Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZZ4_LEIMU

TriTrypDb:

LmxM.28.1750

Length:

917

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.721
CLV_C14_Caspase3-7	486	490	PF00656	0.541
CLV_NRD_NRD_1	124	126	PF00675	0.598
CLV_NRD_NRD_1	189	191	PF00675	0.741
CLV_NRD_NRD_1	211	213	PF00675	0.735
CLV_NRD_NRD_1	259	261	PF00675	0.720
CLV_NRD_NRD_1	539	541	PF00675	0.684
CLV_NRD_NRD_1	716	718	PF00675	0.475
CLV_NRD_NRD_1	738	740	PF00675	0.529
CLV_NRD_NRD_1	85	87	PF00675	0.658
CLV_NRD_NRD_1	878	880	PF00675	0.691
CLV_NRD_NRD_1	891	893	PF00675	0.727
CLV_PCSK_KEX2_1	124	126	PF00082	0.598
CLV_PCSK_KEX2_1	189	191	PF00082	0.729
CLV_PCSK_KEX2_1	211	213	PF00082	0.735
CLV_PCSK_KEX2_1	498	500	PF00082	0.655
CLV_PCSK_KEX2_1	716	718	PF00082	0.441
CLV_PCSK_KEX2_1	738	740	PF00082	0.529
CLV_PCSK_KEX2_1	794	796	PF00082	0.734
CLV_PCSK_KEX2_1	83	85	PF00082	0.676
CLV_PCSK_KEX2_1	878	880	PF00082	0.691
CLV_PCSK_KEX2_1	891	893	PF00082	0.727
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.697
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.734
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.676
CLV_PCSK_SKI1_1	212	216	PF00082	0.813
CLV_PCSK_SKI1_1	224	228	PF00082	0.549
CLV_PCSK_SKI1_1	541	545	PF00082	0.759
CLV_PCSK_SKI1_1	575	579	PF00082	0.713
CLV_PCSK_SKI1_1	739	743	PF00082	0.474
DEG_APCC_DBOX_1	223	231	PF00400	0.683
DEG_SPOP_SBC_1	206	210	PF00917	0.626
DEG_SPOP_SBC_1	570	574	PF00917	0.494
DEG_SPOP_SBC_1	622	626	PF00917	0.692
DEG_SPOP_SBC_1	781	785	PF00917	0.486
DEG_SPOP_SBC_1	817	821	PF00917	0.630
DEG_SPOP_SBC_1	895	899	PF00917	0.790
DOC_CKS1_1	406	411	PF01111	0.553
DOC_CKS1_1	862	867	PF01111	0.602
DOC_CYCLIN_yClb3_PxF_3	861	867	PF00134	0.632
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	525	531	PF00134	0.687
DOC_MAPK_gen_1	549	559	PF00069	0.731
DOC_MAPK_gen_1	716	726	PF00069	0.410
DOC_MAPK_gen_1	83	89	PF00069	0.509
DOC_PP1_RVXF_1	209	216	PF00149	0.623
DOC_SPAK_OSR1_1	797	801	PF12202	0.578
DOC_USP7_MATH_1	206	210	PF00917	0.662
DOC_USP7_MATH_1	273	277	PF00917	0.642
DOC_USP7_MATH_1	309	313	PF00917	0.524
DOC_USP7_MATH_1	425	429	PF00917	0.543
DOC_USP7_MATH_1	490	494	PF00917	0.789
DOC_USP7_MATH_1	510	514	PF00917	0.472
DOC_USP7_MATH_1	521	525	PF00917	0.615
DOC_USP7_MATH_1	584	588	PF00917	0.567
DOC_USP7_MATH_1	617	621	PF00917	0.608
DOC_USP7_MATH_1	622	626	PF00917	0.670
DOC_USP7_MATH_1	63	67	PF00917	0.614
DOC_USP7_MATH_1	662	666	PF00917	0.699
DOC_USP7_MATH_1	71	75	PF00917	0.685
DOC_USP7_MATH_1	781	785	PF00917	0.568
DOC_USP7_MATH_1	817	821	PF00917	0.715
DOC_USP7_MATH_1	842	846	PF00917	0.727
DOC_USP7_MATH_1	848	852	PF00917	0.634
DOC_WW_Pin1_4	166	171	PF00397	0.637
DOC_WW_Pin1_4	276	281	PF00397	0.487
DOC_WW_Pin1_4	405	410	PF00397	0.654
DOC_WW_Pin1_4	415	420	PF00397	0.549
DOC_WW_Pin1_4	46	51	PF00397	0.612
DOC_WW_Pin1_4	506	511	PF00397	0.726
DOC_WW_Pin1_4	541	546	PF00397	0.784
DOC_WW_Pin1_4	57	62	PF00397	0.680
DOC_WW_Pin1_4	618	623	PF00397	0.647
DOC_WW_Pin1_4	649	654	PF00397	0.780
DOC_WW_Pin1_4	674	679	PF00397	0.651
DOC_WW_Pin1_4	854	859	PF00397	0.763
DOC_WW_Pin1_4	861	866	PF00397	0.637
DOC_WW_Pin1_4	896	901	PF00397	0.721
LIG_14-3-3_CanoR_1	212	221	PF00244	0.694
LIG_14-3-3_CanoR_1	272	282	PF00244	0.630
LIG_14-3-3_CanoR_1	288	293	PF00244	0.521
LIG_14-3-3_CanoR_1	304	309	PF00244	0.502
LIG_14-3-3_CanoR_1	375	383	PF00244	0.618
LIG_14-3-3_CanoR_1	540	548	PF00244	0.682
LIG_14-3-3_CanoR_1	616	622	PF00244	0.645
LIG_14-3-3_CanoR_1	780	790	PF00244	0.732
LIG_14-3-3_CanoR_1	795	801	PF00244	0.498
LIG_14-3-3_CanoR_1	84	90	PF00244	0.718
LIG_Actin_WH2_2	706	721	PF00022	0.462
LIG_BIR_III_2	489	493	PF00653	0.704
LIG_BIR_III_2	682	686	PF00653	0.557
LIG_BRCT_BRCA1_1	689	693	PF00533	0.461
LIG_CaM_NSCaTE_8	484	491	PF13499	0.591
LIG_FHA_1	102	108	PF00498	0.772
LIG_FHA_1	125	131	PF00498	0.490
LIG_FHA_1	229	235	PF00498	0.744
LIG_FHA_1	236	242	PF00498	0.713
LIG_FHA_1	282	288	PF00498	0.588
LIG_FHA_1	3	9	PF00498	0.686
LIG_FHA_1	398	404	PF00498	0.772
LIG_FHA_1	756	762	PF00498	0.510
LIG_FHA_1	819	825	PF00498	0.506
LIG_FHA_2	379	385	PF00498	0.668
LIG_FHA_2	425	431	PF00498	0.604
LIG_FHA_2	587	593	PF00498	0.698
LIG_FHA_2	707	713	PF00498	0.569
LIG_GBD_Chelix_1	89	97	PF00786	0.633
LIG_LIR_Gen_1	140	150	PF02991	0.511
LIG_LIR_Gen_1	344	351	PF02991	0.706
LIG_LIR_Gen_1	4	15	PF02991	0.682
LIG_LIR_Gen_1	602	612	PF02991	0.560
LIG_LIR_Gen_1	686	697	PF02991	0.457
LIG_LIR_Nem_3	140	145	PF02991	0.553
LIG_LIR_Nem_3	21	25	PF02991	0.608
LIG_LIR_Nem_3	26	32	PF02991	0.567
LIG_LIR_Nem_3	344	350	PF02991	0.613
LIG_LIR_Nem_3	4	10	PF02991	0.585
