ATPase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

ATPase-like protein

Gene product:

ATPase-like protein

Species:

Leishmania mexicana

UniProt:

E9AZZ8_LEIMU

TriTrypDb:

LmxM.28.1790

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005694	chromosome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZZ8

Function

Biological processes
Term	Name	Level	Count
GO:0007049	cell cycle	2	6
GO:0009987	cellular process	1	7
GO:0022414	reproductive process	1	7
GO:0051321	meiotic cell cycle	2	6
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007131	reciprocal meiotic recombination	3	1
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010639	negative regulation of organelle organization	6	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0022402	cell cycle process	2	1
GO:0033043	regulation of organelle organization	5	1
GO:0033313	meiotic cell cycle checkpoint signaling	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035556	intracellular signal transduction	3	1
GO:0035825	homologous recombination	6	1
GO:0040020	regulation of meiotic nuclear division	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045835	negative regulation of meiotic nuclear division	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051129	negative regulation of cellular component organization	5	1
GO:0051445	regulation of meiotic cell cycle	4	1
GO:0051447	negative regulation of meiotic cell cycle	5	1
GO:0051598	meiotic recombination checkpoint signaling	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0051783	regulation of nuclear division	6	1
GO:0051784	negative regulation of nuclear division	7	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1903046	meiotic cell cycle process	2	1
GO:2000241	regulation of reproductive process	3	1
GO:2000242	negative regulation of reproductive process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0016887	ATP hydrolysis activity	7	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.596
CLV_C14_Caspase3-7	68	72	PF00656	0.481
CLV_NRD_NRD_1	2	4	PF00675	0.504
CLV_NRD_NRD_1	51	53	PF00675	0.386
CLV_PCSK_KEX2_1	185	187	PF00082	0.363
CLV_PCSK_KEX2_1	2	4	PF00082	0.504
CLV_PCSK_KEX2_1	267	269	PF00082	0.386
CLV_PCSK_KEX2_1	355	357	PF00082	0.295
CLV_PCSK_KEX2_1	51	53	PF00082	0.386
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.363
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.386
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.295
CLV_PCSK_SKI1_1	212	216	PF00082	0.295
CLV_PCSK_SKI1_1	267	271	PF00082	0.295
CLV_PCSK_SKI1_1	514	518	PF00082	0.372
DEG_APCC_DBOX_1	245	253	PF00400	0.295
DEG_APCC_DBOX_1	557	565	PF00400	0.451
DEG_Nend_UBRbox_1	1	4	PF02207	0.501
DEG_SPOP_SBC_1	468	472	PF00917	0.639
DOC_ANK_TNKS_1	406	413	PF00023	0.490
DOC_CDC14_PxL_1	516	524	PF14671	0.351
DOC_CDC14_PxL_1	69	77	PF14671	0.401
DOC_CYCLIN_RxL_1	364	374	PF00134	0.375
DOC_MAPK_MEF2A_6	18	25	PF00069	0.386
DOC_PP1_RVXF_1	210	217	PF00149	0.341
DOC_PP4_FxxP_1	216	219	PF00568	0.295
DOC_PP4_MxPP_1	465	468	PF00568	0.485
DOC_USP7_MATH_1	119	123	PF00917	0.647
DOC_USP7_MATH_1	201	205	PF00917	0.361
DOC_USP7_MATH_1	300	304	PF00917	0.386
DOC_USP7_MATH_1	310	314	PF00917	0.295
DOC_USP7_MATH_1	468	472	PF00917	0.575
DOC_USP7_MATH_1	92	96	PF00917	0.293
DOC_USP7_MATH_2	11	17	PF00917	0.564
DOC_WW_Pin1_4	155	160	PF00397	0.382
DOC_WW_Pin1_4	388	393	PF00397	0.452
DOC_WW_Pin1_4	4	9	PF00397	0.670
LIG_14-3-3_CanoR_1	118	127	PF00244	0.566
LIG_14-3-3_CanoR_1	197	203	PF00244	0.357
LIG_14-3-3_CanoR_1	2	11	PF00244	0.666
LIG_14-3-3_CanoR_1	238	244	PF00244	0.386
LIG_14-3-3_CanoR_1	26	34	PF00244	0.461
LIG_14-3-3_CanoR_1	260	269	PF00244	0.295
LIG_BIR_III_2	71	75	PF00653	0.492
LIG_BRCT_BRCA1_1	180	184	PF00533	0.355
LIG_BRCT_BRCA1_1	203	207	PF00533	0.436
LIG_BRCT_BRCA1_1	258	262	PF00533	0.295
LIG_CtBP_PxDLS_1	66	70	PF00389	0.292
LIG_EH1_1	494	502	PF00400	0.406
LIG_eIF4E_1	244	250	PF01652	0.295
LIG_eIF4E_1	495	501	PF01652	0.395
LIG_FHA_1	152	158	PF00498	0.406
LIG_FHA_1	336	342	PF00498	0.317
LIG_FHA_1	389	395	PF00498	0.718
LIG_FHA_2	25	31	PF00498	0.449
LIG_FHA_2	320	326	PF00498	0.295
LIG_GBD_Chelix_1	231	239	PF00786	0.386
LIG_GBD_Chelix_1	316	324	PF00786	0.332
LIG_Integrin_isoDGR_2	512	514	PF01839	0.373
LIG_LIR_Gen_1	166	174	PF02991	0.358
LIG_LIR_Gen_1	209	216	PF02991	0.327
LIG_LIR_Gen_1	43	49	PF02991	0.425
LIG_LIR_Gen_1	95	104	PF02991	0.379
LIG_LIR_Nem_3	16	22	PF02991	0.436
LIG_LIR_Nem_3	166	172	PF02991	0.361
LIG_LIR_Nem_3	209	213	PF02991	0.341
LIG_LIR_Nem_3	31	37	PF02991	0.398
LIG_LIR_Nem_3	43	47	PF02991	0.355
LIG_LYPXL_yS_3	19	22	PF13949	0.293
LIG_MYND_1	8	12	PF01753	0.468
LIG_Pex14_1	169	173	PF04695	0.333
LIG_Pex14_2	258	262	PF04695	0.295
LIG_SH2_CRK	372	376	PF00017	0.451
LIG_SH2_NCK_1	372	376	PF00017	0.398
LIG_SH2_PTP2	358	361	PF00017	0.274
LIG_SH2_PTP2	44	47	PF00017	0.358
LIG_SH2_SRC	560	563	PF00017	0.442
LIG_SH2_STAT5	103	106	PF00017	0.235
LIG_SH2_STAT5	191	194	PF00017	0.350
LIG_SH2_STAT5	358	361	PF00017	0.274
LIG_SH2_STAT5	44	47	PF00017	0.358
LIG_SH2_STAT5	560	563	PF00017	0.442
LIG_SH3_3	356	362	PF00018	0.386
LIG_SH3_3	381	387	PF00018	0.429
LIG_SH3_3	389	395	PF00018	0.533
LIG_SH3_3	451	457	PF00018	0.621
LIG_SH3_3	472	478	PF00018	0.662
LIG_SH3_3	480	486	PF00018	0.573
LIG_SH3_3	5	11	PF00018	0.659
LIG_SH3_3	548	554	PF00018	0.519
LIG_SH3_3	57	63	PF00018	0.394
LIG_SH3_3	85	91	PF00018	0.349
LIG_SH3_5	556	560	PF00018	0.473
LIG_SUMO_SIM_anti_2	346	351	PF11976	0.201
LIG_SUMO_SIM_par_1	19	24	PF11976	0.383
LIG_SUMO_SIM_par_1	332	339	PF11976	0.294
LIG_SUMO_SIM_par_1	65	71	PF11976	0.482
LIG_TRAF2_1	374	377	PF00917	0.342
LIG_TYR_ITSM	15	22	PF00017	0.474
LIG_UBA3_1	500	506	PF00899	0.251
LIG_WW_2	8	11	PF00397	0.473
MOD_CK1_1	122	128	PF00069	0.595
