YTH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZY1_LEIMU

TriTrypDb:

LmxM.28.1610

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZY1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.652
CLV_PCSK_SKI1_1	184	188	PF00082	0.649
CLV_PCSK_SKI1_1	302	306	PF00082	0.580
DEG_Nend_UBRbox_3	1	3	PF02207	0.766
DEG_SPOP_SBC_1	70	74	PF00917	0.714
DOC_CKS1_1	35	40	PF01111	0.613
DOC_MAPK_gen_1	184	192	PF00069	0.669
DOC_PP1_RVXF_1	126	133	PF00149	0.663
DOC_PP4_FxxP_1	132	135	PF00568	0.507
DOC_USP7_MATH_1	226	230	PF00917	0.790
DOC_USP7_MATH_1	311	315	PF00917	0.699
DOC_USP7_MATH_1	319	323	PF00917	0.653
DOC_USP7_MATH_1	71	75	PF00917	0.800
DOC_USP7_MATH_2	296	302	PF00917	0.631
DOC_USP7_UBL2_3	8	12	PF12436	0.702
DOC_WW_Pin1_4	10	15	PF00397	0.794
DOC_WW_Pin1_4	190	195	PF00397	0.643
DOC_WW_Pin1_4	206	211	PF00397	0.638
DOC_WW_Pin1_4	21	26	PF00397	0.625
DOC_WW_Pin1_4	215	220	PF00397	0.670
DOC_WW_Pin1_4	250	255	PF00397	0.726
DOC_WW_Pin1_4	34	39	PF00397	0.562
DOC_WW_Pin1_4	99	104	PF00397	0.804
LIG_14-3-3_CanoR_1	120	126	PF00244	0.582
LIG_14-3-3_CanoR_1	151	159	PF00244	0.549
LIG_14-3-3_CanoR_1	184	189	PF00244	0.377
LIG_14-3-3_CanoR_1	19	27	PF00244	0.722
LIG_14-3-3_CanoR_1	313	317	PF00244	0.739
LIG_14-3-3_CanoR_1	82	91	PF00244	0.506
LIG_BRCT_BRCA1_1	269	273	PF00533	0.751
LIG_EVH1_2	293	297	PF00568	0.700
LIG_FHA_1	153	159	PF00498	0.592
LIG_FHA_1	53	59	PF00498	0.584
LIG_FHA_1	90	96	PF00498	0.476
LIG_FHA_2	100	106	PF00498	0.811
LIG_FHA_2	35	41	PF00498	0.682
LIG_LIR_Apic_2	215	219	PF02991	0.526
LIG_LIR_Nem_3	44	48	PF02991	0.621
LIG_PAM2_1	250	262	PF00658	0.754
LIG_RPA_C_Fungi	174	186	PF08784	0.647
LIG_SH2_CRK	216	220	PF00017	0.604
LIG_SH2_CRK	35	39	PF00017	0.773
LIG_SH2_CRK	45	49	PF00017	0.572
LIG_SH2_CRK	68	72	PF00017	0.771
LIG_SH2_NCK_1	216	220	PF00017	0.604
LIG_SH2_STAP1	299	303	PF00017	0.530
LIG_SH2_STAT5	57	60	PF00017	0.720
LIG_SH3_1	216	222	PF00018	0.527
LIG_SH3_3	207	213	PF00018	0.807
LIG_SH3_3	216	222	PF00018	0.670
LIG_SH3_3	290	296	PF00018	0.694
LIG_TRAF2_1	102	105	PF00917	0.812
MOD_CDC14_SPxK_1	218	221	PF00782	0.604
MOD_CDK_SPK_2	34	39	PF00069	0.699
MOD_CDK_SPxK_1	215	221	PF00069	0.607
MOD_CK1_1	21	27	PF00069	0.765
MOD_CK1_1	215	221	PF00069	0.661
MOD_CK1_1	98	104	PF00069	0.567
MOD_CK2_1	151	157	PF00069	0.593
MOD_CK2_1	164	170	PF00069	0.489
MOD_CK2_1	312	318	PF00069	0.710
MOD_CK2_1	99	105	PF00069	0.806
MOD_GlcNHglycan	145	148	PF01048	0.679
MOD_GlcNHglycan	166	169	PF01048	0.651
MOD_GlcNHglycan	172	176	PF01048	0.555
MOD_GlcNHglycan	20	23	PF01048	0.769
MOD_GlcNHglycan	228	231	PF01048	0.825
MOD_GlcNHglycan	246	249	PF01048	0.510
MOD_GSK3_1	208	215	PF00069	0.573
MOD_GSK3_1	240	247	PF00069	0.734
MOD_GSK3_1	274	281	PF00069	0.757
MOD_GSK3_1	283	290	PF00069	0.657
MOD_GSK3_1	319	326	PF00069	0.810
MOD_GSK3_1	48	55	PF00069	0.644
MOD_GSK3_1	89	96	PF00069	0.765
MOD_LATS_1	111	117	PF00433	0.730
MOD_N-GLC_1	143	148	PF02516	0.695
MOD_N-GLC_1	274	279	PF02516	0.779
MOD_N-GLC_1	282	287	PF02516	0.740
MOD_NEK2_1	164	169	PF00069	0.642
MOD_NEK2_1	282	287	PF00069	0.728
MOD_NEK2_1	48	53	PF00069	0.738
MOD_NEK2_1	94	99	PF00069	0.779
MOD_NEK2_2	240	245	PF00069	0.535
MOD_PIKK_1	106	112	PF00454	0.736
MOD_PIKK_1	323	329	PF00454	0.709
MOD_PIKK_1	71	77	PF00454	0.652
MOD_PK_1	113	119	PF00069	0.801
MOD_PKA_1	184	190	PF00069	0.381
MOD_PKA_2	18	24	PF00069	0.815
MOD_PKA_2	312	318	PF00069	0.738
MOD_PKA_2	81	87	PF00069	0.743
MOD_Plk_1	171	177	PF00069	0.651
MOD_Plk_1	282	288	PF00069	0.614
MOD_Plk_1	53	59	PF00069	0.725
MOD_Plk_4	113	119	PF00069	0.685
MOD_Plk_4	240	246	PF00069	0.744
MOD_Plk_4	283	289	PF00069	0.712
MOD_Plk_4	53	59	PF00069	0.725
MOD_ProDKin_1	10	16	PF00069	0.796
MOD_ProDKin_1	190	196	PF00069	0.650
MOD_ProDKin_1	206	212	PF00069	0.635
MOD_ProDKin_1	21	27	PF00069	0.626
MOD_ProDKin_1	215	221	PF00069	0.672
MOD_ProDKin_1	250	256	PF00069	0.729
MOD_ProDKin_1	34	40	PF00069	0.555
MOD_ProDKin_1	99	105	PF00069	0.806
TRG_DiLeu_BaEn_1	157	162	PF01217	0.631
TRG_DiLeu_BaLyEn_6	125	130	PF01217	0.576
TRG_DiLeu_LyEn_5	44	49	PF01217	0.738
TRG_ENDOCYTIC_2	45	48	PF00928	0.619
TRG_ER_diArg_1	79	82	PF00400	0.630
TRG_NES_CRM1_1	157	170	PF08389	0.522
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID56	Leishmania donovani	86%	100%
A4HGL4	Leishmania braziliensis	74%	99%
A4I3P0	Leishmania infantum	86%	100%
Q4Q8A4	Leishmania major	84%	100%