Kelch repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Galactose oxidase, central domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AZX9_LEIMU

TriTrypDb:

LmxM.28.1590

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.540
CLV_NRD_NRD_1	41	43	PF00675	0.566
CLV_PCSK_KEX2_1	157	159	PF00082	0.540
CLV_PCSK_KEX2_1	41	43	PF00082	0.566
CLV_PCSK_SKI1_1	372	376	PF00082	0.521
CLV_PCSK_SKI1_1	397	401	PF00082	0.480
CLV_PCSK_SKI1_1	87	91	PF00082	0.487
DEG_APCC_DBOX_1	157	165	PF00400	0.499
DEG_MDM2_SWIB_1	275	283	PF02201	0.483
DEG_Nend_UBRbox_2	1	3	PF02207	0.518
DOC_CKS1_1	409	414	PF01111	0.599
DOC_CYCLIN_RxL_1	242	250	PF00134	0.532
DOC_MAPK_gen_1	157	166	PF00069	0.287
DOC_MAPK_HePTP_8	4	16	PF00069	0.259
DOC_MAPK_MEF2A_6	160	168	PF00069	0.266
DOC_MAPK_MEF2A_6	245	253	PF00069	0.445
DOC_MAPK_MEF2A_6	7	16	PF00069	0.259
DOC_PP1_RVXF_1	354	361	PF00149	0.429
DOC_PP2B_LxvP_1	21	24	PF13499	0.611
DOC_PP4_FxxP_1	253	256	PF00568	0.423
DOC_USP7_MATH_1	104	108	PF00917	0.271
DOC_USP7_MATH_1	234	238	PF00917	0.450
DOC_USP7_MATH_1	24	28	PF00917	0.690
DOC_USP7_MATH_1	377	381	PF00917	0.572
DOC_USP7_MATH_1	52	56	PF00917	0.558
DOC_USP7_MATH_1	63	67	PF00917	0.522
DOC_WW_Pin1_4	170	175	PF00397	0.554
DOC_WW_Pin1_4	232	237	PF00397	0.389
DOC_WW_Pin1_4	238	243	PF00397	0.343
DOC_WW_Pin1_4	297	302	PF00397	0.760
DOC_WW_Pin1_4	372	377	PF00397	0.550
DOC_WW_Pin1_4	386	391	PF00397	0.314
DOC_WW_Pin1_4	408	413	PF00397	0.615
DOC_WW_Pin1_4	59	64	PF00397	0.673
DOC_WW_Pin1_4	79	84	PF00397	0.542
LIG_14-3-3_CanoR_1	245	250	PF00244	0.525
LIG_14-3-3_CanoR_1	330	338	PF00244	0.578
LIG_APCC_ABBA_1	164	169	PF00400	0.503
LIG_BIR_III_2	122	126	PF00653	0.674
LIG_BIR_III_2	171	175	PF00653	0.576
LIG_BRCT_BRCA1_1	249	253	PF00533	0.484
LIG_deltaCOP1_diTrp_1	277	281	PF00928	0.477
LIG_DLG_GKlike_1	245	252	PF00625	0.420
LIG_FHA_1	111	117	PF00498	0.495
LIG_FHA_1	183	189	PF00498	0.311
LIG_FHA_1	255	261	PF00498	0.484
LIG_FHA_1	387	393	PF00498	0.401
LIG_FHA_1	416	422	PF00498	0.578
LIG_FHA_1	80	86	PF00498	0.517
LIG_FHA_2	185	191	PF00498	0.493
LIG_FHA_2	298	304	PF00498	0.759
LIG_FHA_2	52	58	PF00498	0.602
LIG_LIR_Apic_2	250	256	PF02991	0.484
LIG_LIR_Gen_1	274	283	PF02991	0.471
LIG_LIR_Gen_1	285	296	PF02991	0.485
LIG_LIR_Gen_1	65	74	PF02991	0.467
LIG_LIR_Nem_3	257	262	PF02991	0.471
LIG_LIR_Nem_3	274	278	PF02991	0.442
LIG_LIR_Nem_3	285	291	PF02991	0.377
LIG_LIR_Nem_3	65	70	PF02991	0.433
LIG_Pex14_2	275	279	PF04695	0.476
LIG_SH2_GRB2like	74	77	PF00017	0.603
LIG_SH2_SRC	162	165	PF00017	0.232
LIG_SH2_STAP1	162	166	PF00017	0.488
LIG_SH2_STAT5	146	149	PF00017	0.439
LIG_SH2_STAT5	205	208	PF00017	0.402
LIG_SH2_STAT5	221	224	PF00017	0.269
LIG_SH2_STAT5	337	340	PF00017	0.519
LIG_SH2_STAT5	388	391	PF00017	0.413
LIG_SH2_STAT5	74	77	PF00017	0.314
LIG_SH3_3	17	23	PF00018	0.591
LIG_SH3_3	287	293	PF00018	0.572
LIG_SH3_3	312	318	PF00018	0.582
LIG_SH3_3	406	412	PF00018	0.626
LIG_SH3_3	46	52	PF00018	0.541
LIG_SH3_3	6	12	PF00018	0.508
LIG_SH3_3	94	100	PF00018	0.554
LIG_SH3_CIN85_PxpxPR_1	240	245	PF14604	0.389
LIG_SUMO_SIM_anti_2	248	253	PF11976	0.469
LIG_SUMO_SIM_anti_2	26	40	PF11976	0.638
LIG_SUMO_SIM_par_1	245	250	PF11976	0.497
LIG_SUMO_SIM_par_1	415	420	PF11976	0.560
LIG_TRAF2_1	301	304	PF00917	0.703
LIG_TRAF2_2	293	298	PF00917	0.624
LIG_WRC_WIRS_1	272	277	PF05994	0.498
MOD_CDK_SPK_2	59	64	PF00069	0.524
MOD_CDK_SPxxK_3	238	245	PF00069	0.480
MOD_CK1_1	235	241	PF00069	0.402
MOD_CK1_1	420	426	PF00069	0.582
MOD_CK1_1	59	65	PF00069	0.657
MOD_CK2_1	184	190	PF00069	0.580
MOD_CK2_1	297	303	PF00069	0.751
MOD_CK2_1	59	65	PF00069	0.577
MOD_GlcNHglycan	116	119	PF01048	0.672
MOD_GlcNHglycan	131	134	PF01048	0.636
MOD_GlcNHglycan	333	336	PF01048	0.587
MOD_GlcNHglycan	379	382	PF01048	0.644
MOD_GlcNHglycan	412	415	PF01048	0.560
MOD_GlcNHglycan	422	425	PF01048	0.509
MOD_GlcNHglycan	46	49	PF01048	0.525
MOD_GlcNHglycan	57	61	PF01048	0.599
MOD_GlcNHglycan	79	82	PF01048	0.528
MOD_GSK3_1	104	111	PF00069	0.574
MOD_GSK3_1	210	217	PF00069	0.459
MOD_GSK3_1	234	241	PF00069	0.417
MOD_GSK3_1	282	289	PF00069	0.484
MOD_GSK3_1	329	336	PF00069	0.585
MOD_GSK3_1	388	395	PF00069	0.552
MOD_GSK3_1	52	59	PF00069	0.596
MOD_GSK3_1	75	82	PF00069	0.404
MOD_N-GLC_1	346	351	PF02516	0.568
MOD_N-GLC_1	75	80	PF02516	0.588
MOD_NEK2_1	247	252	PF00069	0.425
MOD_NEK2_1	331	336	PF00069	0.528
MOD_NEK2_1	415	420	PF00069	0.532
MOD_NEK2_1	56	61	PF00069	0.660
MOD_PIKK_1	210	216	PF00454	0.447
MOD_PKA_2	329	335	PF00069	0.602
MOD_PKA_2	63	69	PF00069	0.577
MOD_Plk_2-3	271	277	PF00069	0.415
MOD_Plk_4	111	117	PF00069	0.495
MOD_Plk_4	247	253	PF00069	0.438
MOD_Plk_4	255	261	PF00069	0.457
MOD_Plk_4	333	339	PF00069	0.537
MOD_Plk_4	388	394	PF00069	0.475
MOD_Plk_4	63	69	PF00069	0.575
MOD_ProDKin_1	170	176	PF00069	0.554
MOD_ProDKin_1	232	238	PF00069	0.389
MOD_ProDKin_1	297	303	PF00069	0.765
MOD_ProDKin_1	372	378	PF00069	0.549
MOD_ProDKin_1	386	392	PF00069	0.310
MOD_ProDKin_1	408	414	PF00069	0.598
MOD_ProDKin_1	59	65	PF00069	0.657
MOD_ProDKin_1	79	85	PF00069	0.539
TRG_DiLeu_BaEn_1	396	401	PF01217	0.561
TRG_DiLeu_BaEn_1	65	70	PF01217	0.467
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.347
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.507
TRG_ER_diArg_1	4	7	PF00400	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P824	Leptomonas seymouri	52%	100%
A0A1X0NSF3	Trypanosomatidae	34%	100%
A0A3R7MSX4	Trypanosoma rangeli	39%	100%
A0A3S7X1L8	Leishmania donovani	92%	100%
A4HGL2	Leishmania braziliensis	84%	100%
A4I3N8	Leishmania infantum	92%	100%
D0A8C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q8A6	Leishmania major	91%	100%
V5AVA5	Trypanosoma cruzi	37%	100%