UPF0573 protein C2orf70 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4586), putative

Species:

Leishmania mexicana

UniProt:

E9B005_LEIMU

TriTrypDb:

LmxM.28.1860

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	26
GO:0005815	microtubule organizing center	2	26
GO:0110165	cellular anatomical entity	1	26

Expansion

Sequence features

E9B005

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B005

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	252	254	PF00675	0.307
CLV_NRD_NRD_1	64	66	PF00675	0.268
CLV_PCSK_KEX2_1	120	122	PF00082	0.284
CLV_PCSK_KEX2_1	212	214	PF00082	0.288
CLV_PCSK_KEX2_1	286	288	PF00082	0.516
CLV_PCSK_KEX2_1	63	65	PF00082	0.259
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.274
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.284
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.556
CLV_PCSK_SKI1_1	73	77	PF00082	0.232
DOC_CKS1_1	100	105	PF01111	0.523
DOC_MAPK_gen_1	261	269	PF00069	0.491
DOC_MAPK_MEF2A_6	201	209	PF00069	0.385
DOC_PP4_FxxP_1	3	6	PF00568	0.455
DOC_USP7_UBL2_3	257	261	PF12436	0.465
DOC_WW_Pin1_4	128	133	PF00397	0.443
DOC_WW_Pin1_4	191	196	PF00397	0.474
DOC_WW_Pin1_4	269	274	PF00397	0.335
DOC_WW_Pin1_4	73	78	PF00397	0.443
DOC_WW_Pin1_4	81	86	PF00397	0.424
DOC_WW_Pin1_4	99	104	PF00397	0.562
LIG_14-3-3_CanoR_1	126	132	PF00244	0.456
LIG_BRCT_BRCA1_1	281	285	PF00533	0.432
LIG_deltaCOP1_diTrp_1	275	285	PF00928	0.474
LIG_FHA_1	25	31	PF00498	0.477
LIG_FHA_1	278	284	PF00498	0.452
LIG_FHA_2	143	149	PF00498	0.436
LIG_FHA_2	154	160	PF00498	0.406
LIG_FHA_2	188	194	PF00498	0.441
LIG_FHA_2	236	242	PF00498	0.464
LIG_LIR_Apic_2	13	18	PF02991	0.464
LIG_LIR_Apic_2	241	246	PF02991	0.433
LIG_LIR_Gen_1	101	111	PF02991	0.483
LIG_LIR_Gen_1	140	149	PF02991	0.347
LIG_LIR_Nem_3	101	107	PF02991	0.452
LIG_LIR_Nem_3	140	144	PF02991	0.455
LIG_LIR_Nem_3	244	250	PF02991	0.425
LIG_LIR_Nem_3	282	288	PF02991	0.607
LIG_LIR_Nem_3	7	11	PF02991	0.430
LIG_LIR_Nem_3	94	99	PF02991	0.453
LIG_Pex14_1	243	247	PF04695	0.446
LIG_SH2_CRK	129	133	PF00017	0.436
LIG_SH2_CRK	15	19	PF00017	0.464
LIG_SH2_CRK	82	86	PF00017	0.466
LIG_SH2_NCK_1	104	108	PF00017	0.385
LIG_SH2_NCK_1	129	133	PF00017	0.421
LIG_SH2_NCK_1	141	145	PF00017	0.430
LIG_SH2_NCK_1	82	86	PF00017	0.485
LIG_SH2_SRC	104	107	PF00017	0.385
LIG_SH2_SRC	141	144	PF00017	0.403
LIG_SH2_STAP1	279	283	PF00017	0.432
LIG_SH2_STAT3	158	161	PF00017	0.507
LIG_SH2_STAT5	129	132	PF00017	0.442
LIG_SH2_STAT5	153	156	PF00017	0.426
LIG_SH2_STAT5	203	206	PF00017	0.468
LIG_SH2_STAT5	232	235	PF00017	0.446
LIG_SH2_STAT5	259	262	PF00017	0.511
LIG_SH2_STAT5	279	282	PF00017	0.444
LIG_SH2_STAT5	8	11	PF00017	0.469
LIG_SH2_STAT5	95	98	PF00017	0.468
LIG_SH3_1	174	180	PF00018	0.523
LIG_SH3_2	108	113	PF14604	0.477
LIG_SH3_2	177	182	PF14604	0.447
LIG_SH3_3	105	111	PF00018	0.432
LIG_SH3_3	174	180	PF00018	0.462
LIG_SH3_3	223	229	PF00018	0.449
LIG_SH3_3	257	263	PF00018	0.458
LIG_SH3_3	264	270	PF00018	0.472
LIG_SH3_3	27	33	PF00018	0.491
LIG_TRAF2_1	208	211	PF00917	0.442
LIG_TYR_ITSM	100	107	PF00017	0.385
LIG_UBA3_1	204	212	PF00899	0.402
LIG_WW_3	123	127	PF00397	0.403
MOD_CDK_SPxxK_3	128	135	PF00069	0.525
MOD_CK1_1	137	143	PF00069	0.417
MOD_CK1_1	194	200	PF00069	0.446
MOD_CK1_1	4	10	PF00069	0.457
MOD_CK1_1	83	89	PF00069	0.484
MOD_CK2_1	153	159	PF00069	0.546
MOD_CK2_1	187	193	PF00069	0.440
MOD_CK2_1	235	241	PF00069	0.504
MOD_GlcNHglycan	136	139	PF01048	0.202
MOD_GlcNHglycan	69	72	PF01048	0.243
MOD_GSK3_1	144	151	PF00069	0.505
MOD_GSK3_1	187	194	PF00069	0.459
MOD_GSK3_1	24	31	PF00069	0.482
MOD_N-GLC_1	73	78	PF02516	0.261
MOD_NEK2_1	1	6	PF00069	0.306
MOD_NEK2_1	277	282	PF00069	0.444
MOD_NEK2_1	28	33	PF00069	0.528
MOD_NEK2_1	80	85	PF00069	0.496
MOD_NEK2_2	153	158	PF00069	0.440
MOD_PIKK_1	277	283	PF00454	0.459
MOD_PKA_1	261	267	PF00069	0.464
MOD_Plk_2-3	187	193	PF00069	0.523
MOD_Plk_4	153	159	PF00069	0.420
MOD_Plk_4	24	30	PF00069	0.464
MOD_Plk_4	279	285	PF00069	0.476
MOD_Plk_4	4	10	PF00069	0.457
MOD_Plk_4	91	97	PF00069	0.456
MOD_ProDKin_1	128	134	PF00069	0.450
MOD_ProDKin_1	191	197	PF00069	0.474
MOD_ProDKin_1	269	275	PF00069	0.335
MOD_ProDKin_1	73	79	PF00069	0.443
MOD_ProDKin_1	81	87	PF00069	0.424
MOD_ProDKin_1	99	105	PF00069	0.562
MOD_SUMO_for_1	119	122	PF00179	0.528
TRG_ENDOCYTIC_2	104	107	PF00928	0.462
TRG_ENDOCYTIC_2	141	144	PF00928	0.486
TRG_ENDOCYTIC_2	8	11	PF00928	0.457
TRG_ER_diArg_1	62	65	PF00400	0.479
TRG_NLS_MonoExtC_3	172	177	PF00514	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4L7	Leptomonas seymouri	31%	96%
A0A0N1I8Z0	Leptomonas seymouri	76%	100%
A0A0S4IPI4	Bodo saltans	28%	86%
A0A0S4IYY4	Bodo saltans	33%	99%
A0A0S4KM52	Bodo saltans	44%	99%
A0A1X0NMW4	Trypanosomatidae	33%	97%
A0A1X0NRI3	Trypanosomatidae	56%	100%
A0A1X0P929	Trypanosomatidae	29%	82%
A0A3Q8IGT8	Leishmania donovani	94%	100%
A0A3R7NAQ1	Trypanosoma rangeli	28%	84%
A0A3S5H6B7	Leishmania donovani	29%	94%
A0A3S7X2W5	Leishmania donovani	29%	85%
A0A422NDP9	Trypanosoma rangeli	32%	97%
A0A422NZ19	Trypanosoma rangeli	57%	100%
A4H5J6	Leishmania braziliensis	30%	100%
A4HGN9	Leishmania braziliensis	87%	100%
A4HHQ4	Leishmania braziliensis	32%	100%
A4HTT9	Leishmania infantum	30%	94%
A4I3R2	Leishmania infantum	94%	100%
D0A896	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
D0A995	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	99%
E9AEB8	Leishmania major	31%	70%
E9AMM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	98%
Q0P4C5	Danio rerio	26%	93%
Q2T9M0	Bos taurus	28%	93%
Q4Q880	Leishmania major	93%	100%
Q4QI05	Leishmania major	29%	98%
V5BSF6	Trypanosoma cruzi	30%	96%
V5DTV3	Trypanosoma cruzi	26%	84%