J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B009_LEIMU

TriTrypDb:

LmxM.28.1900

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B009

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B009

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.742
CLV_C14_Caspase3-7	404	408	PF00656	0.733
CLV_NRD_NRD_1	152	154	PF00675	0.745
CLV_NRD_NRD_1	229	231	PF00675	0.765
CLV_NRD_NRD_1	308	310	PF00675	0.836
CLV_NRD_NRD_1	351	353	PF00675	0.733
CLV_NRD_NRD_1	535	537	PF00675	0.813
CLV_NRD_NRD_1	83	85	PF00675	0.426
CLV_PCSK_FUR_1	305	309	PF00082	0.842
CLV_PCSK_FUR_1	533	537	PF00082	0.729
CLV_PCSK_KEX2_1	147	149	PF00082	0.741
CLV_PCSK_KEX2_1	152	154	PF00082	0.735
CLV_PCSK_KEX2_1	229	231	PF00082	0.765
CLV_PCSK_KEX2_1	307	309	PF00082	0.843
CLV_PCSK_KEX2_1	351	353	PF00082	0.654
CLV_PCSK_KEX2_1	535	537	PF00082	0.813
CLV_PCSK_KEX2_1	82	84	PF00082	0.406
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.541
CLV_PCSK_PC7_1	148	154	PF00082	0.539
CLV_PCSK_SKI1_1	148	152	PF00082	0.643
CLV_PCSK_SKI1_1	240	244	PF00082	0.654
CLV_PCSK_SKI1_1	572	576	PF00082	0.665
DEG_Nend_UBRbox_3	1	3	PF02207	0.704
DEG_SIAH_1	261	269	PF03145	0.520
DEG_SPOP_SBC_1	142	146	PF00917	0.528
DEG_SPOP_SBC_1	166	170	PF00917	0.637
DEG_SPOP_SBC_1	235	239	PF00917	0.638
DEG_SPOP_SBC_1	487	491	PF00917	0.785
DOC_CDC14_PxL_1	325	333	PF14671	0.812
DOC_CYCLIN_yClb3_PxF_3	185	191	PF00134	0.811
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.729
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.436
DOC_MAPK_gen_1	82	92	PF00069	0.426
DOC_MAPK_MEF2A_6	470	478	PF00069	0.606
DOC_MAPK_MEF2A_6	83	92	PF00069	0.426
DOC_PP2B_LxvP_1	183	186	PF13499	0.723
DOC_PP4_FxxP_1	427	430	PF00568	0.729
DOC_USP7_MATH_1	122	126	PF00917	0.511
DOC_USP7_MATH_1	135	139	PF00917	0.653
DOC_USP7_MATH_1	140	144	PF00917	0.706
DOC_USP7_MATH_1	211	215	PF00917	0.595
DOC_USP7_MATH_1	234	238	PF00917	0.675
DOC_USP7_MATH_1	443	447	PF00917	0.669
DOC_USP7_MATH_1	483	487	PF00917	0.607
DOC_USP7_MATH_1	515	519	PF00917	0.523
DOC_USP7_MATH_1	528	532	PF00917	0.774
DOC_WW_Pin1_4	178	183	PF00397	0.793
DOC_WW_Pin1_4	185	190	PF00397	0.644
DOC_WW_Pin1_4	216	221	PF00397	0.768
DOC_WW_Pin1_4	479	484	PF00397	0.658
DOC_WW_Pin1_4	488	493	PF00397	0.762
DOC_WW_Pin1_4	511	516	PF00397	0.521
LIG_14-3-3_CanoR_1	196	200	PF00244	0.568
LIG_14-3-3_CanoR_1	201	207	PF00244	0.568
LIG_14-3-3_CanoR_1	447	456	PF00244	0.605
LIG_APCC_ABBA_1	90	95	PF00400	0.529
LIG_BIR_III_2	289	293	PF00653	0.741
LIG_BRCT_BRCA1_1	102	106	PF00533	0.529
LIG_BRCT_BRCA1_1	168	172	PF00533	0.534
LIG_BRCT_BRCA1_1	187	191	PF00533	0.778
LIG_EVH1_2	251	255	PF00568	0.812
LIG_EVH1_2	284	288	PF00568	0.802
LIG_EVH1_2	329	333	PF00568	0.820
LIG_FHA_1	398	404	PF00498	0.649
LIG_FHA_1	469	475	PF00498	0.626
LIG_FHA_2	144	150	PF00498	0.536
LIG_FHA_2	29	35	PF00498	0.616
LIG_FHA_2	372	378	PF00498	0.678
LIG_LIR_Apic_2	520	526	PF02991	0.505
LIG_LIR_Gen_1	103	113	PF02991	0.529
LIG_LIR_Gen_1	19	28	PF02991	0.367
LIG_LIR_Nem_3	103	109	PF02991	0.529
LIG_LIR_Nem_3	111	116	PF02991	0.397
LIG_LIR_Nem_3	19	24	PF02991	0.363
LIG_MYND_1	185	189	PF01753	0.807
LIG_NRBOX	374	380	PF00104	0.679
LIG_PTAP_UEV_1	243	248	PF05743	0.527
LIG_SH2_CRK	523	527	PF00017	0.513
LIG_SH2_CRK	85	89	PF00017	0.529
LIG_SH2_STAT5	115	118	PF00017	0.480
LIG_SH2_STAT5	165	168	PF00017	0.734
LIG_SH2_STAT5	511	514	PF00017	0.527
LIG_SH3_1	217	223	PF00018	0.635
LIG_SH3_1	53	59	PF00018	0.616
LIG_SH3_2	224	229	PF14604	0.730
LIG_SH3_3	179	185	PF00018	0.815
LIG_SH3_3	217	223	PF00018	0.635
LIG_SH3_3	241	247	PF00018	0.754
LIG_SH3_3	264	270	PF00018	0.528
LIG_SH3_3	277	283	PF00018	0.659
LIG_SH3_3	324	330	PF00018	0.718
LIG_SH3_3	367	373	PF00018	0.765
LIG_SH3_3	503	509	PF00018	0.695
LIG_SH3_3	53	59	PF00018	0.551
LIG_TRAF2_1	31	34	PF00917	0.539
LIG_TRAF2_1	501	504	PF00917	0.679
LIG_WW_3	219	223	PF00397	0.815
LIG_WW_3	302	306	PF00397	0.534
MOD_CDC14_SPxK_1	219	222	PF00782	0.750
MOD_CDK_SPxK_1	216	222	PF00069	0.766
MOD_CK1_1	100	106	PF00069	0.529
MOD_CK1_1	143	149	PF00069	0.630
MOD_CK1_1	164	170	PF00069	0.739
MOD_CK1_1	171	177	PF00069	0.694
MOD_CK1_1	181	187	PF00069	0.622
MOD_CK1_1	192	198	PF00069	0.584
MOD_CK1_1	202	208	PF00069	0.648
MOD_CK1_1	409	415	PF00069	0.574
MOD_CK1_1	441	447	PF00069	0.716
MOD_CK1_1	448	454	PF00069	0.632
MOD_CK1_1	479	485	PF00069	0.787
MOD_CK1_1	486	492	PF00069	0.719
MOD_CK1_1	531	537	PF00069	0.810
MOD_CK1_1	545	551	PF00069	0.593
MOD_CK1_1	74	80	PF00069	0.529
MOD_CK2_1	108	114	PF00069	0.465
MOD_CK2_1	115	121	PF00069	0.369
MOD_CK2_1	28	34	PF00069	0.633
MOD_CK2_1	371	377	PF00069	0.691
MOD_CK2_1	490	496	PF00069	0.695
MOD_GlcNHglycan	123	127	PF01048	0.571
MOD_GlcNHglycan	14	17	PF01048	0.755
MOD_GlcNHglycan	176	179	PF01048	0.654
MOD_GlcNHglycan	213	216	PF01048	0.608
MOD_GlcNHglycan	232	235	PF01048	0.674
MOD_GlcNHglycan	244	247	PF01048	0.744
MOD_GlcNHglycan	257	260	PF01048	0.597
MOD_GlcNHglycan	337	340	PF01048	0.641
MOD_GlcNHglycan	342	346	PF01048	0.763
MOD_GlcNHglycan	411	414	PF01048	0.839
MOD_GlcNHglycan	427	430	PF01048	0.672
MOD_GlcNHglycan	440	443	PF01048	0.629
MOD_GlcNHglycan	45	49	PF01048	0.618
MOD_GlcNHglycan	457	461	PF01048	0.638
MOD_GlcNHglycan	485	488	PF01048	0.737
MOD_GlcNHglycan	515	518	PF01048	0.709
MOD_GlcNHglycan	545	548	PF01048	0.813
MOD_GlcNHglycan	554	557	PF01048	0.636
MOD_GlcNHglycan	77	80	PF01048	0.500
MOD_GSK3_1	1	8	PF00069	0.799
MOD_GSK3_1	12	19	PF00069	0.652
MOD_GSK3_1	136	143	PF00069	0.711
MOD_GSK3_1	161	168	PF00069	0.660
MOD_GSK3_1	170	177	PF00069	0.659
MOD_GSK3_1	181	188	PF00069	0.762
MOD_GSK3_1	190	197	PF00069	0.615
MOD_GSK3_1	202	209	PF00069	0.598
MOD_GSK3_1	230	237	PF00069	0.613
MOD_GSK3_1	309	316	PF00069	0.828
MOD_GSK3_1	350	357	PF00069	0.554
MOD_GSK3_1	397	404	PF00069	0.684
MOD_GSK3_1	425	432	PF00069	0.566
MOD_GSK3_1	434	441	PF00069	0.725
MOD_GSK3_1	479	486	PF00069	0.790
MOD_GSK3_1	487	494	PF00069	0.658
MOD_GSK3_1	511	518	PF00069	0.715
MOD_GSK3_1	527	534	PF00069	0.808
MOD_GSK3_1	543	550	PF00069	0.559
MOD_GSK3_1	71	78	PF00069	0.342
MOD_GSK3_1	96	103	PF00069	0.373
MOD_N-GLC_1	340	345	PF02516	0.539
MOD_N-GLC_1	409	414	PF02516	0.755
MOD_N-GLC_1	448	453	PF02516	0.751
MOD_N-GLC_1	96	101	PF02516	0.446
MOD_N-GLC_2	7	9	PF02516	0.510
MOD_NEK2_1	108	113	PF00069	0.446
MOD_NEK2_1	172	177	PF00069	0.631
MOD_NEK2_1	199	204	PF00069	0.544
MOD_NEK2_1	255	260	PF00069	0.611
MOD_NEK2_1	273	278	PF00069	0.807
MOD_NEK2_1	434	439	PF00069	0.747
MOD_NEK2_1	456	461	PF00069	0.706
MOD_NEK2_1	476	481	PF00069	0.738
MOD_NEK2_1	527	532	PF00069	0.810
MOD_NEK2_1	75	80	PF00069	0.329
MOD_NEK2_2	528	533	PF00069	0.724
MOD_PIKK_1	354	360	PF00454	0.609
MOD_PIKK_1	441	447	PF00454	0.545
MOD_PIKK_1	97	103	PF00454	0.323
MOD_PKA_1	308	314	PF00069	0.749
MOD_PKA_2	195	201	PF00069	0.538
MOD_PKA_2	308	314	PF00069	0.811
MOD_PKA_2	350	356	PF00069	0.644
MOD_PKA_2	364	370	PF00069	0.524
MOD_PKB_1	307	315	PF00069	0.830
MOD_Plk_2-3	371	377	PF00069	0.691
MOD_Plk_4	161	167	PF00069	0.644
MOD_ProDKin_1	178	184	PF00069	0.791
MOD_ProDKin_1	185	191	PF00069	0.647
MOD_ProDKin_1	216	222	PF00069	0.766
MOD_ProDKin_1	479	485	PF00069	0.658
MOD_ProDKin_1	488	494	PF00069	0.758
MOD_ProDKin_1	511	517	PF00069	0.521
TRG_DiLeu_BaEn_1	104	109	PF01217	0.344
TRG_ENDOCYTIC_2	85	88	PF00928	0.413
TRG_ER_diArg_1	151	153	PF00400	0.753
TRG_ER_diArg_1	229	231	PF00400	0.723
TRG_ER_diArg_1	304	307	PF00400	0.824
TRG_ER_diArg_1	532	535	PF00400	0.722
TRG_ER_diArg_1	569	572	PF00400	0.581
TRG_ER_diArg_1	81	84	PF00400	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IB27	Leishmania donovani	82%	100%
A4HGP3	Leishmania braziliensis	57%	100%
A4I3R6	Leishmania infantum	81%	100%
Q4Q876	Leishmania major	79%	100%