Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZX2_LEIMU

TriTrypDb:

LmxM.28.1520

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZX2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.458
CLV_NRD_NRD_1	121	123	PF00675	0.374
CLV_NRD_NRD_1	151	153	PF00675	0.506
CLV_NRD_NRD_1	227	229	PF00675	0.486
CLV_NRD_NRD_1	256	258	PF00675	0.461
CLV_NRD_NRD_1	273	275	PF00675	0.444
CLV_NRD_NRD_1	35	37	PF00675	0.497
CLV_NRD_NRD_1	399	401	PF00675	0.539
CLV_NRD_NRD_1	426	428	PF00675	0.570
CLV_NRD_NRD_1	583	585	PF00675	0.680
CLV_NRD_NRD_1	610	612	PF00675	0.477
CLV_PCSK_FUR_1	149	153	PF00082	0.509
CLV_PCSK_FUR_1	33	37	PF00082	0.441
CLV_PCSK_KEX2_1	112	114	PF00082	0.458
CLV_PCSK_KEX2_1	151	153	PF00082	0.506
CLV_PCSK_KEX2_1	227	229	PF00082	0.555
CLV_PCSK_KEX2_1	256	258	PF00082	0.461
CLV_PCSK_KEX2_1	273	275	PF00082	0.444
CLV_PCSK_KEX2_1	32	34	PF00082	0.444
CLV_PCSK_KEX2_1	35	37	PF00082	0.439
CLV_PCSK_KEX2_1	399	401	PF00082	0.527
CLV_PCSK_KEX2_1	426	428	PF00082	0.535
CLV_PCSK_KEX2_1	583	585	PF00082	0.674
CLV_PCSK_KEX2_1	610	612	PF00082	0.531
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.444
CLV_PCSK_SKI1_1	151	155	PF00082	0.492
CLV_PCSK_SKI1_1	290	294	PF00082	0.577
CLV_PCSK_SKI1_1	326	330	PF00082	0.536
CLV_PCSK_SKI1_1	45	49	PF00082	0.359
CLV_PCSK_SKI1_1	451	455	PF00082	0.571
CLV_PCSK_SKI1_1	522	526	PF00082	0.536
CLV_PCSK_SKI1_1	557	561	PF00082	0.523
CLV_PCSK_SKI1_1	620	624	PF00082	0.470
CLV_PCSK_SKI1_1	91	95	PF00082	0.400
DEG_APCC_DBOX_1	216	224	PF00400	0.540
DOC_CYCLIN_RxL_1	625	639	PF00134	0.582
DOC_CYCLIN_yClb5_NLxxxL_5	368	376	PF00134	0.475
DOC_MAPK_MEF2A_6	572	579	PF00069	0.589
DOC_USP7_MATH_1	153	157	PF00917	0.569
DOC_USP7_MATH_1	185	189	PF00917	0.545
DOC_USP7_MATH_1	492	496	PF00917	0.560
LIG_14-3-3_CanoR_1	112	121	PF00244	0.434
LIG_14-3-3_CanoR_1	273	282	PF00244	0.514
LIG_14-3-3_CanoR_1	295	301	PF00244	0.599
LIG_14-3-3_CanoR_1	347	351	PF00244	0.555
LIG_14-3-3_CanoR_1	610	616	PF00244	0.389
LIG_14-3-3_CanoR_1	96	104	PF00244	0.548
LIG_Actin_WH2_2	107	124	PF00022	0.469
LIG_Actin_WH2_2	282	299	PF00022	0.398
LIG_Actin_WH2_2	431	449	PF00022	0.418
LIG_APCC_ABBA_1	25	30	PF00400	0.422
LIG_APCC_ABBAyCdc20_2	620	626	PF00400	0.553
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_CaM_IQ_9	315	331	PF13499	0.415
LIG_CaM_IQ_9	588	603	PF13499	0.586
LIG_Clathr_ClatBox_1	387	391	PF01394	0.511
LIG_eIF4E_1	138	144	PF01652	0.488
LIG_FHA_1	291	297	PF00498	0.523
LIG_FHA_1	399	405	PF00498	0.616
LIG_FHA_1	433	439	PF00498	0.565
LIG_FHA_1	52	58	PF00498	0.401
LIG_FHA_1	531	537	PF00498	0.485
LIG_FHA_1	566	572	PF00498	0.584
LIG_FHA_1	630	636	PF00498	0.533
LIG_FHA_2	14	20	PF00498	0.472
LIG_FHA_2	198	204	PF00498	0.505
LIG_FHA_2	274	280	PF00498	0.508
LIG_FHA_2	296	302	PF00498	0.505
LIG_FHA_2	355	361	PF00498	0.416
LIG_FHA_2	376	382	PF00498	0.528
LIG_FHA_2	408	414	PF00498	0.454
LIG_FHA_2	553	559	PF00498	0.590
LIG_GBD_Chelix_1	58	66	PF00786	0.438
LIG_LIR_Gen_1	360	366	PF02991	0.570
LIG_LIR_Nem_3	134	138	PF02991	0.487
LIG_LIR_Nem_3	360	365	PF02991	0.577
LIG_NRBOX	266	272	PF00104	0.590
LIG_PCNA_yPIPBox_3	257	271	PF02747	0.528
LIG_PCNA_yPIPBox_3	26	38	PF02747	0.508
LIG_PDZ_Class_2	637	642	PF00595	0.624
LIG_SH2_PTP2	362	365	PF00017	0.534
LIG_SH2_STAT3	624	627	PF00017	0.494
LIG_SH2_STAT5	13	16	PF00017	0.512
LIG_SH2_STAT5	362	365	PF00017	0.534
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.459
LIG_SUMO_SIM_par_1	284	291	PF11976	0.464
LIG_SUMO_SIM_par_1	386	393	PF11976	0.464
LIG_SUMO_SIM_par_1	481	487	PF11976	0.513
LIG_SUMO_SIM_par_1	573	578	PF11976	0.585
LIG_TRAF2_1	180	183	PF00917	0.486
LIG_TRAF2_1	200	203	PF00917	0.413
LIG_TRAF2_1	277	280	PF00917	0.457
LIG_TRAF2_1	299	302	PF00917	0.554
LIG_TRAF2_1	389	392	PF00917	0.477
LIG_TRAF2_1	410	413	PF00917	0.564
LIG_TRAF2_1	506	509	PF00917	0.568
MOD_CK1_1	304	310	PF00069	0.547
MOD_CK1_1	377	383	PF00069	0.510
MOD_CK1_1	566	572	PF00069	0.631
MOD_CK2_1	13	19	PF00069	0.474
MOD_CK2_1	197	203	PF00069	0.581
MOD_CK2_1	273	279	PF00069	0.529
MOD_CK2_1	295	301	PF00069	0.503
MOD_CK2_1	336	342	PF00069	0.618
MOD_CK2_1	375	381	PF00069	0.531
MOD_CK2_1	386	392	PF00069	0.401
MOD_CK2_1	407	413	PF00069	0.469
MOD_CK2_1	552	558	PF00069	0.653
MOD_CK2_1	570	576	PF00069	0.612
MOD_CMANNOS	193	196	PF00535	0.549
MOD_GlcNHglycan	114	117	PF01048	0.476
MOD_GlcNHglycan	155	159	PF01048	0.499
MOD_GlcNHglycan	187	190	PF01048	0.412
MOD_GlcNHglycan	205	208	PF01048	0.607
MOD_GlcNHglycan	301	306	PF01048	0.603
MOD_GlcNHglycan	381	384	PF01048	0.487
MOD_GlcNHglycan	611	614	PF01048	0.502
MOD_GlcNHglycan	79	82	PF01048	0.451
MOD_GSK3_1	139	146	PF00069	0.614
MOD_GSK3_1	375	382	PF00069	0.450
MOD_GSK3_1	386	393	PF00069	0.449
MOD_GSK3_1	408	415	PF00069	0.567
MOD_GSK3_1	566	573	PF00069	0.674
MOD_N-GLC_1	563	568	PF02516	0.576
MOD_N-GLC_2	281	283	PF02516	0.393
MOD_NEK2_1	139	144	PF00069	0.446
MOD_NEK2_1	154	159	PF00069	0.329
MOD_NEK2_1	322	327	PF00069	0.569
MOD_NEK2_1	439	444	PF00069	0.652
MOD_NEK2_1	57	62	PF00069	0.436
MOD_PIKK_1	197	203	PF00454	0.502
MOD_PIKK_1	408	414	PF00454	0.573
MOD_PIKK_1	439	445	PF00454	0.645
MOD_PIKK_1	466	472	PF00454	0.413
MOD_PIKK_1	492	498	PF00454	0.562
MOD_PIKK_1	52	58	PF00454	0.480
MOD_PIKK_1	72	78	PF00454	0.283
MOD_PK_1	386	392	PF00069	0.586
MOD_PKA_1	112	118	PF00069	0.409
MOD_PKA_1	273	279	PF00069	0.511
MOD_PKA_2	112	118	PF00069	0.383
MOD_PKA_2	273	279	PF00069	0.529
MOD_PKA_2	322	328	PF00069	0.495
MOD_PKA_2	346	352	PF00069	0.560
MOD_PKA_2	398	404	PF00069	0.486
MOD_PKA_2	408	414	PF00069	0.474
MOD_PKA_2	446	452	PF00069	0.599
MOD_PKA_2	609	615	PF00069	0.465
MOD_PKA_2	95	101	PF00069	0.539
MOD_Plk_1	38	44	PF00069	0.509
MOD_Plk_1	390	396	PF00069	0.488
MOD_Plk_1	566	572	PF00069	0.684
MOD_Plk_1	575	581	PF00069	0.681
MOD_Plk_1	636	642	PF00069	0.574
MOD_Plk_2-3	336	342	PF00069	0.601
MOD_Plk_2-3	354	360	PF00069	0.436
MOD_Plk_2-3	89	95	PF00069	0.459
MOD_Plk_4	139	145	PF00069	0.615
MOD_Plk_4	390	396	PF00069	0.464
MOD_Plk_4	566	572	PF00069	0.649
MOD_SUMO_for_1	463	466	PF00179	0.538
MOD_SUMO_for_1	539	542	PF00179	0.529
MOD_SUMO_rev_2	230	236	PF00179	0.394
MOD_SUMO_rev_2	255	263	PF00179	0.497
MOD_SUMO_rev_2	29	34	PF00179	0.420
TRG_DiLeu_BaEn_4	301	307	PF01217	0.551
TRG_DiLeu_BaEn_4	353	359	PF01217	0.458
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.564
TRG_ENDOCYTIC_2	362	365	PF00928	0.522
TRG_ER_diArg_1	111	113	PF00400	0.457
TRG_ER_diArg_1	256	258	PF00400	0.476
TRG_ER_diArg_1	272	274	PF00400	0.647
TRG_ER_diArg_1	33	36	PF00400	0.442
TRG_ER_diArg_1	425	427	PF00400	0.575
TRG_ER_diArg_1	601	604	PF00400	0.567
TRG_NLS_MonoExtC_3	31	36	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9P5	Leptomonas seymouri	49%	100%
A0A1X0P087	Trypanosomatidae	25%	100%
A0A3S7X1I5	Leishmania donovani	90%	100%
A4HGK5	Leishmania braziliensis	82%	100%
A4I3N1	Leishmania infantum	90%	100%
Q4Q8B3	Leishmania major	89%	100%
V5B7Y0	Trypanosoma cruzi	27%	100%