Putative zinc transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc transporter 3, putative

Species:

Leishmania mexicana

UniProt:

E9B012_LEIMU

TriTrypDb:

LmxM.28.1930

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	34
GO:0110165	cellular anatomical entity	1	34
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	4

Expansion

Sequence features

E9B012

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B012

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	4
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	4
GO:0006812	monoatomic cation transport	5	4
GO:0006829	zinc ion transport	8	4
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0009987	cellular process	1	4
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	4
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0034220	monoatomic ion transmembrane transport	3	4
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055069	obsolete zinc ion homeostasis	8	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	4
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071577	zinc ion transmembrane transport	6	4
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098655	monoatomic cation transmembrane transport	4	4
GO:0098660	inorganic ion transmembrane transport	4	4
GO:0098662	inorganic cation transmembrane transport	5	4
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	34
GO:0008324	monoatomic cation transmembrane transporter activity	4	34
GO:0015075	monoatomic ion transmembrane transporter activity	3	34
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	34
GO:0022857	transmembrane transporter activity	2	34
GO:0022890	inorganic cation transmembrane transporter activity	4	34
GO:0046873	metal ion transmembrane transporter activity	5	34
GO:0005385	zinc ion transmembrane transporter activity	7	4
GO:0046915	transition metal ion transmembrane transporter activity	6	4
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0015093	ferrous iron transmembrane transporter activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.625
CLV_NRD_NRD_1	231	233	PF00675	0.371
CLV_PCSK_KEX2_1	125	127	PF00082	0.319
CLV_PCSK_KEX2_1	423	425	PF00082	0.248
CLV_PCSK_KEX2_1	428	430	PF00082	0.249
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.319
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.289
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.284
CLV_PCSK_PC7_1	424	430	PF00082	0.205
CLV_PCSK_SKI1_1	375	379	PF00082	0.580
DOC_MAPK_gen_1	125	132	PF00069	0.594
DOC_MAPK_MEF2A_6	125	132	PF00069	0.445
DOC_MAPK_MEF2A_6	318	326	PF00069	0.295
DOC_MAPK_MEF2A_6	345	354	PF00069	0.574
DOC_MAPK_NFAT4_5	345	353	PF00069	0.514
DOC_PP4_FxxP_1	358	361	PF00568	0.340
DOC_USP7_MATH_1	34	38	PF00917	0.399
DOC_USP7_MATH_1	340	344	PF00917	0.531
DOC_USP7_MATH_1	384	388	PF00917	0.300
DOC_USP7_MATH_2	28	34	PF00917	0.401
DOC_WW_Pin1_4	155	160	PF00397	0.195
LIG_14-3-3_CanoR_1	61	67	PF00244	0.642
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_BIR_III_1	1	5	PF00653	0.402
LIG_BIR_III_3	1	5	PF00653	0.402
LIG_Clathr_ClatBox_1	405	409	PF01394	0.463
LIG_CtBP_PxDLS_1	279	283	PF00389	0.553
LIG_deltaCOP1_diTrp_1	178	184	PF00928	0.242
LIG_eIF4E_1	400	406	PF01652	0.360
LIG_FHA_1	143	149	PF00498	0.402
LIG_FHA_1	3	9	PF00498	0.364
LIG_FHA_1	366	372	PF00498	0.293
LIG_FHA_1	37	43	PF00498	0.403
LIG_FHA_1	380	386	PF00498	0.280
LIG_FHA_2	236	242	PF00498	0.434
LIG_FXI_DFP_1	407	411	PF00024	0.199
LIG_LIR_Apic_2	357	361	PF02991	0.340
LIG_LIR_Gen_1	178	188	PF02991	0.238
LIG_LIR_Gen_1	381	390	PF02991	0.352
LIG_LIR_Gen_1	41	49	PF02991	0.473
LIG_LIR_Nem_3	178	183	PF02991	0.296
LIG_LIR_Nem_3	302	307	PF02991	0.391
LIG_LIR_Nem_3	381	386	PF02991	0.377
LIG_LIR_Nem_3	41	47	PF02991	0.469
LIG_PDZ_Wminus1_1	448	450	PF00595	0.382
LIG_Pex14_1	180	184	PF04695	0.490
LIG_Pex14_2	326	330	PF04695	0.418
LIG_Pex14_2	403	407	PF04695	0.406
LIG_SH2_CRK	383	387	PF00017	0.242
LIG_SH2_CRK	44	48	PF00017	0.377
LIG_SH2_NCK_1	383	387	PF00017	0.242
LIG_SH2_SRC	135	138	PF00017	0.548
LIG_SH2_SRC	66	69	PF00017	0.442
LIG_SH2_STAP1	66	70	PF00017	0.539
LIG_SH2_STAT5	135	138	PF00017	0.522
LIG_SH2_STAT5	400	403	PF00017	0.336
LIG_SH3_1	213	219	PF00018	0.438
LIG_SH3_3	213	219	PF00018	0.546
LIG_SH3_3	273	279	PF00018	0.580
LIG_SH3_3	405	411	PF00018	0.377
LIG_SUMO_SIM_anti_2	349	354	PF11976	0.475
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.363
LIG_SUMO_SIM_par_1	147	152	PF11976	0.340
LIG_SxIP_EBH_1	113	126	PF03271	0.376
LIG_TYR_ITIM	42	47	PF00017	0.369
LIG_TYR_ITSM	379	386	PF00017	0.242
LIG_UBA3_1	119	125	PF00899	0.272
LIG_WRC_WIRS_1	355	360	PF05994	0.312
MOD_CK1_1	142	148	PF00069	0.435
MOD_CK1_1	158	164	PF00069	0.247
MOD_CK1_1	312	318	PF00069	0.330
MOD_CK1_1	379	385	PF00069	0.341
MOD_CK1_1	51	57	PF00069	0.447
MOD_CK1_1	62	68	PF00069	0.556
MOD_CK1_1	76	82	PF00069	0.567
MOD_CK1_1	88	94	PF00069	0.569
MOD_CK2_1	165	171	PF00069	0.253
MOD_CK2_1	62	68	PF00069	0.636
MOD_Cter_Amidation	123	126	PF01082	0.372
MOD_GlcNHglycan	113	116	PF01048	0.214
MOD_GlcNHglycan	141	144	PF01048	0.465
MOD_GlcNHglycan	206	209	PF01048	0.275
MOD_GlcNHglycan	32	35	PF01048	0.726
MOD_GlcNHglycan	358	361	PF01048	0.399
MOD_GlcNHglycan	36	39	PF01048	0.712
MOD_GlcNHglycan	378	381	PF01048	0.384
MOD_GlcNHglycan	386	389	PF01048	0.351
MOD_GlcNHglycan	53	56	PF01048	0.741
MOD_GlcNHglycan	68	71	PF01048	0.817
MOD_GlcNHglycan	78	81	PF01048	0.785
MOD_GlcNHglycan	90	93	PF01048	0.681
MOD_GSK3_1	111	118	PF00069	0.336
MOD_GSK3_1	165	172	PF00069	0.201
MOD_GSK3_1	30	37	PF00069	0.435
MOD_GSK3_1	340	347	PF00069	0.529
MOD_GSK3_1	38	45	PF00069	0.482
MOD_GSK3_1	62	69	PF00069	0.624
MOD_N-GLC_1	312	317	PF02516	0.423
MOD_N-GLC_2	226	228	PF02516	0.238
MOD_NEK2_1	111	116	PF00069	0.352
MOD_NEK2_1	149	154	PF00069	0.329
MOD_NEK2_1	296	301	PF00069	0.378
MOD_NEK2_1	354	359	PF00069	0.366
MOD_NEK2_1	378	383	PF00069	0.321
MOD_NEK2_2	340	345	PF00069	0.476
MOD_PIKK_1	42	48	PF00454	0.559
MOD_PKA_2	204	210	PF00069	0.549
MOD_PKA_2	62	68	PF00069	0.635
MOD_Plk_1	340	346	PF00069	0.441
MOD_Plk_4	115	121	PF00069	0.359
MOD_Plk_4	149	155	PF00069	0.269
MOD_Plk_4	158	164	PF00069	0.259
MOD_Plk_4	299	305	PF00069	0.364
MOD_Plk_4	4	10	PF00069	0.351
MOD_ProDKin_1	155	161	PF00069	0.195
TRG_DiLeu_BaEn_2	177	183	PF01217	0.286
TRG_ENDOCYTIC_2	383	386	PF00928	0.342
TRG_ENDOCYTIC_2	400	403	PF00928	0.344
TRG_ENDOCYTIC_2	433	436	PF00928	0.408
TRG_ENDOCYTIC_2	44	47	PF00928	0.480
TRG_ER_diArg_1	61	64	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU5	Leptomonas seymouri	41%	100%
A0A1X0NR51	Trypanosomatidae	45%	100%
A0A1X0NSB9	Trypanosomatidae	38%	100%
A0A1X0NSI7	Trypanosomatidae	37%	100%
A0A3R7LZX6	Trypanosoma rangeli	39%	100%
A0A3S7X1N7	Leishmania donovani	83%	97%
A0A3S7X501	Leishmania donovani	41%	100%
A0A3S7X7B0	Leishmania donovani	36%	100%
A0A422MUI2	Trypanosoma rangeli	38%	100%
A4HGP7	Leishmania braziliensis	79%	100%
A4HJU9	Leishmania braziliensis	44%	100%
A4HJV0	Leishmania braziliensis	44%	100%
A4HJV1	Leishmania braziliensis	37%	100%
A4HM27	Leishmania braziliensis	33%	94%
A4I3R9	Leishmania infantum	84%	97%
A4I7B1	Leishmania infantum	41%	100%
A4I9G1	Leishmania infantum	35%	100%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A889	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B2A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B2A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B4F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
O04089	Arabidopsis thaliana	29%	100%
O23039	Arabidopsis thaliana	29%	100%
O81123	Arabidopsis thaliana	24%	100%
O81850	Arabidopsis thaliana	24%	100%
O82643	Arabidopsis thaliana	28%	100%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q0DHE3	Oryza sativa subsp. japonica	25%	100%
Q12436	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q38856	Arabidopsis thaliana	23%	100%
Q4Q3L6	Leishmania major	34%	94%
Q4Q5V0	Leishmania major	41%	100%
Q4Q5V1	Leishmania major	41%	100%
Q4Q873	Leishmania major	83%	99%
Q6L8F7	Oryza sativa subsp. japonica	28%	100%
Q6L8G0	Oryza sativa subsp. japonica	28%	100%
Q6L8G1	Oryza sativa subsp. japonica	30%	100%
Q75HB1	Oryza sativa subsp. japonica	29%	100%
Q7XLD4	Oryza sativa subsp. japonica	30%	100%
Q8S3W4	Arabidopsis thaliana	23%	100%
Q8W245	Arabidopsis thaliana	24%	100%
Q8W246	Arabidopsis thaliana	27%	100%
Q9FIS2	Arabidopsis thaliana	25%	100%
Q9SLG3	Arabidopsis thaliana	28%	100%
V5AWN3	Trypanosoma cruzi	37%	100%
V5BC34	Trypanosoma cruzi	37%	100%
V5DCU2	Trypanosoma cruzi	47%	100%