LeishMANIAdb
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Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial RNA binding complex 1 subunit
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B000_LEIMU
TriTrypDb:
LmxM.28.1810
Length:
143

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B000
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B000

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009451 RNA modification 5 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009894 regulation of catabolic process 4 1
GO:0009895 negative regulation of catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010628 positive regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0016553 base conversion or substitution editing 6 1
GO:0016554 cytidine to uridine editing 7 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0031330 negative regulation of cellular catabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043487 regulation of RNA stability 3 1
GO:0043488 regulation of mRNA stability 4 1
GO:0043489 RNA stabilization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6 1
GO:0046483 heterocycle metabolic process 3 1
GO:0048255 mRNA stabilization 5 1
GO:0048518 positive regulation of biological process 3 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051253 negative regulation of RNA metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061013 regulation of mRNA catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1902369 negative regulation of RNA catabolic process 7 1
GO:1902373 negative regulation of mRNA catabolic process 7 1
GO:1903311 regulation of mRNA metabolic process 6 1
GO:1903312 negative regulation of mRNA metabolic process 7 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 28 30 PF00675 0.540
CLV_PCSK_KEX2_1 28 30 PF00082 0.540
DOC_CKS1_1 51 56 PF01111 0.641
DOC_USP7_MATH_1 104 108 PF00917 0.497
DOC_USP7_MATH_1 20 24 PF00917 0.513
DOC_USP7_MATH_1 60 64 PF00917 0.712
DOC_USP7_MATH_1 67 71 PF00917 0.546
DOC_USP7_MATH_1 86 90 PF00917 0.533
DOC_USP7_UBL2_3 133 137 PF12436 0.419
DOC_WW_Pin1_4 50 55 PF00397 0.722
LIG_14-3-3_CanoR_1 17 25 PF00244 0.695
LIG_FHA_1 6 12 PF00498 0.604
LIG_LIR_Gen_1 100 108 PF02991 0.496
LIG_LIR_Nem_3 100 105 PF02991 0.428
LIG_Pex14_2 131 135 PF04695 0.355
LIG_SH2_STAT5 130 133 PF00017 0.349
LIG_SH2_STAT5 31 34 PF00017 0.577
LIG_SH3_3 53 59 PF00018 0.671
LIG_TRFH_1 30 34 PF08558 0.519
MOD_CK1_1 63 69 PF00069 0.613
MOD_CK2_1 104 110 PF00069 0.514
MOD_GlcNHglycan 12 16 PF01048 0.693
MOD_GlcNHglycan 65 68 PF01048 0.630
MOD_GlcNHglycan 71 74 PF01048 0.511
MOD_GSK3_1 63 70 PF00069 0.569
MOD_N-GLC_1 5 10 PF02516 0.615
MOD_N-GLC_1 67 72 PF02516 0.596
MOD_Plk_4 119 125 PF00069 0.443
MOD_Plk_4 20 26 PF00069 0.441
MOD_ProDKin_1 50 56 PF00069 0.718
MOD_SUMO_rev_2 111 121 PF00179 0.411
TRG_ER_diArg_1 28 30 PF00400 0.597

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM51 Leptomonas seymouri 57% 80%
A0A0S4JEB4 Bodo saltans 47% 83%
A0A3Q8ID67 Leishmania donovani 90% 81%
A0A3R7M7X7 Trypanosoma rangeli 65% 72%
A4HGN4 Leishmania braziliensis 77% 100%
A4I3Q7 Leishmania infantum 90% 100%
Q4Q885 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS