LeishMANIAdb
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TRUD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TRUD domain-containing protein
Gene product:
tRNA pseudouridine synthase D (TruD), putative
Species:
Leishmania mexicana
UniProt:
E9AZY2_LEIMU
TriTrypDb:
LmxM.28.1620
Length:
852

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AZY2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZY2

Function

Biological processes
Term Name Level Count
GO:0001522 pseudouridine synthesis 6 10
GO:0006139 nucleobase-containing compound metabolic process 3 10
GO:0006725 cellular aromatic compound metabolic process 3 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0009451 RNA modification 5 10
GO:0009987 cellular process 1 10
GO:0016070 RNA metabolic process 5 10
GO:0034641 cellular nitrogen compound metabolic process 3 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043412 macromolecule modification 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0046483 heterocycle metabolic process 3 10
GO:0071704 organic substance metabolic process 2 10
GO:0090304 nucleic acid metabolic process 4 10
GO:1901360 organic cyclic compound metabolic process 3 10
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0009982 pseudouridine synthase activity 4 12
GO:0016853 isomerase activity 2 12
GO:0016866 intramolecular transferase activity 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0004730 pseudouridylate synthase activity 5 2
GO:0016829 lyase activity 2 2
GO:0016835 carbon-oxygen lyase activity 3 2
GO:0016836 hydro-lyase activity 4 2
GO:0106029 tRNA pseudouridine synthase activity 5 1
GO:0140098 catalytic activity, acting on RNA 3 1
GO:0140101 catalytic activity, acting on a tRNA 4 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 234 238 PF00656 0.450
CLV_C14_Caspase3-7 461 465 PF00656 0.325
CLV_NRD_NRD_1 105 107 PF00675 0.719
CLV_NRD_NRD_1 156 158 PF00675 0.666
CLV_NRD_NRD_1 308 310 PF00675 0.390
CLV_NRD_NRD_1 311 313 PF00675 0.386
CLV_NRD_NRD_1 416 418 PF00675 0.297
CLV_NRD_NRD_1 429 431 PF00675 0.309
CLV_NRD_NRD_1 433 435 PF00675 0.311
CLV_NRD_NRD_1 491 493 PF00675 0.303
CLV_NRD_NRD_1 531 533 PF00675 0.219
CLV_NRD_NRD_1 540 542 PF00675 0.453
CLV_NRD_NRD_1 616 618 PF00675 0.303
CLV_NRD_NRD_1 734 736 PF00675 0.619
CLV_NRD_NRD_1 751 753 PF00675 0.515
CLV_NRD_NRD_1 802 804 PF00675 0.561
CLV_NRD_NRD_1 805 807 PF00675 0.577
CLV_NRD_NRD_1 818 820 PF00675 0.617
CLV_PCSK_FUR_1 309 313 PF00082 0.421
CLV_PCSK_FUR_1 802 806 PF00082 0.591
CLV_PCSK_FUR_1 816 820 PF00082 0.580
CLV_PCSK_KEX2_1 105 107 PF00082 0.645
CLV_PCSK_KEX2_1 156 158 PF00082 0.613
CLV_PCSK_KEX2_1 308 310 PF00082 0.423
CLV_PCSK_KEX2_1 311 313 PF00082 0.425
CLV_PCSK_KEX2_1 428 430 PF00082 0.303
CLV_PCSK_KEX2_1 433 435 PF00082 0.302
CLV_PCSK_KEX2_1 491 493 PF00082 0.303
CLV_PCSK_KEX2_1 531 533 PF00082 0.237
CLV_PCSK_KEX2_1 540 542 PF00082 0.446
CLV_PCSK_KEX2_1 751 753 PF00082 0.515
CLV_PCSK_KEX2_1 760 762 PF00082 0.471
CLV_PCSK_KEX2_1 794 796 PF00082 0.531
CLV_PCSK_KEX2_1 802 804 PF00082 0.505
CLV_PCSK_KEX2_1 805 807 PF00082 0.523
CLV_PCSK_KEX2_1 818 820 PF00082 0.585
CLV_PCSK_PC1ET2_1 760 762 PF00082 0.615
CLV_PCSK_PC1ET2_1 794 796 PF00082 0.542
CLV_PCSK_PC1ET2_1 804 806 PF00082 0.542
CLV_PCSK_PC7_1 429 435 PF00082 0.303
CLV_PCSK_PC7_1 747 753 PF00082 0.524
CLV_PCSK_SKI1_1 233 237 PF00082 0.737
CLV_PCSK_SKI1_1 340 344 PF00082 0.282
CLV_PCSK_SKI1_1 350 354 PF00082 0.390
CLV_PCSK_SKI1_1 410 414 PF00082 0.317
CLV_PCSK_SKI1_1 491 495 PF00082 0.313
CLV_PCSK_SKI1_1 636 640 PF00082 0.429
CLV_PCSK_SKI1_1 70 74 PF00082 0.658
CLV_PCSK_SKI1_1 760 764 PF00082 0.584
CLV_PCSK_SKI1_1 99 103 PF00082 0.493
CLV_Separin_Metazoa 610 614 PF03568 0.303
DEG_APCC_DBOX_1 291 299 PF00400 0.319
DEG_APCC_DBOX_1 339 347 PF00400 0.340
DOC_ANK_TNKS_1 326 333 PF00023 0.171
DOC_CDC14_PxL_1 445 453 PF14671 0.315
DOC_CDC14_PxL_1 76 84 PF14671 0.458
DOC_CKS1_1 4 9 PF01111 0.518
DOC_CYCLIN_RxL_1 613 625 PF00134 0.388
DOC_CYCLIN_RxL_1 758 767 PF00134 0.580
DOC_MAPK_gen_1 308 319 PF00069 0.330
DOC_MAPK_gen_1 428 440 PF00069 0.381
DOC_PP1_RVXF_1 758 765 PF00149 0.634
DOC_PP2B_LxvP_1 667 670 PF13499 0.508
DOC_PP2B_LxvP_1 725 728 PF13499 0.567
DOC_PP4_FxxP_1 4 7 PF00568 0.431
DOC_PP4_FxxP_1 608 611 PF00568 0.303
DOC_PP4_FxxP_1 74 77 PF00568 0.628
DOC_USP7_MATH_1 207 211 PF00917 0.718
DOC_USP7_MATH_1 598 602 PF00917 0.424
DOC_USP7_MATH_1 711 715 PF00917 0.699
DOC_USP7_MATH_1 78 82 PF00917 0.686
DOC_USP7_MATH_1 789 793 PF00917 0.645
DOC_USP7_MATH_1 93 97 PF00917 0.719
DOC_WW_Pin1_4 296 301 PF00397 0.303
DOC_WW_Pin1_4 3 8 PF00397 0.431
DOC_WW_Pin1_4 807 812 PF00397 0.665
DOC_WW_Pin1_4 819 824 PF00397 0.578
LIG_14-3-3_CanoR_1 165 174 PF00244 0.461
LIG_14-3-3_CanoR_1 228 236 PF00244 0.609
LIG_14-3-3_CanoR_1 275 280 PF00244 0.424
LIG_14-3-3_CanoR_1 373 377 PF00244 0.303
LIG_14-3-3_CanoR_1 497 502 PF00244 0.298
LIG_14-3-3_CanoR_1 532 538 PF00244 0.193
LIG_14-3-3_CanoR_1 818 823 PF00244 0.692
LIG_Actin_WH2_2 464 482 PF00022 0.405
LIG_AP2alpha_2 732 734 PF02296 0.635
LIG_APCC_ABBA_1 544 549 PF00400 0.171
LIG_BRCT_BRCA1_1 68 72 PF00533 0.696
LIG_BRCT_BRCA1_1 846 850 PF00533 0.642
LIG_CaM_IQ_9 124 139 PF13499 0.588
LIG_CtBP_PxDLS_1 619 623 PF00389 0.319
LIG_deltaCOP1_diTrp_1 542 547 PF00928 0.424
LIG_EH1_1 22 30 PF00400 0.394
LIG_eIF4E_1 324 330 PF01652 0.337
LIG_FHA_1 197 203 PF00498 0.692
LIG_FHA_1 24 30 PF00498 0.419
LIG_FHA_1 324 330 PF00498 0.315
LIG_FHA_1 506 512 PF00498 0.319
LIG_FHA_1 515 521 PF00498 0.319
LIG_FHA_1 661 667 PF00498 0.659
LIG_FHA_1 832 838 PF00498 0.720
LIG_FHA_2 173 179 PF00498 0.743
LIG_FHA_2 238 244 PF00498 0.321
LIG_FHA_2 37 43 PF00498 0.754
LIG_FHA_2 401 407 PF00498 0.324
LIG_FHA_2 421 427 PF00498 0.454
LIG_FHA_2 441 447 PF00498 0.259
LIG_FHA_2 459 465 PF00498 0.180
LIG_FHA_2 533 539 PF00498 0.360
LIG_FHA_2 558 564 PF00498 0.358
LIG_FHA_2 685 691 PF00498 0.579
LIG_LIR_Apic_2 607 611 PF02991 0.304
LIG_LIR_Apic_2 71 77 PF02991 0.552
LIG_LIR_Gen_1 382 393 PF02991 0.303
LIG_LIR_Gen_1 542 551 PF02991 0.424
LIG_LIR_Nem_3 123 129 PF02991 0.551
LIG_LIR_Nem_3 362 368 PF02991 0.336
LIG_LIR_Nem_3 382 388 PF02991 0.293
LIG_LIR_Nem_3 481 486 PF02991 0.335
LIG_LIR_Nem_3 542 547 PF02991 0.424
LIG_LIR_Nem_3 570 574 PF02991 0.330
LIG_LIR_Nem_3 671 677 PF02991 0.572
LIG_LIR_Nem_3 690 695 PF02991 0.373
LIG_LIR_Nem_3 839 843 PF02991 0.664
LIG_LIR_Nem_3 9 15 PF02991 0.481
LIG_NRBOX 408 414 PF00104 0.303
LIG_PCNA_PIPBox_1 578 587 PF02747 0.337
LIG_PCNA_yPIPBox_3 578 591 PF02747 0.430
LIG_PCNA_yPIPBox_3 641 653 PF02747 0.303
LIG_Pex14_1 543 547 PF04695 0.424
LIG_Pex14_2 12 16 PF04695 0.448
LIG_Pex14_2 335 339 PF04695 0.303
LIG_Pex14_2 395 399 PF04695 0.319
LIG_RPA_C_Fungi 143 155 PF08784 0.382
LIG_SH2_CRK 585 589 PF00017 0.384
LIG_SH2_CRK 644 648 PF00017 0.303
LIG_SH2_CRK 797 801 PF00017 0.651
LIG_SH2_GRB2like 644 647 PF00017 0.303
LIG_SH2_NCK_1 626 630 PF00017 0.369
LIG_SH2_NCK_1 644 648 PF00017 0.235
LIG_SH2_SRC 626 629 PF00017 0.431
LIG_SH2_SRC 644 647 PF00017 0.222
LIG_SH2_SRC 695 698 PF00017 0.663
LIG_SH2_STAP1 626 630 PF00017 0.390
LIG_SH2_STAP1 644 648 PF00017 0.236
LIG_SH2_STAP1 797 801 PF00017 0.651
LIG_SH2_STAT3 369 372 PF00017 0.328
LIG_SH2_STAT3 584 587 PF00017 0.319
LIG_SH2_STAT5 247 250 PF00017 0.303
LIG_SH2_STAT5 285 288 PF00017 0.319
LIG_SH2_STAT5 402 405 PF00017 0.306
LIG_SH2_STAT5 483 486 PF00017 0.379
LIG_SH2_STAT5 559 562 PF00017 0.388
LIG_SH2_STAT5 684 687 PF00017 0.482
LIG_SH3_3 115 121 PF00018 0.680
LIG_SH3_3 325 331 PF00018 0.300
LIG_SH3_3 343 349 PF00018 0.303
LIG_SH3_3 561 567 PF00018 0.303
LIG_SH3_3 608 614 PF00018 0.303
LIG_SH3_3 74 80 PF00018 0.546
LIG_SH3_3 782 788 PF00018 0.534
LIG_SUMO_SIM_anti_2 661 668 PF11976 0.543
LIG_SUMO_SIM_par_1 26 36 PF11976 0.608
LIG_SUMO_SIM_par_1 618 623 PF11976 0.446
LIG_TRAF2_1 39 42 PF00917 0.529
LIG_WRC_WIRS_1 498 503 PF05994 0.424
LIG_WRC_WIRS_1 837 842 PF05994 0.710
LIG_WW_2 77 80 PF00397 0.681
LIG_WW_3 610 614 PF00397 0.303
MOD_CDK_SPK_2 807 812 PF00069 0.665
MOD_CK1_1 187 193 PF00069 0.755
MOD_CK1_1 320 326 PF00069 0.317
MOD_CK1_1 36 42 PF00069 0.728
MOD_CK1_1 767 773 PF00069 0.530
MOD_CK1_1 810 816 PF00069 0.489
MOD_CK1_1 825 831 PF00069 0.713
MOD_CK1_1 833 839 PF00069 0.624
MOD_CK2_1 172 178 PF00069 0.585
MOD_CK2_1 211 217 PF00069 0.630
MOD_CK2_1 237 243 PF00069 0.419
MOD_CK2_1 36 42 PF00069 0.730
MOD_CK2_1 405 411 PF00069 0.327
MOD_CK2_1 420 426 PF00069 0.343
MOD_CK2_1 709 715 PF00069 0.657
MOD_DYRK1A_RPxSP_1 819 823 PF00069 0.704
MOD_GlcNHglycan 167 170 PF01048 0.553
MOD_GlcNHglycan 186 189 PF01048 0.754
MOD_GlcNHglycan 199 202 PF01048 0.581
MOD_GlcNHglycan 209 212 PF01048 0.613
MOD_GlcNHglycan 224 227 PF01048 0.673
MOD_GlcNHglycan 32 38 PF01048 0.451
MOD_GlcNHglycan 456 459 PF01048 0.372
MOD_GlcNHglycan 59 62 PF01048 0.626
MOD_GlcNHglycan 602 605 PF01048 0.388
MOD_GlcNHglycan 711 714 PF01048 0.652
MOD_GlcNHglycan 791 794 PF01048 0.637
MOD_GlcNHglycan 830 833 PF01048 0.739
MOD_GSK3_1 183 190 PF00069 0.761
MOD_GSK3_1 207 214 PF00069 0.639
MOD_GSK3_1 224 231 PF00069 0.705
MOD_GSK3_1 32 39 PF00069 0.621
MOD_GSK3_1 454 461 PF00069 0.363
MOD_GSK3_1 487 494 PF00069 0.337
MOD_GSK3_1 658 665 PF00069 0.515
MOD_GSK3_1 709 716 PF00069 0.712
MOD_GSK3_1 817 824 PF00069 0.765
MOD_GSK3_1 827 834 PF00069 0.729
MOD_GSK3_1 844 851 PF00069 0.496
MOD_LATS_1 273 279 PF00433 0.424
MOD_N-GLC_1 296 301 PF02516 0.296
MOD_N-GLC_1 400 405 PF02516 0.378
MOD_N-GLC_1 789 794 PF02516 0.651
MOD_NEK2_1 248 253 PF00069 0.448
MOD_NEK2_1 400 405 PF00069 0.265
MOD_NEK2_1 652 657 PF00069 0.530
MOD_NEK2_1 72 77 PF00069 0.646
MOD_NEK2_1 764 769 PF00069 0.523
MOD_NEK2_1 817 822 PF00069 0.718
MOD_NEK2_2 631 636 PF00069 0.446
MOD_PIKK_1 187 193 PF00454 0.544
MOD_PIKK_1 420 426 PF00454 0.446
MOD_PIKK_1 6 12 PF00454 0.474
MOD_PIKK_1 739 745 PF00454 0.622
MOD_PIKK_1 767 773 PF00454 0.593
MOD_PK_1 275 281 PF00069 0.395
MOD_PK_1 344 350 PF00069 0.446
MOD_PKA_1 491 497 PF00069 0.303
MOD_PKA_1 531 537 PF00069 0.171
MOD_PKA_1 818 824 PF00069 0.720
MOD_PKA_2 197 203 PF00069 0.643
MOD_PKA_2 372 378 PF00069 0.303
MOD_PKA_2 491 497 PF00069 0.292
MOD_PKA_2 531 537 PF00069 0.258
MOD_PKA_2 549 555 PF00069 0.443
MOD_PKA_2 557 563 PF00069 0.121
MOD_PKA_2 746 752 PF00069 0.614
MOD_PKA_2 817 823 PF00069 0.683
MOD_PKB_1 220 228 PF00069 0.531
MOD_PKB_1 816 824 PF00069 0.735
MOD_Plk_1 122 128 PF00069 0.642
MOD_Plk_1 191 197 PF00069 0.631
MOD_Plk_1 320 326 PF00069 0.317
MOD_Plk_1 344 350 PF00069 0.416
MOD_Plk_1 405 411 PF00069 0.337
MOD_Plk_1 620 626 PF00069 0.414
MOD_Plk_1 764 770 PF00069 0.633
MOD_Plk_2-3 237 243 PF00069 0.321
MOD_Plk_4 122 128 PF00069 0.575
MOD_Plk_4 497 503 PF00069 0.313
MOD_Plk_4 662 668 PF00069 0.584
MOD_ProDKin_1 296 302 PF00069 0.303
MOD_ProDKin_1 3 9 PF00069 0.429
MOD_ProDKin_1 807 813 PF00069 0.670
MOD_ProDKin_1 819 825 PF00069 0.576
MOD_SUMO_for_1 229 232 PF00179 0.659
MOD_SUMO_rev_2 69 75 PF00179 0.742
MOD_SUMO_rev_2 709 718 PF00179 0.650
MOD_SUMO_rev_2 753 762 PF00179 0.589
TRG_DiLeu_BaLyEn_6 162 167 PF01217 0.454
TRG_DiLeu_BaLyEn_6 758 763 PF01217 0.642
TRG_ENDOCYTIC_2 483 486 PF00928 0.361
TRG_ENDOCYTIC_2 585 588 PF00928 0.333
TRG_ENDOCYTIC_2 644 647 PF00928 0.317
TRG_ENDOCYTIC_2 797 800 PF00928 0.649
TRG_ER_diArg_1 131 134 PF00400 0.635
TRG_ER_diArg_1 155 157 PF00400 0.612
TRG_ER_diArg_1 292 295 PF00400 0.303
TRG_ER_diArg_1 308 310 PF00400 0.392
TRG_ER_diArg_1 427 430 PF00400 0.303
TRG_ER_diArg_1 432 434 PF00400 0.302
TRG_ER_diArg_1 491 493 PF00400 0.303
TRG_ER_diArg_1 530 532 PF00400 0.237
TRG_ER_diArg_1 556 559 PF00400 0.446
TRG_ER_diArg_1 801 803 PF00400 0.523
TRG_ER_diArg_1 805 807 PF00400 0.558
TRG_ER_diArg_1 815 818 PF00400 0.654
TRG_NES_CRM1_1 284 296 PF08389 0.360
TRG_NLS_Bipartite_1 794 808 PF00514 0.613
TRG_NLS_MonoCore_2 802 807 PF00514 0.666
TRG_NLS_MonoExtN_4 802 808 PF00514 0.636
TRG_Pf-PMV_PEXEL_1 407 411 PF00026 0.307
TRG_Pf-PMV_PEXEL_1 433 437 PF00026 0.393
TRG_Pf-PMV_PEXEL_1 491 496 PF00026 0.319
TRG_Pf-PMV_PEXEL_1 518 523 PF00026 0.455
TRG_Pf-PMV_PEXEL_1 657 662 PF00026 0.635
TRG_Pf-PMV_PEXEL_1 66 71 PF00026 0.654
TRG_Pf-PMV_PEXEL_1 761 765 PF00026 0.587
TRG_Pf-PMV_PEXEL_1 766 771 PF00026 0.549

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P820 Leptomonas seymouri 66% 86%
A0A0S4K0L8 Bodo saltans 45% 84%
A0A1X0NQX7 Trypanosomatidae 56% 93%
A0A3Q8II50 Leishmania donovani 91% 100%
A0A3S5ISD4 Trypanosoma rangeli 58% 97%
A4HGL5 Leishmania braziliensis 85% 99%
A4I3P1 Leishmania infantum 94% 100%
D0A8C3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 92%
Q08647 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
Q4Q8A3 Leishmania major 90% 100%
V5BFB8 Trypanosoma cruzi 56% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS