Similar to Prokaryotic YgdD inner membrane proteins.. Topology is somewhat unclear but likely to start / end in cytoplasm. Might have been acquired by horizontal gene transfer.
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 6 |
| NetGPI | no | yes: 0, no: 6 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 7 |
| GO:0110165 | cellular anatomical entity | 1 | 7 |
Related structures:
AlphaFold database: E9AZW8
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 82 | 84 | PF00675 | 0.280 |
| CLV_PCSK_KEX2_1 | 82 | 84 | PF00082 | 0.296 |
| CLV_PCSK_SKI1_1 | 6 | 10 | PF00082 | 0.441 |
| DEG_APCC_DBOX_1 | 5 | 13 | PF00400 | 0.493 |
| DOC_CDC14_PxL_1 | 111 | 119 | PF14671 | 0.178 |
| DOC_USP7_MATH_1 | 31 | 35 | PF00917 | 0.379 |
| LIG_14-3-3_CanoR_1 | 99 | 108 | PF00244 | 0.403 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.645 |
| LIG_BRCT_BRCA1_1 | 33 | 37 | PF00533 | 0.379 |
| LIG_LIR_Gen_1 | 34 | 41 | PF02991 | 0.313 |
| LIG_LIR_Nem_3 | 34 | 40 | PF02991 | 0.296 |
| LIG_LIR_Nem_3 | 43 | 49 | PF02991 | 0.313 |
| LIG_SH2_CRK | 102 | 106 | PF00017 | 0.298 |
| LIG_SH2_CRK | 55 | 59 | PF00017 | 0.379 |
| LIG_SH2_NCK_1 | 49 | 53 | PF00017 | 0.308 |
| LIG_SH2_SRC | 100 | 103 | PF00017 | 0.357 |
| LIG_SH2_STAP1 | 85 | 89 | PF00017 | 0.403 |
| LIG_SH2_STAT5 | 100 | 103 | PF00017 | 0.448 |
| LIG_SH3_3 | 102 | 108 | PF00018 | 0.313 |
| LIG_SH3_3 | 70 | 76 | PF00018 | 0.379 |
| MOD_GlcNHglycan | 1 | 4 | PF01048 | 0.423 |
| MOD_GlcNHglycan | 21 | 24 | PF01048 | 0.379 |
| MOD_GlcNHglycan | 9 | 12 | PF01048 | 0.370 |
| MOD_NEK2_1 | 131 | 136 | PF00069 | 0.448 |
| MOD_NEK2_1 | 25 | 30 | PF00069 | 0.189 |
| MOD_NEK2_1 | 40 | 45 | PF00069 | 0.306 |
| MOD_NEK2_1 | 57 | 62 | PF00069 | 0.480 |
| MOD_NEK2_1 | 95 | 100 | PF00069 | 0.415 |
| MOD_Plk_4 | 89 | 95 | PF00069 | 0.365 |
| TRG_ENDOCYTIC_2 | 102 | 105 | PF00928 | 0.313 |
| TRG_ENDOCYTIC_2 | 55 | 58 | PF00928 | 0.379 |
| TRG_ENDOCYTIC_2 | 85 | 88 | PF00928 | 0.379 |
| TRG_ER_diArg_1 | 81 | 83 | PF00400 | 0.513 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1HUH3 | Leptomonas seymouri | 78% | 100% |
| A0A0N1I149 | Leptomonas seymouri | 27% | 100% |
| A0A0N1I2H5 | Leptomonas seymouri | 30% | 100% |
| A0A0S4JA03 | Bodo saltans | 30% | 100% |
| A0A1X0NW75 | Trypanosomatidae | 32% | 100% |
| A0A1X0NYR3 | Trypanosomatidae | 35% | 100% |
| A0A3Q8IGS2 | Leishmania donovani | 28% | 100% |
| A0A3R7NJS9 | Trypanosoma rangeli | 31% | 100% |
| A0A3S7X1H0 | Leishmania donovani | 34% | 100% |
| A0A3S7X1J0 | Leishmania donovani | 91% | 100% |
| A4HGK1 | Leishmania braziliensis | 80% | 100% |
| A4HGK2 | Leishmania braziliensis | 30% | 100% |
| A4HGK3 | Leishmania braziliensis | 29% | 100% |
| A4I3M7 | Leishmania infantum | 91% | 100% |
| A4I3M8 | Leishmania infantum | 28% | 100% |
| A4I3M9 | Leishmania infantum | 34% | 100% |
| A4K526 | Bufo gargarizans | 33% | 100% |
| D0A7U8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 30% | 100% |
| D0A857 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 27% | 100% |
| E9AZW9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 100% |
| E9AZX0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 100% |
| Q4Q8B5 | Leishmania major | 33% | 100% |
| Q4Q8B6 | Leishmania major | 28% | 100% |
| Q4Q8B7 | Leishmania major | 91% | 100% |
| Q568J8 | Danio rerio | 36% | 100% |