Qa-SNARE protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Qa-SNARE protein

Gene product:

Qa-SNARE protein

Species:

Leishmania mexicana

UniProt:

E9AZW7_LEIMU

TriTrypDb:

LmxM.28.1470

Length:

344

Annotations

LeishMANIAdb annotations

Homologous to animal syntaxin proteins, involved in vesulcular fusion to membranes. Although most proteins appear to be membrane-embedded, some Lesihmaniid members are likely not.. For some reason, multiple copies are seen in Leptomonas

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	2
GO:0012505	endomembrane system	2	2
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2

Expansion

Sequence features

E9AZW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZW7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0016192	vesicle-mediated transport	4	13
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13
GO:0006886	intracellular protein transport	4	2
GO:0006887	exocytosis	4	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0022406	membrane docking	2	2
GO:0032940	secretion by cell	3	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046903	secretion	4	2
GO:0046907	intracellular transport	3	2
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2
GO:0140352	export from cell	2	2

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.586
CLV_C14_Caspase3-7	138	142	PF00656	0.416
CLV_C14_Caspase3-7	195	199	PF00656	0.480
CLV_C14_Caspase3-7	59	63	PF00656	0.475
CLV_NRD_NRD_1	294	296	PF00675	0.322
CLV_NRD_NRD_1	300	302	PF00675	0.331
CLV_PCSK_KEX2_1	294	296	PF00082	0.292
CLV_PCSK_SKI1_1	120	124	PF00082	0.358
CLV_PCSK_SKI1_1	188	192	PF00082	0.279
CLV_PCSK_SKI1_1	228	232	PF00082	0.289
CLV_PCSK_SKI1_1	287	291	PF00082	0.283
DEG_Nend_UBRbox_2	1	3	PF02207	0.590
DEG_SPOP_SBC_1	128	132	PF00917	0.444
DOC_CDC14_PxL_1	1	9	PF14671	0.551
DOC_CYCLIN_yClb1_LxF_4	255	261	PF00134	0.479
DOC_PP4_FxxP_1	46	49	PF00568	0.571
DOC_USP7_MATH_1	103	107	PF00917	0.395
DOC_USP7_MATH_1	197	201	PF00917	0.491
DOC_USP7_UBL2_3	298	302	PF12436	0.536
DOC_WW_Pin1_4	13	18	PF00397	0.601
DOC_WW_Pin1_4	22	27	PF00397	0.625
DOC_WW_Pin1_4	31	36	PF00397	0.664
LIG_14-3-3_CanoR_1	173	182	PF00244	0.505
LIG_Actin_WH2_2	122	139	PF00022	0.493
LIG_BRCT_BRCA1_1	220	224	PF00533	0.521
LIG_CaM_IQ_9	273	289	PF13499	0.516
LIG_FHA_1	131	137	PF00498	0.480
LIG_FHA_1	19	25	PF00498	0.764
LIG_FHA_1	278	284	PF00498	0.476
LIG_FHA_2	193	199	PF00498	0.511
LIG_FHA_2	235	241	PF00498	0.480
LIG_FHA_2	315	321	PF00498	0.420
LIG_FHA_2	93	99	PF00498	0.533
LIG_GBD_Chelix_1	160	168	PF00786	0.378
LIG_IBAR_NPY_1	311	313	PF08397	0.171
LIG_LIR_Gen_1	154	164	PF02991	0.558
LIG_LIR_Nem_3	154	160	PF02991	0.492
LIG_LIR_Nem_3	62	68	PF02991	0.384
LIG_PCNA_PIPBox_1	248	257	PF02747	0.521
LIG_PCNA_yPIPBox_3	263	272	PF02747	0.419
LIG_SH2_GRB2like	194	197	PF00017	0.480
LIG_SH2_NCK_1	194	198	PF00017	0.461
LIG_SH2_STAT3	171	174	PF00017	0.479
LIG_SH2_STAT3	182	185	PF00017	0.482
LIG_SH2_STAT5	194	197	PF00017	0.491
LIG_SH2_STAT5	282	285	PF00017	0.521
LIG_SH2_STAT5	313	316	PF00017	0.283
LIG_SH2_STAT5	321	324	PF00017	0.364
LIG_SH3_3	306	312	PF00018	0.254
LIG_SH3_3	328	334	PF00018	0.383
LIG_SUMO_SIM_par_1	20	25	PF11976	0.594
LIG_UBA3_1	254	263	PF00899	0.364
MOD_CDK_SPK_2	31	36	PF00069	0.578
MOD_CK1_1	112	118	PF00069	0.568
MOD_CK1_1	130	136	PF00069	0.522
MOD_CK1_1	25	31	PF00069	0.611
MOD_CK1_1	74	80	PF00069	0.580
MOD_CK2_1	173	179	PF00069	0.523
MOD_CK2_1	230	236	PF00069	0.578
MOD_CK2_1	31	37	PF00069	0.595
MOD_CK2_1	92	98	PF00069	0.552
MOD_GlcNHglycan	146	149	PF01048	0.376
MOD_GlcNHglycan	198	202	PF01048	0.321
MOD_GSK3_1	135	142	PF00069	0.516
MOD_GSK3_1	18	25	PF00069	0.672
MOD_GSK3_1	230	237	PF00069	0.578
MOD_GSK3_1	44	51	PF00069	0.556
MOD_N-GLC_1	216	221	PF02516	0.283
MOD_N-GLC_1	31	36	PF02516	0.507
MOD_NEK2_1	129	134	PF00069	0.400
MOD_NEK2_1	162	167	PF00069	0.444
MOD_PIKK_1	183	189	PF00454	0.532
MOD_PK_1	135	141	PF00069	0.498
MOD_PKA_2	112	118	PF00069	0.559
MOD_Plk_1	244	250	PF00069	0.480
MOD_Plk_1	314	320	PF00069	0.234
MOD_Plk_2-3	54	60	PF00069	0.490
MOD_Plk_4	219	225	PF00069	0.517
MOD_Plk_4	230	236	PF00069	0.494
MOD_ProDKin_1	13	19	PF00069	0.604
MOD_ProDKin_1	22	28	PF00069	0.624
MOD_ProDKin_1	31	37	PF00069	0.664
MOD_SUMO_rev_2	338	343	PF00179	0.326
TRG_DiLeu_BaEn_1	264	269	PF01217	0.539
TRG_ENDOCYTIC_2	157	160	PF00928	0.567
TRG_ENDOCYTIC_2	65	68	PF00928	0.384
TRG_ER_diArg_1	294	296	PF00400	0.552
TRG_ER_diArg_1	304	307	PF00400	0.406
TRG_NES_CRM1_1	156	170	PF08389	0.364
TRG_NLS_Bipartite_1	291	306	PF00514	0.505
TRG_NLS_MonoExtC_3	290	295	PF00514	0.488
TRG_NLS_MonoExtC_3	297	302	PF00514	0.488
TRG_NLS_MonoExtN_4	295	302	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JI44	Bodo saltans	24%	100%
A0A1X0NYQ5	Trypanosomatidae	51%	100%
A0A3Q8IDT6	Leishmania donovani	94%	100%
A0A3R7L4L2	Trypanosoma rangeli	46%	100%
A0A3S7X1I6	Leishmania donovani	91%	100%
A0A422NLX7	Trypanosoma rangeli	23%	100%
A4HGJ9	Leishmania braziliensis	82%	100%
A4HGK0	Leishmania braziliensis	78%	100%
A8WVD0	Caenorhabditis briggsae	29%	100%
D0A863	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AHG5	Leishmania infantum	91%	100%
O16000	Caenorhabditis elegans	29%	100%
O35526	Mus musculus	29%	100%
O64791	Arabidopsis thaliana	28%	100%
O75558	Homo sapiens	24%	100%
P32850	Bos taurus	30%	100%
P32851	Rattus norvegicus	29%	100%
P32856	Homo sapiens	29%	100%
P50279	Rattus norvegicus	28%	100%
P61264	Mus musculus	27%	100%
P61265	Rattus norvegicus	27%	100%
P61266	Homo sapiens	27%	100%
P61267	Bos taurus	27%	100%
P61268	Ovis aries	27%	100%
P70452	Mus musculus	26%	100%
Q00262	Mus musculus	27%	100%
Q08850	Rattus norvegicus	26%	100%
Q16623	Homo sapiens	29%	100%
Q16932	Aplysia californica	28%	100%
Q20024	Caenorhabditis elegans	22%	100%
Q24547	Drosophila melanogaster	28%	100%
Q3SWZ3	Bos taurus	25%	100%
Q42374	Arabidopsis thaliana	27%	100%
Q4Q8B8	Leishmania major	90%	100%
Q4Q8B9	Leishmania major	94%	100%
Q5R4L2	Pongo abelii	29%	100%
Q8VZU2	Arabidopsis thaliana	27%	100%
Q9SRV7	Arabidopsis thaliana	23%	100%
Q9SVC2	Arabidopsis thaliana	28%	100%
Q9SWH4	Arabidopsis thaliana	25%	100%
Q9SXB0	Arabidopsis thaliana	29%	100%
Q9USH7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	20%	100%
Q9ZQZ8	Arabidopsis thaliana	28%	100%
Q9ZSD4	Arabidopsis thaliana	29%	99%
V5B7Y5	Trypanosoma cruzi	50%	100%
V5BNX1	Trypanosoma cruzi	21%	100%