LeishMANIAdb
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Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine-rich repeat protein
Gene product:
Leucine-rich repeat protein 1, putative
Species:
Leishmania mexicana
UniProt:
E9B018_LEIMU
TriTrypDb:
LmxM.28.1990
Length:
753

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005929 cilium 4 9
GO:0042995 cell projection 2 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0110165 cellular anatomical entity 1 9
GO:0120025 plasma membrane bounded cell projection 3 9

Expansion

Sequence features

E9B018
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B018

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005096 GTPase activator activity 4 9
GO:0008047 enzyme activator activity 3 9
GO:0030234 enzyme regulator activity 2 9
GO:0030695 GTPase regulator activity 4 9
GO:0060589 nucleoside-triphosphatase regulator activity 3 9
GO:0098772 molecular function regulator activity 1 9
GO:0140677 molecular function activator activity 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 402 406 PF00656 0.789
CLV_C14_Caspase3-7 642 646 PF00656 0.597
CLV_NRD_NRD_1 350 352 PF00675 0.643
CLV_NRD_NRD_1 373 375 PF00675 0.582
CLV_NRD_NRD_1 381 383 PF00675 0.641
CLV_NRD_NRD_1 417 419 PF00675 0.852
CLV_NRD_NRD_1 454 456 PF00675 0.792
CLV_NRD_NRD_1 463 465 PF00675 0.704
CLV_NRD_NRD_1 572 574 PF00675 0.618
CLV_NRD_NRD_1 745 747 PF00675 0.654
CLV_PCSK_FUR_1 461 465 PF00082 0.579
CLV_PCSK_KEX2_1 17 19 PF00082 0.563
CLV_PCSK_KEX2_1 350 352 PF00082 0.757
CLV_PCSK_KEX2_1 373 375 PF00082 0.582
CLV_PCSK_KEX2_1 381 383 PF00082 0.641
CLV_PCSK_KEX2_1 417 419 PF00082 0.852
CLV_PCSK_KEX2_1 454 456 PF00082 0.792
CLV_PCSK_KEX2_1 463 465 PF00082 0.704
CLV_PCSK_KEX2_1 572 574 PF00082 0.618
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.524
CLV_PCSK_PC7_1 377 383 PF00082 0.626
CLV_PCSK_SKI1_1 33 37 PF00082 0.512
CLV_PCSK_SKI1_1 539 543 PF00082 0.647
CLV_Separin_Metazoa 228 232 PF03568 0.422
DEG_APCC_DBOX_1 349 357 PF00400 0.605
DEG_Kelch_Keap1_1 707 712 PF01344 0.736
DEG_SCF_FBW7_1 233 239 PF00400 0.488
DOC_ANK_TNKS_1 400 407 PF00023 0.704
DOC_CDC14_PxL_1 177 185 PF14671 0.398
DOC_CKS1_1 233 238 PF01111 0.489
DOC_CKS1_1 485 490 PF01111 0.681
DOC_CKS1_1 529 534 PF01111 0.645
DOC_CYCLIN_RxL_1 66 77 PF00134 0.460
DOC_MAPK_DCC_7 350 358 PF00069 0.637
DOC_MAPK_gen_1 350 358 PF00069 0.549
DOC_MAPK_gen_1 553 561 PF00069 0.569
DOC_PP2B_LxvP_1 741 744 PF13499 0.664
DOC_PP4_FxxP_1 275 278 PF00568 0.409
DOC_PP4_FxxP_1 335 338 PF00568 0.521
DOC_PP4_FxxP_1 78 81 PF00568 0.494
DOC_USP7_MATH_1 368 372 PF00917 0.542
DOC_USP7_MATH_1 450 454 PF00917 0.716
DOC_USP7_MATH_1 477 481 PF00917 0.764
DOC_USP7_MATH_1 498 502 PF00917 0.743
DOC_USP7_MATH_1 511 515 PF00917 0.637
DOC_USP7_MATH_1 591 595 PF00917 0.739
DOC_USP7_MATH_1 613 617 PF00917 0.741
DOC_USP7_MATH_1 693 697 PF00917 0.713
DOC_USP7_UBL2_3 305 309 PF12436 0.527
DOC_USP7_UBL2_3 542 546 PF12436 0.569
DOC_WW_Pin1_4 232 237 PF00397 0.517
DOC_WW_Pin1_4 274 279 PF00397 0.497
DOC_WW_Pin1_4 432 437 PF00397 0.728
DOC_WW_Pin1_4 446 451 PF00397 0.711
DOC_WW_Pin1_4 456 461 PF00397 0.743
DOC_WW_Pin1_4 484 489 PF00397 0.788
DOC_WW_Pin1_4 528 533 PF00397 0.643
DOC_WW_Pin1_4 587 592 PF00397 0.784
DOC_WW_Pin1_4 689 694 PF00397 0.713
DOC_WW_Pin1_4 733 738 PF00397 0.731
LIG_14-3-3_CanoR_1 382 390 PF00244 0.586
LIG_14-3-3_CanoR_1 444 450 PF00244 0.757
LIG_14-3-3_CanoR_1 486 492 PF00244 0.747
LIG_14-3-3_CanoR_1 689 693 PF00244 0.774
LIG_14-3-3_CanoR_1 746 750 PF00244 0.710
LIG_APCC_ABBA_1 255 260 PF00400 0.386
LIG_BIR_II_1 1 5 PF00653 0.584
LIG_BIR_III_4 645 649 PF00653 0.655
LIG_BRCT_BRCA1_1 749 753 PF00533 0.712
LIG_Clathr_ClatBox_1 296 300 PF01394 0.475
LIG_FHA_1 211 217 PF00498 0.395
LIG_FHA_1 235 241 PF00498 0.475
LIG_FHA_1 252 258 PF00498 0.492
LIG_FHA_1 264 270 PF00498 0.353
LIG_FHA_1 293 299 PF00498 0.342
LIG_FHA_1 309 315 PF00498 0.581
LIG_FHA_1 367 373 PF00498 0.587
LIG_FHA_1 42 48 PF00498 0.520
LIG_FHA_1 523 529 PF00498 0.577
LIG_FHA_1 535 541 PF00498 0.575
LIG_FHA_1 561 567 PF00498 0.452
LIG_FHA_1 602 608 PF00498 0.820
LIG_FHA_1 690 696 PF00498 0.775
LIG_FHA_2 400 406 PF00498 0.700
LIG_FHA_2 529 535 PF00498 0.640
LIG_FHA_2 562 568 PF00498 0.587
LIG_FHA_2 59 65 PF00498 0.488
LIG_FHA_2 640 646 PF00498 0.695
LIG_FHA_2 683 689 PF00498 0.798
LIG_IRF3_LxIS_1 7 14 PF10401 0.307
LIG_LIR_Apic_2 334 338 PF02991 0.476
LIG_LIR_Apic_2 75 81 PF02991 0.473
LIG_LIR_Gen_1 623 632 PF02991 0.657
LIG_LIR_Nem_3 623 628 PF02991 0.720
LIG_LIR_Nem_3 649 655 PF02991 0.629
LIG_LRP6_Inhibitor_1 92 98 PF00058 0.446
LIG_PCNA_yPIPBox_3 321 329 PF02747 0.542
LIG_SH2_CRK 190 194 PF00017 0.333
LIG_SH2_CRK 625 629 PF00017 0.686
LIG_SH2_CRK 637 641 PF00017 0.606
LIG_SH2_NCK_1 375 379 PF00017 0.636
LIG_SH2_PTP2 357 360 PF00017 0.541
LIG_SH2_STAT3 172 175 PF00017 0.392
LIG_SH2_STAT3 655 658 PF00017 0.713
LIG_SH2_STAT5 12 15 PF00017 0.390
LIG_SH2_STAT5 172 175 PF00017 0.392
LIG_SH2_STAT5 357 360 PF00017 0.547
LIG_SH2_STAT5 366 369 PF00017 0.589
LIG_SH3_3 469 475 PF00018 0.684
LIG_SH3_3 507 513 PF00018 0.566
LIG_SUMO_SIM_anti_2 295 300 PF11976 0.400
LIG_SUMO_SIM_anti_2 311 316 PF11976 0.521
LIG_SUMO_SIM_anti_2 518 527 PF11976 0.616
LIG_SUMO_SIM_par_1 127 133 PF11976 0.333
LIG_SUMO_SIM_par_1 154 159 PF11976 0.368
LIG_SUMO_SIM_par_1 212 217 PF11976 0.410
LIG_SUMO_SIM_par_1 294 300 PF11976 0.394
LIG_SUMO_SIM_par_1 69 75 PF11976 0.453
LIG_TRAF2_1 317 320 PF00917 0.550
LIG_TRAF2_1 437 440 PF00917 0.719
LIG_TYR_ITIM 188 193 PF00017 0.333
LIG_TYR_ITIM 635 640 PF00017 0.658
LIG_UBA3_1 297 305 PF00899 0.400
LIG_UBA3_1 540 546 PF00899 0.463
MOD_CDC14_SPxK_1 590 593 PF00782 0.776
MOD_CDK_SPK_2 446 451 PF00069 0.734
MOD_CDK_SPK_2 456 461 PF00069 0.596
MOD_CDK_SPK_2 484 489 PF00069 0.695
MOD_CDK_SPxK_1 587 593 PF00069 0.773
MOD_CDK_SPxxK_3 456 463 PF00069 0.589
MOD_CK1_1 428 434 PF00069 0.723
MOD_CK1_1 445 451 PF00069 0.689
MOD_CK1_1 470 476 PF00069 0.711
MOD_CK1_1 494 500 PF00069 0.799
MOD_CK1_1 587 593 PF00069 0.740
MOD_CK1_1 676 682 PF00069 0.775
MOD_CK2_1 432 438 PF00069 0.729
MOD_CK2_1 548 554 PF00069 0.451
MOD_CK2_1 561 567 PF00069 0.592
MOD_CK2_1 682 688 PF00069 0.735
MOD_DYRK1A_RPxSP_1 432 436 PF00069 0.686
MOD_GlcNHglycan 121 124 PF01048 0.468
MOD_GlcNHglycan 13 16 PF01048 0.454
MOD_GlcNHglycan 287 290 PF01048 0.435
MOD_GlcNHglycan 456 459 PF01048 0.875
MOD_GlcNHglycan 469 472 PF01048 0.664
MOD_GlcNHglycan 479 482 PF01048 0.710
MOD_GlcNHglycan 496 499 PF01048 0.754
MOD_GlcNHglycan 586 589 PF01048 0.727
MOD_GlcNHglycan 593 596 PF01048 0.803
MOD_GlcNHglycan 617 620 PF01048 0.699
MOD_GlcNHglycan 708 712 PF01048 0.822
MOD_GlcNHglycan 722 725 PF01048 0.609
MOD_GSK3_1 115 122 PF00069 0.365
MOD_GSK3_1 210 217 PF00069 0.436
MOD_GSK3_1 232 239 PF00069 0.483
MOD_GSK3_1 373 380 PF00069 0.589
MOD_GSK3_1 381 388 PF00069 0.636
MOD_GSK3_1 389 396 PF00069 0.630
MOD_GSK3_1 407 414 PF00069 0.792
MOD_GSK3_1 421 428 PF00069 0.596
MOD_GSK3_1 442 449 PF00069 0.736
MOD_GSK3_1 450 457 PF00069 0.656
MOD_GSK3_1 487 494 PF00069 0.768
MOD_GSK3_1 544 551 PF00069 0.486
MOD_GSK3_1 580 587 PF00069 0.695
MOD_GSK3_1 613 620 PF00069 0.701
MOD_GSK3_1 667 674 PF00069 0.742
MOD_GSK3_1 689 696 PF00069 0.716
MOD_LATS_1 452 458 PF00433 0.703
MOD_N-GLC_1 134 139 PF02516 0.514
MOD_N-GLC_1 264 269 PF02516 0.430
MOD_N-GLC_1 292 297 PF02516 0.340
MOD_N-GLC_1 321 326 PF02516 0.497
MOD_N-GLC_1 664 669 PF02516 0.632
MOD_N-GLC_2 681 683 PF02516 0.544
MOD_NEK2_1 11 16 PF00069 0.547
MOD_NEK2_1 119 124 PF00069 0.448
MOD_NEK2_1 214 219 PF00069 0.390
MOD_NEK2_1 548 553 PF00069 0.656
MOD_NEK2_1 671 676 PF00069 0.727
MOD_NEK2_1 720 725 PF00069 0.649
MOD_NEK2_1 745 750 PF00069 0.750
MOD_NEK2_2 368 373 PF00069 0.549
MOD_PIKK_1 442 448 PF00454 0.791
MOD_PIKK_1 554 560 PF00454 0.533
MOD_PIKK_1 613 619 PF00454 0.784
MOD_PIKK_1 63 69 PF00454 0.450
MOD_PIKK_1 653 659 PF00454 0.605
MOD_PIKK_1 676 682 PF00454 0.706
MOD_PIKK_1 693 699 PF00454 0.718
MOD_PK_1 425 431 PF00069 0.678
MOD_PKA_1 373 379 PF00069 0.578
MOD_PKA_1 381 387 PF00069 0.598
MOD_PKA_1 454 460 PF00069 0.703
MOD_PKA_2 219 225 PF00069 0.514
MOD_PKA_2 373 379 PF00069 0.587
MOD_PKA_2 381 387 PF00069 0.634
MOD_PKA_2 416 422 PF00069 0.794
MOD_PKA_2 450 456 PF00069 0.798
MOD_PKA_2 499 505 PF00069 0.852
MOD_PKA_2 676 682 PF00069 0.730
MOD_PKA_2 688 694 PF00069 0.783
MOD_PKA_2 745 751 PF00069 0.712
MOD_Plk_1 156 162 PF00069 0.383
MOD_Plk_1 264 270 PF00069 0.391
MOD_Plk_1 292 298 PF00069 0.351
MOD_Plk_1 321 327 PF00069 0.636
MOD_Plk_1 63 69 PF00069 0.449
MOD_Plk_1 74 80 PF00069 0.469
MOD_Plk_2-3 522 528 PF00069 0.564
MOD_Plk_4 168 174 PF00069 0.398
MOD_Plk_4 251 257 PF00069 0.524
MOD_Plk_4 264 270 PF00069 0.348
MOD_Plk_4 292 298 PF00069 0.407
MOD_Plk_4 682 688 PF00069 0.596
MOD_ProDKin_1 232 238 PF00069 0.511
MOD_ProDKin_1 274 280 PF00069 0.503
MOD_ProDKin_1 432 438 PF00069 0.729
MOD_ProDKin_1 446 452 PF00069 0.711
MOD_ProDKin_1 456 462 PF00069 0.743
MOD_ProDKin_1 484 490 PF00069 0.789
MOD_ProDKin_1 528 534 PF00069 0.640
MOD_ProDKin_1 587 593 PF00069 0.787
MOD_ProDKin_1 689 695 PF00069 0.716
MOD_ProDKin_1 733 739 PF00069 0.731
MOD_SUMO_rev_2 32 38 PF00179 0.620
TRG_DiLeu_BaEn_4 348 354 PF01217 0.668
TRG_ENDOCYTIC_2 190 193 PF00928 0.333
TRG_ENDOCYTIC_2 625 628 PF00928 0.720
TRG_ENDOCYTIC_2 637 640 PF00928 0.720
TRG_ER_diArg_1 372 374 PF00400 0.573
TRG_ER_diArg_1 460 463 PF00400 0.717
TRG_Pf-PMV_PEXEL_1 60 64 PF00026 0.620
TRG_Pf-PMV_PEXEL_1 69 74 PF00026 0.316

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NQV7 Trypanosomatidae 43% 100%
A0A3Q8II72 Leishmania donovani 93% 100%
A0A422NBD9 Trypanosoma rangeli 43% 100%
A4HGP9 Leishmania braziliensis 74% 100%
A4I3S6 Leishmania infantum 93% 100%
D0A881 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
Q4Q867 Leishmania major 91% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS