AMP-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AMP-binding enzyme/Ankyrin repeats (3 copies), putative

Species:

Leishmania mexicana

UniProt:

E9B025_LEIMU

TriTrypDb:

LmxM.28.2050

Length:

1002

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B025

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B025

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019748	secondary metabolic process	2	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043038	amino acid activation	4	1
GO:0043041	amino acid activation for nonribosomal peptide biosynthetic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0044550	secondary metabolite biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0019842	vitamin binding	3	1
GO:0031177	phosphopantetheine binding	3	1
GO:0033218	amide binding	2	1
GO:0036094	small molecule binding	2	1
GO:0072341	modified amino acid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.210
CLV_NRD_NRD_1	158	160	PF00675	0.395
CLV_NRD_NRD_1	186	188	PF00675	0.307
CLV_NRD_NRD_1	491	493	PF00675	0.376
CLV_NRD_NRD_1	578	580	PF00675	0.485
CLV_NRD_NRD_1	82	84	PF00675	0.517
CLV_NRD_NRD_1	846	848	PF00675	0.485
CLV_NRD_NRD_1	90	92	PF00675	0.452
CLV_NRD_NRD_1	945	947	PF00675	0.673
CLV_NRD_NRD_1	959	961	PF00675	0.644
CLV_NRD_NRD_1	975	977	PF00675	0.597
CLV_PCSK_FUR_1	156	160	PF00082	0.258
CLV_PCSK_FUR_1	489	493	PF00082	0.501
CLV_PCSK_FUR_1	983	987	PF00082	0.641
CLV_PCSK_KEX2_1	156	158	PF00082	0.386
CLV_PCSK_KEX2_1	491	493	PF00082	0.376
CLV_PCSK_KEX2_1	578	580	PF00082	0.485
CLV_PCSK_KEX2_1	70	72	PF00082	0.527
CLV_PCSK_KEX2_1	81	83	PF00082	0.455
CLV_PCSK_KEX2_1	846	848	PF00082	0.485
CLV_PCSK_KEX2_1	90	92	PF00082	0.566
CLV_PCSK_KEX2_1	943	945	PF00082	0.714
CLV_PCSK_KEX2_1	975	977	PF00082	0.724
CLV_PCSK_KEX2_1	985	987	PF00082	0.592
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.527
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.455
CLV_PCSK_PC1ET2_1	943	945	PF00082	0.828
CLV_PCSK_PC1ET2_1	985	987	PF00082	0.719
CLV_PCSK_PC7_1	153	159	PF00082	0.430
CLV_PCSK_SKI1_1	241	245	PF00082	0.501
CLV_PCSK_SKI1_1	337	341	PF00082	0.376
CLV_PCSK_SKI1_1	502	506	PF00082	0.518
CLV_PCSK_SKI1_1	579	583	PF00082	0.483
CLV_PCSK_SKI1_1	83	87	PF00082	0.538
CLV_PCSK_SKI1_1	846	850	PF00082	0.423
DEG_APCC_DBOX_1	355	363	PF00400	0.410
DEG_APCC_DBOX_1	501	509	PF00400	0.516
DEG_APCC_DBOX_1	772	780	PF00400	0.467
DEG_SCF_FBW7_2	99	106	PF00400	0.534
DOC_CKS1_1	277	282	PF01111	0.430
DOC_CKS1_1	310	315	PF01111	0.376
DOC_CKS1_1	590	595	PF01111	0.671
DOC_CKS1_1	896	901	PF01111	0.544
DOC_CYCLIN_RxL_1	840	852	PF00134	0.431
DOC_CYCLIN_yClb5_NLxxxL_5	232	239	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	689	695	PF00134	0.549
DOC_MAPK_DCC_7	197	207	PF00069	0.210
DOC_MAPK_gen_1	187	194	PF00069	0.307
DOC_MAPK_gen_1	489	498	PF00069	0.385
DOC_MAPK_gen_1	596	604	PF00069	0.551
DOC_MAPK_gen_1	666	675	PF00069	0.443
DOC_MAPK_gen_1	785	795	PF00069	0.636
DOC_MAPK_gen_1	81	87	PF00069	0.321
DOC_MAPK_gen_1	859	869	PF00069	0.376
DOC_MAPK_MEF2A_6	143	151	PF00069	0.506
DOC_MAPK_MEF2A_6	232	239	PF00069	0.210
DOC_MAPK_MEF2A_6	666	675	PF00069	0.466
DOC_MAPK_MEF2A_6	788	797	PF00069	0.595
DOC_PP1_RVXF_1	577	584	PF00149	0.501
DOC_PP2B_LxvP_1	3	6	PF13499	0.449
DOC_PP2B_LxvP_1	569	572	PF13499	0.441
DOC_PP2B_LxvP_1	644	647	PF13499	0.545
DOC_PP2B_LxvP_1	689	692	PF13499	0.633
DOC_PP2B_LxvP_1	739	742	PF13499	0.592
DOC_PP4_FxxP_1	265	268	PF00568	0.430
DOC_PP4_FxxP_1	574	577	PF00568	0.481
DOC_USP7_MATH_1	409	413	PF00917	0.355
DOC_USP7_MATH_1	448	452	PF00917	0.424
DOC_USP7_MATH_1	796	800	PF00917	0.441
DOC_USP7_MATH_1	838	842	PF00917	0.410
DOC_USP7_MATH_1	870	874	PF00917	0.430
DOC_WW_Pin1_4	195	200	PF00397	0.395
DOC_WW_Pin1_4	260	265	PF00397	0.399
DOC_WW_Pin1_4	276	281	PF00397	0.171
DOC_WW_Pin1_4	309	314	PF00397	0.376
DOC_WW_Pin1_4	451	456	PF00397	0.461
DOC_WW_Pin1_4	531	536	PF00397	0.647
DOC_WW_Pin1_4	589	594	PF00397	0.649
DOC_WW_Pin1_4	788	793	PF00397	0.534
DOC_WW_Pin1_4	824	829	PF00397	0.350
DOC_WW_Pin1_4	895	900	PF00397	0.546
DOC_WW_Pin1_4	99	104	PF00397	0.689
LIG_14-3-3_CanoR_1	344	350	PF00244	0.355
LIG_14-3-3_CanoR_1	474	483	PF00244	0.424
LIG_14-3-3_CanoR_1	527	535	PF00244	0.446
LIG_14-3-3_CanoR_1	634	640	PF00244	0.569
LIG_14-3-3_CanoR_1	788	792	PF00244	0.635
LIG_14-3-3_CanoR_1	82	88	PF00244	0.356
LIG_14-3-3_CanoR_1	822	828	PF00244	0.404
LIG_14-3-3_CanoR_1	862	867	PF00244	0.378
LIG_14-3-3_CanoR_1	90	94	PF00244	0.544
LIG_14-3-3_CanoR_1	960	965	PF00244	0.643
LIG_APCC_ABBA_1	436	441	PF00400	0.397
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_BIR_III_2	615	619	PF00653	0.465
LIG_BRCT_BRCA1_1	261	265	PF00533	0.378
LIG_BRCT_BRCA1_1	411	415	PF00533	0.474
LIG_BRCT_BRCA1_1	452	456	PF00533	0.457
LIG_deltaCOP1_diTrp_1	893	902	PF00928	0.490
LIG_FHA_1	136	142	PF00498	0.504
LIG_FHA_1	305	311	PF00498	0.376
LIG_FHA_1	331	337	PF00498	0.210
LIG_FHA_1	467	473	PF00498	0.376
LIG_FHA_1	509	515	PF00498	0.440
LIG_FHA_1	532	538	PF00498	0.612
LIG_FHA_1	542	548	PF00498	0.628
LIG_FHA_1	592	598	PF00498	0.592
LIG_FHA_1	650	656	PF00498	0.551
LIG_FHA_1	788	794	PF00498	0.522
LIG_FHA_1	807	813	PF00498	0.570
LIG_FHA_1	876	882	PF00498	0.424
LIG_FHA_1	907	913	PF00498	0.575
LIG_FHA_1	918	924	PF00498	0.534
LIG_FHA_2	100	106	PF00498	0.656
LIG_FHA_2	286	292	PF00498	0.501
LIG_FHA_2	350	356	PF00498	0.501
LIG_FHA_2	379	385	PF00498	0.501
LIG_FHA_2	84	90	PF00498	0.360
LIG_FHA_2	961	967	PF00498	0.658
LIG_GBD_Chelix_1	559	567	PF00786	0.504
LIG_Integrin_RGD_1	26	28	PF01839	0.494
LIG_LIR_Apic_2	262	268	PF02991	0.430
LIG_LIR_Apic_2	573	577	PF02991	0.569
LIG_LIR_Gen_1	121	131	PF02991	0.433
LIG_LIR_Gen_1	138	147	PF02991	0.527
LIG_LIR_Gen_1	30	41	PF02991	0.353
LIG_LIR_Gen_1	369	379	PF02991	0.353
LIG_LIR_Gen_1	638	648	PF02991	0.516
LIG_LIR_Gen_1	952	959	PF02991	0.677
LIG_LIR_Gen_1	966	974	PF02991	0.633
LIG_LIR_Nem_3	121	127	PF02991	0.437
LIG_LIR_Nem_3	138	142	PF02991	0.497
LIG_LIR_Nem_3	30	36	PF02991	0.466
LIG_LIR_Nem_3	358	363	PF02991	0.364
LIG_LIR_Nem_3	369	374	PF02991	0.305
LIG_LIR_Nem_3	431	436	PF02991	0.429
LIG_LIR_Nem_3	630	636	PF02991	0.517
LIG_LIR_Nem_3	753	759	PF02991	0.510
LIG_LIR_Nem_3	952	958	PF02991	0.682
LIG_LIR_Nem_3	963	967	PF02991	0.642
LIG_MLH1_MIPbox_1	262	266	PF16413	0.430
LIG_NRBOX	562	568	PF00104	0.592
LIG_NRBOX	844	850	PF00104	0.430
LIG_PCNA_PIPBox_1	513	522	PF02747	0.518
LIG_PCNA_yPIPBox_3	513	527	PF02747	0.389
LIG_Pex3_1	563	574	PF04882	0.585
LIG_REV1ctd_RIR_1	464	472	PF16727	0.410
LIG_REV1ctd_RIR_1	752	761	PF16727	0.288
LIG_RPA_C_Fungi	551	563	PF08784	0.556
LIG_RPA_C_Fungi	835	847	PF08784	0.326
LIG_SH2_CRK	124	128	PF00017	0.425
LIG_SH2_CRK	633	637	PF00017	0.535
LIG_SH2_SRC	654	657	PF00017	0.556
LIG_SH2_STAP1	124	128	PF00017	0.425
LIG_SH2_STAT3	439	442	PF00017	0.385
LIG_SH2_STAT5	217	220	PF00017	0.438
LIG_SH2_STAT5	238	241	PF00017	0.376
LIG_SH2_STAT5	285	288	PF00017	0.402
LIG_SH2_STAT5	654	657	PF00017	0.550
LIG_SH2_STAT5	672	675	PF00017	0.345
LIG_SH2_STAT5	707	710	PF00017	0.466
LIG_SH2_STAT5	964	967	PF00017	0.678
LIG_SH3_3	141	147	PF00018	0.518
LIG_SH3_3	307	313	PF00018	0.376
LIG_SH3_3	587	593	PF00018	0.637
LIG_SH3_3	689	695	PF00018	0.511
LIG_SUMO_SIM_par_1	190	196	PF11976	0.307
LIG_SUMO_SIM_par_1	83	89	PF11976	0.343
LIG_TRAF2_1	178	181	PF00917	0.424
LIG_TRAF2_1	22	25	PF00917	0.434
LIG_TRAF2_1	504	507	PF00917	0.507
LIG_TRAF2_1	562	565	PF00917	0.526
LIG_TRAF2_1	606	609	PF00917	0.556
LIG_TRAF2_1	626	629	PF00917	0.535
LIG_TYR_ITIM	965	970	PF00017	0.584
LIG_TYR_ITSM	367	374	PF00017	0.430
LIG_WRC_WIRS_1	571	576	PF05994	0.569
MOD_CDK_SPxK_1	195	201	PF00069	0.326
MOD_CDK_SPxxK_3	451	458	PF00069	0.210
MOD_CDK_SPxxK_3	589	596	PF00069	0.660
MOD_CK1_1	119	125	PF00069	0.503
MOD_CK1_1	195	201	PF00069	0.330
MOD_CK1_1	219	225	PF00069	0.376
MOD_CK1_1	317	323	PF00069	0.482
MOD_CK1_1	451	457	PF00069	0.440
MOD_CK1_1	799	805	PF00069	0.548
MOD_CK1_1	921	927	PF00069	0.649
MOD_CK2_1	175	181	PF00069	0.492
MOD_CK2_1	378	384	PF00069	0.440
MOD_CK2_1	474	480	PF00069	0.439
MOD_CK2_1	623	629	PF00069	0.695
MOD_CK2_1	743	749	PF00069	0.620
MOD_CK2_1	945	951	PF00069	0.556
MOD_CK2_1	960	966	PF00069	0.693
MOD_CK2_1	991	997	PF00069	0.726
MOD_Cter_Amidation	489	492	PF01082	0.376
MOD_GlcNHglycan	15	18	PF01048	0.499
MOD_GlcNHglycan	180	185	PF01048	0.372
MOD_GlcNHglycan	218	221	PF01048	0.376
MOD_GlcNHglycan	427	430	PF01048	0.414
MOD_GlcNHglycan	52	55	PF01048	0.612
MOD_GlcNHglycan	529	532	PF01048	0.671
MOD_GlcNHglycan	746	749	PF01048	0.404
MOD_GlcNHglycan	840	843	PF01048	0.430
MOD_GlcNHglycan	872	875	PF01048	0.380
MOD_GlcNHglycan	947	950	PF01048	0.626
MOD_GSK3_1	163	170	PF00069	0.424
MOD_GSK3_1	176	183	PF00069	0.392
MOD_GSK3_1	193	200	PF00069	0.450
MOD_GSK3_1	215	222	PF00069	0.378
MOD_GSK3_1	279	286	PF00069	0.383
MOD_GSK3_1	304	311	PF00069	0.408
MOD_GSK3_1	314	321	PF00069	0.376
MOD_GSK3_1	324	331	PF00069	0.171
MOD_GSK3_1	366	373	PF00069	0.423
MOD_GSK3_1	527	534	PF00069	0.594
MOD_GSK3_1	585	592	PF00069	0.557
MOD_GSK3_1	917	924	PF00069	0.624
MOD_GSK3_1	945	952	PF00069	0.701
MOD_N-GLC_1	618	623	PF02516	0.549
MOD_N-GLC_1	949	954	PF02516	0.714
MOD_NEK2_1	127	132	PF00069	0.391
MOD_NEK2_1	135	140	PF00069	0.435
MOD_NEK2_1	216	221	PF00069	0.410
MOD_NEK2_1	259	264	PF00069	0.376
MOD_NEK2_1	349	354	PF00069	0.430
MOD_NEK2_1	41	46	PF00069	0.613
MOD_NEK2_1	425	430	PF00069	0.424
MOD_NEK2_1	49	54	PF00069	0.655
MOD_NEK2_1	665	670	PF00069	0.463
MOD_NEK2_1	836	841	PF00069	0.501
MOD_NEK2_1	917	922	PF00069	0.622
MOD_PIKK_1	116	122	PF00454	0.387
MOD_PIKK_1	285	291	PF00454	0.430
MOD_PIKK_1	343	349	PF00454	0.423
MOD_PIKK_1	518	524	PF00454	0.508
MOD_PIKK_1	597	603	PF00454	0.625
MOD_PIKK_1	713	719	PF00454	0.427
MOD_PKA_1	945	951	PF00069	0.733
MOD_PKA_1	960	966	PF00069	0.646
MOD_PKA_2	343	349	PF00069	0.355
MOD_PKA_2	66	72	PF00069	0.474
MOD_PKA_2	787	793	PF00069	0.642
MOD_PKA_2	821	827	PF00069	0.404
MOD_PKA_2	89	95	PF00069	0.566
MOD_PKA_2	945	951	PF00069	0.763
MOD_Plk_1	167	173	PF00069	0.513
MOD_Plk_1	207	213	PF00069	0.444
MOD_Plk_1	366	372	PF00069	0.376
MOD_Plk_1	876	882	PF00069	0.210
MOD_Plk_1	950	956	PF00069	0.646
MOD_Plk_1	996	1002	PF00069	0.576
MOD_Plk_2-3	966	972	PF00069	0.514
MOD_Plk_4	119	125	PF00069	0.447
MOD_Plk_4	168	174	PF00069	0.501
MOD_Plk_4	279	285	PF00069	0.498
MOD_Plk_4	324	330	PF00069	0.444
MOD_Plk_4	366	372	PF00069	0.376
MOD_Plk_4	570	576	PF00069	0.531
MOD_Plk_4	635	641	PF00069	0.566
MOD_Plk_4	862	868	PF00069	0.402
MOD_Plk_4	960	966	PF00069	0.724
MOD_ProDKin_1	195	201	PF00069	0.395
MOD_ProDKin_1	260	266	PF00069	0.399
MOD_ProDKin_1	276	282	PF00069	0.171
MOD_ProDKin_1	309	315	PF00069	0.376
MOD_ProDKin_1	451	457	PF00069	0.461
MOD_ProDKin_1	531	537	PF00069	0.635
MOD_ProDKin_1	589	595	PF00069	0.656
MOD_ProDKin_1	788	794	PF00069	0.524
MOD_ProDKin_1	824	830	PF00069	0.350
MOD_ProDKin_1	895	901	PF00069	0.548
MOD_ProDKin_1	99	105	PF00069	0.695
MOD_SUMO_rev_2	219	228	PF00179	0.376
MOD_SUMO_rev_2	493	498	PF00179	0.501
MOD_SUMO_rev_2	718	726	PF00179	0.691
TRG_DiLeu_BaEn_1	877	882	PF01217	0.430
TRG_DiLeu_BaEn_2	950	956	PF01217	0.466
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.498
TRG_DiLeu_BaLyEn_6	733	738	PF01217	0.684
TRG_DiLeu_BaLyEn_6	767	772	PF01217	0.582
TRG_DiLeu_BaLyEn_6	844	849	PF01217	0.451
TRG_DiLeu_LyEn_5	877	882	PF01217	0.501
TRG_ENDOCYTIC_2	124	127	PF00928	0.425
TRG_ENDOCYTIC_2	371	374	PF00928	0.353
TRG_ENDOCYTIC_2	422	425	PF00928	0.341
TRG_ENDOCYTIC_2	433	436	PF00928	0.480
TRG_ENDOCYTIC_2	633	636	PF00928	0.538
TRG_ENDOCYTIC_2	672	675	PF00928	0.479
TRG_ENDOCYTIC_2	967	970	PF00928	0.619
TRG_ER_diArg_1	156	159	PF00400	0.388
TRG_ER_diArg_1	36	39	PF00400	0.520
TRG_ER_diArg_1	395	398	PF00400	0.501
TRG_ER_diArg_1	488	491	PF00400	0.451
TRG_ER_diArg_1	577	579	PF00400	0.492
TRG_ER_diArg_1	82	84	PF00400	0.517
TRG_ER_diArg_1	845	847	PF00400	0.424
TRG_ER_diArg_1	944	946	PF00400	0.751
TRG_ER_diArg_1	975	977	PF00400	0.655
TRG_NES_CRM1_1	806	818	PF08389	0.430
TRG_NLS_Bipartite_1	70	85	PF00514	0.402
TRG_NLS_Bipartite_1	943	964	PF00514	0.703
TRG_NLS_MonoCore_2	942	947	PF00514	0.742
TRG_NLS_MonoExtN_4	957	964	PF00514	0.665
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	846	850	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5E5	Leptomonas seymouri	51%	98%
A0A0S4JM65	Bodo saltans	31%	84%
A0A3Q8IEY8	Leishmania donovani	91%	100%
A4HGQ9	Leishmania braziliensis	80%	100%
A4I3T3	Leishmania infantum	91%	100%
Q4Q861	Leishmania major	91%	100%