DUF3342 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3342), putative

Species:

Leishmania mexicana

UniProt:

E9AZY3_LEIMU

TriTrypDb:

LmxM.28.1630

Length:

606

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.367
CLV_C14_Caspase3-7	371	375	PF00656	0.537
CLV_NRD_NRD_1	276	278	PF00675	0.557
CLV_NRD_NRD_1	347	349	PF00675	0.429
CLV_PCSK_KEX2_1	347	349	PF00082	0.429
CLV_PCSK_SKI1_1	15	19	PF00082	0.398
DEG_APCC_DBOX_1	14	22	PF00400	0.340
DEG_APCC_DBOX_1	346	354	PF00400	0.332
DEG_COP1_1	416	424	PF00400	0.580
DEG_SPOP_SBC_1	552	556	PF00917	0.717
DOC_CYCLIN_RxL_1	342	354	PF00134	0.325
DOC_MAPK_gen_1	347	355	PF00069	0.426
DOC_PP2B_LxvP_1	218	221	PF13499	0.574
DOC_PP2B_LxvP_1	302	305	PF13499	0.563
DOC_PP4_FxxP_1	370	373	PF00568	0.510
DOC_USP7_MATH_1	194	198	PF00917	0.622
DOC_USP7_MATH_1	212	216	PF00917	0.489
DOC_USP7_MATH_1	256	260	PF00917	0.751
DOC_USP7_MATH_1	42	46	PF00917	0.345
DOC_USP7_MATH_1	442	446	PF00917	0.636
DOC_USP7_MATH_1	461	465	PF00917	0.649
DOC_USP7_MATH_1	475	479	PF00917	0.484
DOC_USP7_MATH_1	560	564	PF00917	0.695
DOC_USP7_MATH_1	584	588	PF00917	0.577
DOC_USP7_MATH_1	597	601	PF00917	0.615
DOC_WW_Pin1_4	203	208	PF00397	0.555
DOC_WW_Pin1_4	259	264	PF00397	0.557
DOC_WW_Pin1_4	295	300	PF00397	0.559
DOC_WW_Pin1_4	321	326	PF00397	0.476
DOC_WW_Pin1_4	369	374	PF00397	0.514
DOC_WW_Pin1_4	400	405	PF00397	0.518
DOC_WW_Pin1_4	43	48	PF00397	0.366
DOC_WW_Pin1_4	471	476	PF00397	0.679
DOC_WW_Pin1_4	533	538	PF00397	0.662
DOC_WW_Pin1_4	593	598	PF00397	0.664
LIG_14-3-3_CanoR_1	135	143	PF00244	0.356
LIG_14-3-3_CanoR_1	243	253	PF00244	0.603
LIG_14-3-3_CanoR_1	295	299	PF00244	0.699
LIG_14-3-3_CanoR_1	362	370	PF00244	0.581
LIG_14-3-3_CanoR_1	521	529	PF00244	0.614
LIG_Actin_WH2_2	121	137	PF00022	0.458
LIG_APCC_ABBA_1	150	155	PF00400	0.465
LIG_BRCT_BRCA1_1	119	123	PF00533	0.373
LIG_BRCT_BRCA1_1	93	97	PF00533	0.291
LIG_CaM_NSCaTE_8	333	340	PF13499	0.386
LIG_CSL_BTD_1	204	207	PF09270	0.614
LIG_deltaCOP1_diTrp_1	331	335	PF00928	0.348
LIG_FHA_1	128	134	PF00498	0.367
LIG_FHA_1	221	227	PF00498	0.556
LIG_FHA_1	245	251	PF00498	0.623
LIG_FHA_1	295	301	PF00498	0.639
LIG_FHA_1	325	331	PF00498	0.547
LIG_FHA_1	455	461	PF00498	0.597
LIG_FHA_2	3	9	PF00498	0.370
LIG_IRF3_LxIS_1	529	536	PF10401	0.545
LIG_LIR_Gen_1	379	389	PF02991	0.326
LIG_LIR_Gen_1	481	490	PF02991	0.459
LIG_LIR_Gen_1	68	76	PF02991	0.294
LIG_LIR_Gen_1	94	103	PF02991	0.291
LIG_LIR_Nem_3	379	385	PF02991	0.402
LIG_LIR_Nem_3	595	601	PF02991	0.661
LIG_LIR_Nem_3	68	72	PF02991	0.294
LIG_LYPXL_yS_3	528	531	PF13949	0.461
LIG_NRBOX	351	357	PF00104	0.460
LIG_SH2_CRK	407	411	PF00017	0.603
LIG_SH2_CRK	598	602	PF00017	0.668
LIG_SH2_STAT5	110	113	PF00017	0.340
LIG_SH2_STAT5	173	176	PF00017	0.371
LIG_SH2_STAT5	30	33	PF00017	0.346
LIG_SH2_STAT5	343	346	PF00017	0.354
LIG_SH2_STAT5	382	385	PF00017	0.451
LIG_SH2_STAT5	389	392	PF00017	0.482
LIG_SH2_STAT5	489	492	PF00017	0.584
LIG_SH2_STAT5	506	509	PF00017	0.414
LIG_SH3_3	250	256	PF00018	0.626
LIG_SH3_3	3	9	PF00018	0.398
LIG_SH3_3	41	47	PF00018	0.367
LIG_SH3_3	416	422	PF00018	0.605
LIG_SUMO_SIM_anti_2	500	505	PF11976	0.517
LIG_SUMO_SIM_par_1	297	303	PF11976	0.619
LIG_SUMO_SIM_par_1	351	357	PF11976	0.460
LIG_SUMO_SIM_par_1	416	423	PF11976	0.590
LIG_SUMO_SIM_par_1	495	502	PF11976	0.533
LIG_TYR_ITIM	380	385	PF00017	0.329
LIG_UBA3_1	108	116	PF00899	0.412
LIG_UBA3_1	72	79	PF00899	0.319
LIG_WRC_WIRS_1	421	426	PF05994	0.586
MOD_CK1_1	127	133	PF00069	0.263
MOD_CK1_1	248	254	PF00069	0.646
MOD_CK1_1	259	265	PF00069	0.656
MOD_CK1_1	314	320	PF00069	0.636
MOD_CK1_1	324	330	PF00069	0.489
MOD_CK1_1	432	438	PF00069	0.479
MOD_CK1_1	45	51	PF00069	0.222
MOD_CK1_1	474	480	PF00069	0.586
MOD_CK1_1	553	559	PF00069	0.714
MOD_CK1_1	600	606	PF00069	0.699
MOD_CK2_1	423	429	PF00069	0.638
MOD_CK2_1	43	49	PF00069	0.224
MOD_Cter_Amidation	275	278	PF01082	0.560
MOD_GlcNHglycan	154	159	PF01048	0.529
MOD_GlcNHglycan	197	200	PF01048	0.637
MOD_GlcNHglycan	214	217	PF01048	0.706
MOD_GlcNHglycan	250	253	PF01048	0.595
MOD_GlcNHglycan	258	261	PF01048	0.629
MOD_GlcNHglycan	312	316	PF01048	0.650
MOD_GlcNHglycan	407	410	PF01048	0.598
MOD_GlcNHglycan	434	437	PF01048	0.742
MOD_GlcNHglycan	440	443	PF01048	0.620
MOD_GlcNHglycan	463	466	PF01048	0.699
MOD_GlcNHglycan	477	480	PF01048	0.604
MOD_GlcNHglycan	522	525	PF01048	0.555
MOD_GlcNHglycan	567	570	PF01048	0.657
MOD_GlcNHglycan	580	583	PF01048	0.737
MOD_GSK3_1	119	126	PF00069	0.484
MOD_GSK3_1	212	219	PF00069	0.623
MOD_GSK3_1	244	251	PF00069	0.636
MOD_GSK3_1	43	50	PF00069	0.270
MOD_GSK3_1	432	439	PF00069	0.705
MOD_GSK3_1	461	468	PF00069	0.743
MOD_GSK3_1	471	478	PF00069	0.635
MOD_GSK3_1	550	557	PF00069	0.600
MOD_GSK3_1	560	567	PF00069	0.665
MOD_GSK3_1	593	600	PF00069	0.730
MOD_GSK3_1	87	94	PF00069	0.269
MOD_N-GLC_1	466	471	PF02516	0.528
MOD_N-GLC_1	578	583	PF02516	0.739
MOD_NEK2_1	123	128	PF00069	0.428
MOD_NEK2_1	134	139	PF00069	0.412
MOD_NEK2_1	165	170	PF00069	0.428
MOD_NEK2_1	187	192	PF00069	0.458
MOD_NEK2_1	244	249	PF00069	0.528
MOD_NEK2_1	356	361	PF00069	0.437
MOD_NEK2_1	405	410	PF00069	0.599
MOD_NEK2_1	454	459	PF00069	0.644
MOD_NEK2_1	482	487	PF00069	0.602
MOD_NEK2_1	531	536	PF00069	0.673
MOD_NEK2_1	551	556	PF00069	0.448
MOD_NEK2_1	601	606	PF00069	0.640
MOD_NEK2_1	93	98	PF00069	0.342
MOD_PIKK_1	185	191	PF00454	0.512
MOD_PIKK_1	245	251	PF00454	0.575
MOD_PIKK_1	356	362	PF00454	0.355
MOD_PKA_1	368	374	PF00069	0.537
MOD_PKA_2	134	140	PF00069	0.438
MOD_PKA_2	245	251	PF00069	0.703
MOD_PKA_2	294	300	PF00069	0.494
MOD_PKA_2	361	367	PF00069	0.458
MOD_PKA_2	432	438	PF00069	0.489
MOD_PKA_2	520	526	PF00069	0.615
MOD_PKA_2	531	537	PF00069	0.694
MOD_PKA_2	584	590	PF00069	0.649
MOD_PKB_1	575	583	PF00069	0.661
MOD_Plk_1	123	129	PF00069	0.464
MOD_Plk_1	2	8	PF00069	0.342
MOD_Plk_4	165	171	PF00069	0.429
MOD_Plk_4	351	357	PF00069	0.505
MOD_Plk_4	597	603	PF00069	0.492
MOD_Plk_4	93	99	PF00069	0.416
MOD_ProDKin_1	203	209	PF00069	0.555
MOD_ProDKin_1	259	265	PF00069	0.558
MOD_ProDKin_1	295	301	PF00069	0.561
MOD_ProDKin_1	321	327	PF00069	0.463
MOD_ProDKin_1	369	375	PF00069	0.520
MOD_ProDKin_1	400	406	PF00069	0.529
MOD_ProDKin_1	43	49	PF00069	0.366
MOD_ProDKin_1	471	477	PF00069	0.678
MOD_ProDKin_1	533	539	PF00069	0.662
MOD_ProDKin_1	593	599	PF00069	0.667
MOD_SUMO_rev_2	374	383	PF00179	0.451
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.367
TRG_ENDOCYTIC_2	382	385	PF00928	0.323
TRG_ENDOCYTIC_2	528	531	PF00928	0.582
TRG_ENDOCYTIC_2	598	601	PF00928	0.668
TRG_ER_diArg_1	60	63	PF00400	0.367
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G4	Leptomonas seymouri	45%	93%
A0A3Q8IDU2	Leishmania donovani	87%	97%
A0A3S5ISD3	Trypanosoma rangeli	28%	97%
A4HGL7	Leishmania braziliensis	73%	100%
A4I3P2	Leishmania infantum	88%	100%
D0A8C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q8A2	Leishmania major	88%	100%