MOD_CK1_1	141	147	PF00069	0.443
MOD_CK1_1	151	157	PF00069	0.451
MOD_CK1_1	256	262	PF00069	0.295
MOD_CK1_1	399	405	PF00069	0.484
MOD_CK1_1	471	477	PF00069	0.740
MOD_CK2_1	371	377	PF00069	0.463
MOD_Cter_Amidation	265	268	PF01082	0.386
MOD_GlcNHglycan	121	124	PF01048	0.650
MOD_GlcNHglycan	143	146	PF01048	0.597
MOD_GlcNHglycan	150	153	PF01048	0.508
MOD_GlcNHglycan	264	267	PF01048	0.295
MOD_GlcNHglycan	302	305	PF01048	0.309
MOD_GlcNHglycan	396	401	PF01048	0.492
MOD_GlcNHglycan	434	437	PF01048	0.758
MOD_GlcNHglycan	471	474	PF01048	0.586
MOD_GlcNHglycan	532	535	PF01048	0.502
MOD_GlcNHglycan	540	543	PF01048	0.625
MOD_GlcNHglycan	546	550	PF01048	0.689
MOD_GlcNHglycan	580	583	PF01048	0.545
MOD_GSK3_1	118	125	PF00069	0.651
MOD_GSK3_1	151	158	PF00069	0.533
MOD_GSK3_1	174	181	PF00069	0.465
MOD_GSK3_1	187	194	PF00069	0.277
MOD_GSK3_1	202	209	PF00069	0.462
MOD_GSK3_1	219	226	PF00069	0.256
MOD_GSK3_1	24	31	PF00069	0.369
MOD_GSK3_1	256	263	PF00069	0.310
MOD_GSK3_1	335	342	PF00069	0.295
MOD_GSK3_1	36	43	PF00069	0.360
MOD_GSK3_1	467	474	PF00069	0.725
MOD_GSK3_1	484	491	PF00069	0.540
MOD_N-GLC_1	339	344	PF02516	0.295
MOD_NEK2_1	196	201	PF00069	0.416
MOD_NEK2_1	239	244	PF00069	0.295
MOD_NEK2_1	262	267	PF00069	0.295
MOD_NEK2_1	336	341	PF00069	0.304
MOD_NEK2_1	371	376	PF00069	0.393
MOD_NEK2_1	40	45	PF00069	0.352
MOD_NEK2_1	469	474	PF00069	0.504
MOD_NEK2_1	490	495	PF00069	0.537
MOD_NEK2_2	310	315	PF00069	0.295
MOD_PIKK_1	126	132	PF00454	0.520
MOD_PIKK_1	319	325	PF00454	0.295
MOD_PKA_1	2	8	PF00069	0.495
MOD_PKA_2	196	202	PF00069	0.418
MOD_PKA_2	2	8	PF00069	0.683
MOD_PKA_2	25	31	PF00069	0.449
MOD_PKA_2	300	306	PF00069	0.304
MOD_Plk_1	14	20	PF00069	0.510
MOD_Plk_1	35	41	PF00069	0.375
MOD_Plk_1	446	452	PF00069	0.628
MOD_Plk_1	86	92	PF00069	0.367
MOD_Plk_2-3	187	193	PF00069	0.345
MOD_Plk_4	168	174	PF00069	0.332
MOD_Plk_4	187	193	PF00069	0.480
MOD_Plk_4	239	245	PF00069	0.397
MOD_Plk_4	253	259	PF00069	0.214
MOD_Plk_4	36	42	PF00069	0.315
MOD_ProDKin_1	155	161	PF00069	0.376
MOD_ProDKin_1	388	394	PF00069	0.453
MOD_ProDKin_1	4	10	PF00069	0.669
MOD_SUMO_rev_2	325	333	PF00179	0.265
TRG_DiLeu_BaEn_1	36	41	PF01217	0.450
TRG_DiLeu_BaEn_4	446	452	PF01217	0.628
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.245
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.481
TRG_ENDOCYTIC_2	103	106	PF00928	0.243
TRG_ENDOCYTIC_2	19	22	PF00928	0.482
TRG_ENDOCYTIC_2	372	375	PF00928	0.449
TRG_ENDOCYTIC_2	44	47	PF00928	0.358
TRG_ER_diArg_1	1	3	PF00400	0.499
TRG_ER_diArg_1	51	53	PF00400	0.386
TRG_NES_CRM1_1	36	48	PF08389	0.446
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P830	Leptomonas seymouri	54%	100%
A0A3Q8IEP0	Leishmania donovani	91%	100%
A4HGN2	Leishmania braziliensis	79%	100%
E9AHG7	Leishmania infantum	91%	100%
Q4Q887	Leishmania major	90%	100%
Q9FGM0	Arabidopsis thaliana	26%	72%