LIG_LIR_Nem_3	42	48	PF02991	0.663
LIG_LIR_Nem_3	602	607	PF02991	0.567
LIG_LIR_Nem_3	610	615	PF02991	0.549
LIG_LIR_Nem_3	686	692	PF02991	0.401
LIG_Pex14_1	913	917	PF04695	0.664
LIG_RPA_C_Fungi	762	774	PF08784	0.361
LIG_SH2_CRK	25	29	PF00017	0.601
LIG_SH2_CRK	612	616	PF00017	0.562
LIG_SH2_CRK	689	693	PF00017	0.461
LIG_SH2_NCK_1	689	693	PF00017	0.461
LIG_SH2_PTP2	142	145	PF00017	0.483
LIG_SH2_STAP1	25	29	PF00017	0.602
LIG_SH2_STAP1	689	693	PF00017	0.416
LIG_SH2_STAT5	119	122	PF00017	0.682
LIG_SH2_STAT5	142	145	PF00017	0.455
LIG_SH2_STAT5	22	25	PF00017	0.607
LIG_SH2_STAT5	43	46	PF00017	0.614
LIG_SH2_STAT5	604	607	PF00017	0.559
LIG_SH2_STAT5	614	617	PF00017	0.570
LIG_SH3_3	238	244	PF00018	0.676
LIG_SH3_3	310	316	PF00018	0.580
LIG_SH3_3	367	373	PF00018	0.723
LIG_SH3_3	578	584	PF00018	0.667
LIG_SH3_3	588	594	PF00018	0.659
LIG_SH3_3	644	650	PF00018	0.797
LIG_SH3_3	783	789	PF00018	0.480
LIG_SH3_3	855	861	PF00018	0.714
LIG_SH3_3	877	883	PF00018	0.769
LIG_Sin3_3	332	339	PF02671	0.652
LIG_SUMO_SIM_anti_2	430	436	PF11976	0.463
LIG_SUMO_SIM_par_1	148	154	PF11976	0.488
LIG_SUMO_SIM_par_1	457	462	PF11976	0.481
LIG_SUMO_SIM_par_1	555	560	PF11976	0.576
LIG_TRAF2_1	512	515	PF00917	0.619
LIG_TRAF2_1	653	656	PF00917	0.700
MOD_CDK_SPxxK_3	861	868	PF00069	0.601
MOD_CK1_1	109	115	PF00069	0.589
MOD_CK1_1	166	172	PF00069	0.578
MOD_CK1_1	197	203	PF00069	0.633
MOD_CK1_1	268	274	PF00069	0.836
MOD_CK1_1	276	282	PF00069	0.633
MOD_CK1_1	343	349	PF00069	0.715
MOD_CK1_1	374	380	PF00069	0.771
MOD_CK1_1	393	399	PF00069	0.676
MOD_CK1_1	509	515	PF00069	0.530
MOD_CK1_1	618	624	PF00069	0.693
MOD_CK1_1	665	671	PF00069	0.606
MOD_CK1_1	687	693	PF00069	0.393
MOD_CK1_1	819	825	PF00069	0.746
MOD_CK1_1	851	857	PF00069	0.731
MOD_CK2_1	146	152	PF00069	0.562
MOD_CK2_1	378	384	PF00069	0.668
MOD_CK2_1	509	515	PF00069	0.622
MOD_CK2_1	586	592	PF00069	0.696
MOD_CK2_1	667	673	PF00069	0.732
MOD_CK2_1	706	712	PF00069	0.572
MOD_CK2_1	85	91	PF00069	0.642
MOD_Cter_Amidation	889	892	PF01082	0.539
MOD_GlcNHglycan	111	114	PF01048	0.589
MOD_GlcNHglycan	191	194	PF01048	0.650
MOD_GlcNHglycan	267	270	PF01048	0.605
MOD_GlcNHglycan	275	278	PF01048	0.601
MOD_GlcNHglycan	360	363	PF01048	0.726
MOD_GlcNHglycan	500	503	PF01048	0.761
MOD_GlcNHglycan	541	544	PF01048	0.692
MOD_GlcNHglycan	566	569	PF01048	0.739
MOD_GlcNHglycan	586	589	PF01048	0.573
MOD_GlcNHglycan	617	620	PF01048	0.632
MOD_GlcNHglycan	73	76	PF01048	0.685
MOD_GlcNHglycan	836	839	PF01048	0.737
MOD_GlcNHglycan	844	847	PF01048	0.641
MOD_GlcNHglycan	888	891	PF01048	0.634
MOD_GSK3_1	103	110	PF00069	0.617
MOD_GSK3_1	124	131	PF00069	0.504
MOD_GSK3_1	162	169	PF00069	0.695
MOD_GSK3_1	235	242	PF00069	0.552
MOD_GSK3_1	268	275	PF00069	0.739
MOD_GSK3_1	290	297	PF00069	0.550
MOD_GSK3_1	349	356	PF00069	0.614
MOD_GSK3_1	374	381	PF00069	0.746
MOD_GSK3_1	392	399	PF00069	0.684
MOD_GSK3_1	401	408	PF00069	0.591
MOD_GSK3_1	506	513	PF00069	0.741
MOD_GSK3_1	571	578	PF00069	0.660
MOD_GSK3_1	617	624	PF00069	0.674
MOD_GSK3_1	662	669	PF00069	0.742
MOD_GSK3_1	683	690	PF00069	0.472
MOD_GSK3_1	71	78	PF00069	0.724
MOD_GSK3_1	816	823	PF00069	0.687
MOD_GSK3_1	844	851	PF00069	0.723
MOD_GSK3_1	853	860	PF00069	0.597
MOD_GSK3_1	882	889	PF00069	0.729
MOD_GSK3_1	894	901	PF00069	0.657
MOD_N-GLC_1	128	133	PF02516	0.537
MOD_N-GLC_1	182	187	PF02516	0.682
MOD_NEK2_1	213	218	PF00069	0.800
MOD_NEK2_1	234	239	PF00069	0.553
MOD_NEK2_1	248	253	PF00069	0.696
MOD_NEK2_1	497	502	PF00069	0.583
MOD_NEK2_1	516	521	PF00069	0.712
MOD_NEK2_1	571	576	PF00069	0.525
MOD_NEK2_1	615	620	PF00069	0.577
MOD_NEK2_1	805	810	PF00069	0.469
MOD_NEK2_1	816	821	PF00069	0.507
MOD_NEK2_1	853	858	PF00069	0.747
MOD_NEK2_2	119	124	PF00069	0.671
MOD_NEK2_2	796	801	PF00069	0.605
MOD_NEK2_2	873	878	PF00069	0.762
MOD_OFUCOSY	126	132	PF10250	0.538
MOD_PIKK_1	197	203	PF00454	0.662
MOD_PIKK_1	281	287	PF00454	0.572
MOD_PIKK_1	684	690	PF00454	0.510
MOD_PIKK_1	75	81	PF00454	0.773
MOD_PIKK_1	755	761	PF00454	0.526
MOD_PKA_1	124	130	PF00069	0.546
MOD_PKA_1	189	195	PF00069	0.572
MOD_PKA_1	498	504	PF00069	0.770
MOD_PKA_1	85	91	PF00069	0.670
MOD_PKA_2	124	130	PF00069	0.546
MOD_PKA_2	189	195	PF00069	0.759
MOD_PKA_2	197	203	PF00069	0.669
MOD_PKA_2	228	234	PF00069	0.633
MOD_PKA_2	273	279	PF00069	0.583
MOD_PKA_2	374	380	PF00069	0.721
MOD_PKA_2	498	504	PF00069	0.770
MOD_PKA_2	539	545	PF00069	0.661
MOD_PKA_2	584	590	PF00069	0.701
MOD_PKA_2	615	621	PF00069	0.594
MOD_PKA_2	635	641	PF00069	0.652
MOD_PKA_2	665	671	PF00069	0.590
MOD_PKA_2	796	802	PF00069	0.518
MOD_PKA_2	85	91	PF00069	0.730
