Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZY6_LEIMU

TriTrypDb:

LmxM.28.1660

Length:

798

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.486
CLV_C14_Caspase3-7	441	445	PF00656	0.511
CLV_C14_Caspase3-7	533	537	PF00656	0.436
CLV_NRD_NRD_1	454	456	PF00675	0.567
CLV_NRD_NRD_1	72	74	PF00675	0.509
CLV_PCSK_KEX2_1	400	402	PF00082	0.401
CLV_PCSK_KEX2_1	454	456	PF00082	0.567
CLV_PCSK_KEX2_1	72	74	PF00082	0.509
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.384
CLV_PCSK_PC7_1	396	402	PF00082	0.414
CLV_PCSK_SKI1_1	137	141	PF00082	0.443
CLV_PCSK_SKI1_1	691	695	PF00082	0.406
CLV_PCSK_SKI1_1	743	747	PF00082	0.373
DEG_APCC_DBOX_1	354	362	PF00400	0.469
DEG_APCC_DBOX_1	742	750	PF00400	0.403
DEG_SPOP_SBC_1	210	214	PF00917	0.516
DOC_CKS1_1	157	162	PF01111	0.612
DOC_CYCLIN_yCln2_LP_2	190	196	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	685	688	PF00134	0.396
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.353
DOC_MAPK_gen_1	760	767	PF00069	0.489
DOC_MAPK_MEF2A_6	642	650	PF00069	0.544
DOC_MAPK_MEF2A_6	760	767	PF00069	0.419
DOC_PP1_RVXF_1	15	21	PF00149	0.452
DOC_PP2B_LxvP_1	190	193	PF13499	0.431
DOC_PP2B_LxvP_1	316	319	PF13499	0.631
DOC_PP2B_LxvP_1	467	470	PF13499	0.442
DOC_PP2B_LxvP_1	648	651	PF13499	0.551
DOC_PP2B_LxvP_1	685	688	PF13499	0.424
DOC_PP2B_LxvP_1	87	90	PF13499	0.316
DOC_PP4_FxxP_1	41	44	PF00568	0.469
DOC_PP4_MxPP_1	47	50	PF00568	0.462
DOC_SPAK_OSR1_1	434	438	PF12202	0.530
DOC_USP7_MATH_1	202	206	PF00917	0.660
DOC_USP7_MATH_1	217	221	PF00917	0.602
DOC_USP7_MATH_1	224	228	PF00917	0.648
DOC_USP7_MATH_1	240	244	PF00917	0.738
DOC_USP7_MATH_1	262	266	PF00917	0.585
DOC_USP7_MATH_1	296	300	PF00917	0.527
DOC_USP7_MATH_1	353	357	PF00917	0.451
DOC_USP7_MATH_1	457	461	PF00917	0.459
DOC_USP7_MATH_1	541	545	PF00917	0.422
DOC_USP7_MATH_1	571	575	PF00917	0.444
DOC_USP7_MATH_1	6	10	PF00917	0.441
DOC_USP7_MATH_1	74	78	PF00917	0.641
DOC_USP7_UBL2_3	587	591	PF12436	0.408
DOC_WW_Pin1_4	156	161	PF00397	0.711
DOC_WW_Pin1_4	230	235	PF00397	0.782
DOC_WW_Pin1_4	329	334	PF00397	0.599
DOC_WW_Pin1_4	347	352	PF00397	0.640
DOC_WW_Pin1_4	474	479	PF00397	0.388
DOC_WW_Pin1_4	537	542	PF00397	0.447
LIG_14-3-3_CanoR_1	267	274	PF00244	0.510
LIG_14-3-3_CanoR_1	301	308	PF00244	0.667
LIG_14-3-3_CanoR_1	355	359	PF00244	0.494
LIG_14-3-3_CanoR_1	409	417	PF00244	0.417
LIG_14-3-3_CanoR_1	458	465	PF00244	0.572
LIG_14-3-3_CanoR_1	58	65	PF00244	0.579
LIG_14-3-3_CanoR_1	637	642	PF00244	0.557
LIG_14-3-3_CanoR_1	72	80	PF00244	0.512
LIG_BIR_III_2	337	341	PF00653	0.622
LIG_BIR_III_2	669	673	PF00653	0.457
LIG_BIR_III_2	692	696	PF00653	0.440
LIG_BRCT_BRCA1_1	37	41	PF00533	0.466
LIG_CtBP_PxDLS_1	44	48	PF00389	0.460
LIG_eIF4E_1	668	674	PF01652	0.458
LIG_FHA_1	101	107	PF00498	0.520
LIG_FHA_1	116	122	PF00498	0.646
LIG_FHA_1	202	208	PF00498	0.647
LIG_FHA_1	268	274	PF00498	0.499
LIG_FHA_1	355	361	PF00498	0.496
LIG_FHA_1	368	374	PF00498	0.374
LIG_FHA_1	501	507	PF00498	0.457
LIG_FHA_1	537	543	PF00498	0.539
