SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania mexicana

UniProt:

E9AZZ3_LEIMU

TriTrypDb:

LmxM.28.1740

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZZ3

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0070475	rRNA base methylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.595
CLV_C14_Caspase3-7	86	90	PF00656	0.530
CLV_NRD_NRD_1	139	141	PF00675	0.706
CLV_NRD_NRD_1	174	176	PF00675	0.448
CLV_NRD_NRD_1	179	181	PF00675	0.502
CLV_NRD_NRD_1	210	212	PF00675	0.635
CLV_NRD_NRD_1	26	28	PF00675	0.418
CLV_NRD_NRD_1	309	311	PF00675	0.557
CLV_NRD_NRD_1	348	350	PF00675	0.301
CLV_NRD_NRD_1	437	439	PF00675	0.581
CLV_NRD_NRD_1	446	448	PF00675	0.461
CLV_NRD_NRD_1	493	495	PF00675	0.229
CLV_PCSK_FUR_1	136	140	PF00082	0.623
CLV_PCSK_FUR_1	172	176	PF00082	0.419
CLV_PCSK_KEX2_1	138	140	PF00082	0.702
CLV_PCSK_KEX2_1	174	176	PF00082	0.434
CLV_PCSK_KEX2_1	181	183	PF00082	0.468
CLV_PCSK_KEX2_1	206	208	PF00082	0.682
CLV_PCSK_KEX2_1	210	212	PF00082	0.685
CLV_PCSK_KEX2_1	348	350	PF00082	0.235
CLV_PCSK_KEX2_1	355	357	PF00082	0.248
CLV_PCSK_KEX2_1	437	439	PF00082	0.581
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.624
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.478
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.747
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.235
CLV_PCSK_SKI1_1	206	210	PF00082	0.722
CLV_PCSK_SKI1_1	287	291	PF00082	0.610
CLV_PCSK_SKI1_1	381	385	PF00082	0.239
CLV_PCSK_SKI1_1	494	498	PF00082	0.229
CLV_PCSK_SKI1_1	527	531	PF00082	0.214
CLV_Separin_Metazoa	524	528	PF03568	0.516
DEG_APCC_DBOX_1	309	317	PF00400	0.394
DEG_Nend_UBRbox_2	1	3	PF02207	0.350
DOC_CDC14_PxL_1	96	104	PF14671	0.274
DOC_CYCLIN_RxL_1	19	29	PF00134	0.370
DOC_CYCLIN_RxL_1	488	500	PF00134	0.460
DOC_MAPK_gen_1	155	164	PF00069	0.327
DOC_MAPK_MEF2A_6	158	166	PF00069	0.358
DOC_PP2B_LxvP_1	151	154	PF13499	0.477
DOC_PP2B_LxvP_1	333	336	PF13499	0.414
DOC_PP2B_PxIxI_1	335	341	PF00149	0.504
DOC_SPAK_OSR1_1	565	569	PF12202	0.470
DOC_USP7_MATH_1	186	190	PF00917	0.643
DOC_USP7_MATH_1	193	197	PF00917	0.708
DOC_USP7_MATH_1	246	250	PF00917	0.424
DOC_USP7_MATH_1	391	395	PF00917	0.414
DOC_USP7_UBL2_3	28	32	PF12436	0.394
DOC_USP7_UBL2_3	284	288	PF12436	0.748
LIG_14-3-3_CanoR_1	158	163	PF00244	0.322
LIG_14-3-3_CanoR_1	210	219	PF00244	0.667
LIG_14-3-3_CanoR_1	257	265	PF00244	0.310
LIG_14-3-3_CanoR_1	356	361	PF00244	0.429
LIG_14-3-3_CanoR_1	381	389	PF00244	0.529
LIG_Actin_WH2_2	159	176	PF00022	0.387
LIG_BIR_III_2	268	272	PF00653	0.490
LIG_Clathr_ClatBox_1	501	505	PF01394	0.425
LIG_FHA_1	159	165	PF00498	0.382
LIG_FHA_1	325	331	PF00498	0.438
LIG_FHA_1	34	40	PF00498	0.356
LIG_FHA_1	382	388	PF00498	0.433
LIG_FHA_1	512	518	PF00498	0.437
LIG_FHA_1	550	556	PF00498	0.392
LIG_FHA_2	297	303	PF00498	0.451
LIG_FHA_2	341	347	PF00498	0.516
LIG_FHA_2	398	404	PF00498	0.430
LIG_FHA_2	84	90	PF00498	0.444
LIG_LIR_Gen_1	36	44	PF02991	0.350
LIG_LIR_Gen_1	364	373	PF02991	0.427
LIG_LIR_Nem_3	104	109	PF02991	0.393
LIG_LIR_Nem_3	36	40	PF02991	0.356
LIG_LIR_Nem_3	364	368	PF02991	0.454
LIG_LIR_Nem_3	372	376	PF02991	0.428
LIG_LIR_Nem_3	58	63	PF02991	0.377
LIG_PTB_Apo_2	367	374	PF02174	0.371
LIG_SH2_CRK	156	160	PF00017	0.310
LIG_SH2_CRK	37	41	PF00017	0.348
LIG_SH2_CRK	76	80	PF00017	0.332
LIG_SH2_GRB2like	365	368	PF00017	0.425
LIG_SH2_NCK_1	156	160	PF00017	0.310
LIG_SH2_PTP2	365	368	PF00017	0.439
LIG_SH2_SRC	365	368	PF00017	0.439
LIG_SH2_STAP1	76	80	PF00017	0.346
LIG_SH2_STAT3	62	65	PF00017	0.528
LIG_SH2_STAT5	101	104	PF00017	0.377
LIG_SH2_STAT5	315	318	PF00017	0.430
LIG_SH2_STAT5	365	368	PF00017	0.447
LIG_SH2_STAT5	581	584	PF00017	0.432
LIG_SH3_3	111	117	PF00018	0.527
LIG_SH3_3	213	219	PF00018	0.616
LIG_SH3_3	224	230	PF00018	0.380
LIG_SH3_3	231	237	PF00018	0.400
LIG_SUMO_SIM_par_1	270	276	PF11976	0.516
LIG_SUMO_SIM_par_1	51	58	PF11976	0.428
LIG_TRAF2_1	165	168	PF00917	0.497
LIG_TRAF2_1	450	453	PF00917	0.711
LIG_WRC_WIRS_1	501	506	PF05994	0.425
LIG_WW_3	115	119	PF00397	0.497
MOD_CK1_1	147	153	PF00069	0.644
MOD_CK1_1	464	470	PF00069	0.639
MOD_CK1_1	500	506	PF00069	0.449
MOD_CK1_1	513	519	PF00069	0.373
MOD_CK2_1	162	168	PF00069	0.357
MOD_CK2_1	477	483	PF00069	0.319
MOD_CK2_1	513	519	PF00069	0.439
MOD_Cter_Amidation	136	139	PF01082	0.623
MOD_Cter_Amidation	285	288	PF01082	0.531
MOD_GlcNHglycan	140	143	PF01048	0.683
MOD_GlcNHglycan	175	178	PF01048	0.542
MOD_GlcNHglycan	248	251	PF01048	0.419
MOD_GlcNHglycan	280	283	PF01048	0.569
MOD_GlcNHglycan	393	396	PF01048	0.214
MOD_GlcNHglycan	466	469	PF01048	0.723
MOD_GlcNHglycan	97	100	PF01048	0.411
MOD_GSK3_1	158	165	PF00069	0.468
MOD_GSK3_1	206	213	PF00069	0.731
MOD_GSK3_1	389	396	PF00069	0.414
MOD_GSK3_1	429	436	PF00069	0.520
MOD_GSK3_1	506	513	PF00069	0.425
MOD_GSK3_1	83	90	PF00069	0.443
MOD_N-GLC_1	17	22	PF02516	0.460
MOD_N-GLC_1	324	329	PF02516	0.214
MOD_N-GLC_1	87	92	PF02516	0.559
MOD_NEK2_1	433	438	PF00069	0.534
MOD_NEK2_1	497	502	PF00069	0.494
MOD_NEK2_1	564	569	PF00069	0.414
MOD_PIKK_1	325	331	PF00454	0.439
MOD_PIKK_1	412	418	PF00454	0.367
MOD_PKA_1	138	144	PF00069	0.744
MOD_PKA_1	206	212	PF00069	0.730
MOD_PKA_1	33	39	PF00069	0.362
MOD_PKA_1	437	443	PF00069	0.583
MOD_PKA_2	138	144	PF00069	0.681
MOD_PKA_2	173	179	PF00069	0.552
MOD_PKA_2	206	212	PF00069	0.709
MOD_PKA_2	256	262	PF00069	0.310
MOD_PKA_2	296	302	PF00069	0.500
MOD_PKA_2	437	443	PF00069	0.578
MOD_PKA_2	540	546	PF00069	0.551
MOD_PKA_2	564	570	PF00069	0.445
MOD_Plk_4	497	503	PF00069	0.497
MOD_SUMO_rev_2	119	123	PF00179	0.418
MOD_SUMO_rev_2	421	431	PF00179	0.454
MOD_SUMO_rev_2	440	450	PF00179	0.473
TRG_ENDOCYTIC_2	106	109	PF00928	0.395
TRG_ENDOCYTIC_2	156	159	PF00928	0.313
TRG_ENDOCYTIC_2	365	368	PF00928	0.433
TRG_ENDOCYTIC_2	37	40	PF00928	0.362
TRG_ENDOCYTIC_2	47	50	PF00928	0.393
TRG_ENDOCYTIC_2	76	79	PF00928	0.324
TRG_ER_diArg_1	172	175	PF00400	0.420
TRG_NLS_MonoExtC_3	137	143	PF00514	0.619
TRG_NLS_MonoExtC_3	179	184	PF00514	0.553
TRG_NLS_MonoExtN_4	136	142	PF00514	0.618
TRG_NLS_MonoExtN_4	284	291	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I291	Leptomonas seymouri	70%	100%
A0A0S4JC42	Bodo saltans	53%	100%
A0A1X0NQY2	Trypanosomatidae	58%	100%
A0A3S7X1L9	Leishmania donovani	89%	100%
A0A422NZ09	Trypanosoma rangeli	57%	100%
A4HGM7	Leishmania braziliensis	81%	98%
A4I3Q1	Leishmania infantum	89%	100%
D0A8B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
O14039	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q4Q892	Leishmania major	90%	100%
Q8GYE8	Arabidopsis thaliana	27%	100%
V5BAN7	Trypanosoma cruzi	58%	100%