Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine-rich repeat protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9B018_LEIMU

TriTrypDb:

LmxM.28.1990

Length:

753

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

E9B018

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B018

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	9
GO:0008047	enzyme activator activity	3	9
GO:0030234	enzyme regulator activity	2	9
GO:0030695	GTPase regulator activity	4	9
GO:0060589	nucleoside-triphosphatase regulator activity	3	9
GO:0098772	molecular function regulator activity	1	9
GO:0140677	molecular function activator activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.789
CLV_C14_Caspase3-7	642	646	PF00656	0.597
CLV_NRD_NRD_1	350	352	PF00675	0.643
CLV_NRD_NRD_1	373	375	PF00675	0.582
CLV_NRD_NRD_1	381	383	PF00675	0.641
CLV_NRD_NRD_1	417	419	PF00675	0.852
CLV_NRD_NRD_1	454	456	PF00675	0.792
CLV_NRD_NRD_1	463	465	PF00675	0.704
CLV_NRD_NRD_1	572	574	PF00675	0.618
CLV_NRD_NRD_1	745	747	PF00675	0.654
CLV_PCSK_FUR_1	461	465	PF00082	0.579
CLV_PCSK_KEX2_1	17	19	PF00082	0.563
CLV_PCSK_KEX2_1	350	352	PF00082	0.757
CLV_PCSK_KEX2_1	373	375	PF00082	0.582
CLV_PCSK_KEX2_1	381	383	PF00082	0.641
CLV_PCSK_KEX2_1	417	419	PF00082	0.852
CLV_PCSK_KEX2_1	454	456	PF00082	0.792
CLV_PCSK_KEX2_1	463	465	PF00082	0.704
CLV_PCSK_KEX2_1	572	574	PF00082	0.618
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.524
CLV_PCSK_PC7_1	377	383	PF00082	0.626
CLV_PCSK_SKI1_1	33	37	PF00082	0.512
CLV_PCSK_SKI1_1	539	543	PF00082	0.647
CLV_Separin_Metazoa	228	232	PF03568	0.422
DEG_APCC_DBOX_1	349	357	PF00400	0.605
DEG_Kelch_Keap1_1	707	712	PF01344	0.736
DEG_SCF_FBW7_1	233	239	PF00400	0.488
DOC_ANK_TNKS_1	400	407	PF00023	0.704
DOC_CDC14_PxL_1	177	185	PF14671	0.398
DOC_CKS1_1	233	238	PF01111	0.489
DOC_CKS1_1	485	490	PF01111	0.681
DOC_CKS1_1	529	534	PF01111	0.645
DOC_CYCLIN_RxL_1	66	77	PF00134	0.460
DOC_MAPK_DCC_7	350	358	PF00069	0.637
DOC_MAPK_gen_1	350	358	PF00069	0.549
DOC_MAPK_gen_1	553	561	PF00069	0.569
DOC_PP2B_LxvP_1	741	744	PF13499	0.664
DOC_PP4_FxxP_1	275	278	PF00568	0.409
DOC_PP4_FxxP_1	335	338	PF00568	0.521
DOC_PP4_FxxP_1	78	81	PF00568	0.494
DOC_USP7_MATH_1	368	372	PF00917	0.542
DOC_USP7_MATH_1	450	454	PF00917	0.716
DOC_USP7_MATH_1	477	481	PF00917	0.764
DOC_USP7_MATH_1	498	502	PF00917	0.743
