_Plk_1	182	188	PF00069	0.336
MOD_Plk_4	203	209	PF00069	0.505
MOD_Plk_4	251	257	PF00069	0.479
MOD_Plk_4	28	34	PF00069	0.304
MOD_Plk_4	283	289	PF00069	0.460
MOD_Plk_4	333	339	PF00069	0.454
MOD_Plk_4	96	102	PF00069	0.289
MOD_ProDKin_1	102	108	PF00069	0.265
MOD_ProDKin_1	149	155	PF00069	0.293
MOD_ProDKin_1	232	238	PF00069	0.483
MOD_ProDKin_1	245	251	PF00069	0.406
MOD_ProDKin_1	254	260	PF00069	0.362
MOD_ProDKin_1	306	312	PF00069	0.526
MOD_ProDKin_1	5	11	PF00069	0.484
MOD_SUMO_for_1	187	190	PF00179	0.413
MOD_SUMO_rev_2	17	25	PF00179	0.148
MOD_SUMO_rev_2	184	194	PF00179	0.401
TRG_AP2beta_CARGO_1	316	326	PF09066	0.419
TRG_DiLeu_BaEn_1	190	195	PF01217	0.440
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.466
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.293
TRG_ENDOCYTIC_2	160	163	PF00928	0.413
TRG_ENDOCYTIC_2	305	308	PF00928	0.452
TRG_ER_diArg_1	12	14	PF00400	0.510
TRG_ER_diArg_1	198	200	PF00400	0.293
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.261
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P4	Leptomonas seymouri	78%	100%
A0A0S4J813	Bodo saltans	45%	80%
A0A1X0NQV4	Trypanosomatidae	55%	100%
A0A3R7RHL4	Trypanosoma rangeli	54%	100%
A0A3S5H7J7	Leishmania donovani	92%	99%
A4I3T5	Leishmania infantum	92%	99%
D0A873	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AIT1	Leishmania braziliensis	90%	100%
Q4Q859	Leishmania major	90%	100%
Q970S6	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	36%	100%
V5BC26	Trypanosoma cruzi	55%	99%