Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZX5_LEIMU

TriTrypDb:

LmxM.28.1550

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AZX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	64	70	PF00089	0.627
CLV_NRD_NRD_1	148	150	PF00675	0.402
CLV_NRD_NRD_1	166	168	PF00675	0.209
CLV_NRD_NRD_1	189	191	PF00675	0.307
CLV_NRD_NRD_1	97	99	PF00675	0.315
CLV_PCSK_KEX2_1	148	150	PF00082	0.402
CLV_PCSK_KEX2_1	166	168	PF00082	0.209
CLV_PCSK_KEX2_1	97	99	PF00082	0.315
DEG_APCC_DBOX_1	66	74	PF00400	0.327
DEG_Nend_UBRbox_2	1	3	PF02207	0.644
DOC_MAPK_gen_1	164	174	PF00069	0.496
DOC_MAPK_MEF2A_6	166	174	PF00069	0.633
DOC_MAPK_MEF2A_6	7	14	PF00069	0.549
DOC_MAPK_NFAT4_5	167	175	PF00069	0.533
DOC_PP1_RVXF_1	73	79	PF00149	0.241
DOC_PP4_FxxP_1	142	145	PF00568	0.573
DOC_PP4_FxxP_1	31	34	PF00568	0.635
LIG_14-3-3_CanoR_1	67	71	PF00244	0.339
LIG_APCC_ABBA_1	113	118	PF00400	0.586
LIG_APCC_ABBA_1	208	213	PF00400	0.551
LIG_BRCT_BRCA1_1	192	196	PF00533	0.591
LIG_eIF4E_1	155	161	PF01652	0.554
LIG_FHA_1	192	198	PF00498	0.562
LIG_FHA_1	219	225	PF00498	0.537
LIG_FHA_1	88	94	PF00498	0.336
LIG_FHA_2	215	221	PF00498	0.596
LIG_LIR_Apic_2	139	145	PF02991	0.573
LIG_LIR_Gen_1	47	57	PF02991	0.409
LIG_LIR_Nem_3	130	136	PF02991	0.549
LIG_LIR_Nem_3	200	206	PF02991	0.502
LIG_LIR_Nem_3	230	236	PF02991	0.551
LIG_LIR_Nem_3	47	52	PF02991	0.409
LIG_NRBOX	156	162	PF00104	0.550
LIG_NRBOX	167	173	PF00104	0.496
LIG_Pex14_2	78	82	PF04695	0.265
LIG_REV1ctd_RIR_1	56	64	PF16727	0.437
LIG_SH2_CRK	203	207	PF00017	0.583
LIG_SH2_CRK	233	237	PF00017	0.532
LIG_SH2_CRK	41	45	PF00017	0.358
LIG_SH2_NCK_1	41	45	PF00017	0.323
LIG_SH2_PTP2	62	65	PF00017	0.387
LIG_SH2_STAP1	19	23	PF00017	0.611
LIG_SH2_STAP1	89	93	PF00017	0.279
LIG_SH2_STAT5	56	59	PF00017	0.360
LIG_SH2_STAT5	62	65	PF00017	0.386
LIG_SH2_STAT5	89	92	PF00017	0.297
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.489
LIG_SUMO_SIM_anti_2	220	226	PF11976	0.548
LIG_SUMO_SIM_par_1	89	94	PF11976	0.325
LIG_TYR_ITIM	231	236	PF00017	0.514
LIG_TYR_ITIM	39	44	PF00017	0.358
LIG_UBA3_1	160	164	PF00899	0.545
LIG_UBA3_1	170	175	PF00899	0.499
LIG_UBA3_1	222	227	PF00899	0.568
MOD_CK1_1	42	48	PF00069	0.285
MOD_CK1_1	66	72	PF00069	0.368
MOD_CK1_1	80	86	PF00069	0.173
MOD_CK2_1	176	182	PF00069	0.620
MOD_CK2_1	214	220	PF00069	0.575
MOD_GlcNHglycan	151	154	PF01048	0.398
MOD_GlcNHglycan	178	181	PF01048	0.422
MOD_GlcNHglycan	20	24	PF01048	0.420
MOD_GlcNHglycan	26	29	PF01048	0.374
MOD_GlcNHglycan	79	82	PF01048	0.298
MOD_GSK3_1	123	130	PF00069	0.549
MOD_GSK3_1	132	139	PF00069	0.583
MOD_GSK3_1	15	22	PF00069	0.528
MOD_GSK3_1	151	158	PF00069	0.523
MOD_GSK3_1	191	198	PF00069	0.545
MOD_GSK3_1	202	209	PF00069	0.464
MOD_GSK3_1	214	221	PF00069	0.576
MOD_GSK3_1	87	94	PF00069	0.404
MOD_N-GLC_1	107	112	PF02516	0.287
MOD_N-GLC_1	136	141	PF02516	0.386
MOD_N-GLC_1	213	218	PF02516	0.381
MOD_NEK2_1	170	175	PF00069	0.592
MOD_NEK2_1	196	201	PF00069	0.558
MOD_NEK2_1	206	211	PF00069	0.524
MOD_NEK2_1	5	10	PF00069	0.652
MOD_PIKK_1	5	11	PF00454	0.600
MOD_PK_1	204	210	PF00069	0.585
MOD_PKA_1	190	196	PF00069	0.540
MOD_PKA_2	24	30	PF00069	0.643
MOD_PKA_2	66	72	PF00069	0.345
MOD_PKB_1	149	157	PF00069	0.565
MOD_Plk_1	107	113	PF00069	0.488
MOD_Plk_1	15	21	PF00069	0.577
MOD_Plk_2-3	15	21	PF00069	0.575
MOD_Plk_4	102	108	PF00069	0.574
MOD_Plk_4	218	224	PF00069	0.589
MOD_Plk_4	91	97	PF00069	0.422
MOD_SUMO_rev_2	207	217	PF00179	0.642
TRG_DiLeu_BaEn_1	156	161	PF01217	0.554
TRG_DiLeu_BaEn_1	220	225	PF01217	0.592
TRG_DiLeu_BaEn_2	191	197	PF01217	0.532
TRG_ENDOCYTIC_2	203	206	PF00928	0.584
TRG_ENDOCYTIC_2	233	236	PF00928	0.577
TRG_ENDOCYTIC_2	41	44	PF00928	0.358
TRG_ENDOCYTIC_2	56	59	PF00928	0.286
TRG_ENDOCYTIC_2	62	65	PF00928	0.309
TRG_ER_diArg_1	147	149	PF00400	0.581
TRG_ER_diArg_1	166	168	PF00400	0.540
TRG_ER_diArg_1	96	98	PF00400	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N3	Leptomonas seymouri	79%	82%
A0A0S4J943	Bodo saltans	55%	76%
A0A1X0NYS0	Trypanosomatidae	59%	86%
A0A3Q8IB08	Leishmania donovani	97%	100%
A0A3R7KJ52	Trypanosoma rangeli	63%	85%
A4HGK8	Leishmania braziliensis	92%	100%
A4I3N4	Leishmania infantum	97%	100%
D0A864	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	86%
Q4Q8B0	Leishmania major	97%	100%
V5ASF1	Trypanosoma cruzi	63%	85%