LIG_FHA_1	545	551	PF00498	0.398
LIG_FHA_1	573	579	PF00498	0.418
LIG_FHA_2	231	237	PF00498	0.636
LIG_FHA_2	280	286	PF00498	0.635
LIG_FHA_2	581	587	PF00498	0.410
LIG_FHA_2	628	634	PF00498	0.482
LIG_LIR_Apic_2	38	44	PF02991	0.468
LIG_LIR_Apic_2	422	426	PF02991	0.484
LIG_LIR_Apic_2	713	718	PF02991	0.414
LIG_LIR_Gen_1	370	380	PF02991	0.509
LIG_LIR_Gen_1	544	553	PF02991	0.386
LIG_LIR_Gen_1	599	608	PF02991	0.384
LIG_LIR_Nem_3	370	375	PF02991	0.415
LIG_LIR_Nem_3	392	398	PF02991	0.460
LIG_LIR_Nem_3	475	479	PF02991	0.491
LIG_LIR_Nem_3	544	549	PF02991	0.392
LIG_LIR_Nem_3	596	600	PF02991	0.405
LIG_LIR_Nem_3	706	711	PF02991	0.409
LIG_NRBOX	577	583	PF00104	0.428
LIG_PCNA_yPIPBox_3	165	178	PF02747	0.604
LIG_Rb_pABgroove_1	662	670	PF01858	0.397
LIG_SH2_CRK	476	480	PF00017	0.415
LIG_SH2_CRK	579	583	PF00017	0.435
LIG_SH2_CRK	618	622	PF00017	0.360
LIG_SH2_CRK	668	672	PF00017	0.472
LIG_SH2_NCK_1	194	198	PF00017	0.485
LIG_SH2_NCK_1	423	427	PF00017	0.359
LIG_SH2_SRC	194	197	PF00017	0.485
LIG_SH2_SRC	423	426	PF00017	0.416
LIG_SH2_STAP1	624	628	PF00017	0.409
LIG_SH2_STAT5	367	370	PF00017	0.396
LIG_SH2_STAT5	398	401	PF00017	0.433
LIG_SH2_STAT5	405	408	PF00017	0.355
LIG_SH2_STAT5	476	479	PF00017	0.601
LIG_SH2_STAT5	512	515	PF00017	0.402
LIG_SH2_STAT5	711	714	PF00017	0.420
LIG_SH2_STAT5	770	773	PF00017	0.343
LIG_SH3_1	286	292	PF00018	0.669
LIG_SH3_3	154	160	PF00018	0.616
LIG_SH3_3	178	184	PF00018	0.455
LIG_SH3_3	190	196	PF00018	0.451
LIG_SH3_3	242	248	PF00018	0.731
LIG_SH3_3	256	262	PF00018	0.674
LIG_SH3_3	286	292	PF00018	0.641
LIG_SH3_3	363	369	PF00018	0.493
LIG_SH3_3	377	383	PF00018	0.359
LIG_SH3_3	467	473	PF00018	0.433
LIG_SH3_3	640	646	PF00018	0.605
LIG_SH3_3	715	721	PF00018	0.495
LIG_SH3_3	728	734	PF00018	0.414
LIG_SH3_3	744	750	PF00018	0.410
LIG_SH3_3	96	102	PF00018	0.509
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.474
LIG_SUMO_SIM_anti_2	680	687	PF11976	0.387
LIG_SUMO_SIM_anti_2	722	727	PF11976	0.430
LIG_SUMO_SIM_par_1	179	185	PF11976	0.529
LIG_SUMO_SIM_par_1	547	555	PF11976	0.583
LIG_WRC_WIRS_1	597	602	PF05994	0.387
LIG_WW_3	455	459	PF00397	0.531
MOD_CK1_1	156	162	PF00069	0.610
MOD_CK1_1	227	233	PF00069	0.762
MOD_CK1_1	265	271	PF00069	0.655
MOD_CK1_1	276	282	PF00069	0.673
MOD_CK1_1	332	338	PF00069	0.662
MOD_CK1_1	411	417	PF00069	0.430
MOD_CK1_1	544	550	PF00069	0.317
MOD_CK1_1	580	586	PF00069	0.435
MOD_CK1_1	596	602	PF00069	0.399
MOD_CK1_1	758	764	PF00069	0.438
MOD_CK2_1	279	285	PF00069	0.513
MOD_CK2_1	580	586	PF00069	0.391
MOD_CK2_1	704	710	PF00069	0.447
MOD_GlcNHglycan	184	187	PF01048	0.522
MOD_GlcNHglycan	204	207	PF01048	0.687
MOD_GlcNHglycan	252	255	PF01048	0.746
MOD_GlcNHglycan	303	306	PF01048	0.704
MOD_GlcNHglycan	334	337	PF01048	0.729
MOD_GlcNHglycan	347	350	PF01048	0.626
MOD_GlcNHglycan	4	7	PF01048	0.490
MOD_GlcNHglycan	440	443	PF01048	0.586
MOD_GlcNHglycan	447	450	PF01048	0.556
MOD_GlcNHglycan	50	53	PF01048	0.508
MOD_GlcNHglycan	569	572	PF01048	0.495
MOD_GlcNHglycan	610	613	PF01048	0.310
MOD_GlcNHglycan	66	69	PF01048	0.585
MOD_GlcNHglycan	76	79	PF01048	0.638
MOD_GlcNHglycan	789	792	PF01048	0.367
MOD_GlcNHglycan	8	11	PF01048	0.475
MOD_GSK3_1	111	118	PF00069	0.633
MOD_GSK3_1	19	26	PF00069	0.441
MOD_GSK3_1	2	9	PF00069	0.445
MOD_GSK3_1	224	231	PF00069	0.731
MOD_GSK3_1	250	257	PF00069	0.731
MOD_GSK3_1	262	269	PF00069	0.720
MOD_GSK3_1	296	303	PF00069	0.677
MOD_GSK3_1	367	374	PF00069	0.456
MOD_GSK3_1	537	544	PF00069	0.509
MOD_GSK3_1	567	574	PF00069	0.381
MOD_GSK3_1	585	592	PF00069	0.373
MOD_GSK3_1	59	66	PF00069	0.620
MOD_GSK3_1	751	758	PF00069	0.495
MOD_GSK3_1	769	776	PF00069	0.260
MOD_N-GLC_1	329	334	PF02516	0.594
MOD_NEK2_1	235	240	PF00069	0.660
MOD_NEK2_1	266	271	PF00069	0.598
MOD_NEK2_1	354	359	PF00069	0.641
MOD_NEK2_1	408	413	PF00069	0.354
MOD_NEK2_1	500	505	PF00069	0.441
MOD_NEK2_1	513	518	PF00069	0.434
MOD_NEK2_2	262	267	PF00069	0.529
MOD_NEK2_2	391	396	PF00069	0.359
MOD_PIKK_1	166	172	PF00454	0.440
MOD_PIKK_1	235	241	PF00454	0.525
MOD_PIKK_1	513	519	PF00454	0.388
MOD_PIKK_1	580	586	PF00454	0.407
MOD_PIKK_1	589	595	PF00454	0.610
MOD_PKA_2	266	272	PF00069	0.571
MOD_PKA_2	300	306	PF00069	0.669
MOD_PKA_2	354	360	PF00069	0.501
MOD_PKA_2	408	414	PF00069	0.658
MOD_PKA_2	457	463	PF00069	0.496
MOD_PKB_1	635	643	PF00069	0.551
MOD_Plk_1	391	397	PF00069	0.473
MOD_Plk_1	585	591	PF00069	0.429
MOD_Plk_4	35	41	PF00069	0.507
MOD_Plk_4	367	373	PF00069	0.385
MOD_Plk_4	541	547	PF00069	0.401
MOD_Plk_4	577	583	PF00069	0.378
MOD_Plk_4	596	602	PF00069	0.399
MOD_Plk_4	627	633	PF00069	0.454
MOD_Plk_4	681	687	PF00069	0.439
MOD_Plk_4	719	725	PF00069	0.440
MOD_ProDKin_1	156	162	PF00069	0.707
MOD_ProDKin_1	230	236	PF00069	0.796
MOD_ProDKin_1	329	335	PF00069	0.601
MOD_ProDKin_1	347	353	PF00069	0.632
MOD_ProDKin_1	474	480	PF00069	0.392
MOD_ProDKin_1	537	543	PF00069	0.447
MOD_SUMO_for_1	729	732	PF00179	0.503
TRG_DiLeu_BaEn_1	681	686	PF01217	0.384
TRG_DiLeu_BaLyEn_6	448	453	PF01217	0.480
TRG_DiLeu_BaLyEn_6	744	749	PF01217	0.412
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.417
TRG_ENDOCYTIC_2	405	408	PF00928	0.340
TRG_ENDOCYTIC_2	476	479	PF00928	0.407
TRG_ENDOCYTIC_2	512	515	PF00928	0.404
TRG_ENDOCYTIC_2	579	582	PF00928	0.472
TRG_ENDOCYTIC_2	618	621	PF00928	0.388
TRG_ENDOCYTIC_2	668	671	PF00928	0.488
TRG_ER_diArg_1	121	124	PF00400	0.466
TRG_ER_diArg_1	417	420	PF00400	0.481
TRG_ER_diArg_1	453	455	PF00400	0.621
TRG_ER_diArg_1	520	523	PF00400	0.400
TRG_ER_diArg_1	635	638	PF00400	0.538
TRG_ER_diArg_1	72	74	PF00400	0.509
TRG_ER_diArg_1	759	762	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	619	623	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE00	Leptomonas seymouri	55%	100%
A0A3S7X1J9	Leishmania donovani	89%	100%
A4HGM0	Leishmania braziliensis	80%	100%
A4HHZ8	Leishmania braziliensis	26%	100%
A4I3P5	Leishmania infantum	89%	100%
E9B0H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q899	Leishmania major	87%	100%
V5B7S2	Trypanosoma cruzi	27%	100%