Arrestin_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZZ1_LEIMU

TriTrypDb:

LmxM.28.1720

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZZ1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006869	lipid transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0071702	organic substance transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0008289	lipid binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.662
CLV_MEL_PAP_1	341	347	PF00089	0.514
CLV_PCSK_SKI1_1	444	448	PF00082	0.449
DEG_APCC_DBOX_1	343	351	PF00400	0.439
DEG_SCF_FBW7_1	80	87	PF00400	0.553
DEG_SPOP_SBC_1	203	207	PF00917	0.512
DEG_SPOP_SBC_1	285	289	PF00917	0.622
DEG_SPOP_SBC_1	29	33	PF00917	0.479
DOC_MAPK_MEF2A_6	134	143	PF00069	0.561
DOC_MAPK_MEF2A_6	337	345	PF00069	0.467
DOC_PP1_RVXF_1	143	149	PF00149	0.519
DOC_PP2B_LxvP_1	451	454	PF13499	0.470
DOC_SPAK_OSR1_1	315	319	PF12202	0.449
DOC_USP7_MATH_1	128	132	PF00917	0.791
DOC_USP7_MATH_1	203	207	PF00917	0.586
DOC_USP7_MATH_1	21	25	PF00917	0.567
DOC_USP7_MATH_1	285	289	PF00917	0.665
DOC_USP7_MATH_1	299	303	PF00917	0.456
DOC_USP7_MATH_1	62	66	PF00917	0.679
DOC_USP7_MATH_1	7	11	PF00917	0.637
DOC_USP7_MATH_1	84	88	PF00917	0.707
DOC_USP7_MATH_1	98	102	PF00917	0.626
DOC_USP7_MATH_2	62	68	PF00917	0.669
DOC_WW_Pin1_4	120	125	PF00397	0.702
DOC_WW_Pin1_4	148	153	PF00397	0.545
DOC_WW_Pin1_4	199	204	PF00397	0.618
DOC_WW_Pin1_4	250	255	PF00397	0.673
DOC_WW_Pin1_4	378	383	PF00397	0.457
DOC_WW_Pin1_4	80	85	PF00397	0.648
LIG_14-3-3_CanoR_1	315	321	PF00244	0.456
LIG_14-3-3_CanoR_1	344	348	PF00244	0.456
LIG_14-3-3_CanoR_1	458	464	PF00244	0.534
LIG_Actin_WH2_2	329	346	PF00022	0.515
LIG_Actin_WH2_2	432	450	PF00022	0.471
LIG_BRCT_BRCA1_1	289	293	PF00533	0.490
LIG_BRCT_BRCA1_1	403	407	PF00533	0.642
LIG_BRCT_BRCA1_1	64	68	PF00533	0.675
LIG_deltaCOP1_diTrp_1	147	154	PF00928	0.407
LIG_FHA_1	110	116	PF00498	0.497
LIG_FHA_1	210	216	PF00498	0.689
LIG_FHA_1	218	224	PF00498	0.600
LIG_FHA_1	368	374	PF00498	0.324
LIG_FHA_1	389	395	PF00498	0.579
LIG_FHA_2	192	198	PF00498	0.639
LIG_IRF3_LxIS_1	25	31	PF10401	0.481
LIG_LIR_Apic_2	372	377	PF02991	0.453
LIG_LIR_Gen_1	151	160	PF02991	0.527
LIG_LIR_Gen_1	359	366	PF02991	0.427
LIG_LIR_Gen_1	405	416	PF02991	0.560
LIG_LIR_Nem_3	151	157	PF02991	0.479
LIG_LIR_Nem_3	359	364	PF02991	0.424
LIG_LIR_Nem_3	405	411	PF02991	0.568
LIG_LIR_Nem_3	87	91	PF02991	0.589
LIG_PCNA_yPIPBox_3	355	367	PF02747	0.430
LIG_Pex14_2	407	411	PF04695	0.614
LIG_SH2_GRB2like	429	432	PF00017	0.562
LIG_SH2_PTP2	361	364	PF00017	0.370
LIG_SH2_SRC	140	143	PF00017	0.567
LIG_SH2_STAT3	280	283	PF00017	0.471
LIG_SH2_STAT5	140	143	PF00017	0.567
LIG_SH2_STAT5	204	207	PF00017	0.712
LIG_SH2_STAT5	313	316	PF00017	0.407
LIG_SH2_STAT5	361	364	PF00017	0.422
LIG_SH2_STAT5	429	432	PF00017	0.562
LIG_SH3_3	161	167	PF00018	0.391
LIG_SH3_3	291	297	PF00018	0.619
LIG_SH3_3	303	309	PF00018	0.495
LIG_SH3_3	342	348	PF00018	0.429
LIG_SH3_3	376	382	PF00018	0.487
LIG_SH3_3	454	460	PF00018	0.440
LIG_TYR_ITIM	138	143	PF00017	0.572
MOD_CK1_1	101	107	PF00069	0.625
MOD_CK1_1	122	128	PF00069	0.647
MOD_CK1_1	14	20	PF00069	0.662
MOD_CK1_1	202	208	PF00069	0.690
MOD_CK1_1	209	215	PF00069	0.629
MOD_CK1_1	237	243	PF00069	0.624
MOD_CK1_1	287	293	PF00069	0.749
MOD_CK1_1	302	308	PF00069	0.416
MOD_CK1_1	414	420	PF00069	0.656
MOD_CK1_1	93	99	PF00069	0.646
MOD_CK2_1	191	197	PF00069	0.813
MOD_CK2_1	292	298	PF00069	0.654
MOD_GlcNHglycan	106	109	PF01048	0.646
MOD_GlcNHglycan	13	16	PF01048	0.613
MOD_GlcNHglycan	130	133	PF01048	0.695
MOD_GlcNHglycan	25	28	PF01048	0.765
MOD_GlcNHglycan	267	270	PF01048	0.749
MOD_GlcNHglycan	38	41	PF01048	0.747
MOD_GlcNHglycan	423	428	PF01048	0.757
MOD_GlcNHglycan	5	8	PF01048	0.654
MOD_GlcNHglycan	64	67	PF01048	0.819
MOD_GlcNHglycan	92	95	PF01048	0.659
MOD_GSK3_1	191	198	PF00069	0.715
MOD_GSK3_1	199	206	PF00069	0.636
MOD_GSK3_1	211	218	PF00069	0.598
MOD_GSK3_1	242	249	PF00069	0.640
MOD_GSK3_1	284	291	PF00069	0.606
MOD_GSK3_1	3	10	PF00069	0.756
MOD_GSK3_1	316	323	PF00069	0.260
MOD_GSK3_1	402	409	PF00069	0.701
MOD_GSK3_1	410	417	PF00069	0.592
MOD_GSK3_1	459	466	PF00069	0.528
MOD_GSK3_1	60	67	PF00069	0.776
MOD_GSK3_1	80	87	PF00069	0.749
MOD_GSK3_1	90	97	PF00069	0.613
MOD_N-GLC_1	234	239	PF02516	0.621
MOD_N-GLC_1	80	85	PF02516	0.587
MOD_N-GLC_2	369	371	PF02516	0.366
MOD_NEK2_1	215	220	PF00069	0.741
MOD_NEK2_1	28	33	PF00069	0.660
MOD_NEK2_1	316	321	PF00069	0.363
MOD_NEK2_1	324	329	PF00069	0.387
MOD_NEK2_1	343	348	PF00069	0.444
MOD_NEK2_1	388	393	PF00069	0.588
MOD_NEK2_1	411	416	PF00069	0.641
MOD_NEK2_1	447	452	PF00069	0.523
MOD_NEK2_2	320	325	PF00069	0.273
MOD_PIKK_1	288	294	PF00454	0.748
MOD_PIKK_1	433	439	PF00454	0.423
MOD_PKA_2	198	204	PF00069	0.737
MOD_PKA_2	343	349	PF00069	0.503
MOD_PKA_2	388	394	PF00069	0.421
MOD_PKA_2	447	453	PF00069	0.484
MOD_Plk_1	433	439	PF00069	0.465
MOD_Plk_4	211	217	PF00069	0.732
MOD_Plk_4	302	308	PF00069	0.521
MOD_Plk_4	380	386	PF00069	0.486
MOD_Plk_4	44	50	PF00069	0.623
MOD_Plk_4	447	453	PF00069	0.485
MOD_ProDKin_1	120	126	PF00069	0.700
MOD_ProDKin_1	148	154	PF00069	0.544
MOD_ProDKin_1	199	205	PF00069	0.618
MOD_ProDKin_1	250	256	PF00069	0.667
MOD_ProDKin_1	378	384	PF00069	0.450
MOD_ProDKin_1	80	86	PF00069	0.646
TRG_DiLeu_BaEn_2	433	439	PF01217	0.483
TRG_ENDOCYTIC_2	140	143	PF00928	0.567
TRG_ENDOCYTIC_2	313	316	PF00928	0.423
TRG_ENDOCYTIC_2	361	364	PF00928	0.430
TRG_ENDOCYTIC_2	408	411	PF00928	0.613
TRG_ER_diArg_1	387	390	PF00400	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P822	Leptomonas seymouri	57%	75%
A0A3S7X1N8	Leishmania donovani	85%	75%
A4HGM5	Leishmania braziliensis	72%	100%
A4I3P9	Leishmania infantum	85%	100%
D0A8B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q894	Leishmania major	89%	99%
V5DBB8	Trypanosoma cruzi	28%	100%