LeishMANIAdb
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Putative zinc transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative zinc transporter
Gene product:
Zinc transporter 3, putative
Species:
Leishmania mexicana
UniProt:
E9B012_LEIMU
TriTrypDb:
LmxM.28.1930 *
Length:
450

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 33
NetGPI no yes: 0, no: 33
Cellular components
Term Name Level Count
GO:0016020 membrane 2 34
GO:0110165 cellular anatomical entity 1 34
GO:0005737 cytoplasm 2 1
GO:0005886 plasma membrane 3 4

Expansion

Sequence features

E9B012
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B012

Function

Biological processes
Term Name Level Count
GO:0000041 transition metal ion transport 7 4
GO:0006810 transport 3 4
GO:0006811 monoatomic ion transport 4 4
GO:0006812 monoatomic cation transport 5 4
GO:0006829 zinc ion transport 8 4
GO:0006873 intracellular monoatomic ion homeostasis 4 1
GO:0006875 obsolete intracellular metal ion homeostasis 6 1
GO:0006882 intracellular zinc ion homeostasis 7 1
GO:0009987 cellular process 1 4
GO:0019725 cellular homeostasis 2 1
GO:0030001 metal ion transport 6 4
GO:0030003 intracellular monoatomic cation homeostasis 5 1
GO:0034220 monoatomic ion transmembrane transport 3 4
GO:0042592 homeostatic process 3 1
GO:0046916 obsolete intracellular transition metal ion homeostasis 7 1
GO:0048878 chemical homeostasis 4 1
GO:0050801 monoatomic ion homeostasis 5 1
GO:0051179 localization 1 4
GO:0051234 establishment of localization 2 4
GO:0055065 obsolete metal ion homeostasis 7 1
GO:0055069 obsolete zinc ion homeostasis 8 1
GO:0055076 obsolete transition metal ion homeostasis 8 1
GO:0055080 monoatomic cation homeostasis 6 1
GO:0055082 intracellular chemical homeostasis 3 1
GO:0055085 transmembrane transport 2 4
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071577 zinc ion transmembrane transport 6 4
GO:0072503 obsolete cellular divalent inorganic cation homeostasis 6 1
GO:0072507 obsolete divalent inorganic cation homeostasis 7 1
GO:0098655 monoatomic cation transmembrane transport 4 4
GO:0098660 inorganic ion transmembrane transport 4 4
GO:0098662 inorganic cation transmembrane transport 5 4
GO:0098771 inorganic ion homeostasis 6 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 34
GO:0008324 monoatomic cation transmembrane transporter activity 4 34
GO:0015075 monoatomic ion transmembrane transporter activity 3 34
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 34
GO:0022857 transmembrane transporter activity 2 34
GO:0022890 inorganic cation transmembrane transporter activity 4 34
GO:0046873 metal ion transmembrane transporter activity 5 34
GO:0005385 zinc ion transmembrane transporter activity 7 4
GO:0046915 transition metal ion transmembrane transporter activity 6 4
GO:0005381 iron ion transmembrane transporter activity 7 1
GO:0015093 ferrous iron transmembrane transporter activity 8 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 79 83 PF00656 0.625
CLV_NRD_NRD_1 231 233 PF00675 0.371
CLV_PCSK_KEX2_1 125 127 PF00082 0.319
CLV_PCSK_KEX2_1 423 425 PF00082 0.248
CLV_PCSK_KEX2_1 428 430 PF00082 0.249
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.319
CLV_PCSK_PC1ET2_1 423 425 PF00082 0.289
CLV_PCSK_PC1ET2_1 428 430 PF00082 0.284
CLV_PCSK_PC7_1 424 430 PF00082 0.205
CLV_PCSK_SKI1_1 375 379 PF00082 0.580
DOC_MAPK_gen_1 125 132 PF00069 0.594
DOC_MAPK_MEF2A_6 125 132 PF00069 0.445
DOC_MAPK_MEF2A_6 318 326 PF00069 0.295
DOC_MAPK_MEF2A_6 345 354 PF00069 0.574
DOC_MAPK_NFAT4_5 345 353 PF00069 0.514
DOC_PP4_FxxP_1 358 361 PF00568 0.340
DOC_USP7_MATH_1 34 38 PF00917 0.399
DOC_USP7_MATH_1 340 344 PF00917 0.531
DOC_USP7_MATH_1 384 388 PF00917 0.300
DOC_USP7_MATH_2 28 34 PF00917 0.401
DOC_WW_Pin1_4 155 160 PF00397 0.195
LIG_14-3-3_CanoR_1 61 67 PF00244 0.642
LIG_BIR_II_1 1 5 PF00653 0.559
LIG_BIR_III_1 1 5 PF00653 0.402
LIG_BIR_III_3 1 5 PF00653 0.402
LIG_Clathr_ClatBox_1 405 409 PF01394 0.463
LIG_CtBP_PxDLS_1 279 283 PF00389 0.553
LIG_deltaCOP1_diTrp_1 178 184 PF00928 0.242
LIG_eIF4E_1 400 406 PF01652 0.360
LIG_FHA_1 143 149 PF00498 0.402
LIG_FHA_1 3 9 PF00498 0.364
LIG_FHA_1 366 372 PF00498 0.293
LIG_FHA_1 37 43 PF00498 0.403
LIG_FHA_1 380 386 PF00498 0.280
LIG_FHA_2 236 242 PF00498 0.434
LIG_FXI_DFP_1 407 411 PF00024 0.199
LIG_LIR_Apic_2 357 361 PF02991 0.340
LIG_LIR_Gen_1 178 188 PF02991 0.238
LIG_LIR_Gen_1 381 390 PF02991 0.352
LIG_LIR_Gen_1 41 49 PF02991 0.473
LIG_LIR_Nem_3 178 183 PF02991 0.296
LIG_LIR_Nem_3 302 307 PF02991 0.391
LIG_LIR_Nem_3 381 386 PF02991 0.377
LIG_LIR_Nem_3 41 47 PF02991 0.469
LIG_PDZ_Wminus1_1 448 450 PF00595 0.382
LIG_Pex14_1 180 184 PF04695 0.490
LIG_Pex14_2 326 330 PF04695 0.418
LIG_Pex14_2 403 407 PF04695 0.406
LIG_SH2_CRK 383 387 PF00017 0.242
LIG_SH2_CRK 44 48 PF00017 0.377
LIG_SH2_NCK_1 383 387 PF00017 0.242
LIG_SH2_SRC 135 138 PF00017 0.548
LIG_SH2_SRC 66 69 PF00017 0.442
LIG_SH2_STAP1 66 70 PF00017 0.539
LIG_SH2_STAT5 135 138 PF00017 0.522
LIG_SH2_STAT5 400 403 PF00017 0.336
LIG_SH3_1 213 219 PF00018 0.438
LIG_SH3_3 213 219 PF00018 0.546
LIG_SH3_3 273 279 PF00018 0.580
LIG_SH3_3 405 411 PF00018 0.377
LIG_SUMO_SIM_anti_2 349 354 PF11976 0.475
LIG_SUMO_SIM_anti_2 5 10 PF11976 0.363
LIG_SUMO_SIM_par_1 147 152 PF11976 0.340
LIG_SxIP_EBH_1 113 126 PF03271 0.376
LIG_TYR_ITIM 42 47 PF00017 0.369
LIG_TYR_ITSM 379 386 PF00017 0.242
LIG_UBA3_1 119 125 PF00899 0.272
LIG_WRC_WIRS_1 355 360 PF05994 0.312
MOD_CK1_1 142 148 PF00069 0.435
MOD_CK1_1 158 164 PF00069 0.247
MOD_CK1_1 312 318 PF00069 0.330
MOD_CK1_1 379 385 PF00069 0.341
MOD_CK1_1 51 57 PF00069 0.447
MOD_CK1_1 62 68 PF00069 0.556
MOD_CK1_1 76 82 PF00069 0.567
MOD_CK1_1 88 94 PF00069 0.569
MOD_CK2_1 165 171 PF00069 0.253
MOD_CK2_1 62 68 PF00069 0.636
MOD_Cter_Amidation 123 126 PF01082 0.372
MOD_GlcNHglycan 113 116 PF01048 0.214
MOD_GlcNHglycan 141 144 PF01048 0.465
MOD_GlcNHglycan 206 209 PF01048 0.275
MOD_GlcNHglycan 32 35 PF01048 0.726
MOD_GlcNHglycan 358 361 PF01048 0.399
MOD_GlcNHglycan 36 39 PF01048 0.712
MOD_GlcNHglycan 378 381 PF01048 0.384
MOD_GlcNHglycan 386 389 PF01048 0.351
MOD_GlcNHglycan 53 56 PF01048 0.741
MOD_GlcNHglycan 68 71 PF01048 0.817
MOD_GlcNHglycan 78 81 PF01048 0.785
MOD_GlcNHglycan 90 93 PF01048 0.681
MOD_GSK3_1 111 118 PF00069 0.336
MOD_GSK3_1 165 172 PF00069 0.201
MOD_GSK3_1 30 37 PF00069 0.435
MOD_GSK3_1 340 347 PF00069 0.529
MOD_GSK3_1 38 45 PF00069 0.482
MOD_GSK3_1 62 69 PF00069 0.624
MOD_N-GLC_1 312 317 PF02516 0.423
MOD_N-GLC_2 226 228 PF02516 0.238
MOD_NEK2_1 111 116 PF00069 0.352
MOD_NEK2_1 149 154 PF00069 0.329
MOD_NEK2_1 296 301 PF00069 0.378
MOD_NEK2_1 354 359 PF00069 0.366
MOD_NEK2_1 378 383 PF00069 0.321
MOD_NEK2_2 340 345 PF00069 0.476
MOD_PIKK_1 42 48 PF00454 0.559
MOD_PKA_2 204 210 PF00069 0.549
MOD_PKA_2 62 68 PF00069 0.635
MOD_Plk_1 340 346 PF00069 0.441
MOD_Plk_4 115 121 PF00069 0.359
MOD_Plk_4 149 155 PF00069 0.269
MOD_Plk_4 158 164 PF00069 0.259
MOD_Plk_4 299 305 PF00069 0.364
MOD_Plk_4 4 10 PF00069 0.351
MOD_ProDKin_1 155 161 PF00069 0.195
TRG_DiLeu_BaEn_2 177 183 PF01217 0.286
TRG_ENDOCYTIC_2 383 386 PF00928 0.342
TRG_ENDOCYTIC_2 400 403 PF00928 0.344
TRG_ENDOCYTIC_2 433 436 PF00928 0.408
TRG_ENDOCYTIC_2 44 47 PF00928 0.480
TRG_ER_diArg_1 61 64 PF00400 0.461
TRG_Pf-PMV_PEXEL_1 10 15 PF00026 0.576

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCU5 Leptomonas seymouri 41% 100%
A0A1X0NR51 Trypanosomatidae 45% 100%
A0A1X0NSB9 Trypanosomatidae 38% 100%
A0A1X0NSI7 Trypanosomatidae 37% 100%
A0A3R7LZX6 Trypanosoma rangeli 39% 100%
A0A3S7X1N7 Leishmania donovani 83% 97%
A0A3S7X501 Leishmania donovani 41% 100%
A0A3S7X7B0 Leishmania donovani 36% 100%
A0A422MUI2 Trypanosoma rangeli 38% 100%
A4HGP7 Leishmania braziliensis 79% 100%
A4HJU9 Leishmania braziliensis 44% 100%
A4HJV0 Leishmania braziliensis 44% 100%
A4HJV1 Leishmania braziliensis 37% 100%
A4HM27 Leishmania braziliensis 33% 94%
A4I3R9 Leishmania infantum 84% 97%
A4I7B1 Leishmania infantum 41% 100%
A4I9G1 Leishmania infantum 35% 100%
D0A885 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
D0A886 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
D0A887 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
D0A888 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
D0A889 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9B2A5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B2A6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9B4F9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
O04089 Arabidopsis thaliana 29% 100%
O23039 Arabidopsis thaliana 29% 100%
O81123 Arabidopsis thaliana 24% 100%
O81850 Arabidopsis thaliana 24% 100%
O82643 Arabidopsis thaliana 28% 100%
O94639 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 100%
P32804 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
Q0DHE3 Oryza sativa subsp. japonica 25% 100%
Q12436 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 27% 100%
Q38856 Arabidopsis thaliana 23% 100%
Q4Q3L6 Leishmania major 34% 94%
Q4Q5V0 Leishmania major 41% 100%
Q4Q5V1 Leishmania major 41% 100%
Q4Q873 Leishmania major 83% 99%
Q6L8F7 Oryza sativa subsp. japonica 28% 100%
Q6L8G0 Oryza sativa subsp. japonica 28% 100%
Q6L8G1 Oryza sativa subsp. japonica 30% 100%
Q75HB1 Oryza sativa subsp. japonica 29% 100%
Q7XLD4 Oryza sativa subsp. japonica 30% 100%
Q8S3W4 Arabidopsis thaliana 23% 100%
Q8W245 Arabidopsis thaliana 24% 100%
Q8W246 Arabidopsis thaliana 27% 100%
Q9FIS2 Arabidopsis thaliana 25% 100%
Q9SLG3 Arabidopsis thaliana 28% 100%
V5AWN3 Trypanosoma cruzi 37% 100%
V5BC34 Trypanosoma cruzi 37% 100%
V5DCU2 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS