LeishMANIAdb
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Putative ATPase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATPase
Gene product:
Cell division control protein 48, putative
Species:
Leishmania mexicana
UniProt:
E9AZW6_LEIMU
TriTrypDb:
LmxM.28.1460
Length:
771

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZW6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZW6

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 1
GO:0051301 cell division 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 539 543 PF00656 0.577
CLV_C14_Caspase3-7 714 718 PF00656 0.572
CLV_MEL_PAP_1 90 96 PF00089 0.502
CLV_NRD_NRD_1 113 115 PF00675 0.518
CLV_NRD_NRD_1 141 143 PF00675 0.525
CLV_NRD_NRD_1 145 147 PF00675 0.510
CLV_NRD_NRD_1 156 158 PF00675 0.508
CLV_NRD_NRD_1 302 304 PF00675 0.517
CLV_NRD_NRD_1 401 403 PF00675 0.471
CLV_NRD_NRD_1 442 444 PF00675 0.439
CLV_NRD_NRD_1 495 497 PF00675 0.303
CLV_NRD_NRD_1 534 536 PF00675 0.660
CLV_NRD_NRD_1 617 619 PF00675 0.419
CLV_NRD_NRD_1 623 625 PF00675 0.403
CLV_NRD_NRD_1 675 677 PF00675 0.496
CLV_NRD_NRD_1 729 731 PF00675 0.574
CLV_NRD_NRD_1 737 739 PF00675 0.499
CLV_NRD_NRD_1 92 94 PF00675 0.509
CLV_PCSK_KEX2_1 113 115 PF00082 0.517
CLV_PCSK_KEX2_1 141 143 PF00082 0.525
CLV_PCSK_KEX2_1 145 147 PF00082 0.510
CLV_PCSK_KEX2_1 156 158 PF00082 0.503
CLV_PCSK_KEX2_1 302 304 PF00082 0.517
CLV_PCSK_KEX2_1 401 403 PF00082 0.471
CLV_PCSK_KEX2_1 428 430 PF00082 0.453
CLV_PCSK_KEX2_1 442 444 PF00082 0.361
CLV_PCSK_KEX2_1 495 497 PF00082 0.322
CLV_PCSK_KEX2_1 533 535 PF00082 0.650
CLV_PCSK_KEX2_1 623 625 PF00082 0.396
CLV_PCSK_KEX2_1 675 677 PF00082 0.496
CLV_PCSK_KEX2_1 731 733 PF00082 0.542
CLV_PCSK_KEX2_1 737 739 PF00082 0.524
CLV_PCSK_KEX2_1 92 94 PF00082 0.509
CLV_PCSK_PC1ET2_1 428 430 PF00082 0.518
CLV_PCSK_PC1ET2_1 731 733 PF00082 0.362
CLV_PCSK_PC7_1 141 147 PF00082 0.467
CLV_PCSK_PC7_1 438 444 PF00082 0.546
CLV_PCSK_SKI1_1 141 145 PF00082 0.539
CLV_PCSK_SKI1_1 146 150 PF00082 0.528
CLV_PCSK_SKI1_1 302 306 PF00082 0.416
CLV_PCSK_SKI1_1 429 433 PF00082 0.385
CLV_PCSK_SKI1_1 462 466 PF00082 0.279
CLV_PCSK_SKI1_1 666 670 PF00082 0.495
CLV_PCSK_SKI1_1 686 690 PF00082 0.427
CLV_PCSK_SKI1_1 738 742 PF00082 0.452
DEG_APCC_DBOX_1 17 25 PF00400 0.585
DEG_SCF_FBW7_2 172 179 PF00400 0.441
DEG_SPOP_SBC_1 208 212 PF00917 0.740
DEG_SPOP_SBC_1 388 392 PF00917 0.260
DOC_CDC14_PxL_1 479 487 PF14671 0.279
DOC_CKS1_1 294 299 PF01111 0.399
DOC_CYCLIN_yCln2_LP_2 593 599 PF00134 0.410
DOC_MAPK_gen_1 113 120 PF00069 0.449
DOC_MAPK_gen_1 262 271 PF00069 0.435
DOC_MAPK_gen_1 401 409 PF00069 0.474
DOC_MAPK_gen_1 445 454 PF00069 0.424
DOC_MAPK_gen_1 505 513 PF00069 0.279
DOC_MAPK_gen_1 600 610 PF00069 0.279
DOC_MAPK_gen_1 730 736 PF00069 0.409
DOC_MAPK_MEF2A_6 262 271 PF00069 0.259
DOC_MAPK_MEF2A_6 402 411 PF00069 0.481
DOC_MAPK_MEF2A_6 505 513 PF00069 0.279
DOC_PP2B_LxvP_1 322 325 PF13499 0.519
DOC_PP2B_LxvP_1 608 611 PF13499 0.422
DOC_PP4_FxxP_1 305 308 PF00568 0.484
DOC_SPAK_OSR1_1 443 447 PF12202 0.468
DOC_USP7_MATH_1 10 14 PF00917 0.714
DOC_USP7_MATH_1 133 137 PF00917 0.512
DOC_USP7_MATH_1 160 164 PF00917 0.596
DOC_USP7_MATH_1 355 359 PF00917 0.515
DOC_USP7_MATH_1 388 392 PF00917 0.468
DOC_USP7_MATH_1 536 540 PF00917 0.724
DOC_USP7_MATH_1 617 621 PF00917 0.391
DOC_USP7_UBL2_3 424 428 PF12436 0.477
DOC_WW_Pin1_4 100 105 PF00397 0.732
DOC_WW_Pin1_4 16 21 PF00397 0.498
DOC_WW_Pin1_4 172 177 PF00397 0.618
DOC_WW_Pin1_4 293 298 PF00397 0.443
DOC_WW_Pin1_4 353 358 PF00397 0.517
DOC_WW_Pin1_4 360 365 PF00397 0.603
DOC_WW_Pin1_4 505 510 PF00397 0.318
LIG_14-3-3_CanoR_1 113 121 PF00244 0.435
LIG_14-3-3_CanoR_1 213 221 PF00244 0.782
LIG_14-3-3_CanoR_1 230 235 PF00244 0.486
LIG_14-3-3_CanoR_1 265 270 PF00244 0.421
LIG_14-3-3_CanoR_1 359 363 PF00244 0.722
LIG_14-3-3_CanoR_1 401 409 PF00244 0.445
LIG_14-3-3_CanoR_1 42 47 PF00244 0.392
LIG_14-3-3_CanoR_1 429 434 PF00244 0.456
LIG_14-3-3_CanoR_1 562 571 PF00244 0.305
LIG_14-3-3_CanoR_1 618 622 PF00244 0.390
LIG_14-3-3_CanoR_1 686 692 PF00244 0.409
LIG_Actin_WH2_2 510 526 PF00022 0.410
LIG_Actin_WH2_2 586 602 PF00022 0.280
LIG_APCC_ABBAyCdc20_2 623 629 PF00400 0.445
LIG_BIR_II_1 1 5 PF00653 0.704
LIG_BRCT_BRCA1_1 402 406 PF00533 0.497
LIG_BRCT_BRCA1_1 509 513 PF00533 0.279
LIG_BRCT_BRCA1_1 676 680 PF00533 0.469
LIG_Clathr_ClatBox_1 183 187 PF01394 0.431
LIG_Clathr_ClatBox_1 511 515 PF01394 0.410
LIG_CtBP_PxDLS_1 662 666 PF00389 0.302
LIG_deltaCOP1_diTrp_1 629 633 PF00928 0.379
LIG_FHA_1 103 109 PF00498 0.735
LIG_FHA_1 113 119 PF00498 0.440
LIG_FHA_1 258 264 PF00498 0.517
LIG_FHA_1 271 277 PF00498 0.247
LIG_FHA_1 332 338 PF00498 0.390
LIG_FHA_1 41 47 PF00498 0.608
LIG_FHA_1 430 436 PF00498 0.493
LIG_FHA_1 448 454 PF00498 0.268
LIG_FHA_1 526 532 PF00498 0.357
LIG_FHA_1 586 592 PF00498 0.302
LIG_FHA_1 639 645 PF00498 0.617
LIG_FHA_1 739 745 PF00498 0.459
LIG_FHA_2 145 151 PF00498 0.491
LIG_FHA_2 294 300 PF00498 0.404
LIG_FHA_2 394 400 PF00498 0.499
LIG_FHA_2 410 416 PF00498 0.388
LIG_FHA_2 555 561 PF00498 0.355
LIG_FHA_2 604 610 PF00498 0.279
LIG_FHA_2 658 664 PF00498 0.499
LIG_GBD_Chelix_1 563 571 PF00786 0.322
LIG_LIR_Gen_1 241 251 PF02991 0.409
LIG_LIR_Gen_1 403 411 PF02991 0.437
LIG_LIR_Gen_1 412 421 PF02991 0.364
LIG_LIR_Gen_1 476 486 PF02991 0.279
LIG_LIR_Gen_1 578 587 PF02991 0.314
LIG_LIR_Nem_3 233 238 PF02991 0.479
LIG_LIR_Nem_3 241 246 PF02991 0.351
LIG_LIR_Nem_3 338 342 PF02991 0.408
LIG_LIR_Nem_3 403 409 PF02991 0.424
LIG_LIR_Nem_3 412 417 PF02991 0.377
LIG_LIR_Nem_3 439 444 PF02991 0.516
LIG_LIR_Nem_3 476 482 PF02991 0.279
LIG_LIR_Nem_3 499 503 PF02991 0.410
LIG_LIR_Nem_3 578 584 PF02991 0.314
LIG_LYPXL_S_1 234 238 PF13949 0.520
LIG_LYPXL_yS_3 235 238 PF13949 0.545
LIG_NRBOX 139 145 PF00104 0.550
LIG_NRBOX 27 33 PF00104 0.506
LIG_NRBOX 566 572 PF00104 0.322
LIG_NRBOX 603 609 PF00104 0.355
LIG_Pex14_2 688 692 PF04695 0.386
LIG_RPA_C_Fungi 557 569 PF08784 0.306
LIG_SH2_CRK 243 247 PF00017 0.397
LIG_SH2_CRK 339 343 PF00017 0.346
LIG_SH2_GRB2like 525 528 PF00017 0.355
LIG_SH2_SRC 37 40 PF00017 0.527
LIG_SH2_STAP1 290 294 PF00017 0.548
LIG_SH2_STAP1 525 529 PF00017 0.391
LIG_SH2_STAT5 192 195 PF00017 0.570
LIG_SH2_STAT5 199 202 PF00017 0.685
LIG_SH2_STAT5 243 246 PF00017 0.523
LIG_SH2_STAT5 287 290 PF00017 0.461
LIG_SH2_STAT5 352 355 PF00017 0.536
LIG_SH2_STAT5 389 392 PF00017 0.435
LIG_SH2_STAT5 500 503 PF00017 0.410
LIG_SH3_1 33 39 PF00018 0.515
LIG_SH3_3 117 123 PF00018 0.481
LIG_SH3_3 215 221 PF00018 0.756
LIG_SH3_3 289 295 PF00018 0.635
LIG_SH3_3 33 39 PF00018 0.622
LIG_SH3_3 607 613 PF00018 0.308
LIG_Sin3_3 758 765 PF02671 0.435
LIG_SUMO_SIM_anti_2 178 184 PF11976 0.456
LIG_SUMO_SIM_anti_2 757 764 PF11976 0.448
LIG_SUMO_SIM_par_1 181 187 PF11976 0.393
LIG_SUMO_SIM_par_1 25 30 PF11976 0.390
LIG_SxIP_EBH_1 113 127 PF03271 0.503
LIG_TYR_ITIM 337 342 PF00017 0.338
MOD_CDC14_SPxK_1 356 359 PF00782 0.488
MOD_CDK_SPxK_1 353 359 PF00069 0.456
MOD_CK1_1 358 364 PF00069 0.649
MOD_CK1_1 365 371 PF00069 0.661
MOD_CK1_1 391 397 PF00069 0.468
MOD_CK1_1 551 557 PF00069 0.590
MOD_CK1_1 639 645 PF00069 0.601
MOD_CK1_1 747 753 PF00069 0.605
MOD_CK2_1 16 22 PF00069 0.602
MOD_CK2_1 251 257 PF00069 0.533
MOD_CK2_1 293 299 PF00069 0.406
MOD_CK2_1 393 399 PF00069 0.522
MOD_CK2_1 603 609 PF00069 0.279
MOD_CK2_1 657 663 PF00069 0.515
MOD_CK2_1 678 684 PF00069 0.449
MOD_CK2_1 79 85 PF00069 0.630
MOD_CMANNOS 630 633 PF00535 0.377
MOD_GlcNHglycan 13 16 PF01048 0.713
MOD_GlcNHglycan 158 161 PF01048 0.521
MOD_GlcNHglycan 164 167 PF01048 0.608
MOD_GlcNHglycan 204 207 PF01048 0.748
MOD_GlcNHglycan 226 229 PF01048 0.629
MOD_GlcNHglycan 365 368 PF01048 0.630
MOD_GlcNHglycan 391 394 PF01048 0.387
MOD_GlcNHglycan 402 405 PF01048 0.428
MOD_GlcNHglycan 538 541 PF01048 0.599
MOD_GlcNHglycan 542 545 PF01048 0.576
MOD_GlcNHglycan 550 553 PF01048 0.532
MOD_GlcNHglycan 680 683 PF01048 0.415
MOD_GlcNHglycan 746 749 PF01048 0.592
MOD_GlcNHglycan 94 97 PF01048 0.632
MOD_GSK3_1 112 119 PF00069 0.571
MOD_GSK3_1 156 163 PF00069 0.569
MOD_GSK3_1 168 175 PF00069 0.636
MOD_GSK3_1 204 211 PF00069 0.677
MOD_GSK3_1 219 226 PF00069 0.491
MOD_GSK3_1 241 248 PF00069 0.550
MOD_GSK3_1 331 338 PF00069 0.459
MOD_GSK3_1 358 365 PF00069 0.721
MOD_GSK3_1 387 394 PF00069 0.454
MOD_GSK3_1 50 57 PF00069 0.523
MOD_GSK3_1 536 543 PF00069 0.649
MOD_GSK3_1 548 555 PF00069 0.682
MOD_GSK3_1 638 645 PF00069 0.621
MOD_GSK3_1 674 681 PF00069 0.385
MOD_GSK3_1 743 750 PF00069 0.519
MOD_GSK3_1 92 99 PF00069 0.637
MOD_LATS_1 40 46 PF00433 0.425
MOD_N-GLC_1 473 478 PF02516 0.279
MOD_N-GLC_1 686 691 PF02516 0.427
MOD_N-GLC_2 162 164 PF02516 0.416
MOD_N-GLC_2 68 70 PF02516 0.475
MOD_NEK2_1 144 149 PF00069 0.597
MOD_NEK2_1 27 32 PF00069 0.498
MOD_NEK2_1 473 478 PF00069 0.279
MOD_NEK2_1 716 721 PF00069 0.580
MOD_NEK2_1 743 748 PF00069 0.567
MOD_PIKK_1 251 257 PF00454 0.477
MOD_PIKK_1 657 663 PF00454 0.693
MOD_PK_1 265 271 PF00069 0.475
MOD_PK_1 42 48 PF00069 0.398
MOD_PKA_1 156 162 PF00069 0.468
MOD_PKA_1 92 98 PF00069 0.505
MOD_PKA_2 112 118 PF00069 0.514
MOD_PKA_2 144 150 PF00069 0.495
MOD_PKA_2 156 162 PF00069 0.580
MOD_PKA_2 212 218 PF00069 0.735
MOD_PKA_2 358 364 PF00069 0.590
MOD_PKA_2 4 10 PF00069 0.542
MOD_PKA_2 400 406 PF00069 0.411
MOD_PKA_2 41 47 PF00069 0.351
MOD_PKA_2 437 443 PF00069 0.488
MOD_PKA_2 446 452 PF00069 0.379
MOD_PKA_2 536 542 PF00069 0.684
MOD_PKA_2 617 623 PF00069 0.389
MOD_PKA_2 636 642 PF00069 0.538
MOD_PKA_2 674 680 PF00069 0.489
MOD_PKA_2 92 98 PF00069 0.594
MOD_PKB_1 445 453 PF00069 0.429
MOD_PKB_1 505 513 PF00069 0.279
MOD_PKB_1 533 541 PF00069 0.736
MOD_Plk_1 473 479 PF00069 0.279
MOD_Plk_1 639 645 PF00069 0.449
MOD_Plk_1 686 692 PF00069 0.421
MOD_Plk_4 116 122 PF00069 0.612
MOD_Plk_4 230 236 PF00069 0.624
MOD_Plk_4 241 247 PF00069 0.415
MOD_Plk_4 27 33 PF00069 0.445
MOD_Plk_4 42 48 PF00069 0.369
MOD_Plk_4 460 466 PF00069 0.279
MOD_Plk_4 473 479 PF00069 0.279
MOD_Plk_4 507 513 PF00069 0.279
MOD_Plk_4 603 609 PF00069 0.279
MOD_Plk_4 617 623 PF00069 0.370
MOD_Plk_4 639 645 PF00069 0.669
MOD_Plk_4 687 693 PF00069 0.469
MOD_ProDKin_1 100 106 PF00069 0.732
MOD_ProDKin_1 16 22 PF00069 0.491
MOD_ProDKin_1 172 178 PF00069 0.606
MOD_ProDKin_1 293 299 PF00069 0.442
MOD_ProDKin_1 353 359 PF00069 0.529
MOD_ProDKin_1 360 366 PF00069 0.606
MOD_ProDKin_1 505 511 PF00069 0.318
TRG_DiLeu_BaEn_1 179 184 PF01217 0.495
TRG_DiLeu_BaEn_1 22 27 PF01217 0.447
TRG_DiLeu_BaEn_1 757 762 PF01217 0.267
TRG_DiLeu_BaLyEn_6 139 144 PF01217 0.553
TRG_DiLeu_BaLyEn_6 426 431 PF01217 0.439
TRG_DiLeu_BaLyEn_6 566 571 PF01217 0.391
TRG_DiLeu_BaLyEn_6 593 598 PF01217 0.410
TRG_ENDOCYTIC_2 235 238 PF00928 0.564
TRG_ENDOCYTIC_2 243 246 PF00928 0.391
TRG_ENDOCYTIC_2 339 342 PF00928 0.375
TRG_ENDOCYTIC_2 441 444 PF00928 0.452
TRG_ENDOCYTIC_2 479 482 PF00928 0.279
TRG_ENDOCYTIC_2 500 503 PF00928 0.410
TRG_ER_diArg_1 140 142 PF00400 0.521
TRG_ER_diArg_1 144 146 PF00400 0.475
TRG_ER_diArg_1 155 157 PF00400 0.483
TRG_ER_diArg_1 283 286 PF00400 0.563
TRG_ER_diArg_1 400 402 PF00400 0.457
TRG_ER_diArg_1 435 438 PF00400 0.474
TRG_ER_diArg_1 441 443 PF00400 0.421
TRG_ER_diArg_1 444 447 PF00400 0.429
TRG_ER_diArg_1 495 497 PF00400 0.320
TRG_ER_diArg_1 533 535 PF00400 0.713
TRG_ER_diArg_1 622 624 PF00400 0.534
TRG_ER_diArg_1 674 676 PF00400 0.501
TRG_ER_diArg_1 736 738 PF00400 0.557
TRG_ER_diArg_1 91 93 PF00400 0.504
TRG_ER_diLys_1 767 771 PF00400 0.500
TRG_NES_CRM1_1 695 709 PF08389 0.437
TRG_Pf-PMV_PEXEL_1 146 150 PF00026 0.356
TRG_Pf-PMV_PEXEL_1 429 433 PF00026 0.280
TRG_Pf-PMV_PEXEL_1 495 499 PF00026 0.322

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9Q8 Leptomonas seymouri 54% 100%
A0A1X0NZ99 Trypanosomatidae 42% 100%
A0A3Q8II41 Leishmania donovani 90% 100%
A0A422MTD5 Trypanosoma rangeli 41% 100%
A4HGJ8 Leishmania braziliensis 77% 100%
A4I3M5 Leishmania infantum 90% 100%
D0A856 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
Q4Q8C0 Leishmania major 90% 100%
V5BCT3 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS