Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 20

Species:

Leishmania mexicana

UniProt:

E9AZY5_LEIMU

TriTrypDb:

LmxM.28.1650

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AZY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZY5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	548	552	PF00656	0.518
CLV_C14_Caspase3-7	831	835	PF00656	0.481
CLV_NRD_NRD_1	161	163	PF00675	0.426
CLV_NRD_NRD_1	2	4	PF00675	0.413
CLV_NRD_NRD_1	229	231	PF00675	0.437
CLV_NRD_NRD_1	31	33	PF00675	0.364
CLV_NRD_NRD_1	409	411	PF00675	0.524
CLV_NRD_NRD_1	493	495	PF00675	0.586
CLV_NRD_NRD_1	505	507	PF00675	0.560
CLV_NRD_NRD_1	532	534	PF00675	0.502
CLV_NRD_NRD_1	56	58	PF00675	0.336
CLV_NRD_NRD_1	802	804	PF00675	0.376
CLV_PCSK_KEX2_1	229	231	PF00082	0.446
CLV_PCSK_KEX2_1	31	33	PF00082	0.364
CLV_PCSK_KEX2_1	409	411	PF00082	0.524
CLV_PCSK_KEX2_1	504	506	PF00082	0.557
CLV_PCSK_KEX2_1	55	57	PF00082	0.366
CLV_PCSK_KEX2_1	800	802	PF00082	0.509
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.366
CLV_PCSK_PC1ET2_1	800	802	PF00082	0.461
CLV_PCSK_SKI1_1	131	135	PF00082	0.367
CLV_PCSK_SKI1_1	235	239	PF00082	0.509
CLV_PCSK_SKI1_1	4	8	PF00082	0.398
CLV_PCSK_SKI1_1	534	538	PF00082	0.617
CLV_PCSK_SKI1_1	629	633	PF00082	0.674
CLV_PCSK_SKI1_1	686	690	PF00082	0.605
CLV_PCSK_SKI1_1	735	739	PF00082	0.622
CLV_PCSK_SKI1_1	762	766	PF00082	0.422
CLV_PCSK_SKI1_1	803	807	PF00082	0.385
CLV_Separin_Metazoa	491	495	PF03568	0.583
DEG_APCC_DBOX_1	234	242	PF00400	0.503
DEG_APCC_DBOX_1	514	522	PF00400	0.567
DEG_APCC_DBOX_1	757	765	PF00400	0.394
DEG_Nend_Nbox_1	1	3	PF02207	0.409
DEG_SPOP_SBC_1	280	284	PF00917	0.658
DEG_SPOP_SBC_1	346	350	PF00917	0.641
DEG_SPOP_SBC_1	624	628	PF00917	0.600
DOC_CKS1_1	630	635	PF01111	0.673
DOC_CYCLIN_RxL_1	229	239	PF00134	0.459
DOC_CYCLIN_RxL_1	515	525	PF00134	0.565
DOC_CYCLIN_RxL_1	800	809	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.350
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.455
DOC_MAPK_gen_1	162	171	PF00069	0.437
DOC_MAPK_gen_1	3	9	PF00069	0.406
DOC_MAPK_gen_1	55	64	PF00069	0.369
DOC_MAPK_gen_1	803	813	PF00069	0.417
DOC_MAPK_HePTP_8	159	171	PF00069	0.503
DOC_MAPK_MEF2A_6	162	171	PF00069	0.437
DOC_MAPK_RevD_3	148	163	PF00069	0.455
DOC_PP2B_LxvP_1	146	149	PF13499	0.349
DOC_PP2B_LxvP_1	150	153	PF13499	0.354
DOC_PP2B_LxvP_1	178	181	PF13499	0.416
DOC_USP7_MATH_1	192	196	PF00917	0.703
DOC_USP7_MATH_1	228	232	PF00917	0.439
DOC_USP7_MATH_1	272	276	PF00917	0.633
DOC_USP7_MATH_1	289	293	PF00917	0.586
DOC_USP7_MATH_1	296	300	PF00917	0.651
DOC_USP7_MATH_1	306	310	PF00917	0.571
DOC_USP7_MATH_1	403	407	PF00917	0.591
DOC_USP7_MATH_1	583	587	PF00917	0.614
DOC_USP7_MATH_1	639	643	PF00917	0.731
DOC_USP7_MATH_1	660	664	PF00917	0.700
DOC_USP7_MATH_1	726	730	PF00917	0.677
DOC_USP7_UBL2_3	800	804	PF12436	0.419
DOC_WW_Pin1_4	351	356	PF00397	0.688
DOC_WW_Pin1_4	370	375	PF00397	0.698
DOC_WW_Pin1_4	378	383	PF00397	0.582
DOC_WW_Pin1_4	387	392	PF00397	0.636
DOC_WW_Pin1_4	421	426	PF00397	0.577
DOC_WW_Pin1_4	434	439	PF00397	0.657
DOC_WW_Pin1_4	460	465	PF00397	0.660
DOC_WW_Pin1_4	499	504	PF00397	0.749
DOC_WW_Pin1_4	608	613	PF00397	0.724
DOC_WW_Pin1_4	617	622	PF00397	0.643
DOC_WW_Pin1_4	629	634	PF00397	0.569
DOC_WW_Pin1_4	687	692	PF00397	0.820
DOC_WW_Pin1_4	714	719	PF00397	0.800
LIG_14-3-3_CanoR_1	345	355	PF00244	0.582
LIG_14-3-3_CanoR_1	362	370	PF00244	0.736
LIG_14-3-3_CanoR_1	546	553	PF00244	0.542
LIG_14-3-3_CanoR_1	661	667	PF00244	0.562
LIG_14-3-3_CanoR_1	686	691	PF00244	0.676
LIG_14-3-3_CanoR_1	758	762	PF00244	0.472
LIG_Actin_WH2_2	478	496	PF00022	0.580
LIG_Actin_WH2_2	818	835	PF00022	0.475
LIG_APCC_ABBA_1	47	52	PF00400	0.452
LIG_BRCT_BRCA1_1	662	666	PF00533	0.512
LIG_BRCT_BRCA1_1	676	680	PF00533	0.492
LIG_EVH1_1	693	697	PF00568	0.656
LIG_EVH1_2	570	574	PF00568	0.663
LIG_FHA_1	13	19	PF00498	0.408
LIG_FHA_1	139	145	PF00498	0.500
LIG_FHA_1	263	269	PF00498	0.338
LIG_FHA_1	388	394	PF00498	0.712
LIG_FHA_1	453	459	PF00498	0.759
LIG_FHA_1	477	483	PF00498	0.576
LIG_FHA_1	64	70	PF00498	0.365
LIG_FHA_1	85	91	PF00498	0.408
LIG_FHA_2	203	209	PF00498	0.378
LIG_FHA_2	352	358	PF00498	0.665
LIG_FHA_2	546	552	PF00498	0.513
LIG_FHA_2	772	778	PF00498	0.468
LIG_FHA_2	829	835	PF00498	0.469
LIG_FHA_2	86	92	PF00498	0.451
LIG_IRF3_LxIS_1	778	783	PF10401	0.433
LIG_LIR_Gen_1	677	688	PF02991	0.528
LIG_LIR_Gen_1	71	81	PF02991	0.362
LIG_LIR_Nem_3	573	577	PF02991	0.643
LIG_LIR_Nem_3	677	683	PF02991	0.557
LIG_LIR_Nem_3	71	76	PF02991	0.364
LIG_NRBOX	760	766	PF00104	0.410
LIG_NRBOX	801	807	PF00104	0.457
LIG_PCNA_PIPBox_1	529	538	PF02747	0.494
LIG_PTB_Apo_2	118	125	PF02174	0.440
LIG_SH2_CRK	156	160	PF00017	0.480
LIG_SH2_STAP1	651	655	PF00017	0.648
LIG_SH2_STAT3	155	158	PF00017	0.420
LIG_SH3_2	500	505	PF14604	0.468
LIG_SH3_3	145	151	PF00018	0.346
LIG_SH3_3	268	274	PF00018	0.480
LIG_SH3_3	353	359	PF00018	0.724
LIG_SH3_3	379	385	PF00018	0.638
LIG_SH3_3	393	399	PF00018	0.660
LIG_SH3_3	497	503	PF00018	0.499
LIG_SH3_3	590	596	PF00018	0.633
LIG_SH3_3	615	621	PF00018	0.624
LIG_SH3_3	627	633	PF00018	0.675
LIG_SH3_3	688	694	PF00018	0.825
LIG_SH3_3	697	703	PF00018	0.674
LIG_SH3_3	712	718	PF00018	0.602
LIG_SUMO_SIM_anti_2	551	557	PF11976	0.556
LIG_SUMO_SIM_anti_2	559	565	PF11976	0.516
LIG_SUMO_SIM_anti_2	71	79	PF11976	0.358
LIG_SUMO_SIM_par_1	13	22	PF11976	0.378
LIG_SUMO_SIM_par_1	216	221	PF11976	0.437
LIG_SUMO_SIM_par_1	65	72	PF11976	0.455
LIG_TRAF2_1	39	42	PF00917	0.491
LIG_TRAF2_1	668	671	PF00917	0.651
LIG_TRAF2_1	774	777	PF00917	0.464
LIG_TRAF2_1	97	100	PF00917	0.399
LIG_TYR_ITIM	154	159	PF00017	0.456
MOD_CDC14_SPxK_1	424	427	PF00782	0.612
MOD_CDC14_SPxK_1	502	505	PF00782	0.599
MOD_CDK_SPK_2	462	467	PF00069	0.665
MOD_CDK_SPK_2	499	504	PF00069	0.543
MOD_CDK_SPK_2	629	634	PF00069	0.724
MOD_CDK_SPK_2	687	692	PF00069	0.614
MOD_CDK_SPxK_1	421	427	PF00069	0.584
MOD_CDK_SPxK_1	499	505	PF00069	0.604
MOD_CDK_SPxxK_3	460	467	PF00069	0.616
MOD_CDK_SPxxK_3	499	506	PF00069	0.651
MOD_CDK_SPxxK_3	629	636	PF00069	0.721
MOD_CK1_1	195	201	PF00069	0.587
MOD_CK1_1	251	257	PF00069	0.419
MOD_CK1_1	282	288	PF00069	0.693
MOD_CK1_1	290	296	PF00069	0.611
MOD_CK1_1	307	313	PF00069	0.561
MOD_CK1_1	348	354	PF00069	0.706
MOD_CK1_1	387	393	PF00069	0.721
MOD_CK1_1	608	614	PF00069	0.754
MOD_CK1_1	705	711	PF00069	0.694
MOD_CK1_1	717	723	PF00069	0.631
MOD_CK1_1	72	78	PF00069	0.342
MOD_CK1_1	79	85	PF00069	0.382
MOD_CK2_1	439	445	PF00069	0.727
MOD_CK2_1	665	671	PF00069	0.723
MOD_CK2_1	745	751	PF00069	0.510
MOD_CK2_1	771	777	PF00069	0.443
MOD_CK2_1	780	786	PF00069	0.377
MOD_CK2_1	85	91	PF00069	0.450
MOD_CK2_1	93	99	PF00069	0.427
MOD_DYRK1A_RPxSP_1	629	633	PF00069	0.723
MOD_DYRK1A_RPxSP_1	634	638	PF00069	0.660
MOD_GlcNHglycan	12	15	PF01048	0.406
MOD_GlcNHglycan	164	167	PF01048	0.472
MOD_GlcNHglycan	197	200	PF01048	0.623
MOD_GlcNHglycan	230	233	PF01048	0.437
MOD_GlcNHglycan	284	287	PF01048	0.729
MOD_GlcNHglycan	289	292	PF01048	0.679
MOD_GlcNHglycan	306	309	PF01048	0.569
MOD_GlcNHglycan	312	315	PF01048	0.644
MOD_GlcNHglycan	319	322	PF01048	0.588
MOD_GlcNHglycan	326	329	PF01048	0.542
MOD_GlcNHglycan	386	389	PF01048	0.656
MOD_GlcNHglycan	567	570	PF01048	0.542
MOD_GlcNHglycan	643	646	PF01048	0.664
MOD_GlcNHglycan	655	658	PF01048	0.676
MOD_GlcNHglycan	676	679	PF01048	0.621
MOD_GlcNHglycan	680	683	PF01048	0.671
MOD_GlcNHglycan	710	714	PF01048	0.625
MOD_GlcNHglycan	728	731	PF01048	0.653
MOD_GlcNHglycan	747	750	PF01048	0.462
MOD_GlcNHglycan	813	816	PF01048	0.353
MOD_GlcNHglycan	836	839	PF01048	0.630
MOD_GSK3_1	193	200	PF00069	0.614
MOD_GSK3_1	218	225	PF00069	0.398
MOD_GSK3_1	251	258	PF00069	0.417
MOD_GSK3_1	272	279	PF00069	0.654
MOD_GSK3_1	306	313	PF00069	0.713
MOD_GSK3_1	336	343	PF00069	0.655
MOD_GSK3_1	345	352	PF00069	0.668
MOD_GSK3_1	373	380	PF00069	0.568
MOD_GSK3_1	434	441	PF00069	0.704
MOD_GSK3_1	458	465	PF00069	0.663
MOD_GSK3_1	608	615	PF00069	0.736
MOD_GSK3_1	625	632	PF00069	0.659
MOD_GSK3_1	649	656	PF00069	0.744
MOD_GSK3_1	662	669	PF00069	0.585
MOD_GSK3_1	674	681	PF00069	0.634
MOD_GSK3_1	68	75	PF00069	0.392
MOD_GSK3_1	705	712	PF00069	0.706
MOD_GSK3_1	713	720	PF00069	0.671
MOD_GSK3_1	733	740	PF00069	0.584
MOD_GSK3_1	828	835	PF00069	0.526
MOD_LATS_1	450	456	PF00433	0.543
MOD_N-GLC_1	10	15	PF02516	0.425
MOD_N-GLC_1	192	197	PF02516	0.647
MOD_N-GLC_1	324	329	PF02516	0.838
MOD_N-GLC_1	421	426	PF02516	0.577
MOD_N-GLC_1	624	629	PF02516	0.602
MOD_N-GLC_1	708	713	PF02516	0.729
MOD_NEK2_1	262	267	PF00069	0.506
MOD_NEK2_1	451	456	PF00069	0.797
MOD_NEK2_1	458	463	PF00069	0.673
MOD_NEK2_1	68	73	PF00069	0.466
MOD_NEK2_1	780	785	PF00069	0.446
MOD_NEK2_1	811	816	PF00069	0.275
MOD_NEK2_1	828	833	PF00069	0.437
MOD_PIKK_1	154	160	PF00454	0.409
MOD_PIKK_1	363	369	PF00454	0.801
MOD_PIKK_1	666	672	PF00454	0.698
MOD_PIKK_1	780	786	PF00454	0.440
MOD_PK_1	5	11	PF00069	0.408
MOD_PKA_1	162	168	PF00069	0.469
MOD_PKA_2	228	234	PF00069	0.427
MOD_PKA_2	248	254	PF00069	0.428
MOD_PKA_2	397	403	PF00069	0.643
MOD_PKA_2	451	457	PF00069	0.717
MOD_PKA_2	458	464	PF00069	0.666
MOD_PKA_2	514	520	PF00069	0.535
MOD_PKA_2	545	551	PF00069	0.540
MOD_PKA_2	653	659	PF00069	0.670
MOD_PKA_2	660	666	PF00069	0.618
MOD_PKA_2	757	763	PF00069	0.588
MOD_PKA_2	832	838	PF00069	0.563
MOD_Plk_1	403	409	PF00069	0.537
MOD_Plk_1	750	756	PF00069	0.453
MOD_Plk_1	828	834	PF00069	0.417
MOD_Plk_1	84	90	PF00069	0.456
MOD_Plk_1	93	99	PF00069	0.412
MOD_Plk_2-3	85	91	PF00069	0.462
MOD_Plk_2-3	94	100	PF00069	0.445
MOD_Plk_4	12	18	PF00069	0.373
MOD_Plk_4	251	257	PF00069	0.464
MOD_Plk_4	313	319	PF00069	0.589
MOD_Plk_4	403	409	PF00069	0.562
MOD_Plk_4	63	69	PF00069	0.356
MOD_Plk_4	662	668	PF00069	0.530
MOD_Plk_4	72	78	PF00069	0.342
MOD_Plk_4	85	91	PF00069	0.408
MOD_Plk_4	99	105	PF00069	0.282
MOD_ProDKin_1	351	357	PF00069	0.690
MOD_ProDKin_1	370	376	PF00069	0.700
MOD_ProDKin_1	378	384	PF00069	0.579
MOD_ProDKin_1	387	393	PF00069	0.635
MOD_ProDKin_1	421	427	PF00069	0.584
MOD_ProDKin_1	434	440	PF00069	0.658
MOD_ProDKin_1	460	466	PF00069	0.656
MOD_ProDKin_1	499	505	PF00069	0.749
MOD_ProDKin_1	608	614	PF00069	0.726
MOD_ProDKin_1	617	623	PF00069	0.642
MOD_ProDKin_1	629	635	PF00069	0.567
MOD_ProDKin_1	687	693	PF00069	0.821
MOD_ProDKin_1	714	720	PF00069	0.801
MOD_SUMO_for_1	413	416	PF00179	0.385
MOD_SUMO_rev_2	157	165	PF00179	0.444
MOD_SUMO_rev_2	508	513	PF00179	0.605
TRG_DiLeu_BaEn_1	488	493	PF01217	0.572
TRG_DiLeu_BaEn_2	776	782	PF01217	0.399
TRG_DiLeu_BaEn_4	93	99	PF01217	0.476
TRG_ENDOCYTIC_2	156	159	PF00928	0.478
TRG_ENDOCYTIC_2	50	53	PF00928	0.396
TRG_ER_diArg_1	30	32	PF00400	0.371
TRG_ER_diArg_1	408	410	PF00400	0.529
TRG_ER_diArg_1	503	506	PF00400	0.596
TRG_ER_diArg_1	56	59	PF00400	0.462
TRG_ER_diArg_1	765	768	PF00400	0.439
TRG_ER_diArg_1	842	845	PF00400	0.736
TRG_NLS_MonoExtC_3	54	59	PF00514	0.356
TRG_NLS_MonoExtC_3	799	804	PF00514	0.414
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	519	524	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	768	773	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	803	808	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM49	Leptomonas seymouri	46%	100%
A0A3S7X1L3	Leishmania donovani	92%	99%
A4HGL9	Leishmania braziliensis	73%	100%
A4I3P4	Leishmania infantum	92%	99%
Q4Q8A0	Leishmania major	88%	100%