Putative hydrolase, alpha/beta fold family

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrolase, alpha/beta fold family, putative

Species:

Leishmania mexicana

UniProt:

E9AZX7_LEIMU

TriTrypDb:

LmxM.28.1570

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZX7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	26
GO:0016787	hydrolase activity	2	26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	279	281	PF00675	0.354
CLV_PCSK_KEX2_1	54	56	PF00082	0.449
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.449
CLV_PCSK_SKI1_1	245	249	PF00082	0.274
CLV_PCSK_SKI1_1	280	284	PF00082	0.240
CLV_PCSK_SKI1_1	33	37	PF00082	0.487
CLV_PCSK_SKI1_1	54	58	PF00082	0.411
DOC_MAPK_MEF2A_6	181	189	PF00069	0.389
DOC_MAPK_MEF2A_6	280	289	PF00069	0.271
DOC_MAPK_MEF2A_6	319	328	PF00069	0.400
DOC_PP1_RVXF_1	311	318	PF00149	0.355
DOC_PP2B_LxvP_1	124	127	PF13499	0.294
DOC_PP4_FxxP_1	116	119	PF00568	0.414
DOC_PP4_FxxP_1	63	66	PF00568	0.348
DOC_USP7_MATH_1	12	16	PF00917	0.684
DOC_USP7_MATH_1	27	31	PF00917	0.567
DOC_USP7_MATH_1	6	10	PF00917	0.674
DOC_USP7_UBL2_3	277	281	PF12436	0.219
DOC_WW_Pin1_4	22	27	PF00397	0.536
LIG_14-3-3_CanoR_1	123	127	PF00244	0.341
LIG_14-3-3_CanoR_1	181	186	PF00244	0.261
LIG_14-3-3_CanoR_1	22	26	PF00244	0.370
LIG_14-3-3_CanoR_1	280	285	PF00244	0.293
LIG_AP2alpha_1	39	43	PF02296	0.432
LIG_APCC_ABBA_1	89	94	PF00400	0.196
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	109	113	PF00533	0.364
LIG_DLG_GKlike_1	181	188	PF00625	0.397
LIG_eIF4E_1	303	309	PF01652	0.389
LIG_eIF4E_1	323	329	PF01652	0.189
LIG_FHA_1	2	8	PF00498	0.469
LIG_FHA_1	284	290	PF00498	0.229
LIG_FHA_2	60	66	PF00498	0.362
LIG_GBD_Chelix_1	73	81	PF00786	0.431
LIG_LIR_Apic_2	115	119	PF02991	0.402
LIG_LIR_Apic_2	62	66	PF02991	0.383
LIG_LIR_Gen_1	110	121	PF02991	0.450
LIG_LIR_Gen_1	40	50	PF02991	0.473
LIG_LIR_Gen_1	57	66	PF02991	0.318
LIG_LIR_Nem_3	110	116	PF02991	0.400
LIG_LIR_Nem_3	40	46	PF02991	0.419
LIG_LIR_Nem_3	57	63	PF02991	0.304
LIG_LIR_Nem_3	94	100	PF02991	0.305
LIG_MYND_2	118	122	PF01753	0.196
LIG_Pex14_1	226	230	PF04695	0.389
LIG_Pex14_2	39	43	PF04695	0.432
LIG_Pex14_2	88	92	PF04695	0.322
LIG_SH2_GRB2like	102	105	PF00017	0.299
LIG_SH2_STAP1	205	209	PF00017	0.389
LIG_SH2_STAT3	230	233	PF00017	0.389
LIG_SH2_STAT5	138	141	PF00017	0.305
LIG_SH2_STAT5	230	233	PF00017	0.351
LIG_SH2_STAT5	323	326	PF00017	0.353
LIG_SH2_STAT5	84	87	PF00017	0.326
LIG_SH2_STAT5	98	101	PF00017	0.285
LIG_SH3_3	194	200	PF00018	0.404
LIG_SH3_3	279	285	PF00018	0.316
LIG_SH3_3	292	298	PF00018	0.276
LIG_SH3_3	312	318	PF00018	0.332
LIG_SH3_3	63	69	PF00018	0.414
LIG_SH3_3	80	86	PF00018	0.340
LIG_WRC_WIRS_1	60	65	PF05994	0.309
MOD_CK2_1	128	134	PF00069	0.312
MOD_CK2_1	246	252	PF00069	0.442
MOD_Cter_Amidation	52	55	PF01082	0.467
MOD_GlcNHglycan	215	218	PF01048	0.330
MOD_GSK3_1	1	8	PF00069	0.688
MOD_GSK3_1	104	111	PF00069	0.364
MOD_GSK3_1	12	19	PF00069	0.730
MOD_GSK3_1	22	29	PF00069	0.527
MOD_GSK3_1	45	52	PF00069	0.480
MOD_N-GLC_1	338	343	PF02516	0.391
MOD_NEK2_1	1	6	PF00069	0.501
MOD_NEK2_1	162	167	PF00069	0.338
MOD_NEK2_1	246	251	PF00069	0.222
MOD_NEK2_1	338	343	PF00069	0.439
MOD_NEK2_1	77	82	PF00069	0.395
MOD_PIKK_1	108	114	PF00454	0.196
MOD_PIKK_1	229	235	PF00454	0.389
MOD_PKA_1	280	286	PF00069	0.372
MOD_PKA_1	54	60	PF00069	0.437
MOD_PKA_2	104	110	PF00069	0.390
MOD_PKA_2	122	128	PF00069	0.284
MOD_PKA_2	21	27	PF00069	0.384
MOD_PKA_2	54	60	PF00069	0.464
MOD_Plk_1	338	344	PF00069	0.468
MOD_Plk_4	198	204	PF00069	0.382
MOD_Plk_4	283	289	PF00069	0.229
MOD_Plk_4	77	83	PF00069	0.419
MOD_ProDKin_1	22	28	PF00069	0.524
MOD_SUMO_rev_2	34	44	PF00179	0.503
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.393
TRG_ENDOCYTIC_2	205	208	PF00928	0.389
TRG_ENDOCYTIC_2	323	326	PF00928	0.407
TRG_ENDOCYTIC_2	60	63	PF00928	0.328
TRG_ENDOCYTIC_2	97	100	PF00928	0.309
TRG_NES_CRM1_1	146	158	PF08389	0.253

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D3	Leptomonas seymouri	30%	80%
A0A0N0P3S4	Leptomonas seymouri	40%	95%
A0A0N1PA10	Leptomonas seymouri	67%	100%
A0A0N1PCQ2	Leptomonas seymouri	47%	100%
A0A0S4JQB3	Bodo saltans	40%	100%
A0A1X0NSR3	Trypanosomatidae	38%	77%
A0A1X0NSS6	Trypanosomatidae	45%	100%
A0A3Q8IAY1	Leishmania donovani	37%	89%
A0A3R7KKJ0	Trypanosoma rangeli	43%	100%
A0A3S5IRR1	Trypanosoma rangeli	31%	85%
A0A3S7WUJ3	Leishmania donovani	41%	100%
A0A3S7WUK0	Leishmania donovani	31%	80%
A0A3S7X1K2	Leishmania donovani	90%	100%
A0A422NS41	Trypanosoma rangeli	37%	80%
A4H956	Leishmania braziliensis	44%	100%
A4H959	Leishmania braziliensis	30%	100%
A4H960	Leishmania braziliensis	41%	100%
A4HGL0	Leishmania braziliensis	80%	100%
A4HXH8	Leishmania infantum	41%	100%
A4HXI1	Leishmania infantum	31%	80%
A4HXI2	Leishmania infantum	38%	89%
A4I3N6	Leishmania infantum	90%	100%
C9ZP69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	86%
C9ZP70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AR73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AR76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AR77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
P00632	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	27%	100%
P26495	Pseudomonas oleovorans	27%	100%
Q4Q8A8	Leishmania major	89%	100%
Q4QE86	Leishmania major	38%	100%
Q4QE87	Leishmania major	32%	100%
Q4QE90	Leishmania major	42%	100%
Q54528	Streptomyces purpurascens	32%	100%
Q54809	Streptomyces peucetius	30%	100%
Q55217	Streptomyces sp. (strain C5)	30%	100%
Q59093	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	26%	100%
Q59695	Pseudomonas putida	24%	94%
Q83WC8	Acinetobacter calcoaceticus	24%	100%
V5AZB9	Trypanosoma cruzi	39%	81%
V5BER0	Trypanosoma cruzi	45%	100%
V5BNU9	Trypanosoma cruzi	30%	85%