LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B022_LEIMU
TriTrypDb:
LmxM.28.2020
Length:
579

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005813 centrosome 3 1
GO:0005814 centriole 5 1
GO:0005815 microtubule organizing center 2 1
GO:0036064 ciliary basal body 3 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B022
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B022

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 1
GO:0007098 centrosome cycle 3 1
GO:0009987 cellular process 1 1
GO:0010564 regulation of cell cycle process 5 1
GO:0010638 positive regulation of organelle organization 6 1
GO:0010824 regulation of centrosome duplication 6 1
GO:0016043 cellular component organization 3 1
GO:0022402 cell cycle process 2 1
GO:0031023 microtubule organizing center organization 3 1
GO:0032886 regulation of microtubule-based process 4 1
GO:0033043 regulation of organelle organization 5 1
GO:0044087 regulation of cellular component biogenesis 4 1
GO:0044089 positive regulation of cellular component biogenesis 5 1
GO:0045787 positive regulation of cell cycle 5 1
GO:0046599 regulation of centriole replication 6 1
GO:0046601 positive regulation of centriole replication 7 1
GO:0046605 regulation of centrosome cycle 5 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051128 regulation of cellular component organization 4 1
GO:0051130 positive regulation of cellular component organization 5 1
GO:0051493 regulation of cytoskeleton organization 6 1
GO:0051495 positive regulation of cytoskeleton organization 7 1
GO:0051726 regulation of cell cycle 4 1
GO:0065007 biological regulation 1 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090068 positive regulation of cell cycle process 6 1
GO:1902115 regulation of organelle assembly 5 1
GO:1902117 positive regulation of organelle assembly 6 1
GO:1903722 regulation of centriole elongation 6 1
GO:1903724 positive regulation of centriole elongation 7 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 295 299 PF00656 0.479
CLV_C14_Caspase3-7 442 446 PF00656 0.749
CLV_MEL_PAP_1 152 158 PF00089 0.601
CLV_NRD_NRD_1 125 127 PF00675 0.584
CLV_NRD_NRD_1 168 170 PF00675 0.544
CLV_NRD_NRD_1 238 240 PF00675 0.509
CLV_NRD_NRD_1 256 258 PF00675 0.419
CLV_NRD_NRD_1 413 415 PF00675 0.738
CLV_NRD_NRD_1 422 424 PF00675 0.757
CLV_NRD_NRD_1 50 52 PF00675 0.508
CLV_NRD_NRD_1 530 532 PF00675 0.573
CLV_PCSK_KEX2_1 105 107 PF00082 0.466
CLV_PCSK_KEX2_1 125 127 PF00082 0.287
CLV_PCSK_KEX2_1 167 169 PF00082 0.550
CLV_PCSK_KEX2_1 231 233 PF00082 0.544
CLV_PCSK_KEX2_1 267 269 PF00082 0.662
CLV_PCSK_KEX2_1 422 424 PF00082 0.785
CLV_PCSK_KEX2_1 50 52 PF00082 0.521
CLV_PCSK_KEX2_1 530 532 PF00082 0.573
CLV_PCSK_KEX2_1 90 92 PF00082 0.530
CLV_PCSK_PC1ET2_1 105 107 PF00082 0.509
CLV_PCSK_PC1ET2_1 231 233 PF00082 0.594
CLV_PCSK_PC1ET2_1 267 269 PF00082 0.609
CLV_PCSK_PC1ET2_1 90 92 PF00082 0.513
CLV_PCSK_SKI1_1 105 109 PF00082 0.488
CLV_PCSK_SKI1_1 147 151 PF00082 0.525
CLV_PCSK_SKI1_1 42 46 PF00082 0.543
DEG_APCC_DBOX_1 70 78 PF00400 0.489
DEG_SCF_TRCP1_1 428 434 PF00400 0.713
DEG_SPOP_SBC_1 455 459 PF00917 0.696
DOC_MAPK_DCC_7 336 345 PF00069 0.597
DOC_MAPK_gen_1 145 152 PF00069 0.525
DOC_MAPK_gen_1 207 216 PF00069 0.336
DOC_MAPK_gen_1 336 345 PF00069 0.709
DOC_PP2B_LxvP_1 288 291 PF13499 0.650
DOC_USP7_MATH_1 134 138 PF00917 0.535
DOC_USP7_MATH_1 381 385 PF00917 0.781
DOC_USP7_MATH_1 431 435 PF00917 0.754
DOC_USP7_MATH_1 523 527 PF00917 0.703
DOC_USP7_MATH_1 56 60 PF00917 0.624
DOC_WW_Pin1_4 2 7 PF00397 0.735
DOC_WW_Pin1_4 261 266 PF00397 0.749
DOC_WW_Pin1_4 366 371 PF00397 0.809
DOC_WW_Pin1_4 413 418 PF00397 0.654
DOC_WW_Pin1_4 490 495 PF00397 0.725
DOC_WW_Pin1_4 500 505 PF00397 0.582
LIG_14-3-3_CanoR_1 155 163 PF00244 0.524
LIG_14-3-3_CanoR_1 268 273 PF00244 0.706
LIG_14-3-3_CanoR_1 475 480 PF00244 0.731
LIG_BIR_II_1 1 5 PF00653 0.721
LIG_BRCT_BRCA1_1 285 289 PF00533 0.698
LIG_FHA_1 387 393 PF00498 0.725
LIG_FHA_1 400 406 PF00498 0.640
LIG_FHA_1 431 437 PF00498 0.762
LIG_FHA_1 456 462 PF00498 0.732
LIG_FHA_1 90 96 PF00498 0.612
LIG_FHA_2 125 131 PF00498 0.540
LIG_FHA_2 293 299 PF00498 0.479
LIG_FHA_2 309 315 PF00498 0.421
LIG_FHA_2 344 350 PF00498 0.782
LIG_FHA_2 356 362 PF00498 0.609
LIG_FHA_2 378 384 PF00498 0.810
LIG_FHA_2 396 402 PF00498 0.720
LIG_FHA_2 440 446 PF00498 0.700
LIG_FHA_2 503 509 PF00498 0.701
LIG_LIR_Gen_1 162 171 PF02991 0.504
LIG_LIR_Gen_1 238 247 PF02991 0.525
LIG_LIR_Gen_1 250 259 PF02991 0.611
LIG_LIR_Gen_1 314 323 PF02991 0.646
LIG_LIR_Nem_3 162 166 PF02991 0.500
LIG_LIR_Nem_3 238 244 PF02991 0.449
LIG_LIR_Nem_3 250 256 PF02991 0.538
LIG_LIR_Nem_3 314 320 PF02991 0.580
LIG_LIR_Nem_3 445 451 PF02991 0.572
LIG_LYPXL_yS_3 448 451 PF13949 0.701
LIG_MAD2 410 418 PF02301 0.602
LIG_MYND_1 480 484 PF01753 0.668
LIG_PCNA_PIPBox_1 282 291 PF02747 0.470
LIG_PCNA_yPIPBox_3 276 289 PF02747 0.480
LIG_SH2_CRK 163 167 PF00017 0.525
LIG_SH2_CRK 241 245 PF00017 0.583
LIG_SH2_CRK 317 321 PF00017 0.561
LIG_SH2_NCK_1 20 24 PF00017 0.459
LIG_SH2_STAP1 20 24 PF00017 0.459
LIG_SH2_STAP1 317 321 PF00017 0.343
LIG_SH2_STAP1 570 574 PF00017 0.462
LIG_SH2_STAT3 37 40 PF00017 0.574
LIG_SH2_STAT3 573 576 PF00017 0.586
LIG_SH2_STAT5 116 119 PF00017 0.580
LIG_SH2_STAT5 173 176 PF00017 0.548
LIG_SH2_STAT5 573 576 PF00017 0.586
LIG_SH3_3 345 351 PF00018 0.750
LIG_SH3_3 478 484 PF00018 0.642
LIG_TRAF2_1 127 130 PF00917 0.588
LIG_TRAF2_1 159 162 PF00917 0.597
LIG_TRAF2_1 462 465 PF00917 0.697
LIG_TRAF2_1 505 508 PF00917 0.729
LIG_UBA3_1 319 324 PF00899 0.530
LIG_WRC_WIRS_1 533 538 PF05994 0.532
MOD_CDC14_SPxK_1 264 267 PF00782 0.680
MOD_CDK_SPxK_1 261 267 PF00069 0.662
MOD_CDK_SPxxK_3 261 268 PF00069 0.668
MOD_CDK_SPxxK_3 366 373 PF00069 0.796
MOD_CK1_1 219 225 PF00069 0.559
MOD_CK1_1 366 372 PF00069 0.768
MOD_CK1_1 403 409 PF00069 0.647
MOD_CK1_1 443 449 PF00069 0.665
MOD_CK1_1 470 476 PF00069 0.777
MOD_CK1_1 493 499 PF00069 0.699
MOD_CK1_1 518 524 PF00069 0.500
MOD_CK2_1 124 130 PF00069 0.586
MOD_CK2_1 343 349 PF00069 0.779
MOD_CK2_1 377 383 PF00069 0.768
MOD_CK2_1 395 401 PF00069 0.715
MOD_CK2_1 426 432 PF00069 0.725
MOD_CK2_1 502 508 PF00069 0.742
MOD_GlcNHglycan 11 14 PF01048 0.598
MOD_GlcNHglycan 157 160 PF01048 0.515
MOD_GlcNHglycan 208 212 PF01048 0.591
MOD_GlcNHglycan 285 288 PF01048 0.737
MOD_GlcNHglycan 383 386 PF01048 0.801
MOD_GlcNHglycan 405 408 PF01048 0.756
MOD_GlcNHglycan 428 431 PF01048 0.769
MOD_GlcNHglycan 445 448 PF01048 0.655
MOD_GlcNHglycan 521 524 PF01048 0.616
MOD_GlcNHglycan 525 528 PF01048 0.674
MOD_GSK3_1 190 197 PF00069 0.572
MOD_GSK3_1 351 358 PF00069 0.746
MOD_GSK3_1 359 366 PF00069 0.714
MOD_GSK3_1 371 378 PF00069 0.557
MOD_GSK3_1 387 394 PF00069 0.622
MOD_GSK3_1 395 402 PF00069 0.650
MOD_GSK3_1 426 433 PF00069 0.760
MOD_GSK3_1 439 446 PF00069 0.650
MOD_GSK3_1 470 477 PF00069 0.718
MOD_GSK3_1 515 522 PF00069 0.613
MOD_GSK3_1 547 554 PF00069 0.505
MOD_N-GLC_1 177 182 PF02516 0.582
MOD_N-GLC_1 334 339 PF02516 0.700
MOD_NEK2_1 133 138 PF00069 0.569
MOD_NEK2_1 192 197 PF00069 0.584
MOD_NEK2_1 199 204 PF00069 0.598
MOD_NEK2_1 216 221 PF00069 0.511
MOD_NEK2_1 355 360 PF00069 0.803
MOD_NEK2_1 400 405 PF00069 0.738
MOD_NEK2_1 439 444 PF00069 0.709
MOD_NEK2_1 517 522 PF00069 0.689
MOD_NEK2_1 547 552 PF00069 0.489
MOD_NEK2_2 351 356 PF00069 0.609
MOD_PIKK_1 192 198 PF00454 0.601
MOD_PIKK_1 199 205 PF00454 0.509
MOD_PIKK_1 216 222 PF00454 0.534
MOD_PIKK_1 363 369 PF00454 0.722
MOD_PKA_2 124 130 PF00069 0.586
MOD_PKA_2 14 20 PF00069 0.508
MOD_PKA_2 154 160 PF00069 0.524
MOD_PKA_2 335 341 PF00069 0.737
MOD_PKA_2 474 480 PF00069 0.738
MOD_PKA_2 56 62 PF00069 0.608
MOD_Plk_1 145 151 PF00069 0.411
MOD_Plk_1 396 402 PF00069 0.699
MOD_Plk_1 431 437 PF00069 0.733
MOD_Plk_1 440 446 PF00069 0.697
MOD_Plk_4 431 437 PF00069 0.722
MOD_Plk_4 456 462 PF00069 0.685
MOD_Plk_4 532 538 PF00069 0.539
MOD_ProDKin_1 2 8 PF00069 0.731
MOD_ProDKin_1 261 267 PF00069 0.755
MOD_ProDKin_1 366 372 PF00069 0.808
MOD_ProDKin_1 413 419 PF00069 0.654
MOD_ProDKin_1 490 496 PF00069 0.726
MOD_ProDKin_1 500 506 PF00069 0.577
MOD_SUMO_for_1 323 326 PF00179 0.578
MOD_SUMO_rev_2 55 64 PF00179 0.575
TRG_ENDOCYTIC_2 163 166 PF00928 0.492
TRG_ENDOCYTIC_2 241 244 PF00928 0.472
TRG_ENDOCYTIC_2 317 320 PF00928 0.564
TRG_ENDOCYTIC_2 448 451 PF00928 0.584
TRG_ER_diArg_1 125 128 PF00400 0.588
TRG_ER_diArg_1 166 169 PF00400 0.555
TRG_ER_diArg_1 422 424 PF00400 0.808
TRG_ER_diArg_1 50 52 PF00400 0.562
TRG_NES_CRM1_1 532 545 PF08389 0.539
TRG_NES_CRM1_1 72 86 PF08389 0.480
TRG_NLS_Bipartite_1 90 109 PF00514 0.575
TRG_Pf-PMV_PEXEL_1 147 151 PF00026 0.602
TRG_Pf-PMV_PEXEL_1 172 176 PF00026 0.542
TRG_Pf-PMV_PEXEL_1 204 208 PF00026 0.553
TRG_Pf-PMV_PEXEL_1 487 491 PF00026 0.774
TRG_Pf-PMV_PEXEL_1 50 55 PF00026 0.560

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYF9 Leptomonas seymouri 55% 93%
A0A1X0NR42 Trypanosomatidae 32% 99%
A0A3S5IQW4 Trypanosoma rangeli 33% 95%
A0A3S7X1P3 Leishmania donovani 93% 100%
A4HGQ6 Leishmania braziliensis 83% 100%
A4I3T0 Leishmania infantum 93% 100%
D0A877 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
Q4Q864 Leishmania major 93% 100%
V5AWM8 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS