LeishMANIAdb
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Double-stranded DNA-binding family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Double-stranded DNA-binding family protein
Gene product:
Double-stranded DNA-binding domain containing protein, putative
Species:
Leishmania mexicana
UniProt:
E9B011_LEIMU
TriTrypDb:
LmxM.28.1920
Length:
113

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B011
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B011

PDB structure(s): 6vmt_A

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003677 DNA binding 4 11
GO:0005488 binding 1 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 105 107 PF00675 0.250
CLV_PCSK_FUR_1 47 51 PF00082 0.349
CLV_PCSK_KEX2_1 107 109 PF00082 0.493
CLV_PCSK_KEX2_1 49 51 PF00082 0.349
CLV_PCSK_PC1ET2_1 107 109 PF00082 0.493
CLV_PCSK_PC1ET2_1 49 51 PF00082 0.362
CLV_PCSK_PC7_1 45 51 PF00082 0.328
CLV_PCSK_SKI1_1 85 89 PF00082 0.268
DEG_APCC_DBOX_1 44 52 PF00400 0.250
DEG_APCC_DBOX_1 84 92 PF00400 0.258
DEG_APCC_KENBOX_2 31 35 PF00400 0.381
DOC_MAPK_gen_1 55 64 PF00069 0.337
DOC_MAPK_MEF2A_6 58 66 PF00069 0.144
DOC_PP4_MxPP_1 75 78 PF00568 0.381
DOC_USP7_MATH_1 38 42 PF00917 0.268
LIG_Actin_WH2_2 33 51 PF00022 0.328
LIG_BIR_II_1 1 5 PF00653 0.502
LIG_FHA_2 81 87 PF00498 0.293
LIG_TRAF2_1 20 23 PF00917 0.246
LIG_TRAF2_1 27 30 PF00917 0.326
LIG_TRAF2_1 92 95 PF00917 0.381
MOD_CK1_1 100 106 PF00069 0.329
MOD_CK1_1 80 86 PF00069 0.270
MOD_CK2_1 80 86 PF00069 0.328
MOD_GlcNHglycan 40 43 PF01048 0.293
MOD_Plk_1 80 86 PF00069 0.293
TRG_ER_diArg_1 106 109 PF00400 0.420
TRG_Pf-PMV_PEXEL_1 85 90 PF00026 0.268

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P828 Leptomonas seymouri 88% 100%
A0A0S4JF96 Bodo saltans 70% 99%
A0A1X0NQU5 Trypanosomatidae 62% 99%
A0A3S5ISD1 Trypanosoma rangeli 74% 100%
A0A3S7X1M4 Leishmania donovani 96% 100%
A4G031 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 36% 96%
A4HGP5 Leishmania braziliensis 94% 100%
A4I3R8 Leishmania infantum 96% 100%
A5UL35 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 33% 96%
A6URD8 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 33% 100%
A6UVQ4 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) 37% 95%
A6VIE7 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 34% 95%
A9A8D7 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 36% 96%
B6YWX7 Thermococcus onnurineus (strain NA1) 33% 100%
C3MR75 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 31% 96%
C3MXG4 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 31% 96%
C3MZB0 Sulfolobus islandicus (strain M.16.27) 31% 96%
C3N7D0 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 31% 96%
C3NGA4 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 30% 96%
C4KII8 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 31% 96%
D0A890 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 73% 100%
O13929 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 86%
O27652 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 29% 100%
Q2NGR0 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 36% 96%
Q4J8U0 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 31% 100%
Q4Q874 Leishmania major 96% 100%
Q58103 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 38% 100%
Q6M0W1 Methanococcus maripaludis (strain S2 / LL) 37% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS