Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZY9_LEIMU

TriTrypDb:

LmxM.28.1700

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AZY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.582
CLV_NRD_NRD_1	207	209	PF00675	0.431
CLV_NRD_NRD_1	335	337	PF00675	0.423
CLV_PCSK_KEX2_1	178	180	PF00082	0.583
CLV_PCSK_KEX2_1	335	337	PF00082	0.423
CLV_PCSK_SKI1_1	114	118	PF00082	0.442
CLV_PCSK_SKI1_1	147	151	PF00082	0.431
CLV_PCSK_SKI1_1	195	199	PF00082	0.537
CLV_PCSK_SKI1_1	395	399	PF00082	0.424
CLV_PCSK_SKI1_1	42	46	PF00082	0.643
CLV_PCSK_SKI1_1	480	484	PF00082	0.549
DEG_APCC_DBOX_1	27	35	PF00400	0.625
DEG_SCF_FBW7_1	100	106	PF00400	0.481
DEG_SCF_FBW7_1	12	18	PF00400	0.531
DEG_SPOP_SBC_1	213	217	PF00917	0.729
DEG_SPOP_SBC_1	55	59	PF00917	0.495
DOC_CKS1_1	100	105	PF01111	0.556
DOC_CKS1_1	12	17	PF01111	0.542
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	368	374	PF00134	0.380
DOC_MAPK_DCC_7	114	124	PF00069	0.446
DOC_MAPK_DCC_7	179	189	PF00069	0.518
DOC_MAPK_gen_1	109	117	PF00069	0.438
DOC_MAPK_gen_1	208	214	PF00069	0.442
DOC_MAPK_gen_1	361	370	PF00069	0.547
DOC_MAPK_HePTP_8	247	259	PF00069	0.371
DOC_MAPK_MEF2A_6	250	259	PF00069	0.360
DOC_MAPK_MEF2A_6	364	372	PF00069	0.453
DOC_PP1_RVXF_1	112	118	PF00149	0.460
DOC_PP2B_LxvP_1	10	13	PF13499	0.717
DOC_PP2B_LxvP_1	130	133	PF13499	0.546
DOC_PP2B_LxvP_1	368	371	PF13499	0.402
DOC_PP2B_LxvP_1	436	439	PF13499	0.497
DOC_PP2B_LxvP_1	45	48	PF13499	0.642
DOC_USP7_MATH_1	213	217	PF00917	0.737
DOC_USP7_MATH_1	224	228	PF00917	0.658
DOC_USP7_MATH_1	352	356	PF00917	0.739
DOC_USP7_MATH_1	357	361	PF00917	0.557
DOC_USP7_MATH_1	50	54	PF00917	0.702
DOC_USP7_MATH_1	64	68	PF00917	0.786
DOC_USP7_MATH_1	82	86	PF00917	0.605
DOC_USP7_MATH_1	87	91	PF00917	0.537
DOC_USP7_UBL2_3	405	409	PF12436	0.442
DOC_WW_Pin1_4	11	16	PF00397	0.657
DOC_WW_Pin1_4	115	120	PF00397	0.435
DOC_WW_Pin1_4	218	223	PF00397	0.700
DOC_WW_Pin1_4	227	232	PF00397	0.753
DOC_WW_Pin1_4	60	65	PF00397	0.747
DOC_WW_Pin1_4	73	78	PF00397	0.612
DOC_WW_Pin1_4	99	104	PF00397	0.613
LIG_14-3-3_CanoR_1	208	213	PF00244	0.509
LIG_14-3-3_CanoR_1	399	406	PF00244	0.456
LIG_14-3-3_CanoR_1	422	426	PF00244	0.587
LIG_14-3-3_CanoR_1	452	456	PF00244	0.475
LIG_14-3-3_CanoR_1	54	64	PF00244	0.753
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_BRCT_BRCA1_1	319	323	PF00533	0.284
LIG_eIF4E_1	304	310	PF01652	0.444
LIG_FHA_1	137	143	PF00498	0.405
LIG_FHA_1	15	21	PF00498	0.510
LIG_FHA_1	280	286	PF00498	0.361
LIG_FHA_1	316	322	PF00498	0.375
LIG_FHA_1	336	342	PF00498	0.457
LIG_FHA_1	346	352	PF00498	0.493
LIG_FHA_1	386	392	PF00498	0.371
LIG_FHA_1	431	437	PF00498	0.458
LIG_FHA_1	477	483	PF00498	0.524
LIG_FHA_1	57	63	PF00498	0.602
LIG_FHA_2	139	145	PF00498	0.494
LIG_FHA_2	228	234	PF00498	0.627
LIG_FHA_2	56	62	PF00498	0.726
LIG_LIR_Apic_2	90	95	PF02991	0.539
LIG_LIR_Gen_1	314	324	PF02991	0.376
LIG_LIR_Nem_3	269	275	PF02991	0.524
LIG_LIR_Nem_3	314	319	PF02991	0.358
LIG_LYPXL_yS_3	272	275	PF13949	0.546
LIG_MYND_1	426	430	PF01753	0.531
LIG_PAM2_1	82	94	PF00658	0.551
LIG_Pex14_2	451	455	PF04695	0.466
LIG_SH2_CRK	157	161	PF00017	0.458
LIG_SH2_CRK	248	252	PF00017	0.409
LIG_SH2_CRK	92	96	PF00017	0.568
LIG_SH2_GRB2like	234	237	PF00017	0.563
LIG_SH2_GRB2like	304	307	PF00017	0.385
LIG_SH2_NCK_1	248	252	PF00017	0.516
LIG_SH2_SRC	155	158	PF00017	0.494
LIG_SH2_STAP1	234	238	PF00017	0.562
LIG_SH2_STAP1	411	415	PF00017	0.441
LIG_SH2_STAT3	173	176	PF00017	0.480
LIG_SH2_STAT3	304	307	PF00017	0.518
LIG_SH2_STAT3	447	450	PF00017	0.526
LIG_SH2_STAT5	155	158	PF00017	0.361
LIG_SH2_STAT5	173	176	PF00017	0.596
LIG_SH2_STAT5	304	307	PF00017	0.385
LIG_SH2_STAT5	386	389	PF00017	0.480
LIG_SH3_1	78	84	PF00018	0.679
LIG_SH3_2	359	364	PF14604	0.584
LIG_SH3_3	1	7	PF00018	0.720
LIG_SH3_3	17	23	PF00018	0.704
LIG_SH3_3	216	222	PF00018	0.673
LIG_SH3_3	327	333	PF00018	0.571
LIG_SH3_3	334	340	PF00018	0.664
LIG_SH3_3	356	362	PF00018	0.668
LIG_SH3_3	74	80	PF00018	0.619
LIG_SH3_3	81	87	PF00018	0.469
LIG_SH3_3	9	15	PF00018	0.672
LIG_SH3_3	94	100	PF00018	0.587
LIG_SH3_4	405	412	PF00018	0.492
LIG_SUMO_SIM_par_1	138	144	PF11976	0.437
LIG_SUMO_SIM_par_1	159	164	PF11976	0.491
LIG_SUMO_SIM_par_1	8	14	PF11976	0.489
LIG_TRAF2_1	123	126	PF00917	0.485
LIG_TRAF2_1	340	343	PF00917	0.534
LIG_TRAF2_1	410	413	PF00917	0.433
LIG_UBA3_1	255	260	PF00899	0.451
LIG_WRC_WIRS_1	104	109	PF05994	0.419
LIG_WW_2	81	84	PF00397	0.570
LIG_WW_3	437	441	PF00397	0.588
MOD_CDK_SPK_2	115	120	PF00069	0.502
MOD_CDK_SPK_2	73	78	PF00069	0.571
MOD_CK1_1	11	17	PF00069	0.657
MOD_CK1_1	217	223	PF00069	0.678
MOD_CK1_1	227	233	PF00069	0.577
MOD_CK1_1	360	366	PF00069	0.677
MOD_CK1_1	404	410	PF00069	0.506
MOD_CK2_1	138	144	PF00069	0.508
MOD_CK2_1	227	233	PF00069	0.468
MOD_CK2_1	407	413	PF00069	0.421
MOD_CK2_1	55	61	PF00069	0.786
MOD_Cter_Amidation	333	336	PF01082	0.385
MOD_DYRK1A_RPxSP_1	99	103	PF00069	0.588
MOD_GlcNHglycan	226	229	PF01048	0.742
MOD_GlcNHglycan	31	34	PF01048	0.572
MOD_GlcNHglycan	354	357	PF01048	0.715
MOD_GlcNHglycan	433	436	PF01048	0.516
MOD_GlcNHglycan	468	471	PF01048	0.596
MOD_GSK3_1	11	18	PF00069	0.535
MOD_GSK3_1	208	215	PF00069	0.605
MOD_GSK3_1	311	318	PF00069	0.465
MOD_GSK3_1	346	353	PF00069	0.733
MOD_GSK3_1	385	392	PF00069	0.424
MOD_GSK3_1	400	407	PF00069	0.504
MOD_GSK3_1	50	57	PF00069	0.739
MOD_GSK3_1	60	67	PF00069	0.709
MOD_GSK3_1	68	75	PF00069	0.637
MOD_GSK3_1	99	106	PF00069	0.583
MOD_NEK2_1	214	219	PF00069	0.538
MOD_NEK2_1	315	320	PF00069	0.370
MOD_NEK2_1	40	45	PF00069	0.715
MOD_NEK2_1	400	405	PF00069	0.261
MOD_NEK2_1	451	456	PF00069	0.450
MOD_NEK2_2	103	108	PF00069	0.430
MOD_NEK2_2	234	239	PF00069	0.575
MOD_PIKK_1	201	207	PF00454	0.403
MOD_PIKK_1	22	28	PF00454	0.727
MOD_PK_1	208	214	PF00069	0.512
MOD_PKA_1	208	214	PF00069	0.442
MOD_PKA_1	335	341	PF00069	0.428
MOD_PKA_2	29	35	PF00069	0.753
MOD_PKA_2	335	341	PF00069	0.436
MOD_PKA_2	360	366	PF00069	0.602
MOD_PKA_2	398	404	PF00069	0.429
MOD_PKA_2	421	427	PF00069	0.627
MOD_PKA_2	430	436	PF00069	0.549
MOD_PKA_2	451	457	PF00069	0.487
MOD_Plk_4	281	287	PF00069	0.322
MOD_Plk_4	87	93	PF00069	0.570
MOD_ProDKin_1	11	17	PF00069	0.658
MOD_ProDKin_1	115	121	PF00069	0.440
MOD_ProDKin_1	218	224	PF00069	0.700
MOD_ProDKin_1	227	233	PF00069	0.752
MOD_ProDKin_1	60	66	PF00069	0.747
MOD_ProDKin_1	73	79	PF00069	0.612
MOD_ProDKin_1	99	105	PF00069	0.598
MOD_SUMO_rev_2	407	415	PF00179	0.453
TRG_DiLeu_BaEn_1	125	130	PF01217	0.501
TRG_DiLeu_BaEn_4	125	131	PF01217	0.504
TRG_ENDOCYTIC_2	272	275	PF00928	0.546
TRG_ER_diArg_1	167	170	PF00400	0.440
TRG_ER_diArg_1	177	179	PF00400	0.494
TRG_ER_diArg_1	27	30	PF00400	0.585
TRG_ER_diArg_1	335	337	PF00400	0.423
TRG_NES_CRM1_1	311	325	PF08389	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F3	Leptomonas seymouri	53%	95%
A0A1X0NSE8	Trypanosomatidae	36%	100%
A0A3Q8IB15	Leishmania donovani	89%	100%
A0A422NZ46	Trypanosoma rangeli	34%	100%
D0A8B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AHG6	Leishmania infantum	89%	100%
Q4Q896	Leishmania major	88%	100%
V5DBC1	Trypanosoma cruzi	36%	100%