Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania mexicana

UniProt:

E9AZZ6_LEIMU

TriTrypDb:

LmxM.28.1770

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZZ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.547
CLV_C14_Caspase3-7	281	285	PF00656	0.523
CLV_NRD_NRD_1	64	66	PF00675	0.508
DEG_SPOP_SBC_1	129	133	PF00917	0.543
DEG_SPOP_SBC_1	211	215	PF00917	0.686
DEG_SPOP_SBC_1	46	50	PF00917	0.233
DOC_CKS1_1	81	86	PF01111	0.678
DOC_USP7_MATH_1	129	133	PF00917	0.569
DOC_USP7_MATH_1	189	193	PF00917	0.653
DOC_USP7_MATH_1	212	216	PF00917	0.632
DOC_USP7_MATH_1	258	262	PF00917	0.570
DOC_USP7_UBL2_3	62	66	PF12436	0.410
DOC_WW_Pin1_4	80	85	PF00397	0.635
DOC_WW_Pin1_4	96	101	PF00397	0.800
LIG_14-3-3_CanoR_1	116	125	PF00244	0.486
LIG_BRCT_BRCA1_1	201	205	PF00533	0.632
LIG_FHA_1	211	217	PF00498	0.510
LIG_FHA_1	269	275	PF00498	0.671
LIG_FHA_1	50	56	PF00498	0.470
LIG_FHA_1	91	97	PF00498	0.810
LIG_FHA_2	240	246	PF00498	0.752
LIG_FHA_2	279	285	PF00498	0.561
LIG_FHA_2	81	87	PF00498	0.594
LIG_LIR_Apic_2	123	129	PF02991	0.717
LIG_LIR_Nem_3	155	160	PF02991	0.697
LIG_Pex14_2	205	209	PF04695	0.628
LIG_PTB_Apo_2	67	74	PF02174	0.346
LIG_SH2_GRB2like	68	71	PF00017	0.261
LIG_SH2_NCK_1	169	173	PF00017	0.727
LIG_SH2_STAP1	36	40	PF00017	0.410
LIG_SH2_STAP1	63	67	PF00017	0.484
LIG_SH3_3	188	194	PF00018	0.559
LIG_SH3_3	213	219	PF00018	0.770
LIG_SH3_3	225	231	PF00018	0.667
LIG_SH3_3	234	240	PF00018	0.604
LIG_WW_3	104	108	PF00397	0.556
MOD_CK1_1	132	138	PF00069	0.719
MOD_CK1_1	178	184	PF00069	0.792
MOD_CK1_1	283	289	PF00069	0.678
MOD_CK1_1	90	96	PF00069	0.689
MOD_CK1_1	99	105	PF00069	0.644
MOD_CK2_1	258	264	PF00069	0.618
MOD_CK2_1	45	51	PF00069	0.315
MOD_CK2_1	58	64	PF00069	0.508
MOD_GlcNHglycan	118	121	PF01048	0.595
MOD_GlcNHglycan	196	199	PF01048	0.787
MOD_GlcNHglycan	201	204	PF01048	0.676
MOD_GlcNHglycan	225	228	PF01048	0.698
MOD_GlcNHglycan	256	259	PF01048	0.604
MOD_GlcNHglycan	90	93	PF01048	0.617
MOD_GSK3_1	128	135	PF00069	0.770
MOD_GSK3_1	144	151	PF00069	0.545
MOD_GSK3_1	155	162	PF00069	0.596
MOD_GSK3_1	175	182	PF00069	0.729
MOD_GSK3_1	254	261	PF00069	0.592
MOD_GSK3_1	264	271	PF00069	0.448
MOD_GSK3_1	278	285	PF00069	0.581
MOD_GSK3_1	3	10	PF00069	0.371
MOD_GSK3_1	40	47	PF00069	0.427
MOD_GSK3_1	86	93	PF00069	0.667
MOD_GSK3_1	95	102	PF00069	0.607
MOD_N-GLC_1	199	204	PF02516	0.648
MOD_N-GLC_1	254	259	PF02516	0.687
MOD_NEK2_1	143	148	PF00069	0.701
MOD_NEK2_1	156	161	PF00069	0.472
MOD_NEK2_1	179	184	PF00069	0.529
MOD_NEK2_1	268	273	PF00069	0.614
MOD_NMyristoyl	1	7	PF02799	0.508
MOD_PIKK_1	136	142	PF00454	0.816
MOD_PIKK_1	204	210	PF00454	0.654
MOD_PK_1	7	13	PF00069	0.433
MOD_Plk_4	16	22	PF00069	0.350
MOD_Plk_4	212	218	PF00069	0.777
MOD_Plk_4	264	270	PF00069	0.612
MOD_ProDKin_1	80	86	PF00069	0.648
MOD_ProDKin_1	96	102	PF00069	0.800
MOD_SUMO_rev_2	61	67	PF00179	0.508
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.410
TRG_ER_diArg_1	30	33	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT1	Leptomonas seymouri	41%	74%
A0A3S7X1K9	Leishmania donovani	80%	100%
A4HGN0	Leishmania braziliensis	58%	100%
A4I3Q4	Leishmania infantum	81%	100%
Q4Q889	Leishmania major	79%	100%