Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AZX4_LEIMU

TriTrypDb:

LmxM.28.1540

Length:

865

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.518
CLV_C14_Caspase3-7	41	45	PF00656	0.737
CLV_C14_Caspase3-7	735	739	PF00656	0.678
CLV_NRD_NRD_1	129	131	PF00675	0.688
CLV_NRD_NRD_1	152	154	PF00675	0.488
CLV_NRD_NRD_1	200	202	PF00675	0.702
CLV_NRD_NRD_1	219	221	PF00675	0.682
CLV_NRD_NRD_1	232	234	PF00675	0.731
CLV_NRD_NRD_1	361	363	PF00675	0.630
CLV_NRD_NRD_1	404	406	PF00675	0.374
CLV_NRD_NRD_1	424	426	PF00675	0.492
CLV_NRD_NRD_1	491	493	PF00675	0.688
CLV_NRD_NRD_1	511	513	PF00675	0.443
CLV_NRD_NRD_1	721	723	PF00675	0.702
CLV_PCSK_KEX2_1	129	131	PF00082	0.688
CLV_PCSK_KEX2_1	151	153	PF00082	0.482
CLV_PCSK_KEX2_1	200	202	PF00082	0.702
CLV_PCSK_KEX2_1	221	223	PF00082	0.677
CLV_PCSK_KEX2_1	232	234	PF00082	0.738
CLV_PCSK_KEX2_1	361	363	PF00082	0.630
CLV_PCSK_KEX2_1	404	406	PF00082	0.372
CLV_PCSK_KEX2_1	424	426	PF00082	0.624
CLV_PCSK_KEX2_1	491	493	PF00082	0.688
CLV_PCSK_KEX2_1	511	513	PF00082	0.443
CLV_PCSK_KEX2_1	663	665	PF00082	0.611
CLV_PCSK_KEX2_1	679	681	PF00082	0.662
CLV_PCSK_KEX2_1	720	722	PF00082	0.663
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.688
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.587
CLV_PCSK_PC1ET2_1	663	665	PF00082	0.734
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.662
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.590
CLV_PCSK_PC7_1	125	131	PF00082	0.727
CLV_PCSK_PC7_1	196	202	PF00082	0.697
CLV_PCSK_SKI1_1	134	138	PF00082	0.739
CLV_PCSK_SKI1_1	511	515	PF00082	0.552
CLV_PCSK_SKI1_1	679	683	PF00082	0.619
CLV_PCSK_SKI1_1	726	730	PF00082	0.658
DEG_APCC_DBOX_1	511	519	PF00400	0.571
DEG_APCC_DBOX_1	545	553	PF00400	0.485
DEG_COP1_1	822	831	PF00400	0.721
DEG_SCF_FBW7_1	797	804	PF00400	0.611
DEG_SPOP_SBC_1	224	228	PF00917	0.753
DEG_SPOP_SBC_1	837	841	PF00917	0.734
DOC_CKS1_1	270	275	PF01111	0.513
DOC_MAPK_gen_1	424	430	PF00069	0.518
DOC_MAPK_gen_1	453	461	PF00069	0.516
DOC_MAPK_gen_1	98	105	PF00069	0.504
DOC_MIT_MIM_1	401	410	PF04212	0.548
DOC_PP1_RVXF_1	139	146	PF00149	0.536
DOC_PP1_RVXF_1	425	431	PF00149	0.641
DOC_PP1_RVXF_1	724	731	PF00149	0.697
DOC_PP1_SILK_1	456	461	PF00149	0.432
DOC_PP2B_LxvP_1	826	829	PF13499	0.509
DOC_PP4_FxxP_1	270	273	PF00568	0.723
DOC_USP7_MATH_1	168	172	PF00917	0.597
DOC_USP7_MATH_1	208	212	PF00917	0.795
DOC_USP7_MATH_1	224	228	PF00917	0.731
DOC_USP7_MATH_1	356	360	PF00917	0.805
DOC_USP7_MATH_1	55	59	PF00917	0.664
DOC_USP7_MATH_1	580	584	PF00917	0.787
DOC_USP7_MATH_1	6	10	PF00917	0.499
DOC_USP7_MATH_1	657	661	PF00917	0.545
DOC_USP7_MATH_1	837	841	PF00917	0.707
DOC_USP7_MATH_1	92	96	PF00917	0.790
DOC_USP7_UBL2_3	16	20	PF12436	0.644
DOC_USP7_UBL2_3	853	857	PF12436	0.658
DOC_WW_Pin1_4	156	161	PF00397	0.657
DOC_WW_Pin1_4	166	171	PF00397	0.696
DOC_WW_Pin1_4	199	204	PF00397	0.618
DOC_WW_Pin1_4	213	218	PF00397	0.706
DOC_WW_Pin1_4	249	254	PF00397	0.659
DOC_WW_Pin1_4	269	274	PF00397	0.697
DOC_WW_Pin1_4	331	336	PF00397	0.741
DOC_WW_Pin1_4	368	373	PF00397	0.657
DOC_WW_Pin1_4	604	609	PF00397	0.685
DOC_WW_Pin1_4	62	67	PF00397	0.689
DOC_WW_Pin1_4	641	646	PF00397	0.773
DOC_WW_Pin1_4	671	676	PF00397	0.555
DOC_WW_Pin1_4	710	715	PF00397	0.681
DOC_WW_Pin1_4	759	764	PF00397	0.633
DOC_WW_Pin1_4	797	802	PF00397	0.699
DOC_WW_Pin1_4	8	13	PF00397	0.712
DOC_WW_Pin1_4	827	832	PF00397	0.721
DOC_WW_Pin1_4	833	838	PF00397	0.687
LIG_14-3-3_CanoR_1	151	160	PF00244	0.521
LIG_14-3-3_CanoR_1	163	172	PF00244	0.545
LIG_14-3-3_CanoR_1	196	200	PF00244	0.709
LIG_14-3-3_CanoR_1	222	230	PF00244	0.752
LIG_14-3-3_CanoR_1	232	236	PF00244	0.650
LIG_14-3-3_CanoR_1	512	521	PF00244	0.345
LIG_14-3-3_CanoR_1	581	585	PF00244	0.614
LIG_14-3-3_CanoR_1	721	730	PF00244	0.678
LIG_14-3-3_CanoR_1	740	750	PF00244	0.437
LIG_14-3-3_CanoR_1	835	843	PF00244	0.559
LIG_Actin_WH2_2	771	787	PF00022	0.336
LIG_BIR_III_2	738	742	PF00653	0.669
LIG_BRCT_BRCA1_1	64	68	PF00533	0.591
LIG_DLG_GKlike_1	201	209	PF00625	0.715
LIG_FHA_1	157	163	PF00498	0.708
LIG_FHA_1	190	196	PF00498	0.806
LIG_FHA_1	306	312	PF00498	0.637
LIG_FHA_1	37	43	PF00498	0.803
LIG_FHA_1	411	417	PF00498	0.527
LIG_FHA_1	438	444	PF00498	0.710
LIG_FHA_1	485	491	PF00498	0.455
LIG_FHA_1	502	508	PF00498	0.617
LIG_FHA_1	605	611	PF00498	0.800
LIG_FHA_1	727	733	PF00498	0.653
LIG_FHA_1	747	753	PF00498	0.577
LIG_FHA_1	798	804	PF00498	0.736
LIG_FHA_1	837	843	PF00498	0.814
LIG_FHA_1	84	90	PF00498	0.577
LIG_FHA_2	270	276	PF00498	0.518
LIG_FHA_2	842	848	PF00498	0.569
LIG_Integrin_RGD_1	100	102	PF01839	0.501
LIG_LIR_Apic_2	254	259	PF02991	0.687
LIG_LIR_Gen_1	390	400	PF02991	0.520
LIG_LIR_Gen_1	463	473	PF02991	0.486
LIG_LIR_Gen_1	592	599	PF02991	0.640
LIG_LIR_Gen_1	848	858	PF02991	0.707
LIG_LIR_Nem_3	390	395	PF02991	0.523
LIG_LIR_Nem_3	463	469	PF02991	0.573
LIG_LIR_Nem_3	65	71	PF02991	0.602
LIG_LIR_Nem_3	809	813	PF02991	0.497
LIG_LIR_Nem_3	848	854	PF02991	0.711
LIG_LYPXL_yS_3	132	135	PF13949	0.753
LIG_MLH1_MIPbox_1	64	68	PF16413	0.552
LIG_Pex14_1	306	310	PF04695	0.499
LIG_SH2_CRK	256	260	PF00017	0.648
LIG_SH2_CRK	851	855	PF00017	0.707
LIG_SH2_NCK_1	256	260	PF00017	0.648
LIG_SH2_SRC	256	259	PF00017	0.791
LIG_SH2_STAP1	154	158	PF00017	0.480
LIG_SH2_STAT5	263	266	PF00017	0.643
LIG_SH2_STAT5	310	313	PF00017	0.619
LIG_SH2_STAT5	466	469	PF00017	0.460
LIG_SH2_STAT5	593	596	PF00017	0.490
LIG_SH2_STAT5	67	70	PF00017	0.657
LIG_SH2_STAT5	683	686	PF00017	0.677
LIG_SH2_STAT5	708	711	PF00017	0.739
LIG_SH3_2	675	680	PF14604	0.680
LIG_SH3_3	116	122	PF00018	0.827
LIG_SH3_3	252	258	PF00018	0.689
LIG_SH3_3	640	646	PF00018	0.715
LIG_SH3_3	651	657	PF00018	0.692
LIG_SH3_3	672	678	PF00018	0.566
LIG_SH3_3	825	831	PF00018	0.720
LIG_Sin3_3	766	773	PF02671	0.323
LIG_SUMO_SIM_anti_2	749	754	PF11976	0.592
LIG_SUMO_SIM_par_1	747	754	PF11976	0.603
LIG_SUMO_SIM_par_1	766	772	PF11976	0.520
LIG_TRAF2_1	522	525	PF00917	0.609
LIG_TRFH_1	730	734	PF08558	0.684
LIG_UBA3_1	752	760	PF00899	0.605
LIG_WRC_WIRS_1	470	475	PF05994	0.518
LIG_WRC_WIRS_1	810	815	PF05994	0.494
LIG_WW_3	578	582	PF00397	0.666
MOD_CDC14_SPxK_1	674	677	PF00782	0.528
MOD_CDK_SPK_2	156	161	PF00069	0.657
MOD_CDK_SPK_2	827	832	PF00069	0.727
MOD_CDK_SPxK_1	671	677	PF00069	0.540
MOD_CDK_SPxxK_3	156	163	PF00069	0.493
MOD_CDK_SPxxK_3	213	220	PF00069	0.641
MOD_CK1_1	10	16	PF00069	0.778
MOD_CK1_1	171	177	PF00069	0.771
MOD_CK1_1	194	200	PF00069	0.796
MOD_CK1_1	204	210	PF00069	0.759
MOD_CK1_1	215	221	PF00069	0.768
MOD_CK1_1	26	32	PF00069	0.608
MOD_CK1_1	285	291	PF00069	0.738
MOD_CK1_1	314	320	PF00069	0.671
MOD_CK1_1	35	41	PF00069	0.754
MOD_CK1_1	47	53	PF00069	0.664
MOD_CK1_1	589	595	PF00069	0.627
MOD_CK1_1	598	604	PF00069	0.655
MOD_CK1_1	60	66	PF00069	0.599
MOD_CK1_1	617	623	PF00069	0.475
MOD_CK1_1	633	639	PF00069	0.684
MOD_CK1_1	666	672	PF00069	0.678
MOD_CK1_1	699	705	PF00069	0.686
MOD_CK1_1	712	718	PF00069	0.763
MOD_CK1_1	744	750	PF00069	0.618
MOD_CK1_1	815	821	PF00069	0.695
MOD_CK1_1	830	836	PF00069	0.785
MOD_CK1_1	849	855	PF00069	0.473
MOD_CK2_1	343	349	PF00069	0.710
MOD_CK2_1	35	41	PF00069	0.819
MOD_CK2_1	841	847	PF00069	0.572
MOD_GlcNHglycan	105	108	PF01048	0.653
MOD_GlcNHglycan	166	169	PF01048	0.680
MOD_GlcNHglycan	176	179	PF01048	0.590
MOD_GlcNHglycan	236	239	PF01048	0.830
MOD_GlcNHglycan	279	282	PF01048	0.751
MOD_GlcNHglycan	284	288	PF01048	0.676
MOD_GlcNHglycan	313	316	PF01048	0.719
MOD_GlcNHglycan	335	338	PF01048	0.747
MOD_GlcNHglycan	372	375	PF01048	0.643
MOD_GlcNHglycan	396	399	PF01048	0.451
MOD_GlcNHglycan	49	52	PF01048	0.710
MOD_GlcNHglycan	495	498	PF01048	0.694
MOD_GlcNHglycan	57	60	PF01048	0.628
MOD_GlcNHglycan	588	591	PF01048	0.597
MOD_GlcNHglycan	638	641	PF01048	0.783
MOD_GlcNHglycan	669	672	PF01048	0.785
MOD_GlcNHglycan	743	746	PF01048	0.642
MOD_GlcNHglycan	771	774	PF01048	0.545
MOD_GlcNHglycan	814	817	PF01048	0.695
MOD_GlcNHglycan	95	98	PF01048	0.678
MOD_GSK3_1	101	108	PF00069	0.734
MOD_GSK3_1	15	22	PF00069	0.643
MOD_GSK3_1	152	159	PF00069	0.756
MOD_GSK3_1	164	171	PF00069	0.670
MOD_GSK3_1	173	180	PF00069	0.597
MOD_GSK3_1	190	197	PF00069	0.675
MOD_GSK3_1	204	211	PF00069	0.722
MOD_GSK3_1	23	30	PF00069	0.756
MOD_GSK3_1	282	289	PF00069	0.679
MOD_GSK3_1	32	39	PF00069	0.735
MOD_GSK3_1	366	373	PF00069	0.539
MOD_GSK3_1	40	47	PF00069	0.696
MOD_GSK3_1	435	442	PF00069	0.623
MOD_GSK3_1	461	468	PF00069	0.511
MOD_GSK3_1	480	487	PF00069	0.374
MOD_GSK3_1	51	58	PF00069	0.655
MOD_GSK3_1	591	598	PF00069	0.645
MOD_GSK3_1	6	13	PF00069	0.689
MOD_GSK3_1	614	621	PF00069	0.692
MOD_GSK3_1	630	637	PF00069	0.686
MOD_GSK3_1	659	666	PF00069	0.686
MOD_GSK3_1	667	674	PF00069	0.755
MOD_GSK3_1	704	711	PF00069	0.711
MOD_GSK3_1	795	802	PF00069	0.671
MOD_GSK3_1	811	818	PF00069	0.640
MOD_GSK3_1	833	840	PF00069	0.685
MOD_GSK3_1	841	848	PF00069	0.693
MOD_GSK3_1	857	864	PF00069	0.573
MOD_N-GLC_1	156	161	PF02516	0.703
MOD_N-GLC_1	282	287	PF02516	0.709
MOD_N-GLC_1	32	37	PF02516	0.781
MOD_N-GLC_1	614	619	PF02516	0.703
MOD_N-GLC_1	633	638	PF02516	0.754
MOD_NEK2_1	1	6	PF00069	0.656
MOD_NEK2_1	103	108	PF00069	0.617
MOD_NEK2_1	189	194	PF00069	0.678
MOD_NEK2_1	19	24	PF00069	0.658
MOD_NEK2_1	195	200	PF00069	0.705
MOD_NEK2_1	388	393	PF00069	0.501
MOD_NEK2_1	437	442	PF00069	0.614
MOD_NEK2_1	461	466	PF00069	0.486
MOD_NEK2_1	484	489	PF00069	0.458
MOD_NEK2_1	514	519	PF00069	0.515
MOD_NEK2_1	574	579	PF00069	0.614
MOD_NEK2_1	609	614	PF00069	0.688
MOD_NEK2_1	769	774	PF00069	0.502
MOD_NEK2_1	93	98	PF00069	0.653
MOD_NEK2_2	191	196	PF00069	0.633
MOD_NEK2_2	445	450	PF00069	0.565
MOD_PIKK_1	134	140	PF00454	0.735
MOD_PIKK_1	461	467	PF00454	0.520
MOD_PIKK_1	715	721	PF00454	0.828
MOD_PK_1	663	669	PF00069	0.560
MOD_PKA_1	152	158	PF00069	0.482
MOD_PKA_1	663	669	PF00069	0.560
MOD_PKA_1	7	13	PF00069	0.713
MOD_PKA_1	721	727	PF00069	0.692
MOD_PKA_2	152	158	PF00069	0.610
MOD_PKA_2	195	201	PF00069	0.712
MOD_PKA_2	231	237	PF00069	0.536
MOD_PKA_2	580	586	PF00069	0.655
MOD_PKA_2	663	669	PF00069	0.761
MOD_PKA_2	721	727	PF00069	0.692
MOD_PKA_2	741	747	PF00069	0.495
MOD_PKA_2	784	790	PF00069	0.391
MOD_PKA_2	849	855	PF00069	0.684
MOD_Plk_1	101	107	PF00069	0.511
MOD_Plk_1	274	280	PF00069	0.607
MOD_Plk_1	36	42	PF00069	0.741
MOD_Plk_1	43	49	PF00069	0.643
MOD_Plk_1	614	620	PF00069	0.733
MOD_Plk_1	846	852	PF00069	0.503
MOD_Plk_2-3	343	349	PF00069	0.812
MOD_Plk_2-3	83	89	PF00069	0.499
MOD_Plk_4	105	111	PF00069	0.720
MOD_Plk_4	286	292	PF00069	0.716
MOD_Plk_4	306	312	PF00069	0.712
MOD_Plk_4	454	460	PF00069	0.480
MOD_Plk_4	465	471	PF00069	0.503
MOD_Plk_4	614	620	PF00069	0.512
MOD_Plk_4	704	710	PF00069	0.741
MOD_Plk_4	838	844	PF00069	0.740
MOD_ProDKin_1	156	162	PF00069	0.657
MOD_ProDKin_1	166	172	PF00069	0.697
MOD_ProDKin_1	199	205	PF00069	0.620
MOD_ProDKin_1	213	219	PF00069	0.706
MOD_ProDKin_1	249	255	PF00069	0.656
MOD_ProDKin_1	269	275	PF00069	0.700
MOD_ProDKin_1	331	337	PF00069	0.742
MOD_ProDKin_1	368	374	PF00069	0.657
MOD_ProDKin_1	604	610	PF00069	0.685
MOD_ProDKin_1	62	68	PF00069	0.691
MOD_ProDKin_1	641	647	PF00069	0.774
MOD_ProDKin_1	671	677	PF00069	0.551
MOD_ProDKin_1	710	716	PF00069	0.684
MOD_ProDKin_1	759	765	PF00069	0.627
MOD_ProDKin_1	797	803	PF00069	0.699
MOD_ProDKin_1	8	14	PF00069	0.716
MOD_ProDKin_1	827	833	PF00069	0.722
TRG_DiLeu_BaEn_1	606	611	PF01217	0.800
TRG_ENDOCYTIC_2	132	135	PF00928	0.753
TRG_ENDOCYTIC_2	392	395	PF00928	0.517
TRG_ENDOCYTIC_2	466	469	PF00928	0.482
TRG_ENDOCYTIC_2	593	596	PF00928	0.490
TRG_ENDOCYTIC_2	851	854	PF00928	0.709
TRG_ER_diArg_1	150	153	PF00400	0.555
TRG_ER_diArg_1	160	163	PF00400	0.521
TRG_ER_diArg_1	199	201	PF00400	0.704
TRG_ER_diArg_1	265	268	PF00400	0.513
TRG_ER_diArg_1	404	406	PF00400	0.374
TRG_ER_diArg_1	424	427	PF00400	0.535
TRG_ER_diArg_1	490	492	PF00400	0.677
TRG_ER_diArg_1	721	723	PF00400	0.838
TRG_ER_diArg_1	740	743	PF00400	0.560
TRG_NLS_Bipartite_1	663	683	PF00514	0.502
TRG_NLS_MonoExtC_3	128	133	PF00514	0.675
TRG_NLS_MonoExtC_3	719	725	PF00514	0.531
TRG_NLS_MonoExtN_4	217	224	PF00514	0.604
TRG_NLS_MonoExtN_4	677	683	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.806
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	529	533	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	721	725	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK2	Leptomonas seymouri	41%	100%
A0A3Q8IQL8	Leishmania donovani	80%	100%
A4HGK7	Leishmania braziliensis	56%	98%
A4I3N3	Leishmania infantum	80%	100%
Q4Q8B1	Leishmania major	78%	97%