Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-terminal motor kinesin, putative

Species:

Leishmania mexicana

UniProt:

E9B004_LEIMU

TriTrypDb:

LmxM.28.1850

Length:

965

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	10
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10
GO:0099512	supramolecular fiber	4	10
GO:0099513	polymeric cytoskeletal fiber	5	10
GO:0110165	cellular anatomical entity	1	10
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

E9B004

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B004

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	10
GO:0007018	microtubule-based movement	3	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003774	cytoskeletal motor activity	1	10
GO:0003777	microtubule motor activity	2	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0005524	ATP binding	5	10
GO:0008017	microtubule binding	5	10
GO:0008092	cytoskeletal protein binding	3	10
GO:0015631	tubulin binding	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140657	ATP-dependent activity	1	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.531
CLV_NRD_NRD_1	131	133	PF00675	0.620
CLV_NRD_NRD_1	373	375	PF00675	0.443
CLV_NRD_NRD_1	391	393	PF00675	0.372
CLV_NRD_NRD_1	4	6	PF00675	0.586
CLV_NRD_NRD_1	506	508	PF00675	0.584
CLV_NRD_NRD_1	563	565	PF00675	0.643
CLV_PCSK_FUR_1	212	216	PF00082	0.420
CLV_PCSK_KEX2_1	131	133	PF00082	0.620
CLV_PCSK_KEX2_1	214	216	PF00082	0.422
CLV_PCSK_KEX2_1	26	28	PF00082	0.485
CLV_PCSK_KEX2_1	391	393	PF00082	0.528
CLV_PCSK_KEX2_1	506	508	PF00082	0.584
CLV_PCSK_KEX2_1	6	8	PF00082	0.583
CLV_PCSK_KEX2_1	960	962	PF00082	0.388
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.410
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.485
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.585
CLV_PCSK_PC1ET2_1	960	962	PF00082	0.424
CLV_PCSK_PC7_1	127	133	PF00082	0.614
CLV_PCSK_PC7_1	2	8	PF00082	0.589
CLV_PCSK_SKI1_1	140	144	PF00082	0.524
CLV_PCSK_SKI1_1	629	633	PF00082	0.378
CLV_PCSK_SKI1_1	656	660	PF00082	0.320
CLV_PCSK_SKI1_1	696	700	PF00082	0.285
CLV_PCSK_SKI1_1	750	754	PF00082	0.290
CLV_PCSK_SKI1_1	874	878	PF00082	0.284
CLV_PCSK_SKI1_1	884	888	PF00082	0.355
CLV_PCSK_SKI1_1	960	964	PF00082	0.486
DEG_APCC_DBOX_1	296	304	PF00400	0.355
DEG_APCC_DBOX_1	390	398	PF00400	0.424
DEG_Nend_UBRbox_1	1	4	PF02207	0.603
DEG_SCF_FBW7_1	488	495	PF00400	0.569
DEG_SPOP_SBC_1	487	491	PF00917	0.487
DEG_SPOP_SBC_1	91	95	PF00917	0.519
