P21-C-terminal-binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p21-C-terminal region-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9B010_LEIMU

TriTrypDb:

LmxM.28.1910

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B010

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B010

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.647
CLV_C14_Caspase3-7	231	235	PF00656	0.654
CLV_C14_Caspase3-7	318	322	PF00656	0.711
CLV_C14_Caspase3-7	336	340	PF00656	0.448
CLV_C14_Caspase3-7	438	442	PF00656	0.540
CLV_C14_Caspase3-7	477	481	PF00656	0.535
CLV_C14_Caspase3-7	548	552	PF00656	0.499
CLV_NRD_NRD_1	207	209	PF00675	0.531
CLV_NRD_NRD_1	221	223	PF00675	0.655
CLV_NRD_NRD_1	300	302	PF00675	0.814
CLV_NRD_NRD_1	486	488	PF00675	0.201
CLV_NRD_NRD_1	557	559	PF00675	0.303
CLV_NRD_NRD_1	655	657	PF00675	0.444
CLV_NRD_NRD_1	70	72	PF00675	0.570
CLV_NRD_NRD_1	88	90	PF00675	0.655
CLV_NRD_NRD_1	98	100	PF00675	0.597
CLV_PCSK_FUR_1	610	614	PF00082	0.395
CLV_PCSK_FUR_1	86	90	PF00082	0.528
CLV_PCSK_KEX2_1	221	223	PF00082	0.740
CLV_PCSK_KEX2_1	299	301	PF00082	0.815
CLV_PCSK_KEX2_1	3	5	PF00082	0.643
CLV_PCSK_KEX2_1	612	614	PF00082	0.411
CLV_PCSK_KEX2_1	654	656	PF00082	0.448
CLV_PCSK_KEX2_1	72	74	PF00082	0.587
CLV_PCSK_KEX2_1	88	90	PF00082	0.673
CLV_PCSK_KEX2_1	96	98	PF00082	0.581
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.643
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.411
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.604
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.542
CLV_PCSK_SKI1_1	451	455	PF00082	0.277
CLV_PCSK_SKI1_1	613	617	PF00082	0.424
CLV_PCSK_SKI1_1	72	76	PF00082	0.674
DEG_Kelch_Keap1_1	232	237	PF01344	0.549
DOC_CKS1_1	78	83	PF01111	0.546
DOC_CYCLIN_RxL_1	146	157	PF00134	0.591
DOC_CYCLIN_RxL_1	448	458	PF00134	0.477
DOC_MAPK_DCC_7	3	13	PF00069	0.641
DOC_MAPK_gen_1	3	13	PF00069	0.641
DOC_MAPK_gen_1	449	456	PF00069	0.477
DOC_MAPK_gen_1	96	102	PF00069	0.624
DOC_MAPK_MEF2A_6	358	365	PF00069	0.477
DOC_MAPK_MEF2A_6	461	469	PF00069	0.481
DOC_MAPK_NFAT4_5	358	366	PF00069	0.477
DOC_PP1_RVXF_1	131	137	PF00149	0.654
DOC_PP1_RVXF_1	96	103	PF00149	0.592
DOC_USP7_MATH_1	242	246	PF00917	0.710
DOC_USP7_MATH_1	247	251	PF00917	0.672
DOC_USP7_MATH_1	369	373	PF00917	0.477
DOC_USP7_MATH_1	444	448	PF00917	0.520
DOC_USP7_MATH_1	534	538	PF00917	0.562
DOC_USP7_MATH_1	575	579	PF00917	0.499
DOC_WW_Pin1_4	243	248	PF00397	0.717
DOC_WW_Pin1_4	365	370	PF00397	0.477
DOC_WW_Pin1_4	57	62	PF00397	0.583
DOC_WW_Pin1_4	586	591	PF00397	0.535
DOC_WW_Pin1_4	77	82	PF00397	0.450
LIG_14-3-3_CanoR_1	142	151	PF00244	0.664
LIG_14-3-3_CanoR_1	208	212	PF00244	0.619
LIG_14-3-3_CanoR_1	31	37	PF00244	0.681
LIG_14-3-3_CanoR_1	522	530	PF00244	0.477
LIG_14-3-3_CanoR_1	613	618	PF00244	0.439
LIG_14-3-3_CanoR_1	654	660	PF00244	0.445
LIG_14-3-3_CanoR_1	97	103	PF00244	0.563
LIG_Actin_RPEL_3	417	436	PF02755	0.477
LIG_BIR_III_4	382	386	PF00653	0.481
LIG_BIR_III_4	480	484	PF00653	0.477
LIG_BRCT_BRCA1_1	635	639	PF00533	0.369
LIG_CaM_IQ_9	216	232	PF13499	0.491
LIG_Clathr_ClatBox_1	323	327	PF01394	0.315
LIG_CtBP_PxDLS_1	464	468	PF00389	0.477
LIG_CtBP_PxDLS_1	590	594	PF00389	0.535
LIG_CtBP_PxDLS_1	81	85	PF00389	0.587
LIG_EVH1_1	136	140	PF00568	0.500
LIG_FHA_1	129	135	PF00498	0.521
LIG_FHA_1	369	375	PF00498	0.477
LIG_FHA_1	431	437	PF00498	0.477
LIG_FHA_1	466	472	PF00498	0.488
LIG_FHA_1	592	598	PF00498	0.462
LIG_FHA_2	382	388	PF00498	0.479
LIG_FHA_2	492	498	PF00498	0.535
LIG_LIR_Gen_1	367	376	PF02991	0.477
LIG_LIR_Gen_1	512	520	PF02991	0.453
LIG_LIR_Nem_3	325	331	PF02991	0.477
LIG_LIR_Nem_3	367	373	PF02991	0.477
LIG_LIR_Nem_3	388	394	PF02991	0.487
LIG_LIR_Nem_3	512	517	PF02991	0.453
LIG_SH2_NCK_1	366	370	PF00017	0.462
LIG_SH2_STAT3	625	628	PF00017	0.462
LIG_SH2_STAT5	172	175	PF00017	0.645
LIG_SH2_STAT5	459	462	PF00017	0.477
LIG_SH2_STAT5	596	599	PF00017	0.477
LIG_SH3_1	75	81	PF00018	0.622
LIG_SH3_2	137	142	PF14604	0.691
LIG_SH3_3	131	137	PF00018	0.618
LIG_SH3_3	525	531	PF00018	0.477
LIG_SH3_3	55	61	PF00018	0.741
LIG_SH3_3	584	590	PF00018	0.535
LIG_SH3_3	75	81	PF00018	0.460
LIG_SUMO_SIM_par_1	321	327	PF11976	0.315
LIG_SUMO_SIM_par_1	452	458	PF11976	0.477
LIG_SUMO_SIM_par_1	463	468	PF11976	0.477
LIG_SUMO_SIM_par_1	588	594	PF11976	0.497
LIG_SUMO_SIM_par_1	9	16	PF11976	0.642
LIG_TRAF2_1	197	200	PF00917	0.566
LIG_TRAF2_1	235	238	PF00917	0.585
LIG_TRAF2_1	280	283	PF00917	0.697
LIG_TRAF2_1	284	287	PF00917	0.712
LIG_TRAF2_1	384	387	PF00917	0.477
LIG_UBA3_1	513	519	PF00899	0.477
LIG_WW_2	137	140	PF00397	0.493
MOD_CK1_1	145	151	PF00069	0.603
MOD_CK1_1	182	188	PF00069	0.821
MOD_CK1_1	232	238	PF00069	0.634
MOD_CK1_1	255	261	PF00069	0.783
MOD_CK1_1	29	35	PF00069	0.640
MOD_CK1_1	311	317	PF00069	0.533
MOD_CK1_1	368	374	PF00069	0.478
MOD_CK2_1	152	158	PF00069	0.696
MOD_CK2_1	18	24	PF00069	0.702
MOD_CK2_1	232	238	PF00069	0.655
MOD_CK2_1	277	283	PF00069	0.695
MOD_CK2_1	381	387	PF00069	0.479
MOD_CK2_1	491	497	PF00069	0.535
MOD_CK2_1	57	63	PF00069	0.556
MOD_GlcNHglycan	114	117	PF01048	0.648
MOD_GlcNHglycan	120	123	PF01048	0.639
MOD_GlcNHglycan	144	147	PF01048	0.666
MOD_GlcNHglycan	183	187	PF01048	0.730
MOD_GlcNHglycan	194	197	PF01048	0.555
MOD_GlcNHglycan	234	237	PF01048	0.604
MOD_GlcNHglycan	287	293	PF01048	0.711
MOD_GlcNHglycan	310	313	PF01048	0.528
MOD_GlcNHglycan	46	49	PF01048	0.676
MOD_GlcNHglycan	538	541	PF01048	0.293
MOD_GlcNHglycan	547	550	PF01048	0.304
MOD_GlcNHglycan	577	580	PF01048	0.294
MOD_GSK3_1	141	148	PF00069	0.636
MOD_GSK3_1	178	185	PF00069	0.799
MOD_GSK3_1	188	195	PF00069	0.634
MOD_GSK3_1	243	250	PF00069	0.790
MOD_GSK3_1	252	259	PF00069	0.789
MOD_GSK3_1	26	33	PF00069	0.581
MOD_GSK3_1	277	284	PF00069	0.621
MOD_GSK3_1	365	372	PF00069	0.477
MOD_GSK3_1	39	46	PF00069	0.683
MOD_GSK3_1	430	437	PF00069	0.500
MOD_GSK3_1	536	543	PF00069	0.495
MOD_GSK3_1	565	572	PF00069	0.585
MOD_GSK3_1	573	580	PF00069	0.495
MOD_N-GLC_1	112	117	PF02516	0.725
MOD_N-GLC_1	38	43	PF02516	0.552
MOD_NEK2_1	207	212	PF00069	0.609
MOD_NEK2_1	333	338	PF00069	0.462
MOD_NEK2_1	37	42	PF00069	0.658
MOD_NEK2_1	43	48	PF00069	0.703
MOD_NEK2_1	465	470	PF00069	0.480
MOD_NEK2_1	591	596	PF00069	0.462
MOD_NEK2_2	26	31	PF00069	0.510
MOD_PIKK_1	216	222	PF00454	0.487
MOD_PIKK_1	489	495	PF00454	0.403
MOD_PKA_1	569	575	PF00069	0.535
MOD_PKA_1	655	661	PF00069	0.447
MOD_PKA_1	98	104	PF00069	0.549
MOD_PKA_2	141	147	PF00069	0.710
MOD_PKA_2	207	213	PF00069	0.606
MOD_PKA_2	255	261	PF00069	0.515
MOD_PKA_2	30	36	PF00069	0.643
MOD_PKA_2	43	49	PF00069	0.623
MOD_PKA_2	521	527	PF00069	0.477
MOD_PKA_2	655	661	PF00069	0.447
MOD_PKA_2	98	104	PF00069	0.554
MOD_Plk_1	182	188	PF00069	0.606
MOD_Plk_1	33	39	PF00069	0.515
MOD_Plk_1	465	471	PF00069	0.477
MOD_Plk_1	591	597	PF00069	0.470
MOD_Plk_1	601	607	PF00069	0.490
MOD_Plk_2-3	277	283	PF00069	0.743
MOD_Plk_4	369	375	PF00069	0.477
MOD_Plk_4	393	399	PF00069	0.477
MOD_Plk_4	402	408	PF00069	0.477
MOD_Plk_4	435	441	PF00069	0.477
MOD_Plk_4	509	515	PF00069	0.477
MOD_Plk_4	54	60	PF00069	0.622
MOD_Plk_4	601	607	PF00069	0.450
MOD_Plk_4	613	619	PF00069	0.438
MOD_Plk_4	633	639	PF00069	0.285
MOD_Plk_4	80	86	PF00069	0.586
MOD_ProDKin_1	243	249	PF00069	0.719
MOD_ProDKin_1	365	371	PF00069	0.477
MOD_ProDKin_1	57	63	PF00069	0.580
MOD_ProDKin_1	586	592	PF00069	0.535
MOD_ProDKin_1	77	83	PF00069	0.444
MOD_SUMO_rev_2	480	490	PF00179	0.560
TRG_DiLeu_BaEn_4	199	205	PF01217	0.580
TRG_DiLeu_BaEn_4	601	607	PF01217	0.477
TRG_ER_diArg_1	299	301	PF00400	0.762
TRG_ER_diArg_1	619	622	PF00400	0.433
TRG_ER_diArg_1	653	656	PF00400	0.514
TRG_ER_diArg_1	85	88	PF00400	0.572
TRG_ER_diArg_1	97	99	PF00400	0.595
TRG_NLS_MonoCore_2	95	100	PF00514	0.593
TRG_NLS_MonoExtC_3	70	75	PF00514	0.623
TRG_NLS_MonoExtN_4	2	7	PF00514	0.640
TRG_NLS_MonoExtN_4	69	75	PF00514	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7I5	Leptomonas seymouri	56%	100%
A0A3Q8IEX8	Leishmania donovani	87%	98%
A4HGP4	Leishmania braziliensis	73%	99%
A4I3R7	Leishmania infantum	86%	98%
Q4Q875	Leishmania major	87%	100%