DOC_USP7_MATH_1	511	515	PF00917	0.637
DOC_USP7_MATH_1	591	595	PF00917	0.739
DOC_USP7_MATH_1	613	617	PF00917	0.741
DOC_USP7_MATH_1	693	697	PF00917	0.713
DOC_USP7_UBL2_3	305	309	PF12436	0.527
DOC_USP7_UBL2_3	542	546	PF12436	0.569
DOC_WW_Pin1_4	232	237	PF00397	0.517
DOC_WW_Pin1_4	274	279	PF00397	0.497
DOC_WW_Pin1_4	432	437	PF00397	0.728
DOC_WW_Pin1_4	446	451	PF00397	0.711
DOC_WW_Pin1_4	456	461	PF00397	0.743
DOC_WW_Pin1_4	484	489	PF00397	0.788
DOC_WW_Pin1_4	528	533	PF00397	0.643
DOC_WW_Pin1_4	587	592	PF00397	0.784
DOC_WW_Pin1_4	689	694	PF00397	0.713
DOC_WW_Pin1_4	733	738	PF00397	0.731
LIG_14-3-3_CanoR_1	382	390	PF00244	0.586
LIG_14-3-3_CanoR_1	444	450	PF00244	0.757
LIG_14-3-3_CanoR_1	486	492	PF00244	0.747
LIG_14-3-3_CanoR_1	689	693	PF00244	0.774
LIG_14-3-3_CanoR_1	746	750	PF00244	0.710
LIG_APCC_ABBA_1	255	260	PF00400	0.386
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BIR_III_4	645	649	PF00653	0.655
LIG_BRCT_BRCA1_1	749	753	PF00533	0.712
LIG_Clathr_ClatBox_1	296	300	PF01394	0.475
LIG_FHA_1	211	217	PF00498	0.395
LIG_FHA_1	235	241	PF00498	0.475
LIG_FHA_1	252	258	PF00498	0.492
LIG_FHA_1	264	270	PF00498	0.353
LIG_FHA_1	293	299	PF00498	0.342
LIG_FHA_1	309	315	PF00498	0.581
LIG_FHA_1	367	373	PF00498	0.587
LIG_FHA_1	42	48	PF00498	0.520
LIG_FHA_1	523	529	PF00498	0.577
LIG_FHA_1	535	541	PF00498	0.575
LIG_FHA_1	561	567	PF00498	0.452
LIG_FHA_1	602	608	PF00498	0.820
LIG_FHA_1	690	696	PF00498	0.775
LIG_FHA_2	400	406	PF00498	0.700
LIG_FHA_2	529	535	PF00498	0.640
LIG_FHA_2	562	568	PF00498	0.587
LIG_FHA_2	59	65	PF00498	0.488
LIG_FHA_2	640	646	PF00498	0.695
LIG_FHA_2	683	689	PF00498	0.798
LIG_IRF3_LxIS_1	7	14	PF10401	0.307
LIG_LIR_Apic_2	334	338	PF02991	0.476
LIG_LIR_Apic_2	75	81	PF02991	0.473
LIG_LIR_Gen_1	623	632	PF02991	0.657
LIG_LIR_Nem_3	623	628	PF02991	0.720
LIG_LIR_Nem_3	649	655	PF02991	0.629
LIG_LRP6_Inhibitor_1	92	98	PF00058	0.446
LIG_PCNA_yPIPBox_3	321	329	PF02747	0.542
LIG_SH2_CRK	190	194	PF00017	0.333
LIG_SH2_CRK	625	629	PF00017	0.686
LIG_SH2_CRK	637	641	PF00017	0.606
LIG_SH2_NCK_1	375	379	PF00017	0.636
LIG_SH2_PTP2	357	360	PF00017	0.541
LIG_SH2_STAT3	172	175	PF00017	0.392
LIG_SH2_STAT3	655	658	PF00017	0.713
LIG_SH2_STAT5	12	15	PF00017	0.390
LIG_SH2_STAT5	172	175	PF00017	0.392
LIG_SH2_STAT5	357	360	PF00017	0.547
LIG_SH2_STAT5	366	369	PF00017	0.589
LIG_SH3_3	469	475	PF00018	0.684
LIG_SH3_3	507	513	PF00018	0.566
LIG_SUMO_SIM_anti_2	295	300	PF11976	0.400
LIG_SUMO_SIM_anti_2	311	316	PF11976	0.521
LIG_SUMO_SIM_anti_2	518	527	PF11976	0.616
LIG_SUMO_SIM_par_1	127	133	PF11976	0.333
LIG_SUMO_SIM_par_1	154	159	PF11976	0.368
LIG_SUMO_SIM_par_1	212	217	PF11976	0.410
LIG_SUMO_SIM_par_1	294	300	PF11976	0.394
LIG_SUMO_SIM_par_1	69	75	PF11976	0.453
LIG_TRAF2_1	317	320	PF00917	0.550
LIG_TRAF2_1	437	440	PF00917	0.719
LIG_TYR_ITIM	188	193	PF00017	0.333
LIG_TYR_ITIM	635	640	PF00017	0.658
LIG_UBA3_1	297	305	PF00899	0.400
LIG_UBA3_1	540	546	PF00899	0.463
MOD_CDC14_SPxK_1	590	593	PF00782	0.776
MOD_CDK_SPK_2	446	451	PF00069	0.734
MOD_CDK_SPK_2	456	461	PF00069	0.596
MOD_CDK_SPK_2	484	489	PF00069	0.695
MOD_CDK_SPxK_1	587	593	PF00069	0.773
MOD_CDK_SPxxK_3	456	463	PF00069	0.589
MOD_CK1_1	428	434	PF00069	0.723
MOD_CK1_1	445	451	PF00069	0.689
MOD_CK1_1	470	476	PF00069	0.711
MOD_CK1_1	494	500	PF00069	0.799
MOD_CK1_1	587	593	PF00069	0.740
MOD_CK1_1	676	682	PF00069	0.775
MOD_CK2_1	432	438	PF00069	0.729
MOD_CK2_1	548	554	PF00069	0.451
MOD_CK2_1	561	567	PF00069	0.592
MOD_CK2_1	682	688	PF00069	0.735
MOD_DYRK1A_RPxSP_1	432	436	PF00069	0.686
MOD_GlcNHglycan	121	124	PF01048	0.468
MOD_GlcNHglycan	13	16	PF01048	0.454
MOD_GlcNHglycan	287	290	PF01048	0.435
MOD_GlcNHglycan	456	459	PF01048	0.875
MOD_GlcNHglycan	469	472	PF01048	0.664
MOD_GlcNHglycan	479	482	PF01048	0.710
MOD_GlcNHglycan	496	499	PF01048	0.754
MOD_GlcNHglycan	586	589	PF01048	0.727
MOD_GlcNHglycan	593	596	PF01048	0.803
MOD_GlcNHglycan	617	620	PF01048	0.699
MOD_GlcNHglycan	708	712	PF01048	0.822
MOD_GlcNHglycan	722	725	PF01048	0.609
MOD_GSK3_1	115	122	PF00069	0.365
MOD_GSK3_1	210	217	PF00069	0.436
MOD_GSK3_1	232	239	PF00069	0.483
MOD_GSK3_1	373	380	PF00069	0.589
MOD_GSK3_1	381	388	PF00069	0.636
MOD_GSK3_1	389	396	PF00069	0.630
MOD_GSK3_1	407	414	PF00069	0.792
MOD_GSK3_1	421	428	PF00069	0.596
MOD_GSK3_1	442	449	PF00069	0.736
MOD_GSK3_1	450	457	PF00069	0.656
MOD_GSK3_1	487	494	PF00069	0.768
MOD_GSK3_1	544	551	PF00069	0.486
MOD_GSK3_1	580	587	PF00069	0.695
MOD_GSK3_1	613	620	PF00069	0.701
MOD_GSK3_1	667	674	PF00069	0.742
MOD_GSK3_1	689	696	PF00069	0.716
MOD_LATS_1	452	458	PF00433	0.703
MOD_N-GLC_1	134	139	PF02516	0.514
MOD_N-GLC_1	264	269	PF02516	0.430
MOD_N-GLC_1	292	297	PF02516	0.340
MOD_N-GLC_1	321	326	PF02516	0.497
MOD_N-GLC_1	664	669	PF02516	0.632
MOD_N-GLC_2	681	683	PF02516	0.544
MOD_NEK2_1	11	16	PF00069	0.547
MOD_NEK2_1	119	124	PF00069	0.448
MOD_NEK2_1	214	219	PF00069	0.390
MOD_NEK2_1	548	553	PF00069	0.656
MOD_NEK2_1	671	676	PF00069	0.727
MOD_NEK2_1	720	725	PF00069	0.649
MOD_NEK2_1	745	750	PF00069	0.750
MOD_NEK2_2	368	373	PF00069	0.549
MOD_PIKK_1	442	448	PF00454	0.791
MOD_PIKK_1	554	560	PF00454	0.533
MOD_PIKK_1	613	619	PF00454	0.784
MOD_PIKK_1	63	69	PF00454	0.450
MOD_PIKK_1	653	659	PF00454	0.605
MOD_PIKK_1	676	682	PF00454	0.706
MOD_PIKK_1	693	699	PF00454	0.718
MOD_PK_1	425	431	PF00069	0.678
MOD_PKA_1	373	379	PF00069	0.578
MOD_PKA_1	381	387	PF00069	0.598
MOD_PKA_1	454	460	PF00069	0.703
MOD_PKA_2	219	225	PF00069	0.514
MOD_PKA_2	373	379	PF00069	0.587
MOD_PKA_2	381	387	PF00069	0.634
MOD_PKA_2	416	422	PF00069	0.794
MOD_PKA_2	450	456	PF00069	0.798
MOD_PKA_2	499	505	PF00069	0.852
MOD_PKA_2	676	682	PF00069	0.730
MOD_PKA_2	688	694	PF00069	0.783
MOD_PKA_2	745	751	PF00069	0.712
MOD_Plk_1	156	162	PF00069	0.383
MOD_Plk_1	264	270	PF00069	0.391
MOD_Plk_1	292	298	PF00069	0.351
MOD_Plk_1	321	327	PF00069	0.636
MOD_Plk_1	63	69	PF00069	0.449
MOD_Plk_1	74	80	PF00069	0.469
MOD_Plk_2-3	522	528	PF00069	0.564
MOD_Plk_4	168	174	PF00069	0.398
MOD_Plk_4	251	257	PF00069	0.524
MOD_Plk_4	264	270	PF00069	0.348
MOD_Plk_4	292	298	PF00069	0.407
MOD_Plk_4	682	688	PF00069	0.596
MOD_ProDKin_1	232	238	PF00069	0.511
MOD_ProDKin_1	274	280	PF00069	0.503
MOD_ProDKin_1	432	438	PF00069	0.729
MOD_ProDKin_1	446	452	PF00069	0.711
MOD_ProDKin_1	456	462	PF00069	0.743
MOD_ProDKin_1	484	490	PF00069	0.789
MOD_ProDKin_1	528	534	PF00069	0.640
MOD_ProDKin_1	587	593	PF00069	0.787
MOD_ProDKin_1	689	695	PF00069	0.716
MOD_ProDKin_1	733	739	PF00069	0.731
MOD_SUMO_rev_2	32	38	PF00179	0.620
TRG_DiLeu_BaEn_4	348	354	PF01217	0.668
TRG_ENDOCYTIC_2	190	193	PF00928	0.333
TRG_ENDOCYTIC_2	625	628	PF00928	0.720
TRG_ENDOCYTIC_2	637	640	PF00928	0.720
TRG_ER_diArg_1	372	374	PF00400	0.573
TRG_ER_diArg_1	460	463	PF00400	0.717
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	69	74	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NQV7	Trypanosomatidae	43%	100%
A0A3Q8II72	Leishmania donovani	93%	100%
A0A422NBD9	Trypanosoma rangeli	43%	100%
A4HGP9	Leishmania braziliensis	74%	100%
A4I3S6	Leishmania infantum	93%	100%
D0A881	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
Q4Q867	Leishmania major	91%	99%