Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B021_LEIMU

TriTrypDb:

LmxM.28.2010

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B021

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B021

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.735
CLV_NRD_NRD_1	16	18	PF00675	0.627
CLV_NRD_NRD_1	291	293	PF00675	0.558
CLV_NRD_NRD_1	319	321	PF00675	0.529
CLV_PCSK_KEX2_1	16	18	PF00082	0.627
CLV_PCSK_KEX2_1	291	293	PF00082	0.558
CLV_PCSK_KEX2_1	319	321	PF00082	0.569
CLV_PCSK_KEX2_1	511	513	PF00082	0.573
CLV_PCSK_KEX2_1	543	545	PF00082	0.729
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.606
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.573
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.729
CLV_PCSK_PC7_1	287	293	PF00082	0.561
CLV_PCSK_PC7_1	315	321	PF00082	0.448
CLV_PCSK_SKI1_1	177	181	PF00082	0.387
CLV_PCSK_SKI1_1	201	205	PF00082	0.536
CLV_PCSK_SKI1_1	232	236	PF00082	0.494
DEG_APCC_DBOX_1	3	11	PF00400	0.413
DEG_COP1_1	119	129	PF00400	0.676
DOC_CKS1_1	388	393	PF01111	0.701
DOC_CYCLIN_RxL_1	509	517	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	235	241	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.748
DOC_MAPK_DCC_7	232	241	PF00069	0.559
DOC_MAPK_gen_1	511	518	PF00069	0.561
DOC_MAPK_MEF2A_6	334	342	PF00069	0.600
DOC_MAPK_MEF2A_6	4	11	PF00069	0.521
DOC_MAPK_MEF2A_6	511	518	PF00069	0.561
DOC_MAPK_NFAT4_5	511	519	PF00069	0.586
DOC_PP4_FxxP_1	350	353	PF00568	0.469
DOC_USP7_MATH_1	125	129	PF00917	0.624
DOC_USP7_MATH_1	32	36	PF00917	0.740
DOC_USP7_MATH_1	371	375	PF00917	0.646
DOC_USP7_MATH_1	409	413	PF00917	0.532
DOC_USP7_MATH_1	442	446	PF00917	0.630
DOC_USP7_MATH_1	479	483	PF00917	0.711
DOC_USP7_MATH_1	496	500	PF00917	0.640
DOC_USP7_UBL2_3	319	323	PF12436	0.376
DOC_WW_Pin1_4	167	172	PF00397	0.461
DOC_WW_Pin1_4	239	244	PF00397	0.602
DOC_WW_Pin1_4	349	354	PF00397	0.503
DOC_WW_Pin1_4	387	392	PF00397	0.654
DOC_WW_Pin1_4	421	426	PF00397	0.727
LIG_14-3-3_CanoR_1	184	190	PF00244	0.404
LIG_14-3-3_CanoR_1	246	251	PF00244	0.465
LIG_14-3-3_CanoR_1	265	272	PF00244	0.497
LIG_14-3-3_CanoR_1	334	338	PF00244	0.618
LIG_14-3-3_CanoR_1	372	378	PF00244	0.715
LIG_APCC_ABBA_1	449	454	PF00400	0.520
LIG_BIR_III_2	122	126	PF00653	0.528
LIG_BIR_III_4	397	401	PF00653	0.687
LIG_BRCT_BRCA1_1	185	189	PF00533	0.405
LIG_BRCT_BRCA1_1	211	215	PF00533	0.525
LIG_BRCT_BRCA1_1	255	259	PF00533	0.604
LIG_BRCT_BRCA1_1	444	448	PF00533	0.582
LIG_BRCT_BRCA1_1	7	11	PF00533	0.517
LIG_Clathr_ClatBox_1	343	347	PF01394	0.411
LIG_CSL_BTD_1	388	391	PF09270	0.692
LIG_deltaCOP1_diTrp_1	134	140	PF00928	0.508
LIG_FHA_1	174	180	PF00498	0.415
LIG_FHA_1	22	28	PF00498	0.461
LIG_FHA_1	325	331	PF00498	0.775
LIG_FHA_1	343	349	PF00498	0.505
LIG_FHA_1	388	394	PF00498	0.694
LIG_FHA_1	441	447	PF00498	0.722
LIG_FHA_2	117	123	PF00498	0.668
LIG_FHA_2	173	179	PF00498	0.515
LIG_FHA_2	247	253	PF00498	0.429
LIG_FHA_2	276	282	PF00498	0.530
LIG_FHA_2	397	403	PF00498	0.665
LIG_GBD_Chelix_1	340	348	PF00786	0.557
LIG_Integrin_RGD_1	416	418	PF01839	0.677
LIG_LIR_Apic_2	161	167	PF02991	0.514
LIG_LIR_Apic_2	347	353	PF02991	0.443
LIG_LIR_Nem_3	128	132	PF02991	0.489
LIG_LIR_Nem_3	256	262	PF02991	0.517
LIG_LIR_Nem_3	268	274	PF02991	0.531
LIG_LIR_Nem_3	374	380	PF02991	0.684
LIG_LIR_Nem_3	447	452	PF02991	0.526
LIG_LIR_Nem_3	456	461	PF02991	0.534
LIG_LIR_Nem_3	76	81	PF02991	0.551
LIG_NRBOX	339	345	PF00104	0.546
LIG_Pex14_2	448	452	PF04695	0.548
LIG_REV1ctd_RIR_1	446	454	PF16727	0.522
LIG_REV1ctd_RIR_1	49	57	PF16727	0.455
LIG_SH2_CRK	492	496	PF00017	0.659
LIG_SH2_NCK_1	71	75	PF00017	0.612
LIG_SH2_SRC	54	57	PF00017	0.442
LIG_SH2_SRC	71	74	PF00017	0.567
LIG_SH2_STAP1	78	82	PF00017	0.581
LIG_SH2_STAT5	156	159	PF00017	0.464
LIG_SH2_STAT5	174	177	PF00017	0.494
LIG_SH2_STAT5	358	361	PF00017	0.424
LIG_SH2_STAT5	461	464	PF00017	0.579
LIG_SH2_STAT5	492	495	PF00017	0.607
LIG_SH2_STAT5	54	57	PF00017	0.376
LIG_SH2_STAT5	81	84	PF00017	0.573
LIG_SH3_3	100	106	PF00018	0.597
LIG_SH3_3	266	272	PF00018	0.554
LIG_SH3_3	350	356	PF00018	0.447
LIG_SH3_3	60	66	PF00018	0.474
LIG_SUMO_SIM_anti_2	345	352	PF11976	0.424
LIG_SUMO_SIM_par_1	196	202	PF11976	0.290
LIG_SUMO_SIM_par_1	342	347	PF11976	0.433
LIG_SUMO_SIM_par_1	390	397	PF11976	0.754
LIG_TRAF2_1	435	438	PF00917	0.813
LIG_TRAF2_1	44	47	PF00917	0.535
LIG_TRAF2_1	74	77	PF00917	0.642
LIG_WRC_WIRS_1	126	131	PF05994	0.597
MOD_CDK_SPxxK_3	239	246	PF00069	0.612
MOD_CK1_1	128	134	PF00069	0.495
MOD_CK1_1	226	232	PF00069	0.567
MOD_CK1_1	242	248	PF00069	0.581
MOD_CK1_1	57	63	PF00069	0.337
MOD_CK2_1	128	134	PF00069	0.497
MOD_CK2_1	135	141	PF00069	0.425
MOD_CK2_1	172	178	PF00069	0.480
MOD_CK2_1	275	281	PF00069	0.516
MOD_CMANNOS	386	389	PF00535	0.717
MOD_Cter_Amidation	14	17	PF01082	0.648
MOD_GlcNHglycan	112	115	PF01048	0.756
MOD_GlcNHglycan	225	228	PF01048	0.535
MOD_GlcNHglycan	324	327	PF01048	0.744
MOD_GlcNHglycan	33	37	PF01048	0.769
MOD_GlcNHglycan	360	363	PF01048	0.384
MOD_GlcNHglycan	373	376	PF01048	0.547
MOD_GlcNHglycan	411	414	PF01048	0.640
MOD_GlcNHglycan	462	465	PF01048	0.624
MOD_GlcNHglycan	498	501	PF01048	0.697
MOD_GlcNHglycan	95	98	PF01048	0.776
MOD_GSK3_1	112	119	PF00069	0.746
MOD_GSK3_1	165	172	PF00069	0.382
MOD_GSK3_1	211	218	PF00069	0.541
MOD_GSK3_1	219	226	PF00069	0.574
MOD_GSK3_1	242	249	PF00069	0.486
MOD_GSK3_1	253	260	PF00069	0.519
MOD_GSK3_1	479	486	PF00069	0.736
MOD_GSK3_1	5	12	PF00069	0.456
MOD_GSK3_1	57	64	PF00069	0.520
MOD_N-GLC_1	184	189	PF02516	0.444
MOD_N-GLC_1	57	62	PF02516	0.527
MOD_NEK2_1	183	188	PF00069	0.420
MOD_NEK2_1	215	220	PF00069	0.484
MOD_NEK2_1	223	228	PF00069	0.564
MOD_NEK2_1	257	262	PF00069	0.536
MOD_NEK2_1	299	304	PF00069	0.483
MOD_NEK2_1	469	474	PF00069	0.717
MOD_NEK2_2	135	140	PF00069	0.508
MOD_NEK2_2	21	26	PF00069	0.444
MOD_PIKK_1	201	207	PF00454	0.386
MOD_PIKK_1	381	387	PF00454	0.718
MOD_PKA_2	110	116	PF00069	0.519
MOD_PKA_2	183	189	PF00069	0.396
MOD_PKA_2	264	270	PF00069	0.479
MOD_PKA_2	333	339	PF00069	0.507
MOD_PKA_2	371	377	PF00069	0.713
MOD_Plk_1	215	221	PF00069	0.396
MOD_Plk_1	57	63	PF00069	0.461
MOD_Plk_4	135	141	PF00069	0.466
MOD_Plk_4	169	175	PF00069	0.355
MOD_Plk_4	270	276	PF00069	0.546
MOD_Plk_4	5	11	PF00069	0.449
MOD_Plk_4	77	83	PF00069	0.577
MOD_ProDKin_1	167	173	PF00069	0.448
MOD_ProDKin_1	239	245	PF00069	0.607
MOD_ProDKin_1	349	355	PF00069	0.509
MOD_ProDKin_1	387	393	PF00069	0.660
MOD_ProDKin_1	421	427	PF00069	0.731
TRG_DiLeu_BaEn_1	178	183	PF01217	0.488
TRG_DiLeu_BaEn_1	294	299	PF01217	0.456
TRG_DiLeu_BaEn_1	498	503	PF01217	0.584
TRG_DiLeu_BaEn_2	528	534	PF01217	0.469
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.701
TRG_ENDOCYTIC_2	492	495	PF00928	0.623
TRG_ER_diArg_1	291	293	PF00400	0.553
TRG_NLS_MonoExtN_4	319	324	PF00514	0.387
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL93	Leptomonas seymouri	59%	100%
A0A1X0NQS9	Trypanosomatidae	34%	100%
A0A3S7X1P6	Leishmania donovani	88%	100%
A0A422NBH7	Trypanosoma rangeli	38%	100%
A4HGQ5	Leishmania braziliensis	78%	100%
A4I3S9	Leishmania infantum	88%	100%
D0A878	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q865	Leishmania major	91%	100%
V5DCT5	Trypanosoma cruzi	37%	100%