MOD_PKB_1	263	271	PF00069	0.642
MOD_PKB_1	664	672	PF00069	0.526
MOD_Plk_1	37	43	PF00069	0.421
MOD_Plk_1	706	712	PF00069	0.324
MOD_Plk_1	848	854	PF00069	0.611
MOD_Plk_2-3	384	390	PF00069	0.529
MOD_Plk_4	146	152	PF00069	0.437
MOD_Plk_4	290	296	PF00069	0.643
MOD_Plk_4	309	315	PF00069	0.503
MOD_Plk_4	346	352	PF00069	0.721
MOD_Plk_4	521	527	PF00069	0.721
MOD_Plk_4	687	693	PF00069	0.447
MOD_Plk_4	706	712	PF00069	0.488
MOD_Plk_4	757	763	PF00069	0.494
MOD_Plk_4	85	91	PF00069	0.682
MOD_ProDKin_1	166	172	PF00069	0.640
MOD_ProDKin_1	276	282	PF00069	0.477
MOD_ProDKin_1	405	411	PF00069	0.651
MOD_ProDKin_1	415	421	PF00069	0.545
MOD_ProDKin_1	46	52	PF00069	0.618
MOD_ProDKin_1	506	512	PF00069	0.727
MOD_ProDKin_1	541	547	PF00069	0.783
MOD_ProDKin_1	57	63	PF00069	0.681
MOD_ProDKin_1	618	624	PF00069	0.653
MOD_ProDKin_1	649	655	PF00069	0.782
MOD_ProDKin_1	674	680	PF00069	0.651
MOD_ProDKin_1	854	860	PF00069	0.762
MOD_ProDKin_1	861	867	PF00069	0.640
MOD_ProDKin_1	896	902	PF00069	0.720
MOD_SUMO_rev_2	379	387	PF00179	0.517
TRG_DiLeu_BaEn_2	602	608	PF01217	0.564
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.651
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.651
TRG_ENDOCYTIC_2	142	145	PF00928	0.455
TRG_ENDOCYTIC_2	25	28	PF00928	0.608
TRG_ENDOCYTIC_2	29	32	PF00928	0.563
TRG_ENDOCYTIC_2	45	48	PF00928	0.395
TRG_ENDOCYTIC_2	604	607	PF00928	0.559
TRG_ENDOCYTIC_2	612	615	PF00928	0.553
TRG_ENDOCYTIC_2	689	692	PF00928	0.415
TRG_ER_diArg_1	188	190	PF00400	0.806
TRG_ER_diArg_1	211	213	PF00400	0.672
TRG_ER_diArg_1	257	260	PF00400	0.538
TRG_ER_diArg_1	262	265	PF00400	0.521
TRG_ER_diArg_1	716	719	PF00400	0.476
TRG_ER_diArg_1	737	739	PF00400	0.530
TRG_ER_diArg_1	795	798	PF00400	0.713
TRG_ER_diArg_1	84	86	PF00400	0.672
TRG_ER_diArg_1	878	880	PF00400	0.691
TRG_NES_CRM1_1	285	298	PF08389	0.480
TRG_NLS_MonoCore_2	259	264	PF00514	0.532
TRG_NLS_MonoCore_2	82	87	PF00514	0.668
TRG_NLS_MonoExtN_4	258	264	PF00514	0.739
TRG_NLS_MonoExtN_4	80	87	PF00514	0.631
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.674
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ4	Leptomonas seymouri	37%	100%
A0A3S7X1L5	Leishmania donovani	80%	98%
A4HGM8	Leishmania braziliensis	60%	98%
A4I3Q2	Leishmania infantum	80%	98%
Q4Q891	Leishmania major	79%	100%