Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZX6_LEIMU

TriTrypDb:

LmxM.28.1560

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.683
CLV_C14_Caspase3-7	554	558	PF00656	0.698
CLV_NRD_NRD_1	22	24	PF00675	0.675
CLV_NRD_NRD_1	223	225	PF00675	0.537
CLV_NRD_NRD_1	415	417	PF00675	0.702
CLV_NRD_NRD_1	429	431	PF00675	0.655
CLV_PCSK_KEX2_1	109	111	PF00082	0.727
CLV_PCSK_KEX2_1	22	24	PF00082	0.552
CLV_PCSK_KEX2_1	223	225	PF00082	0.537
CLV_PCSK_KEX2_1	429	431	PF00082	0.800
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.727
CLV_PCSK_PC7_1	105	111	PF00082	0.552
CLV_PCSK_SKI1_1	380	384	PF00082	0.374
CLV_PCSK_SKI1_1	82	86	PF00082	0.661
DEG_APCC_DBOX_1	47	55	PF00400	0.650
DEG_COP1_1	111	121	PF00400	0.533
DEG_Nend_UBRbox_2	1	3	PF02207	0.619
DEG_SCF_FBW7_1	148	154	PF00400	0.660
DEG_SPOP_SBC_1	254	258	PF00917	0.622
DEG_SPOP_SBC_1	537	541	PF00917	0.529
DOC_CDC14_PxL_1	115	123	PF14671	0.528
DOC_CKS1_1	148	153	PF01111	0.661
DOC_CKS1_1	265	270	PF01111	0.508
DOC_MAPK_gen_1	109	115	PF00069	0.538
DOC_MAPK_gen_1	350	357	PF00069	0.540
DOC_MAPK_gen_1	390	398	PF00069	0.637
DOC_MAPK_MEF2A_6	350	357	PF00069	0.540
DOC_MAPK_NFAT4_5	350	358	PF00069	0.489
DOC_PP2B_LxvP_1	396	399	PF13499	0.605
DOC_PP4_FxxP_1	246	249	PF00568	0.543
DOC_PP4_FxxP_1	251	254	PF00568	0.571
DOC_PP4_FxxP_1	78	81	PF00568	0.584
DOC_USP7_MATH_1	117	121	PF00917	0.688
DOC_USP7_MATH_1	151	155	PF00917	0.669
DOC_USP7_MATH_1	254	258	PF00917	0.638
DOC_USP7_MATH_1	295	299	PF00917	0.651
DOC_USP7_MATH_1	373	377	PF00917	0.552
DOC_USP7_MATH_1	433	437	PF00917	0.593
DOC_USP7_MATH_1	519	523	PF00917	0.671
DOC_WW_Pin1_4	144	149	PF00397	0.689
DOC_WW_Pin1_4	158	163	PF00397	0.572
DOC_WW_Pin1_4	250	255	PF00397	0.661
DOC_WW_Pin1_4	264	269	PF00397	0.542
DOC_WW_Pin1_4	28	33	PF00397	0.619
DOC_WW_Pin1_4	77	82	PF00397	0.702
LIG_14-3-3_CanoR_1	105	113	PF00244	0.563
LIG_14-3-3_CanoR_1	275	282	PF00244	0.637
LIG_14-3-3_CanoR_1	48	58	PF00244	0.650
LIG_14-3-3_CanoR_1	523	533	PF00244	0.705
LIG_Actin_WH2_2	218	233	PF00022	0.405
LIG_BIR_III_4	443	447	PF00653	0.659
LIG_BRCT_BRCA1_1	151	155	PF00533	0.679
LIG_BRCT_BRCA1_1	451	455	PF00533	0.693
LIG_CtBP_PxDLS_1	112	116	PF00389	0.534
LIG_eIF4E_1	19	25	PF01652	0.552
LIG_EVH1_1	396	400	PF00568	0.479
LIG_FHA_1	134	140	PF00498	0.690
LIG_FHA_1	207	213	PF00498	0.523
LIG_FHA_1	216	222	PF00498	0.500
LIG_FHA_1	230	236	PF00498	0.410
LIG_FHA_1	488	494	PF00498	0.537
LIG_FHA_2	141	147	PF00498	0.667
LIG_FHA_2	148	154	PF00498	0.603
LIG_FHA_2	163	169	PF00498	0.641
LIG_FHA_2	173	179	PF00498	0.602
LIG_FHA_2	301	307	PF00498	0.651
LIG_FHA_2	438	444	PF00498	0.534
LIG_FHA_2	552	558	PF00498	0.701
LIG_LIR_Apic_2	250	254	PF02991	0.561
LIG_LIR_Apic_2	77	81	PF02991	0.577
LIG_LIR_Gen_1	452	463	PF02991	0.688
LIG_LIR_Nem_3	376	382	PF02991	0.664
LIG_LIR_Nem_3	452	458	PF02991	0.687
LIG_MYND_1	119	123	PF01753	0.654
LIG_SH2_SRC	11	14	PF00017	0.428
LIG_SH2_STAP1	11	15	PF00017	0.609
LIG_SH2_STAP1	533	537	PF00017	0.645
LIG_SH2_STAT5	19	22	PF00017	0.627
LIG_SH2_STAT5	358	361	PF00017	0.345
LIG_SH2_STAT5	38	41	PF00017	0.525
LIG_SH3_1	157	163	PF00018	0.722
LIG_SH3_1	91	97	PF00018	0.677
LIG_SH3_3	116	122	PF00018	0.578
LIG_SH3_3	128	134	PF00018	0.672
LIG_SH3_3	142	148	PF00018	0.627
LIG_SH3_3	157	163	PF00018	0.567
LIG_SH3_3	166	172	PF00018	0.604
LIG_SH3_3	257	263	PF00018	0.615
LIG_SH3_3	326	332	PF00018	0.617
LIG_SH3_3	394	400	PF00018	0.476
LIG_SH3_3	91	97	PF00018	0.677
LIG_SUMO_SIM_par_1	111	116	PF11976	0.534
LIG_SUMO_SIM_par_1	231	237	PF11976	0.528
LIG_TRAF2_1	489	492	PF00917	0.632
LIG_WRC_WIRS_1	248	253	PF05994	0.460
LIG_WW_3	280	284	PF00397	0.573
LIG_WW_3	398	402	PF00397	0.481
MOD_CDC14_SPxK_1	31	34	PF00782	0.530
MOD_CDK_SPK_2	144	149	PF00069	0.560
MOD_CDK_SPK_2	77	82	PF00069	0.650
MOD_CDK_SPxK_1	28	34	PF00069	0.525
MOD_CK1_1	147	153	PF00069	0.690
MOD_CK1_1	250	256	PF00069	0.672
MOD_CK1_1	33	39	PF00069	0.707
MOD_CK1_1	449	455	PF00069	0.637
MOD_CK1_1	464	470	PF00069	0.544
MOD_CK1_1	483	489	PF00069	0.660
MOD_CK1_1	527	533	PF00069	0.707
MOD_CK1_1	535	541	PF00069	0.620
MOD_CK1_1	544	550	PF00069	0.548
MOD_CK1_1	57	63	PF00069	0.622
MOD_CK2_1	11	17	PF00069	0.433
MOD_CK2_1	140	146	PF00069	0.686
MOD_CK2_1	162	168	PF00069	0.663
MOD_CK2_1	172	178	PF00069	0.607
MOD_CK2_1	341	347	PF00069	0.437
MOD_CK2_1	485	491	PF00069	0.703
MOD_GlcNHglycan	114	118	PF01048	0.663
MOD_GlcNHglycan	178	181	PF01048	0.586
MOD_GlcNHglycan	276	279	PF01048	0.631
MOD_GlcNHglycan	308	311	PF01048	0.651
MOD_GlcNHglycan	336	339	PF01048	0.594
MOD_GlcNHglycan	375	378	PF01048	0.367
MOD_GlcNHglycan	424	428	PF01048	0.678
MOD_GlcNHglycan	435	438	PF01048	0.666
MOD_GlcNHglycan	459	462	PF01048	0.716
MOD_GlcNHglycan	51	54	PF01048	0.529
MOD_GlcNHglycan	512	515	PF01048	0.602
MOD_GlcNHglycan	62	65	PF01048	0.659
MOD_GSK3_1	113	120	PF00069	0.704
MOD_GSK3_1	140	147	PF00069	0.730
MOD_GSK3_1	149	156	PF00069	0.664
MOD_GSK3_1	158	165	PF00069	0.553
MOD_GSK3_1	172	179	PF00069	0.511
MOD_GSK3_1	249	256	PF00069	0.604
MOD_GSK3_1	296	303	PF00069	0.774
MOD_GSK3_1	334	341	PF00069	0.590
MOD_GSK3_1	433	440	PF00069	0.586
MOD_GSK3_1	449	456	PF00069	0.743
MOD_GSK3_1	457	464	PF00069	0.723
MOD_GSK3_1	481	488	PF00069	0.763
MOD_GSK3_1	515	522	PF00069	0.586
MOD_GSK3_1	524	531	PF00069	0.692
MOD_GSK3_1	532	539	PF00069	0.610
MOD_GSK3_1	540	547	PF00069	0.550
MOD_GSK3_1	551	558	PF00069	0.575
MOD_GSK3_1	92	99	PF00069	0.554
MOD_LATS_1	378	384	PF00433	0.375
MOD_N-GLC_1	338	343	PF02516	0.709
MOD_N-GLC_1	453	458	PF02516	0.546
MOD_N-GLC_1	555	560	PF02516	0.666
MOD_N-GLC_1	60	65	PF02516	0.695
MOD_N-GLC_1	74	79	PF02516	0.553
MOD_NEK2_1	155	160	PF00069	0.728
MOD_NEK2_1	274	279	PF00069	0.663
MOD_NEK2_1	54	59	PF00069	0.608
MOD_NEK2_1	546	551	PF00069	0.651
MOD_PIKK_1	140	146	PF00454	0.722
MOD_PKA_2	104	110	PF00069	0.594
MOD_PKA_2	200	206	PF00069	0.553
MOD_PKA_2	274	280	PF00069	0.641
MOD_PKA_2	471	477	PF00069	0.659
MOD_PKA_2	524	530	PF00069	0.702
MOD_PKA_2	544	550	PF00069	0.517
MOD_Plk_1	113	119	PF00069	0.533
MOD_Plk_1	172	178	PF00069	0.652
MOD_Plk_1	341	347	PF00069	0.689
MOD_Plk_1	446	452	PF00069	0.640
MOD_Plk_1	74	80	PF00069	0.647
MOD_Plk_4	461	467	PF00069	0.658
MOD_Plk_4	74	80	PF00069	0.663
MOD_ProDKin_1	144	150	PF00069	0.690
MOD_ProDKin_1	158	164	PF00069	0.573
MOD_ProDKin_1	250	256	PF00069	0.665
MOD_ProDKin_1	264	270	PF00069	0.543
MOD_ProDKin_1	28	34	PF00069	0.622
MOD_ProDKin_1	77	83	PF00069	0.704
MOD_SUMO_for_1	349	352	PF00179	0.539
TRG_ENDOCYTIC_2	379	382	PF00928	0.558
TRG_ER_diArg_1	22	24	PF00400	0.505
TRG_ER_diArg_1	223	226	PF00400	0.537
TRG_ER_diArg_1	429	432	PF00400	0.625
TRG_ER_diArg_1	494	497	PF00400	0.590
TRG_ER_diArg_1	5	8	PF00400	0.612
TRG_ER_diArg_1	502	505	PF00400	0.469
TRG_ER_diArg_1	523	526	PF00400	0.700
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X1K0	Leishmania donovani	85%	100%
A4HGK9	Leishmania braziliensis	69%	100%
A4I3N5	Leishmania infantum	85%	100%
Q4Q8A9	Leishmania major	84%	100%