DOC_ANK_TNKS_1	675	682	PF00023	0.284
DOC_CDC14_PxL_1	429	437	PF14671	0.498
DOC_CYCLIN_RxL_1	881	888	PF00134	0.325
DOC_MAPK_FxFP_2	548	551	PF00069	0.587
DOC_MAPK_gen_1	372	382	PF00069	0.466
DOC_MAPK_gen_1	848	857	PF00069	0.400
DOC_MAPK_gen_1	874	882	PF00069	0.284
DOC_MAPK_gen_1	920	930	PF00069	0.284
DOC_MAPK_MEF2A_6	923	930	PF00069	0.284
DOC_PP4_FxxP_1	548	551	PF00568	0.587
DOC_USP7_MATH_1	108	112	PF00917	0.574
DOC_USP7_MATH_1	193	197	PF00917	0.612
DOC_USP7_MATH_1	198	202	PF00917	0.557
DOC_USP7_MATH_1	32	36	PF00917	0.574
DOC_USP7_MATH_1	417	421	PF00917	0.576
DOC_USP7_MATH_1	437	441	PF00917	0.480
DOC_USP7_MATH_1	471	475	PF00917	0.583
DOC_USP7_MATH_1	487	491	PF00917	0.523
DOC_USP7_MATH_1	526	530	PF00917	0.719
DOC_USP7_MATH_1	774	778	PF00917	0.309
DOC_USP7_MATH_1	937	941	PF00917	0.320
DOC_USP7_MATH_1	99	103	PF00917	0.584
DOC_WW_Pin1_4	148	153	PF00397	0.601
DOC_WW_Pin1_4	191	196	PF00397	0.598
DOC_WW_Pin1_4	36	41	PF00397	0.563
DOC_WW_Pin1_4	488	493	PF00397	0.570
DOC_WW_Pin1_4	584	589	PF00397	0.528
DOC_WW_Pin1_4	62	67	PF00397	0.590
DOC_WW_Pin1_4	711	716	PF00397	0.354
DOC_WW_Pin1_4	770	775	PF00397	0.252
LIG_14-3-3_CanoR_1	113	120	PF00244	0.505
LIG_14-3-3_CanoR_1	292	300	PF00244	0.469
LIG_14-3-3_CanoR_1	515	525	PF00244	0.617
LIG_14-3-3_CanoR_1	580	588	PF00244	0.526
LIG_14-3-3_CanoR_1	637	645	PF00244	0.323
LIG_14-3-3_CanoR_1	799	805	PF00244	0.497
LIG_14-3-3_CanoR_1	818	825	PF00244	0.195
LIG_14-3-3_CanoR_1	848	857	PF00244	0.334
LIG_14-3-3_CterR_2	961	965	PF00244	0.442
LIG_Actin_WH2_2	882	899	PF00022	0.284
LIG_APCC_ABBA_1	742	747	PF00400	0.325
LIG_BIR_III_2	197	201	PF00653	0.550
LIG_BIR_III_2	430	434	PF00653	0.498
LIG_BRCT_BRCA1_1	737	741	PF00533	0.284
LIG_BRCT_BRCA1_1	942	946	PF00533	0.284
LIG_Clathr_ClatBox_1	247	251	PF01394	0.359
LIG_FHA_1	234	240	PF00498	0.475
LIG_FHA_1	525	531	PF00498	0.631
LIG_FHA_1	616	622	PF00498	0.432
LIG_FHA_1	792	798	PF00498	0.281
LIG_FHA_1	835	841	PF00498	0.284
LIG_FHA_1	908	914	PF00498	0.325
LIG_FHA_2	208	214	PF00498	0.486
LIG_FHA_2	293	299	PF00498	0.611
LIG_FHA_2	332	338	PF00498	0.484
LIG_FHA_2	537	543	PF00498	0.646
LIG_FHA_2	738	744	PF00498	0.304
LIG_FHA_2	756	762	PF00498	0.284
LIG_Integrin_RGD_1	531	533	PF01839	0.534
LIG_IRF3_LxIS_1	835	841	PF10401	0.320
LIG_LIR_Apic_2	35	40	PF02991	0.527
LIG_LIR_Gen_1	651	662	PF02991	0.298
LIG_LIR_Gen_1	738	749	PF02991	0.322
LIG_LIR_Gen_1	757	764	PF02991	0.377
LIG_LIR_Gen_1	805	815	PF02991	0.412
LIG_LIR_Nem_3	549	553	PF02991	0.549
LIG_LIR_Nem_3	64	70	PF02991	0.513
LIG_LIR_Nem_3	651	657	PF02991	0.298
LIG_LIR_Nem_3	665	671	PF02991	0.384
LIG_LIR_Nem_3	738	744	PF02991	0.322
LIG_LIR_Nem_3	805	810	PF02991	0.329
LIG_LYPXL_yS_3	67	70	PF13949	0.486
LIG_MYND_1	596	600	PF01753	0.578
LIG_NRBOX	908	914	PF00104	0.325
LIG_PCNA_yPIPBox_3	240	254	PF02747	0.469
LIG_PCNA_yPIPBox_3	746	759	PF02747	0.284
LIG_Pex14_2	648	652	PF04695	0.320
LIG_RPA_C_Fungi	273	285	PF08784	0.427
LIG_SH2_CRK	37	41	PF00017	0.525
LIG_SH2_CRK	408	412	PF00017	0.346
LIG_SH2_CRK	47	51	PF00017	0.507
LIG_SH2_CRK	654	658	PF00017	0.284
LIG_SH2_CRK	781	785	PF00017	0.284
LIG_SH2_GRB2like	90	93	PF00017	0.594
LIG_SH2_NCK_1	37	41	PF00017	0.525
LIG_SH2_NCK_1	429	433	PF00017	0.498
LIG_SH2_NCK_1	654	658	PF00017	0.284
LIG_SH2_STAP1	228	232	PF00017	0.479
LIG_SH2_STAP1	47	51	PF00017	0.491
LIG_SH2_STAP1	654	658	PF00017	0.316
LIG_SH2_STAP1	760	764	PF00017	0.284
LIG_SH2_STAT3	911	914	PF00017	0.320
LIG_SH2_STAT5	408	411	PF00017	0.331
LIG_SH2_STAT5	839	842	PF00017	0.241
LIG_SH2_STAT5	911	914	PF00017	0.320
LIG_SH2_STAT5	916	919	PF00017	0.287
LIG_SH2_STAT5	954	957	PF00017	0.425
LIG_SH3_1	132	138	PF00018	0.592
LIG_SH3_1	37	43	PF00018	0.474
LIG_SH3_2	135	140	PF14604	0.614
LIG_SH3_3	132	138	PF00018	0.592
LIG_SH3_3	37	43	PF00018	0.503
LIG_SH3_3	455	461	PF00018	0.579
LIG_SH3_3	618	624	PF00018	0.580
LIG_SH3_3	63	69	PF00018	0.548
LIG_SH3_3	70	76	PF00018	0.532
LIG_SH3_3	82	88	PF00018	0.606
LIG_SUMO_SIM_par_1	484	491	PF11976	0.608
LIG_SUMO_SIM_par_1	923	929	PF11976	0.284
LIG_TRAF2_1	662	665	PF00917	0.313
LIG_TRAF2_1	803	806	PF00917	0.289
LIG_TYR_ITSM	63	70	PF00017	0.501
LIG_UBA3_1	886	891	PF00899	0.284
LIG_WRC_WIRS_1	645	650	PF05994	0.320
MOD_CDK_SPK_2	148	153	PF00069	0.601
MOD_CDK_SPK_2	711	716	PF00069	0.284
MOD_CK1_1	111	117	PF00069	0.575
MOD_CK1_1	146	152	PF00069	0.524
MOD_CK1_1	181	187	PF00069	0.735
MOD_CK1_1	196	202	PF00069	0.479
MOD_CK1_1	296	302	PF00069	0.470
MOD_CK1_1	36	42	PF00069	0.543
MOD_CK1_1	476	482	PF00069	0.563
MOD_CK1_1	490	496	PF00069	0.560
MOD_CK1_1	516	522	PF00069	0.603
MOD_CK1_1	524	530	PF00069	0.641
MOD_CK1_1	55	61	PF00069	0.702
MOD_CK1_1	638	644	PF00069	0.292
MOD_CK1_1	646	652	PF00069	0.316
MOD_CK1_1	694	700	PF00069	0.334
MOD_CK1_1	755	761	PF00069	0.235
MOD_CK1_1	829	835	PF00069	0.325
MOD_CK1_1	940	946	PF00069	0.414
MOD_CK2_1	198	204	PF00069	0.561
MOD_CK2_1	207	213	PF00069	0.446
MOD_CK2_1	292	298	PF00069	0.431
MOD_CK2_1	331	337	PF00069	0.483
MOD_CK2_1	393	399	PF00069	0.503
MOD_CK2_1	536	542	PF00069	0.669
MOD_CK2_1	644	650	PF00069	0.412
MOD_CK2_1	737	743	PF00069	0.339
MOD_CK2_1	755	761	PF00069	0.325
MOD_CK2_1	800	806	PF00069	0.320
MOD_CMANNOS	208	211	PF00535	0.505
MOD_Cter_Amidation	59	62	PF01082	0.585
MOD_GlcNHglycan	108	111	PF01048	0.560
MOD_GlcNHglycan	116	119	PF01048	0.598
MOD_GlcNHglycan	145	148	PF01048	0.605
MOD_GlcNHglycan	261	264	PF01048	0.368
MOD_GlcNHglycan	272	275	PF01048	0.354
MOD_GlcNHglycan	329	332	PF01048	0.527
MOD_GlcNHglycan	359	362	PF01048	0.417
MOD_GlcNHglycan	413	416	PF01048	0.487
MOD_GlcNHglycan	423	426	PF01048	0.564
MOD_GlcNHglycan	473	476	PF01048	0.605
MOD_GlcNHglycan	481	484	PF01048	0.544
MOD_GlcNHglycan	515	518	PF01048	0.667
MOD_GlcNHglycan	557	562	PF01048	0.517
MOD_GlcNHglycan	58	61	PF01048	0.694
MOD_GlcNHglycan	589	592	PF01048	0.652
MOD_GlcNHglycan	693	696	PF01048	0.341
MOD_GlcNHglycan	754	757	PF01048	0.284
MOD_GlcNHglycan	776	779	PF01048	0.369
MOD_GlcNHglycan	786	789	PF01048	0.294
MOD_GlcNHglycan	840	843	PF01048	0.367
MOD_GlcNHglycan	868	871	PF01048	0.309
MOD_GSK3_1	108	115	PF00069	0.599
MOD_GSK3_1	174	181	PF00069	0.577
MOD_GSK3_1	196	203	PF00069	0.586
MOD_GSK3_1	226	233	PF00069	0.390
MOD_GSK3_1	292	299	PF00069	0.448
MOD_GSK3_1	32	39	PF00069	0.562
MOD_GSK3_1	327	334	PF00069	0.514
MOD_GSK3_1	417	424	PF00069	0.599
MOD_GSK3_1	469	476	PF00069	0.555
MOD_GSK3_1	486	493	PF00069	0.549
MOD_GSK3_1	513	520	PF00069	0.657
MOD_GSK3_1	52	59	PF00069	0.578
MOD_GSK3_1	629	636	PF00069	0.383
MOD_GSK3_1	639	646	PF00069	0.250
MOD_GSK3_1	731	738	PF00069	0.307
MOD_GSK3_1	769	776	PF00069	0.361
MOD_GSK3_1	780	787	PF00069	0.234
MOD_GSK3_1	816	823	PF00069	0.465
MOD_GSK3_1	834	841	PF00069	0.201
MOD_GSK3_1	950	957	PF00069	0.368
MOD_N-GLC_1	331	336	PF02516	0.456
MOD_N-GLC_1	638	643	PF02516	0.284
MOD_N-GLC_1	843	848	PF02516	0.284
MOD_N-GLC_1	866	871	PF02516	0.294
MOD_N-GLC_1	882	887	PF02516	0.409
MOD_N-GLC_1	91	96	PF02516	0.619
MOD_NEK2_1	1	6	PF00069	0.528
MOD_NEK2_1	120	125	PF00069	0.516
MOD_NEK2_1	143	148	PF00069	0.631
MOD_NEK2_1	207	212	PF00069	0.472
MOD_NEK2_1	401	406	PF00069	0.373
MOD_NEK2_1	477	482	PF00069	0.553
MOD_NEK2_1	486	491	PF00069	0.573
MOD_NEK2_1	648	653	PF00069	0.320
MOD_NEK2_1	737	742	PF00069	0.322
MOD_NEK2_1	752	757	PF00069	0.304
MOD_NEK2_1	816	821	PF00069	0.355
MOD_NEK2_1	838	843	PF00069	0.301
MOD_NEK2_1	926	931	PF00069	0.305
MOD_NEK2_2	526	531	PF00069	0.514
MOD_NEK2_2	834	839	PF00069	0.284
MOD_PIKK_1	223	229	PF00454	0.458
MOD_PIKK_1	233	239	PF00454	0.430
MOD_PIKK_1	298	304	PF00454	0.433
MOD_PIKK_1	417	423	PF00454	0.581
MOD_PKA_1	61	67	PF00069	0.584
MOD_PKA_2	1	7	PF00069	0.527
MOD_PKA_2	112	118	PF00069	0.594
MOD_PKA_2	293	299	PF00069	0.462
MOD_PKA_2	421	427	PF00069	0.527
MOD_PKA_2	438	444	PF00069	0.559
MOD_PKA_2	521	527	PF00069	0.583
MOD_PKA_2	56	62	PF00069	0.548
MOD_PKA_2	579	585	PF00069	0.509
MOD_PKA_2	817	823	PF00069	0.322
MOD_Plk_1	454	460	PF00069	0.510
MOD_Plk_1	77	83	PF00069	0.543
MOD_Plk_1	788	794	PF00069	0.284
MOD_Plk_1	843	849	PF00069	0.267
MOD_Plk_1	882	888	PF00069	0.325
MOD_Plk_2-3	381	387	PF00069	0.522
MOD_Plk_2-3	393	399	PF00069	0.367
MOD_Plk_2-3	650	656	PF00069	0.284
MOD_Plk_2-3	731	737	PF00069	0.271
MOD_Plk_4	454	460	PF00069	0.564
MOD_Plk_4	717	723	PF00069	0.284
MOD_Plk_4	737	743	PF00069	0.313
MOD_Plk_4	907	913	PF00069	0.320
MOD_Plk_4	950	956	PF00069	0.361
MOD_ProDKin_1	148	154	PF00069	0.600
MOD_ProDKin_1	191	197	PF00069	0.597
MOD_ProDKin_1	36	42	PF00069	0.560
MOD_ProDKin_1	488	494	PF00069	0.570
MOD_ProDKin_1	584	590	PF00069	0.526
MOD_ProDKin_1	62	68	PF00069	0.581
MOD_ProDKin_1	711	717	PF00069	0.354
MOD_ProDKin_1	770	776	PF00069	0.252
MOD_SUMO_rev_2	360	366	PF00179	0.414
MOD_SUMO_rev_2	396	404	PF00179	0.398
TRG_DiLeu_BaEn_1	362	367	PF01217	0.398
TRG_DiLeu_BaEn_1	567	572	PF01217	0.601
TRG_DiLeu_BaEn_4	805	811	PF01217	0.289
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.616
TRG_ENDOCYTIC_2	268	271	PF00928	0.429
TRG_ENDOCYTIC_2	408	411	PF00928	0.331
TRG_ENDOCYTIC_2	47	50	PF00928	0.491
TRG_ENDOCYTIC_2	654	657	PF00928	0.284
TRG_ENDOCYTIC_2	668	671	PF00928	0.284
TRG_ENDOCYTIC_2	67	70	PF00928	0.502
TRG_ENDOCYTIC_2	745	748	PF00928	0.318
TRG_ENDOCYTIC_2	760	763	PF00928	0.307
TRG_ENDOCYTIC_2	781	784	PF00928	0.284
TRG_ENDOCYTIC_2	916	919	PF00928	0.204
TRG_ER_diArg_1	130	132	PF00400	0.602
TRG_ER_diArg_1	168	171	PF00400	0.559
TRG_ER_diArg_1	275	278	PF00400	0.425
TRG_ER_diArg_1	572	575	PF00400	0.602
TRG_ER_diArg_1	704	707	PF00400	0.307
TRG_ER_diArg_1	847	850	PF00400	0.320
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	750	754	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	884	888	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAP4	Leptomonas seymouri	53%	100%
A0A3Q8IDV2	Leishmania donovani	89%	100%
A0A3S5H5N6	Leishmania donovani	23%	100%
A4HGN8	Leishmania braziliensis	76%	100%
A4HSQ9	Leishmania infantum	23%	100%
A4I3R1	Leishmania infantum	88%	100%
E9AKP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q881	Leishmania major	89%	100%