Putative X-pro, dipeptidyl-peptidase,serine peptidase,Clan SC, family S15

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

X-pro, dipeptidyl-peptidase,serine peptidase, Clan SC, family S15, putative

Species:

Leishmania mexicana

UniProt:

E9B014_LEIMU

TriTrypDb:

LmxM.28.1950

Length:

686

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B014

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B014

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008233	peptidase activity	3	9
GO:0008238	exopeptidase activity	4	9
GO:0008239	dipeptidyl-peptidase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0004725	protein tyrosine phosphatase activity	4	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.232
CLV_NRD_NRD_1	53	55	PF00675	0.215
CLV_NRD_NRD_1	679	681	PF00675	0.317
CLV_NRD_NRD_1	682	684	PF00675	0.315
CLV_PCSK_FUR_1	680	684	PF00082	0.430
CLV_PCSK_KEX2_1	139	141	PF00082	0.232
CLV_PCSK_KEX2_1	55	57	PF00082	0.212
CLV_PCSK_KEX2_1	679	681	PF00082	0.317
CLV_PCSK_KEX2_1	682	684	PF00082	0.315
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.212
CLV_PCSK_SKI1_1	290	294	PF00082	0.336
CLV_PCSK_SKI1_1	301	305	PF00082	0.339
CLV_PCSK_SKI1_1	357	361	PF00082	0.263
CLV_PCSK_SKI1_1	439	443	PF00082	0.225
CLV_PCSK_SKI1_1	613	617	PF00082	0.442
CLV_Separin_Metazoa	576	580	PF03568	0.245
DOC_CKS1_1	376	381	PF01111	0.415
DOC_CYCLIN_RxL_1	609	621	PF00134	0.332
DOC_MAPK_MEF2A_6	145	152	PF00069	0.432
DOC_MAPK_NFAT4_5	145	153	PF00069	0.494
DOC_PP2B_LxvP_1	261	264	PF13499	0.441
DOC_PP2B_LxvP_1	32	35	PF13499	0.415
DOC_PP4_FxxP_1	534	537	PF00568	0.399
DOC_USP7_MATH_1	500	504	PF00917	0.507
DOC_USP7_UBL2_3	262	266	PF12436	0.457
DOC_WW_Pin1_4	278	283	PF00397	0.369
DOC_WW_Pin1_4	375	380	PF00397	0.419
DOC_WW_Pin1_4	516	521	PF00397	0.415
DOC_WW_Pin1_4	556	561	PF00397	0.373
LIG_14-3-3_CanoR_1	156	163	PF00244	0.415
LIG_14-3-3_CanoR_1	3	11	PF00244	0.443
LIG_14-3-3_CanoR_1	457	461	PF00244	0.415
LIG_14-3-3_CanoR_1	571	576	PF00244	0.363
LIG_APCC_ABBA_1	314	319	PF00400	0.336
LIG_deltaCOP1_diTrp_1	109	116	PF00928	0.415
LIG_deltaCOP1_diTrp_1	194	200	PF00928	0.415
LIG_deltaCOP1_diTrp_1	294	299	PF00928	0.395
LIG_EH1_1	459	467	PF00400	0.498
LIG_eIF4E_1	460	466	PF01652	0.498
LIG_FHA_1	10	16	PF00498	0.467
LIG_FHA_1	116	122	PF00498	0.498
LIG_FHA_1	156	162	PF00498	0.415
LIG_FHA_1	249	255	PF00498	0.415
LIG_FHA_1	369	375	PF00498	0.561
LIG_FHA_1	426	432	PF00498	0.406
LIG_FHA_1	521	527	PF00498	0.423
LIG_FHA_1	584	590	PF00498	0.341
LIG_FHA_2	19	25	PF00498	0.435
LIG_FHA_2	302	308	PF00498	0.394
LIG_FHA_2	396	402	PF00498	0.421
LIG_FHA_2	603	609	PF00498	0.316
LIG_HCF-1_HBM_1	41	44	PF13415	0.494
LIG_LIR_Apic_2	531	537	PF02991	0.356
LIG_LIR_Gen_1	16	26	PF02991	0.339
LIG_LIR_Gen_1	231	241	PF02991	0.432
LIG_LIR_Gen_1	253	263	PF02991	0.390
LIG_LIR_Gen_1	572	580	PF02991	0.350
LIG_LIR_Gen_1	581	589	PF02991	0.279
LIG_LIR_Gen_1	653	663	PF02991	0.311
LIG_LIR_Nem_3	127	131	PF02991	0.427
LIG_LIR_Nem_3	16	22	PF02991	0.314
LIG_LIR_Nem_3	231	236	PF02991	0.454
LIG_LIR_Nem_3	253	258	PF02991	0.390
LIG_LIR_Nem_3	294	298	PF02991	0.473
LIG_LIR_Nem_3	310	314	PF02991	0.370
LIG_LIR_Nem_3	386	392	PF02991	0.555
LIG_LIR_Nem_3	41	47	PF02991	0.436
LIG_LIR_Nem_3	49	53	PF02991	0.393
LIG_LIR_Nem_3	490	496	PF02991	0.461
LIG_LIR_Nem_3	572	578	PF02991	0.355
LIG_LIR_Nem_3	580	585	PF02991	0.277
LIG_LIR_Nem_3	653	659	PF02991	0.316
LIG_LYPXL_yS_3	44	47	PF13949	0.498
LIG_NRBOX	253	259	PF00104	0.498
LIG_PDZ_Class_3	681	686	PF00595	0.357
LIG_Pex14_1	246	250	PF04695	0.415
LIG_Pex14_1	272	276	PF04695	0.415
LIG_Pex14_2	673	677	PF04695	0.347
LIG_PTB_Apo_2	167	174	PF02174	0.415
LIG_PTB_Apo_2	249	256	PF02174	0.415
LIG_SH2_CRK	233	237	PF00017	0.430
LIG_SH2_CRK	496	500	PF00017	0.498
LIG_SH2_GRB2like	250	253	PF00017	0.415
LIG_SH2_NCK_1	233	237	PF00017	0.419
LIG_SH2_NCK_1	412	416	PF00017	0.498
LIG_SH2_PTP2	19	22	PF00017	0.416
LIG_SH2_PTP2	75	78	PF00017	0.462
LIG_SH2_SRC	575	578	PF00017	0.370
LIG_SH2_SRC	656	659	PF00017	0.323
LIG_SH2_STAP1	220	224	PF00017	0.415
LIG_SH2_STAP1	250	254	PF00017	0.415
LIG_SH2_STAT3	96	99	PF00017	0.415
LIG_SH2_STAT5	19	22	PF00017	0.416
LIG_SH2_STAT5	250	253	PF00017	0.415
LIG_SH2_STAT5	317	320	PF00017	0.413
LIG_SH2_STAT5	412	415	PF00017	0.511
LIG_SH2_STAT5	496	499	PF00017	0.483
LIG_SH2_STAT5	50	53	PF00017	0.415
LIG_SH2_STAT5	584	587	PF00017	0.251
LIG_SH2_STAT5	627	630	PF00017	0.379
LIG_SH2_STAT5	656	659	PF00017	0.307
LIG_SH2_STAT5	75	78	PF00017	0.454
LIG_SH2_STAT5	96	99	PF00017	0.415
LIG_SH3_2	329	334	PF14604	0.465
LIG_SH3_3	326	332	PF00018	0.399
LIG_SH3_3	373	379	PF00018	0.481
LIG_SH3_3	543	549	PF00018	0.498
LIG_SH3_3	560	566	PF00018	0.353
LIG_SH3_3	632	638	PF00018	0.474
LIG_SUMO_SIM_anti_2	102	109	PF11976	0.432
LIG_SUMO_SIM_par_1	238	244	PF11976	0.498
LIG_SUMO_SIM_par_1	371	378	PF11976	0.462
LIG_SUMO_SIM_par_1	522	528	PF11976	0.476
LIG_TRAF2_1	228	231	PF00917	0.498
LIG_TYR_ITIM	573	578	PF00017	0.369
LIG_UBA3_1	254	262	PF00899	0.263
LIG_UBA3_1	47	55	PF00899	0.250
MOD_CDK_SPxxK_3	278	285	PF00069	0.423
MOD_CK1_1	541	547	PF00069	0.488
MOD_CK2_1	225	231	PF00069	0.259
MOD_CK2_1	548	554	PF00069	0.411
MOD_CK2_1	602	608	PF00069	0.324
MOD_CMANNOS	296	299	PF00535	0.283
MOD_GlcNHglycan	385	388	PF01048	0.310
MOD_GlcNHglycan	413	416	PF01048	0.375
MOD_GlcNHglycan	541	544	PF01048	0.537
MOD_GlcNHglycan	623	626	PF01048	0.355
MOD_GSK3_1	246	253	PF00069	0.195
MOD_GSK3_1	411	418	PF00069	0.355
MOD_GSK3_1	425	432	PF00069	0.286
MOD_GSK3_1	500	507	PF00069	0.277
MOD_GSK3_1	516	523	PF00069	0.318
MOD_GSK3_1	555	562	PF00069	0.396
MOD_GSK3_1	580	587	PF00069	0.423
MOD_GSK3_1	621	628	PF00069	0.403
MOD_N-GLC_1	56	61	PF02516	0.366
MOD_N-GLC_1	644	649	PF02516	0.383
MOD_NEK2_1	124	129	PF00069	0.260
MOD_NEK2_1	150	155	PF00069	0.326
MOD_NEK2_1	408	413	PF00069	0.426
MOD_NEK2_1	429	434	PF00069	0.360
MOD_NEK2_1	539	544	PF00069	0.466
MOD_NEK2_1	615	620	PF00069	0.303
MOD_NEK2_1	633	638	PF00069	0.437
MOD_NEK2_1	673	678	PF00069	0.394
MOD_NEK2_2	250	255	PF00069	0.154
MOD_PIKK_1	646	652	PF00454	0.417
MOD_PIKK_1	9	15	PF00454	0.469
MOD_PKA_2	155	161	PF00069	0.250
MOD_PKA_2	456	462	PF00069	0.250
MOD_PKA_2	578	584	PF00069	0.227
MOD_PKA_2	82	88	PF00069	0.160
MOD_PKB_1	54	62	PF00069	0.250
MOD_Plk_1	15	21	PF00069	0.272
MOD_Plk_1	231	237	PF00069	0.366
MOD_Plk_1	318	324	PF00069	0.378
MOD_Plk_1	521	527	PF00069	0.380
MOD_Plk_1	569	575	PF00069	0.365
MOD_Plk_1	613	619	PF00069	0.338
MOD_Plk_1	673	679	PF00069	0.386
MOD_Plk_4	15	21	PF00069	0.227
MOD_Plk_4	250	256	PF00069	0.154
MOD_Plk_4	370	376	PF00069	0.366
MOD_Plk_4	521	527	PF00069	0.374
MOD_Plk_4	541	547	PF00069	0.241
MOD_Plk_4	559	565	PF00069	0.334
MOD_Plk_4	584	590	PF00069	0.488
MOD_ProDKin_1	278	284	PF00069	0.370
MOD_ProDKin_1	375	381	PF00069	0.256
MOD_ProDKin_1	516	522	PF00069	0.250
MOD_ProDKin_1	556	562	PF00069	0.372
MOD_SUMO_for_1	97	100	PF00179	0.366
TRG_DiLeu_BaEn_1	87	92	PF01217	0.250
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.238
TRG_ENDOCYTIC_2	19	22	PF00928	0.416
TRG_ENDOCYTIC_2	233	236	PF00928	0.270
TRG_ENDOCYTIC_2	44	47	PF00928	0.366
TRG_ENDOCYTIC_2	512	515	PF00928	0.366
TRG_ENDOCYTIC_2	575	578	PF00928	0.370
TRG_ENDOCYTIC_2	656	659	PF00928	0.300
TRG_ENDOCYTIC_2	75	78	PF00928	0.309
TRG_ER_diArg_1	139	141	PF00400	0.275
TRG_ER_diArg_1	53	56	PF00400	0.250
TRG_ER_diArg_1	679	682	PF00400	0.325
TRG_NLS_MonoExtN_4	52	58	PF00514	0.366
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.289

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I036	Leptomonas seymouri	80%	100%
A0A1X0NRA9	Trypanosomatidae	56%	100%
A0A3S7X1Q1	Leishmania donovani	93%	100%
A0A422N0C2	Trypanosoma rangeli	56%	100%
A4I3S2	Leishmania infantum	93%	100%
P0A5F6	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	23%	100%
P9WIQ8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	23%	100%
P9WIQ9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	23%	100%
Q4Q871	Leishmania major	93%	100%
Q82MI6	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	22%	100%
Q9L9D7	Rhodococcus sp. (strain MB1 Bresler)	22%	100%
V5BL63	Trypanosoma cruzi	56%	100%